Forty five patients were diagnosed by specialist dentist of the team as periodontal disease patients. Basically they were found to be chronic periodontitis and chronic gingivitis. The study male and female patient groups [25 males and 20 females] were subjected to the detection of oral mucosal cryoglobulin and tempts to use cryoglobulin as a marker for oral mucosal herd immunity among these patients. Oral mucosal cyoprotein solutions were separated and characterized as oral mucosal cryoglobulin [ICD-10-CM Diagnostic code, D89.9 Cryglobulin]. Mucosal cryocrit percentages were ranged from one to seven percent. Oral mucosal cryoglobulin concentrations were ranged between 0.13 up to 2 mg/dl. In chronic periodontitis patients and 0.15 up to1.96 mg/dl.in chronic gingivitis patients. The individuals Mucosal herd immunity constitutes three basic immune fractions; low, moderate and high cryoglobulin responders. The immune herd plot types were matched as Gaussian distribution plot types. The findings of oral mucosal cryoglobulin among these patients in clinically indicative concentrations for the potential role may be played in the pathogenesis of chronic gingivitis and chronic periodontitis as it may cause precipitates in the local blood vessels of gum and periodotium.