You have accessJournal of UrologySexual Function/Dysfunction: Surgical Therapy I (PD20)1 Apr 2020PD20-04 CONTINUATION OF BASELINE ANTITHROMBOTIC THERAPY IN MEN UNDERGOING INFLATABLE PENILE PROSTHESIS SURGERY: AN UPDATE ON OUTCOMES Kevin Hebert*, David Yang, Matthew Ziegelmann, Jack Andrews, Madeleine Manka, Kevin Wymer, Matthew Houlihan, Masaya Jimbo, Ross Avant, Zachary Pfeifer, Landon Trost, and Tobias Kohler Kevin Hebert*Kevin Hebert* More articles by this author , David YangDavid Yang More articles by this author , Matthew ZiegelmannMatthew Ziegelmann More articles by this author , Jack AndrewsJack Andrews More articles by this author , Madeleine MankaMadeleine Manka More articles by this author , Kevin WymerKevin Wymer More articles by this author , Matthew HoulihanMatthew Houlihan More articles by this author , Masaya JimboMasaya Jimbo More articles by this author , Ross AvantRoss Avant More articles by this author , Zachary PfeiferZachary Pfeifer More articles by this author , Landon TrostLandon Trost More articles by this author , and Tobias KohlerTobias Kohler More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000870.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Patients with erectile dysfunction frequently have cardiovascular/cerebrovascular risk factors requiring antithrombotics (anticoagulation/antiplatelets). Limited data are available on perioperative morbidity associated with discontinuation and continuation of antithrombotics at time of IPP surgery. We sought to identify the incidence of postoperative cardiovascular and cerebrovascular events in patients holding antithrombotics at time of IPP surgery while assessing risk of postoperative morbidity in men continuing antithrombotics. METHODS: We reviewed a prospectively collected database of men undergoing IPP surgery at our institution. Statistical analysis was performed to evaluate differences in scrotal drain output, hematoma formation, and postoperative morbidity among patients who continued versus held antithrombotics. RESULTS: 219 patients, median 66 years (IQR 59,72) underwent IPP surgery between July 2017 and June 2019. 118 patients (54%) reported baseline antithrombotic use. 77 of 118 patients (65%) continued antithrombotics through IPP surgery (aspirin 81mg, n=62; aspirin 325mg, n=7; clopidogrel, n=4; apixaban, n=4; warfarin, n=9; rivaroxaban, n=1; and combination therapy, n=8). On univariate analysis, no statistically significant difference (p=0.2) in median postoperative day zero drain output was identified between men continuing antithrombotics versus those not on antithrombotics at surgery, 85 mL (IQR 40, 123) vs 85 mL (IQR 59, 125), respectively. A statistically significant difference in self-resolving hematoma rates were seen in those continuing antithrombotics, 6 of 72 (8%), versus those not on antithrombotics, 3 of 135 (2%), p=0.04. 41 of 118 patients (35%) held antithrombotics with 3 of 41 (7%) experiencing a postoperative cardiovascular or cerebrovascular event. No patients continuing antithrombotic therapy (n=77) through the perioperative period experienced a cardiovascular or cerebrovascular event. CONCLUSIONS: In a small operative series, continuing antithrombotics at the time of IPP surgery increased the rate of postoperative self-resolving hematomas compared to those not on antithrombotics, however holding antithrombotics is not without risk of perioperative cerebrovascular and cardiac events. This data suggests judicious consideration of continuing antithrombotics at the time of IPP surgery and require further validation. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e448-e448 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kevin Hebert* More articles by this author David Yang More articles by this author Matthew Ziegelmann More articles by this author Jack Andrews More articles by this author Madeleine Manka More articles by this author Kevin Wymer More articles by this author Matthew Houlihan More articles by this author Masaya Jimbo More articles by this author Ross Avant More articles by this author Zachary Pfeifer More articles by this author Landon Trost More articles by this author Tobias Kohler More articles by this author Expand All Advertisement PDF downloadLoading ...