Period Of Previous Year Research Articles

Impact of a pulmonary embolism response team initiative on hospital mortality of patients with bilateral pulmonary embolism

IntroductionPulmonary embolism (PE) response teams (PERT) for the management of high-risk PE (HR-PE) and intermediate-high risk PE (IHR-PE) are encouraged in PE guidelines. We aimed to assess the impact of a PERT initiative on mortality in these groups of patients, compared with standard care. MethodsWe conducted a prospective, single-center registry, including consecutive patients with HR-PE and IHR-PE with PERT activation from February-2018 to December-2020 (PERT group, n=78 patients) and compared it with an historic cohort of patients admitted to our hospital in a previous 2-year period (2014–2016), managed with standard of care (SC-group, n=108 patients). ResultsPatients in the PERT group were younger and less comorbid. The risk profile at admission and the percentage of HR-PE was similar in both cohorts (13% in SC-group and 14% in PERT-group, p=0.82). Reperfusion therapy was more frequently indicated in PERT-group (24.4% vs 10.2%, p=0.01), with no differences in fibrinolysis treatment, while catheter-directed therapy (CDT) was more frequent in PERT group (16.7% vs 1.9%, p<0.001). Reperfusion and CDT were associated with lower in-hospital mortality (2.9% vs 15.1%, p=0.001 for reperfusion and 1.5% vs 16.5%, p=0.001 for CDT). The primary outcome, 12-month mortality, was lower in the PERT-group (9% vs 22.2%, p=0.02), There were no differences in 30-day readmissions. In multivariate analysis PERT activation was associated with lower mortality at 12 months (HR 0.25, 95% confidence interval 0.09–0.7, p=0.008). ConclusionA PERT initiative in patients with HR-PE and IHR-PE was associated with a significant reduction in 12-month mortality compared with standard of care, and also with an increase in the use of reperfusion, especially catheter-directed therapies.

Prevalence and Predictors of Seasonal Influenza Vaccine Uptake in Saudi Arabia Post COVID-19: A Web-Based Online Cross-Sectional Study.

In the fall of 2022, the number of influenza-like illnesses (ILIs) and severe acute respiratory infections (SARIs) in Saudi Arabia had significantly increased compared with the corresponding period in previous years. Concerns regarding the population's seasonal influenza vaccine (SIV) uptake rates have emerged. In particular, the SIV uptake rates may have dropped post the COVID-19 pandemic compared with rates prior to the COVID-19 era. In this study, we aimed to estimate the prevalence and predictors of SIV uptake in Saudi Arabia post the COVID-19 pandemic. We conducted a cross-sectional study utilizing an online survey platform. We mainly collected sociodemographic information and determined whether the respondent was a healthcare professional or had a chronic disease. The overall SIV uptake prevalence was 31.8%. A lower SIV uptake was observed among those aged 55 years or older, females, residents of the central region, non-health practitioners, and those without chronic diseases. Several factors were associated with SIV uptake. Those aged 35-44 were over three-fold more likely to receive an SIV than those aged 55 years or older (OR: 3.66; 95% CI: 1.33-10.05). In addition, males had 73% higher odds of SIV uptake than females (OR: 1.73; 95% CI: 1.18-2.55). Health practitioners were more likely to receive an SIV than non-health practitioners (OR: 2.11; 95% CI: 1.45-3.06). Similarly, those with chronic diseases had 86% higher odds of SIV uptake than those without chronic diseases (OR: 1.86; 95% CI: 1.18-2.95). These findings can provide insights into the low prevalence and predictors of SIV uptake in Saudi Arabia. Future studies should be conducted to further explore the potential factors associated with such a low prevalence of SIV uptake post COVID-19 in Saudi Arabia.

