This paper proposes an observer-based quantized controller for parabolic partial differential equation systems interconnected by a nonlinear coupling protocol. First, a Markov jump model is introduced to describe various randomly occurring actuator failures, and an observer-based pointwise controller is designed under the averaged measurement scheme. Furthermore, taking into account the limitation of network communication resources, a quantization method is adopted to relieve bandwidth pressure. In addition, stability conditions of the closed-loop system with ℋ∞ disturbance attenuation performance are derived by utilizing appropriate Lyapunov functional and inequality techniques. Ultimately, the proposed method is applied to the Fisher equation to verify its feasibility and effectiveness.