Pericardial Mesothelioma Research Articles

An Autopsy Case of Primary Malignant Pericardial Mesothelioma -A Comprehensive Review of 95 Cases Reported in Japan-

An Autopsy Case of Primary Malignant Pericardial Mesothelioma -A Comprehensive Review of 95 Cases Reported in Japan-

Primary malignant pericardial mesothelioma in a patient with a history of thoracic radiotherapy and asbestos exposure: A case report

Primary malignant pericardial mesothelioma in a patient with a history of thoracic radiotherapy and asbestos exposure: A case report

Malignant primary pericardial mesothelioma presenting as effusive constrictive pericarditis: a case report study

BackgroundPrimary pericardial mesothelioma (PPM) is a rare malignancy with a high prevalence of mortality. The diagnosis is usually challenging using a variety of imaging modalities and invasive procedures and is generally performed at the later stages of the disease or in autopsy. This case study points to an unconventional presentation of PPM and the challenges in diagnosing this rare mortal malignancy.Case presentationThis study presents a 44-year-old woman with no remarkable medical history with an initial diagnosis of effusive constrictive pericarditis at first hospitalization. Imaging evaluations, including transthoracic echocardiography and chest computed tomography scan, demonstrated visible thickened pericardium, pericardial effusion, and mass-like lesions in pericardium and mediastinum. The definite diagnosis of primary pericardial mesothelioma was established after pericardiectomy and histopathology examinations. Chemotherapy with pemetrexed and carboplatin was administrated to the patient, and she has been through four cycles of chemotherapy with no complications to date.ConclusionConstrictive pericarditis is an uncommon presentation of PPM. Due to the high mortality rate and late presentation, difficulties and uncertainties in diagnosis, being aware of this rare malignant entity in different cardiac manifestations, particularly when there is no clear explanation or response to treatment in such conditions, is highly important.

Pathological Findings of Canine Idiopathic Pericarditis and Pericardial Mesotheliomas: Correlation with Clinical and Survival Data.

Idiopathic pericarditis (IP) and pericardial mesothelioma (PM) are causes of pericardial effusion in dogs. Pericardiectomy can be a definitive treatment in the case of idiopathic pericardial effusion or a short-term intervention for mesothelioma. The aim of the present study was to investigate which histopathologic parameters are correlated with clinical outcomes in a cohort of dogs that underwent pericardiectomy. The histopathological findings of 22 IPs and 5 PMs were compared with clinical and survival data and the immunohistochemical characterization of immune cells (CD3, CD79α, Iba1). In IP, the mesothelium was lost in 20 cases, reactive in 9, atypical in 3, and mesothelial papillary hyperplasia (MPH) was observed in 4 cases. Numerous macrophages were found in both IPs and PMs especially at the superficial layer of the pericardium. T lymphocytes were observed in mild to moderate numbers and were more numerous than B lymphocytes in both IPs and PMs. MPH was correlated with the quantity of lymphoplasmacytic infiltrate in the superficial layer, inversely related to the thickness of the pericardium, and associated with a longer overall survival. Pericardial fibrosis was present in 19 out of 22 IPs and in all mesotheliomas and was correlated with increased time from initial presentation and pericardiectomy and lymphoplasmacytic infiltrate in the deep zone. Pericardial thickness was correlated with the amount of lymphoplasmacytic and macrophagic infiltrate in the deep zone. Mesothelioma was associated with an increased number of pericardiocentesis procedures before pericardiectomy and with the presence of macrophages in the superficial pericardial layer, edema, fibrin, and hemorrhage. Disease-free interval and overall survival were significantly shorter in patients with mesothelioma compared with IP.

Hospitalisation costs of malignant mesothelioma: results from the Italian hospital discharge registry (2001–2018)

ObjectivesThis paper aims to establish hospitalisation costs of mesothelioma in Italy and to evaluate hospital-related trends associated with the 1992 asbestos ban.DesignThis is a retrospective population-based study of Italian hospitalisations...

Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis

Primary pericardial mesothelioma is a rare malignancy of the mesothelial lining of the pericardium. This study aimed to evaluate the clinical characteristics and survival outcomes of these patients using a United States population-based cancer database. We queried the Surveillance, Epidemiology, and End Results program (1973-2015). Primary pericardial mesothelioma patients with complete follow-up data were included, and primary pleural mesothelioma patients were identified as controls. Propensity-score matching was used to balance individual characteristics. Kaplan-Meier analysis and log-rank tests were performed to compare overall survival. Forty-one primary pericardial mesothelioma and 15,970 primary pleural mesothelioma patients were identified. Before matching, when compared to the pleural mesothelioma counterparts, primary pericardial mesothelioma patients were younger (median 57 vs 73 years, P < 0.001), more likely to be female (46.3% vs 20.2%, P < 0.001), more likely to be nonwhite (24.4% vs 8.4%, P=0.001), and less likely to have been diagnosed in the most recent study decade (2006-2015, 34.1% vs 43.5%, P=0.002). The overall 1- and 2-year survival rates were 22.0% and 12.2%, with a median survival of 2 months (IQR: 1-6). After 1:2 nearest neighbor propensity-score matching, 38 pericardial mesothelioma and 76 matched pleural mesothelioma cases were identified. The 2 matched groups had comparable baseline characteristics, including age, sex, race, year of diagnosis, histological type, and cancer history. Compared to their pleural mesothelioma counterparts, primary pericardial mesothelioma patients were less likely to receive chemotherapy (23.7% vs 50.0%, P=0.01) and had worse overall survival (median survival: 2 vs 10 months, log-rank P=0.006). Primary pericardial mesothelioma has worse survival outcomes than pleural mesothelioma, with a median survival of only 2 months. These patients should seek care from experienced multidisciplinary teams at tertiary care centers that handle high volumes of mesothelioma patients.

The value of 18F-FDG PET/CT in two cases of Primary Pericardial Mesothelioma

The value of 18F-FDG PET/CT in two cases of Primary Pericardial Mesothelioma

Case Report: Primary Pericardial Mesothelioma

BACKGROUND: Primary pericardial mesothelioma is an extremely rare mesodermal tumor, among oncological diseases, with a very low incidence. About 350 cases have been described around the world, most of them diagnosed post-mortem. The short term prognosis is poor, regardless of the treatment, which is mostly palliative. We present a case report regarding this pathology. CASE REPORT: 69 year old patient hospitalized with dyspnea and severe anemia. Complementary workup showed pleural effusion and pericardial effusion. Histopathology report of the pericardial fluid revealed pericardial mesothelioma. EVOLUTION: Due to recurrence of pericardial effusion, it was decided to perform pericardiectomy and left pleurectomy as palliative treatment, to alleviate the patient’s symptoms. Chemotherapy was planned after the procedure, but the patient’s general condition deteriorated severely leading to his death. CONCLUSION: Primary pericardial mesothelioma is a rare tumor, whose symptoms are characterized by the associated pericardial effusion, making the diagnosis difficult due to it low incidence. The prognosis is poor in short- term, and there isn’t an established protocol for the treatment with results that showed improve in mortality. KEYWORDS: MESOTHELIOMA, PERICARDIAL EFFUSION, PERICARDIECTOMY, PLEUROTOMY.

Timely diagnosis of primary pericardial mesothelioma

Timely diagnosis of primary pericardial mesothelioma

Cardiovascular images: constrictive pericarditis and tricavitary effusion in a dog with pericardial mesothelioma

This report describes the transthoracic echocardiographic findings and computed tomography features of a 12-year-old West Highland white terrier with constrictive pericarditis (CP) secondary to pericardial mesothelioma. Although pericardial mesothelioma is well described in dogs, its association with CP in the canine population is not as widely reported. In this clinical case, a multidisciplinary imaging approach was helpful to identify anatomical and hemodynamic abnormalities that allowed for a diagnosis of CP.

Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis

Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis

A case report of malignant primary pericardial mesothelioma with atypical imaging appearance: multimodality imaging with histopathological correlation.