The Impact of Coronavirus Disease of 2019 (COVID-19) Lockdown Restrictions on the Criteria Pollutants

Air pollution is accountable for various long-term and short-term respiratory diseases and even deaths. Air pollution is normally associated with a decreasing life expectancy. Governments have been implementing strategies to improve air quality. However, natural events have always played an important role in the concentration of air pollutants. In Australia, the lockdown period followed the Black Summer of 2019–2020 and coincided with the season of prescribed burns. This paper investigates the changes in the concentration of criteria pollutants such as particulate matter, nitrogen dioxide, ozone, and sulphur dioxide. The air quality data for the lockdown period in 2020 was compared with the pre-lockdown period in 2020 and with corresponding periods of previous years from 2016 to 2019. The results were also compared with the post-lockdown scenario of 2020 and 2021 to understand how the concentration levels changed due to behavioural changes and a lack of background events. The results revealed that the COVID-19 restrictions had some impact on the concentration of pollutants; however, the location of monitoring stations played an important role.

Impact of Coronavirus Disease 2019-Related Infection Prevention and Control Measures on the Occurrence of COPD Exacerbations During Inpatient Pulmonary Rehabilitation.

A significant reduction in hospitalizations for acute exacerbations of COPD (AECOPDs) has been reported during the coronavirus disease 2019 (COVID-19) pandemic. It remains unclear whether this reduction is the result of health care avoidance by patients, or of infection prevention and control (IPC) measures. Our objective was to explore the impact of COVID-19-related IPC measures on the occurrence of AECOPD in a real-life inpatient pulmonary rehabilitation (PR) setting, thereby ruling out potential effects of health care avoidance. Patients with COPD admitted for 8 weeks of inpatient PR at Ciro (Horn, the Netherlands) between October 2020 and March 2021, the first winter with full COVID-19-related IPC measures,were compared to patients admitted during the same period in previous years (2017-2018, 2018-2019, and 2019-2020). Electronic medical records were retrospectively screened for the occurrence of moderate to severe AECOPDs, drop-out, and mortality. A total of 501 patients with COPD (median age 66.6 [interquartile range (IQR) 60.3-71.9] years, 43.1% male, forced expiratory volume in 1 second [FEV1] 35.9 [26.8-50.6] % predicted) were analyzed. During 2020-2021, 22 patients (31.0%) experienced ≥1 AECOPD compared to 43 patients (33.6%) in 2019-2020, 55 patients (36.9%) in 2018-2019, and 83 patients (54.2%) in 2017-2018. This represents a 25.4% reduction in 2020-2021 compared to the average of the previous 3 periods, p=0.077. No differences in AECOPD severity, drop-out, or mortality were observed. COVID-19-related IPC measures did not significantly reduce the AECOPD rate during inpatient PR in a single-center setting. The current findings suggest that avoidance of health care may be an important factor in the observed reduction of AECOPD-related hospitalizations during the pandemic and that the value of the strict COVID-19-related IPC measures for the prevention of AECOPDs warrants further research.

Аномальное снижение уровня сейсмического шума в ПетропАвловске-Камчатском в апреле 2020 года

Estimation of the influence of anthropogenic factors on the seismic signal is an important problem in ensuring the quality of seismological data and, accordingly, the quality of scientific research. Due to the unprecedented situation associated with the introduction of measures to prevent the spread of COVID-19, non-working days were established in Russia from April 4 to April 30, 2020. It became possible to assess the impact of a notable decrease in anthropogenic activity on the seismic signal (noise) recorded by seismic instruments in the territory of the largest city of the Kamchatka, Petropavlovsk-Kamchatsky. We study seismic noise by standard technique, based on the analysis of the probability density function of the noise power spectral density obtained from the data of the digital archive of the noise spectra of seismic stations. A decrease in the seismic noise power level below the minimum values of the same periods of previous years was registered at stations installed in schools, residential buildings (boarding schools) or near public and office buildings. The minimal anthropogenic influence stations were selected. The obtained data can be used for determination the features of the work of both stations and individual channels, taking into account their direction and position, relative to the objects of human activity.

