Flow measurement is an important issue for developing the water conservation projects and evaluating the performance of irrigation and drainage networks. Weirs and gates are the most common structures which have been widely used for flow measurement. The main defects related them are deposition of suspended matter behind the weirs and accumulation of floating matter on water behind the gates, respectively. Therefore, the weir-gate structure has been proposed to solve them infirmities. In this study, predicting the discharge coefficient of weir-gate was considered using the artificial neural network (ANN), support vector machine (SVM) and adaptive neuro-fuzzy inference systems (ANFIS). For this purpose, the related dataset were collected from the literature. Assessing the performance of three models show that all of them have suitable accuracy, however, the SVM model with a coefficient of determination (R2 = 0.94) and root mean square of error (RMSE = 0.008) has the best performance in comparison with others. During the preparation of SVM it was found that the radial basic function as kernel function has best performance among the tested kernel functions. Sensitivity analysis of applied models showed that the ANN is the most sensitive model in comparison with others.