Supported inverse metal–metal oxide catalysts have received significant research interest owing to their effective hydrodeoxygenation (HDO) activity toward biomass substrates, but the high cost of the reported catalysts poses a challenge for commercialization. We present the synthesis of a series of metal–metal oxide catalysts, Ir–MOx/SiO2 (M = Re, Mo, W, V, or Nb) and M′–MoOx/SiO2 (M = Rh, Ru, Pt, or Pd) and their HDO performance on multifuran (high carbon) substrates to produce renewable jet and diesel fuels and lubricant base oils. A MoOx-modified Ir/SiO2 catalyst with a Mo/Ir ratio of 0.13 (Ir–MoOx/SiO2) exhibits the highest product yield (78–96%) under mild reaction conditions. Controlled experiments using probe substrates reveal that furan ring hydrogenation and C–O hydrogenolysis of saturated and unsaturated furan rings occur in a sequential manner. The carbon atom adjacent to the furan or saturated furan ring of substrates or intermediate compounds undergoes slow C–C bond scission, resulting in a ...