Analysis of COVID-19 Lockdown Effects on Urban Air Quality: A Case Study of Monterrey, Mexico

The COVID-19 pandemic has caused several millions of deaths and forced the world population to a new normality. This study aims to analyze the air quality variation of several gaseous pollutants (CO, NO2, SO2, O3, PM10, and PM2.5) during the pre-lockdown, lockdown, and unlock period in the city of Monterrey using ground-based measurements. In this research, we proposed to use a control period of previous years to identify parameter variation due to local climate. The results showed a drastic decrease in measured contaminants during the lockdown period as follows: SO2 (−41.9%) &gt; PM10 (−30.5%) &gt; PM2.5 (−25.6%) &gt; NO2 (−14.9%) &gt; CO (−9.8%) compared to the control period (2017–2019). The O3 was the only air pollutant that showed an opposite trend, increasing during lockdown (+15%) and unlock (+2.2%), whereas CO (−16.6%) and NO2 (−30.6%) were further decreased. Moreover, using OMI/AURA satellite data, we detected a NO2 tropospheric column reduction by −1.9% during lockdown concerning the same period in the control interval. Moreover, we found a significant improvement in the Air Quality Index (AQI) due to the lockdown. Our findings indicate an association between air pollutants and economic activity and can be used in future strategies to improve urban air quality.

Exploring the drop in flu cases during the 2020–2021 season: The Italian case study

To explore the 2020-2021 influenza season by describing the case of Italy. FluNet was searched for Italian data on virological samples. French, German, and Spanish data were collected for comparison. InfluNet was used for Italian epidemiological data on influenza-like illness (ILI). Data were extracted for the period from the 42nd week of 2020 to the 16th week of 2021 and for the previous 5-year period. The Containment and Health Index were used to describe the containment measures. Among 6818 samples, 0% were positive in Italy in the 2020-2021 season (28.8% in the previous 5-year period; the percentage change in the total number of tested specimens was -51.3%). In France, Germany, and Spain, the percentage change was -23%, -7%, and -61%, respectively. The Italian ILI incidence remained below the baseline levels (mean 0.0144/100,000 inhabitants; range 0.0085-0.0204). In the previous 5-year period, the mean incidence was 0.041/100,000 inhabitants. With the increase in containment measures, a deflection of ILI incidence was described (P=.015). Despite the reduced number of collected specimens compared to previous seasons and a slight rise in influenza vaccination rates, containment measures represent the most likely factor that helped to reduce cases in the 2020-2021 influenza season in Italy.

Population-scale COVID-19 curfew effects on urban black carbon concentrations and sources in Kigali, Rwanda

COVID-19 lockdowns enabled researchers to examine air quality in response to economic shifts. However, sub-Saharan African studies are limited, and lockdowns in tropical countries coincided with the wet season. We provide the first record of variations (including diurnal change, daytime and nighttime curfew) in concentrations of black carbon related to fossil fuel burning (BCff) and biomass burning (BCbb) for 2020, focused on three periods: before lockdown (P1: February 8–March 21), lockdown (P2: March 22–May 3), and after lockdown (P3: May 04–June 14) in 2020, with the same periods in 2018 and 2019 used as a control. The annual average BC concentration in Kigali City was 7.8 μg/m3 in 2020. During curfew hours, BCff was reduced by 59% between P2 and P3 (not observed in previous years), which indicates that the lockdown improved transport-related air pollution in Kigali only during curfew hours. No significant change was observed in BCbb concentrations. When COVID-19 restrictions were lifted, black carbon exceeded the same period in previous years. There is evidence for a link between the decline in Rwanda's vehicle use and a reduction in BCff, suggesting that air pollution in African cities could be reduced by promoting sustainable transportation.

