"Liver clots" are an uncommon complication following periodontal surgery, characterized by their distinctive gelatinous consistency and color resembling 'liver' tissue. Despite anecdotal reports, there is a lack of comprehensive evidence in the literature regarding its incidence, etiopathogenesis and optimal management strategies. This study aimed to address this knowledge gap by retrospectively analyzing cases to provide insights into this unusual post-operative complication. In this retrospective descriptive study, data spanning a decade (June 2013-June 2024) were collected from various dental centres. The data included patient demographics, medical history, surgical procedures performed, occurrence of "liver clot" formation, management measures and treatment outcomes. The 10-year retrospective data revealed a 2.03% incidence of "liver clots" among various periodontal procedures. The highest occurrence was observed following dental extractions, followed by periodontal surgical procedures. The observations also indicated a higher frequency in systemically healthy individuals. "Liver clot" formation is a rare, but specific complication after periodontal surgery. Minimally invasive management approaches are effective, highlighting the importance of vigilance and prompt intervention for optimal patient outcomes. Further research is warranted to elucidate the exact etiopathogenesis and to establish evidence-based management protocols for this unusual complication.
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