This study uses the Large Eddy Simulation (LES) technique to conduct an exhaustive analysis of the flow characteristics within the Rectangular-to-Elliptical shape Transition (REST) inlet under Mach 6 conditions. It mainly focuses on investigating the influence of the shock wave-turbulence interaction on the swirl distortion at the inlet exit. At the design condition, characterized by 0° Attack and 0° Sideslip, the incident shock wave at the inlet lip undergoes multiple reflections within the boundary layer of the domain wall, culminating in the formation of turbulent structures. The first reflected shock wave has the highest energy, exerting a significant impact on the boundary layer and the exit swirl distortion. On the contrary, the energy of the incident shock wave is progressively reduced due to repeated reflections, which results in reducing the exit swirl distortion. Under off-design conditions, characterized by 6° Attack and 0° Sideslip as well as 6° Attack with 6° Sideslip, variations in the incoming flow make the incident shock wave move inward, decreasing the frequency of shock wave reflections and even significantly reducing the reflected shock waves under conditions of 6° Attack and 6° Sideslip. However, this results in significantly increasing the exit swirl angle and distortion intensity. The obtained results demonstrate that changes in the incoming flow conditions significantly affect the level of exit swirl distortion by modulating the shock wave-turbulence interaction, especially in terms of the positioning of the incident shock wave and the quantity of reflected shock waves. In addition, this paper studies the wall heat transfer coefficient of the inlet. The obtained results show that the interaction between shock waves and the boundary layer significantly affects the heat transfer coefficient. This study provides a foundation for the comprehension and prediction of the performance of hypersonic inlets across a spectrum of flight conditions, and for the guidance of the design and optimization of such inlets.