An Epidemic of Acute Hepatitis of Unknown Etiology in Children

An Epidemic of Acute Hepatitis of Unknown Etiology in Children

The impact of COVID-19 in patients with severe aortic stenosis: Artificial intelligence research

IntroductionUntreated, severe, symptomatic aortic stenosis is associated with an ominous diagnosis without intervention. This study aims to determine the impact of the COVID-19 pandemic on the mortality of patients with severe stenosis during the first wave and compare it with the same period last year. MethodsAll patients who went to the hospitals in a spanish region during the first wave, and in the same period of previous year, were analysed using Artificial Intelligence-based software, evaluating the mortality of patients with severe aortic stenosis with and without COVID-19 during the pandemic and the pre-COVID era. Mortality of the three groups were compared. Regarding cardiac surgeries was a tendency to decrease (p = .07) in patients without COVID-19 between the pandemic and the previous period was observed. A significant decrease of surgeries between patients with COVID-19 and without COVID-19 was shown. ResultsData showed 13.82% less admitted patients during the first wave. 1112 of them, had aortic stenosis and 5.48% were COVID-19 positive. Mortality was higher (p = .01), in COVID-19 negative during the pandemic (4.37%) versus those in the pre-COVID19 era (2.57%); it was also in the COVID-19 positive group (11.47%), versus covid-19 negative (4.37%) during the first wave (p = .01). ConclusionsThe study revealed a decrease in patients who went to the hospital and an excess of mortality in patients with severe AD without infection during the first wave, compared to the same period last year; and also, in COVID-19 positive patients versus COVID-19 negative.

Impact of the COVID-19 pandemic on percutaneous coronary interventions in Portugal

IntroductionThe COVID-19 pandemic has imposed an unprecedented burden on healthcare systems worldwide, changing the profile of interventional cardiology activity. ObjectivesTo quantify and compare the number of percutaneous coronary interventions (PCIs) performed for acute and chronic coronary syndromes during the first COVID-19 outbreak with the corresponding period in previous years. MethodsData on PCI from the prospective multicenter Portuguese Registry on Interventional Cardiology (RNCI) were used to analyze changes in PCI for ST-elevation myocardial infarction (STEMI), non-ST-elevation acute coronary syndromes (NSTE-ACS) and chronic coronary syndromes (CCS). The number of PCIs performed during the initial period of the COVID-19 outbreak in Portugal, from March 1 to May 2, 2020, was compared with the mean frequency of PCIs performed during the corresponding period in the previous three years (2017–2019). ResultsThe total number of PCIs procedures was significantly decreased during the initial COVID-19 outbreak in Portugal (−36%, p<0.001). The reduction in PCI procedures for STEMI, NSTE-ACS and CCS was, respectively, −25% (p<0.019), −20% (p<0.068) and −59% (p<0.001). ConclusionsCompared with the corresponding period in the previous three years, the number of PCI procedures performed for STEMI and CCS decreased markedly during the first wave of the COVID-19 pandemic in Portugal.

Regional Differences in Kawasaki Disease Incidence Reduction Before and After the Onset of the Coronavirus Disease 2019 Pandemic

ObjectiveTo assess regional differences in reduction of the incidence of Kawasaki disease during the mitigation period for the coronavirus disease 2019 pandemic, with a hypothesis that more sparsely populated regions have fewer opportunities for human-to-human contact, resulting in a greater reduction in the incidence of Kawasaki disease.Study designA retrospective ecological study was conducted using data from patients hospitalized for Kawasaki disease as well as infectious diseases surveillance reports in Shiga Prefecture, Japan, during 2015-2020. We defined the periods before and after the onset of pandemic as January 2015-March 2020 and as April 2020-December 2020, respectively. We compared the reductions in the incidence of Kawasaki disease among 6 administrative regions in the prefecture according to the density of the populations.ResultsA total of 1290 patients with Kawasaki disease were identified. The incidence of Kawasaki disease (per 100 000 person-years) was significantly reduced after the coronavirus disease 2019 pandemic onset (period before pandemic onset, 105.6 [95% CI 99.8-111.8]; period after pandemic onset, 68.6 [95% CI 56.7-83.0]). During the period after pandemic onset, the incidence of Kawasaki disease was significantly reduced in May, compared with the corresponding period in previous years. The number of patients aged 2-4 years was significantly reduced after the pandemic onset. Notably, greater reductions in the incidence of Kawasaki disease were found in regions with lower population densities.ConclusionsAssuming that there were fewer opportunities for human-to-human contact in more sparsely populated regions during the pandemic mitigation period, our findings support the hypothesis that human-to-human contact may be associated with development of Kawasaki disease.

