Edible mushrooms are gaining popularity as functional foods, not only for their distinctive taste and subtle flavor but also for their potential health benefits. They are rich in essential nutrients, including carbohydrates, proteins, fiber, minerals, and vitamins. However, it is estimated that up to 30% of total mushroom production generates non-marketable waste, which is currently used as animal feed, fertilizer, or compost. From a circular economy perspective, the objective of this work is to propose a conceptual design for a biorefinery to produce high-value-added products from non-marketable edible mushroom waste and to conduct a comprehensive assessment using modeling and simulation tools for process engineering. The general approach first involves identifying high-potential products, then determining the best processing routes, followed by developing a process flowsheet diagram for a case study (A. bisporus), and ultimately conducting a comprehensive assessment of the biorefinery to evaluate its sustainability. As a result, the proposed biorefinery may produce chitin, citric acid, and fertilizer, demonstrating the technical feasibility of waste valorization in terms of product yields, with positive profitability in terms of the rate of return on investment and payback period, and low environmental impact in terms of water and energy consumption as well as CO2 emissions.
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