Background Primary pericardial mesothelioma is a rare primary cardiac malignancy, with three main histopathological types, sarcomatoid histotype being the rarest. The imaging features were atypical due to concomitant extensive calcification, which resulted in aggravated differential diagnosis.Case summary A 45-year-old man presented to our hospital with non-specific clinical symptoms. According to clinical history, a mediastinal tumour had been suspected with a previous unsuccessful attempt of transthoracic computed tomography-guided biopsy at an overseas hospital with limited data of performed imaging procedures. Multimodality imaging at our centre revealed extensively calcified solid masses in the pericardium, invading the left atrium. As the imaging features suggested an atypical primary pericardial malignancy, a diagnostic thoracoscopy was performed. Histopathological analysis of specimen revealed sarcomatoid type of pericardial mesothelioma with areas of necrosis and foci of osteogenic differentiation. Despite planned treatment, 2 weeks after histological diagnosis, the patient passed away due to perforated peptic ulcer-related sepsis.Discussion The presence of extensive calcification in the lesion resulted in a challenging imaging workup and diagnosis. Initial differential diagnosis included primary or metastatic calcification-prone tumour, secondary calcification due to haemorrhage after previous interventional procedure and other pathologies, such as tuberculous pericarditis, calcified amorphous tumour, among others. Calcification may be part of the histological tumour characteristics; however, proper history taking is crucial as concomitant diseases, previous treatment, and interventional procedures may alter the imaging pattern.

Sinister Face of Primary Cardiac Tumour: A Rapidly Progressive Pericardial Mesothelioma in a Young Female

Sinister Face of Primary Cardiac Tumour: A Rapidly Progressive Pericardial Mesothelioma in a Young Female

EP1.15-26 Cardio Mediastinal Tumors - Diagnosis and Treatment in Two of Our Cases

Malignant cardiac tumors are very rare. Although they are clinically diagnosed and diagnoses very quickly, but in some cases it is very difficult to diagnose or are diagnosed in the late stages. Objective: To analyze our rarely two cases for diagnosis and treatment in delayed diagnoses for cardiac primary tumor invadation in mediastinum and pericardium tumor wih myocardial and mediastinal invasion in the other case. The diagnosis is based on the clinical history, echocardiography in two cases, and, sometimes, computerized tomography and magnetic resonance imaging, FNAB and mediastinotomy. In two cases the diagnosis is based on the clinical history, echocardiography in two cases, and, computerized tomography and magnetic resonance imaging, FNAB and mediastinotomy. Patient A. 66 years old, male patient the diagnosis was established with trans-thoracic biopsies of myosarcoma-derived mass, treated by oncologist and cardiologists. While patient B is a 45 year old female with a pericardiac tumor, with huge pericardial effusion and effusion in the sinister pleural cavity. Liquid cytology with malignant cells. Was performed left mediastinotomy, pericardiotomy, biopsy of intrapericardial mass, pericardial window and drainage pleural sinister. Biopsy results in pericardial sarcomatous mesothelioma with myocardial and mediastinal invasion. Macroscopically hemorrhagic effusion in pericardial and left pleural cavities. Very large tumor and quite intrapericardial hemorrhagic disease. Malignant cardiac tumors are very rare and early stage diagnosis and adequate treatment is difficult.

A rare case of distant metastasis of primary malign pericardial mesothelioma with 18F-FDG PET/CT

A rare case of distant metastasis of primary malign pericardial mesothelioma with 18F-FDG PET/CT

Primary Pericardial Mesothelioma: Report of a Patient and Literature Review

Malignant pericardial mesothelioma is a very rare tumoraccounting for 4% of all cardiac and pericardial tumors. We introduce a rare case of primary pericardial mesotheliomasince patients with mesothelioma mostly present with nonspecific symptomsand one-time diagnosis plays a major role in treatment. Our patient is a 29-year-oldCaucasian man with a complaint of worsening dyspnea and weight loss over the prior three weeks. After transthoracic echocardiography and CT scan, the patient underwent open-heart surgery and biopsy was achieved. Finally, the diagnosis of primary pericardial mesothelioma was confirmed.

Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression

A 6-year-old neutered male Yorkshire Terrier presented with recurrent pericardial effusion. Although clinical examinations including computed tomography were inconclusive, an exploratory thoracotomy revealed multiple small nodules and plaques on the inner surface of the pericardial sac (Day 1). A subtotal pericardiectomy was performed to prevent cardiac tamponade due to the increasing pericardial effusion, and the resected section of the pericardium was histopathologically diagnosed with mesothelioma. After surgery, chemotherapy with intrathoracic carboplatin was commenced. During the course of the treatment, a detailed follow-up ultrasonographic scan was performed to detect early lesions disseminated on the pleura, originating from the primary pericardial mesothelioma. On Day 101, the minute pleural nodules, which were disseminated lesions as predicted, were successfully imaged by ultrasonography. As the clinical stage advanced, the nodules were observed to gradually increase in size and number, implying tumor progression. These observations highlight the feasibility of ultrasonography in detecting minute disseminated lesions at an early stage, monitoring tumor progression, and thereby, predicting the prognosis of canine pericardial mesothelioma.

METASTATIC PERICARDIAL MESOTHELIOMA: A RARE CASE OF CONSTRICTIVE PERICARDITIS

Malignant pericardial mesothelioma accounts for 2-3% of all pericardial tumors, and its prevalence in the general population is <0.002%. Risk factors include asbestos exposure, genetic susceptibility, infection, and radiation exposure. The disease carries a poor prognosis with a median survival of

Cardiac Tamponade from Pericardial Mesothelioma Causing Acute Renal Insufficiency in Dog

Pericardial mesothelioma is a rare malignancy tumor in dog. Due to an aggressive tumor and low survival rates, mesothelioma is frequently diagnosed at an advanced stage. The objective of this clinical report is to highlight the characteristic of this malignancy tumor to help an early diagnosis and to improve the therapeutic outcomes of this neoplastic tumor. A 10-year-old crossbreed was referred to Kasetsart University Veterinary Teaching Hospital Kamphaengsaen for the evaluation of a history of abdominal distension, lethargy and weekness. During the physical examination, the dog was tachycardia and tachypnea. Ultrasonography imaging of spleen revealed an inhomogeneous appearance and thoracic radiograph showed cardiac enlargement. Electrocardigraphy examination revealed low voltage of QRS complex amplitude. A transthoracic echocardiogram showed a large pericardial effusion with cardiac tamponade and masses were visualized in pericardial sac. Pericardiocentesis was immediately performed to alleviate the cardiac tamponade and cytologic examination was performed to identify the characteristic of pericardial effusion fluid. Clinical symptoms of acute kidney injury were progressed from the second visit including azotemia, hyponatraemia, hyperkalemia and anuria. The dog died about 2 days after admission in the critical care unit. Histopathological examination of the pericardial fluid and pericardial mass confirmed the diagnosis of pericardial mesothelioma. Mesothelioma should be considered in the diagnosis of pericardial effusion in dog. An early stage detection of pericardial mesothelioma may significantly reduction in mortality and allow for more beneficial treatment.

Mesotheliomas of the Pericardium: Case Report

Pericardial mesotheliomas are exceedingly rare and fatal neoplasms. This case report reviewed a clinical case of pericardial mesothelioma in a 36-year-old male, and summarised current literature on imaging, pathology, and treatment. Pericaridal mesothelioma is clinically silent for prolonged periods, and typically far progressed at diagnosis. It carries a dire prognosis, with a median survival of less than 1 year. Symptoms are non-specific and frequently mimic constrictive pericarditis, cardiac tamponade, and heart failure. Asbestos exposure is seen in a minority of cases. Echocardiography, computed tomography, and magnetic resonance imaging can establish diagnosis, with positron emission tomography determining extra-cardiac manifestations. Definitive diagnosis is commonly obtained through biopsy, as pericardial aspirate cytology is frequently negative and with low diagnostic yield. Treatment is limited, with chemotherapy and radiotherapy having poor survival benefit. Surgical approaches are often palliative and aimed at alleviating constrictive symptoms, reducing tumour burden, and preventing tamponade.