Covid-19 pandemic impacts on follow-up of child growth and development.

ABSTRACTOBJECTIVE To analyze the impact of the covid-19 pandemic on the use of primary health care services to follow-up the child growth and development in Brazil.METHOD A total of 7.9 million consultations of children (0–2 years old) across Brazil between March 2017 and May 2020 were studied. Differences between medians were analyzed using non-parametric tests, the Global Moran Index (IGM) and the Local Indicators of Spatial Association.RESULTS During the initial period of the pandemic, the median number of consultations was significantly lower than the same period in previous years, reducing more than 50%. The drop in 2020, compared to 2019, ranged from 49% to 62.2% across all regions of the country, except the South. The percentage reduction registered in 2019–2020 showed significant spatial autocorrelation (IGM = 0.20; p = 0.04), with the presence of low-low (states with reduction between 29% and 51%) and high-high (states with reduction between 55% and 69%) spatial clusters.CONCLUSION The covid-19 pandemic impacted the follow-up of child growth and development in primary health care services in Brazil, with a geographically uneven reduction.

Promising role for pleural vent in pneumothorax following CT-guided biopsy of lung lesions.

To evaluate the safety, effectiveness and cost-benefit of ambulatory pleural vent compared to conventional chest drain for pneumothorax following CT-guided biopsy of lung lesions (CTGB). We retrospectively analysed electronic hospital records of patients requiring intervention for pneumothorax following CTGB. All patients treated with pleural vent over a 2-year period (August 2017-July 2019) were included and compared to a control group of all patients treated with chest drain over a previous 2-year period (August 2014-July 2016). Patients managed with a pleural vent had a shorter length of hospital stay compared to the chest drain group (median 0 days vs 4.5 days, p < 0.01). The mean cost of follow-up in the pleural vent group was £530.36 per patient compared to a mean of £2699.38 per patient in the chest drain group (p-value < 0.01). Pleural vent can be a safe and effective alternative to conventional chest drain for the management of CTGB-related pneumothorax which allows patients to be managed on an outpatient basis with reduced hospital stays and lower associated healthcare costs. To the best of our knowledge, this is the first study demonstrating the safety and effectiveness of pleural vent for CTGB-related pneumothorax.

An improved data-driven methodology and field-test verification of yaw misalignment calibration on wind turbines

Yaw misalignment is being gradually recognized as a critical aspect for repowering aged wind turbines. For large-scale wind farms, the detection and calibration of yaw misalignment need to balance the relationship among accuracy, efficiency, and cost. This paper presents a data-driven yaw misalignment calibration method, and implements the field test with slight hardware modification. The specific procedures, including data preprocessing, regionalization and inference are listed step by step, which sustain the calibration direction and value of yaw misalignment calibration. Then, the historical data are extracted from system database of six adjacent commercial 2 MW wind turbines, and the proposed data-driven calibration method is applied, where the nacelle-mounted LiDAR is also introduced for auxiliary calibration and comparison. Field verification is implemented in these six wind turbines, through implementing pre-defined yaw offsets. The performance evaluations are conducted from different aspects, and compared with the same period of previous year. Consistent results show that both power production and yaw control accuracy are improved significantly, while the data-driven calibration method is with the same direction and acceptable deviation as the LiDAR. Hence, the proposed yaw misalignment calibration could be considered a propagable repowering technique with advantages of low cost, high efficiency, and acceptable accuracy.

What causes the great green tide disaster in the South Yellow Sea of China in 2021?

