Recent advances in construction materials and architecture have enhanced the safety of modern structures, which now feature higher, lighter, and more unique designs. Bridges, as critical infrastructure, face increasing load demands due to rising traffic volumes, leading to accelerated structural deterioration. This necessitates more frequent inspections and maintenance, resulting in increased costs and potential operational disruptions. Real-time built-in monitoring systems are thus essential for both new and aging structures. Fiber Optic Sensor (FOS) technology, particularly Fiber Bragg Grating (FBG) sensors, offers a reliable and stable solution for long-term Structural Health Monitoring (SHM). This study evaluates the performance and applicability of FBG sensors (FBGs) in comparison to traditional strain gauges (SGs) for capturing strains, loads, deflections, and temperature in full-scale beams under static loads. Four large-scale reinforced concrete (RC) and CFRP-strengthened beams were tested. Nonlinear finite element analysis (NLFEA) using VecTor2 was employed to simulate the behavior of these beams under static loading. Data from FBGs were compared to those from collocated electrical SGs. The results demonstrated the reliability and flexibility of FBGs in monitoring structural performance. Notably, FBGs continued to provide accurate readings even after the specimens reached their maximum load, showcasing their endurance and resilience compared to conventional SGs.