The largest green tide in the South Yellow Sea (SYS) of China broke out in 2021 since the first outbreak in 2007. What causes the great outbreak has caused widespread concern. In this study, we monitor the green tide in the SYS in 2021 using Normalized Difference Vegetation Index and Google Earth Engine and then identify the main controlling factors from environmental change and human activity. In terms of human activity, Pyropia yezoensis (P. yezoensis) cultivation in Northern Jiangsu shoal of China has an impact on the scale of green tide. Compared with the same period in previous years, the early recycling of P. yezoensis cultivation rafts in 2021 provided more floating seed for green tide. The human activity intensity index in coastal cities in Jiangsu and Shandong provinces of China has been increasing for the past nine years, leading to large amounts of nutrients being released into seawater, providing green tide with the nutrients needed for growth. From the perspective of environmental changes, the sea surface temperature was higher in June and July in the SYS, which was favorable for green tide growth. The abundant solar radiation in May and July is conducive to photosynthesis of Ulva prolifera. The lower photosynthetically active radiation in August is conducive to reduce the effect of photoinhibition and promote algal growth. These findings are useful for further understanding the rules of green tide outbreaks and controlling green tide disasters.

Effect of COVID-19 Response Policy on Air Quality: A Study in South China Context

Mass suspension of anthropogenic activities is extremely rare, the quarantine due to the coronavirus disease 2019 (COVID-19) represents a natural experiment to investigate the impact of anthropogenic activities on air quality. The mitigation of air pollution during the COVID-19 lockdown has been reported from a global perspective; however, the air pollution levels vary in different regions. This study initiated a novel synthesis of multiple-year satellite observations, national ground measurements towards SO2, NO2 and O3 and meteorological conditions to evaluate the impact of the COVID-19 lockdown in Beihai, a specific city in a less developed area in southwest China, to reveal the potential implications of control strategies for air pollution. The levels of the major air pollutants during the COVID-19 lockdown (LP) and during the same period of previous years (SP) were compared and a series of statistical tools were applied to analyze the sources of air pollution in Beihai. The results show that air pollutant levels decreased with substantial diversity during the LP. Satellite-retrieved NO2 and SO2 levels during the LP decreased by 5.26% and 22.06%, while NO2, SO2, PM2.5 and PM10 from ground measurements during the LP were 25.6%, 2.7%, 22.2% and 22.2% lower than during SP, respectively. Ground measured SO2 concentrations during the LP were only 2.7% lower than during the SP, which may be attributed to uninterrupted essential industrial activities, such as power plants. Polar plots analysis shows that NO2 concentrations were strongly associated with local emission sources, such as automobiles and local industry. Additionally, the much lower levels of NO2 concentrations during the LP and the absence of an evening peak may highlight the significant impact of the traffic sector on NO2. The decrease in daily mean O3 concentrations during the LP may be associated with the reduction in NO2 concentrations. Indications in this study could be beneficial for the formulation of atmospheric protection policies.

MO1039: 1-Year Follow-Up Data of Arterial Abnormalities Identified in Kidneys Transplanted into Children During the First Covid-19 Pandemic Wave

BACKGROUND AND AIMSGraft artery stenosis can have a significant short- and long-term negative impact on kidney graft function. We previously reported an unusual number of graft-arterial anomalies following kidney transplantation (KTx) in children during the first coronavirus disease (COVID-19) pandemic wave (Berteloot et al.) [1]. We report herein the 1-year follow-up of these patients.METHODIn this retrospective study, we included all children who received a KTx at our centre from February to July 2020. We compared their outcome to that of paediatric recipients who were transplanted at our centre from 2015 to 2019 and presented an allograft vascular complication (‘Historic’ group) by querying our local data warehouse.RESULTSAmong the 9 children who received a KTx at our centre between February and July 2020 [8 boys, median age 10 years (3–17)], 8 presented Doppler features suggesting arterial stenosis, with an unusual extensive pattern (Figure 1) after a median delay of 13 days (8–113). For comparison, persistent spectral Doppler arterial anomalies were observed in only 5% of children following KTx at our centre over the previous 5-year period and were all focal anastomotic stenoses. In addition, five children had lymphoceles, which required surgical management as compared to only one patient in the 5 previous years (1%). We retrospectively diagnosed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-20 infection in 6/8 children with arterial stenosis on serologies performed at D0, including one boy with a history of positive real time reverse transcription-polymerase chain reaction (RT-PCR) 120 days before KTx. None of the patients had reported any symptom suggestive of COVID-19. The remaining two patients had received a graft from an asymptomatic deceased adolescent donor with a positive serology at D0. These data led us to suspect immune post-viral graft vasculitis, triggered by SARS-CoV-2.At 1-year post-transplantation, the outcome was favourable in the 8 isolated KTx recipients. A total of 4/8 children had normal blood pressure and 4 had controlled high blood pressure on mono or bi-therapy. Doppler anomalies had resolved in 5/8 and persisted in 3/8 with a trend for improvement of peak systolic velocities and no severe consequences on kidney function and histology. Indeed, the median glomerular filtration rate (GFR) was 91 mL/min/1.73 m² (65–129), with unspecific and mild lesions on 4/8 protocol kidney biopsies (IFTA 1 or Cpt 1). One liver-kidney graft recipient had persistent hypertension and diffuse irregular inflammatory parietal thickening of the whole vascular graft associated with a parietal thrombus upstream of the birth of the two hepatic arteries (Figure 2); treated with anti-aggregation and prednisone 10 mg/d.CONCLUSIONOur case series suggests a risk of post-viral kidney graft vasculitis in children with recent SARS-CoV-2 infection in the recipient or donor. Pre-transplant vaccination against COVID-19 is mandatory in children > 5 years and their kidney donor candidates at our centre. We also strongly recommend vaccination of all people aged > 5 years in the household.FIGURE 1:Angio-CT scan of a KTx recipient showing an atypical extensive stenosis, with a diffuse, thin and irregular appearance of the graft artery.FIGURE 2:Angio-CT scan of the liver-kidney graft recipient showing an atypical diffuse irregular inflammatory parietal thickening of the whole vascular graft associated with a parietal thrombus upstream of the birth of the two hepatic arteries.

The Impact of COVID-19 on Academic Cancer Clinical Trials in Canada and the Initial Response from Cancer Centers.

The COVID-19 pandemic resulted in temporary holds placed on new trial startups, patient recruitment and follow up visits for trials which contributed to major disruptions in cancer center trial unit operations. To assess the impact, the Canadian Cancer Clinical Trials Network (3CTN) members participated in regional meetings and a survey to understand the impact of the pandemic to academic cancer clinical trials (ACCT) activity, cancer trial unit operations and supports needed for post-pandemic recovery. Trial performance and recruitment data collected from 1 April 2020–31 March 2021 was compared to the same period in previous years. From 1 April–30 June 2020, patient recruitment decreased by 67.5% and trial site activations decreased by 81% compared to the same period in 2019. Recovery to reopening and recruitment of ACCTs began after three months, which was faster than initially projected. However, ongoing COVID-19 impacts on trial unit staffing and operations continue to contribute to delayed trial activations, lower patient recruitment and may further strain centers’ capacity for participation in academic-sponsored trials.

Direct observations of CO2 emission reductions due to COVID-19 lockdown across European urban districts

The measures taken to contain the spread of COVID-19 in 2020 included restrictions of people's mobility and reductions in economic activities. These drastic changes in daily life, enforced through national lockdowns, led to abrupt reductions of anthropogenic CO2 emissions in urbanized areas all over the world. To examine the effect of social restrictions on local emissions of CO2, we analysed district level CO2 fluxes measured by the eddy-covariance technique from 13 stations in 11 European cities. The data span several years before the pandemic until October 2020 (six months after the pandemic began in Europe). All sites showed a reduction in CO2 emissions during the national lockdowns. The magnitude of these reductions varies in time and space, from city to city as well as between different areas of the same city. We found that, during the first lockdowns, urban CO2 emissions were cut with respect to the same period in previous years by 5% to 87% across the analysed districts, mainly as a result of limitations on mobility. However, as the restrictions were lifted in the following months, emissions quickly rebounded to their pre-COVID levels in the majority of sites.