Attention Function Research Articles

Effect of acetaminophen use on GABA, NMDA, and synaptic plasticity-related genes in the immature mouse brain: A preliminary study

Abstract Background/aim: Acetaminophen is frequently used as an analgesic during pregnancy. The purpose of the present study was to evaluate the effects of acetaminophen administered to pregnant mice on the fetal brain, attention, memory, and learning functions in the postnatal period, and genetic mechanisms in these mice. Materials and methods: The study was designed with two different groups. The first group consisted of pregnant mice that were injected with acetaminophen, while the second group was comprised of pregnant mice that were injected with saline. 1st, 2nd, and 3rd days of pregnancy, one of the mice was injected subcutaneously with 100 mg/kg acetaminophen, and the other mouse was injected subcutaneously with 0.9% saline. On the 21st day after birth, five female and five male mice were randomly selected for the experimental and control groups. Behavioral tests were performed on mice at 2 months of age. In addition, changes in the transcript levels of 93 genes were evaluated by Real-Time PCR in the hippocampus. Results: The control group showed more interest in the new object than the acetaminophen group (p=0.002). In the marble burying test, greater burying activity was observed in the control group than in the acetaminophen group (p=0.0345). No significant difference was observed between the control and acetaminophen groups in the social interaction and tail suspension tests. GABRG3, GRM3, PICK1, CEBPB, and EGR4 mRNA expression levels increased in the acetaminophen group (0.0317, 0.0159, 0.0069, 0.0457, 0.015, p value respectively). Conclusions: Prenatal acetaminophen exposure affected both behavioral tests and transcript levels. Therefore, the potential effects of prenatal acetaminophen exposure should be carefully investigated.

Attention and processing speed tests: Normative data for Spanish-speaking adults in the United States.

Hispanics/Latinos are the largest racial/ethnic group among underrepresented populations in the U.S. and multiple sociodemographic, cultural, and linguistic factors have been found to impact their performances on cognitive testing. Despite this, few normative data are available for the heterogeneous Spanish-speaking population in the U.S. To generate normative data on the Trail-Making Test (TMT), Bells Test, Symbol-Digit Modalities Test (SDMT), and the Brief Test of Attention (BTA) for Spanish speakers residing in the U.S. The sample included 245 Spanish-speaking individuals aged 18- 80 from eight states across the U.S. (California, Connecticut, Florida, Indiana, New Jersey, Oregon, Virginia, and Wisconsin). Participants were administered attention and processing speed measures as part of a comprehensive neuropsychological battery. We used a Bayesian regression approach to estimate normative data, including covariates found to be important for predicting performances on measures of attention and processing speed. Sociodemographic factors including education, time in the U.S., acculturation, age, and/or sex had differential effects on the TMT-A, TMT-B, SDMT, and the BTA whereas the Bells Test was not influenced by any of these sociodemographic factors. Our findings indicate that while sex, age, and educational attainment are important factors to consider, language and acculturation can also influence attention and processing speed performances among Spanish speakers in the U.S.

The impact of attention and task performance on antiphishing performance: a multigoal perspective

PurposePeople are often recognized as the weakest part of thwarting phishing attacks. The goal of preventing phishing can conflict with the goal of keeping a good level of productivity in daily work; however, we still lack an understanding of this multigoal scenario. This paper aims to develop and test a new model of antiphishing performance, especially in relation to individuals' task performance in daily work. Drawing on the extended multiple-goal pursuit model (MGPM*), we examined the relationship between task performance at a time point and the subsequent antiphishing performance as well as how this relationship differs across varying types of phishing emails and attention levels to phishing cues.Design/methodology/approachWe tested the model by conducting a field experiment with a survey questionnaire. Four legitimate work emails and four phishing emails (consisting of two work-related and two work-unrelated emails) were sent to 357 participants. The data were analyzed using generalized estimating equations.FindingsThe results indicate that task performance at a time point has a curvilinear relationship with subsequent antiphishing performance. This relationship is moderated by the types of phishing emails and individuals' attention to phishing cues. For work-related phishing emails, task performance is negatively associated with antiphishing performance when it reaches an intermediate level; however, when task performance is low, or high to an extent, it is positively related to antiphishing performance. For work-unrelated phishing emails, there is a positive association between task performance and antiphishing performance. Moreover, attention to phishing cues moderates the curvilinear relationship between task performance and antiphishing performance such that when task performance reaches an intermediate level, as attention to phishing cues increases, the relationship between task performance and antiphishing performance will turn from negative to positive.Practical implicationsThis paper has practical implications that bear on the conflict between antiphishing performance and task performance.Originality/valueThis paper sheds light on the potential of the extended multiple-goal pursuit model in studying antiphishing behavior.

The effect of cerebellar lesıons on language in Turkısh speakıng indıvıduals

ABSTRACT Background The cerebellum is approximately 10% of the brain volume and is responsible for attention, language, emotion and cognitive functions. Linguistic processing difficulties and cognitive impairments may be observed in individuals with cerebellar lesions depending on the location and severity of the damage. There is no study evaluating language in Turkish-speaking individuals with cerebellar lesions. Objective To determine the differences in linguistic and visuospatial skills of Turkish speaking individuals with cerebellar lesions compared to control groups, including a right hemisphere lesion group and a healthy control group. Method Fifteen patients with cerebellar lesion (without hemispatial neglect and dysarthria), 15 patients with right hemisphere lesion due to right arter cerebri media (without hemispatial neglect) and 15 healthy control were included. To clarify the language impairment specific to cerebellar lesions, we also included individuals with right hemisphere lesions, which are typically assumed not to present with aphasia. The Language Assessment Test for Aphasia (ADD), Benton Judgment of Line Orientation Test, Benton Facial Recognition Test, Single Letter Deletion Test were used. The “Accident Scene” picture was used for collecting narrative speech samples. After a three group comparison a post-hoc pairwise analysis was performed. Results Among the microstructural parameters in the narrative language analysis, the effort ratio was significantly higher in the cerebellar lesion group compared to the healthy control group. Among the non-verbal cognitive tests, the Benton Facial Recognition Test score was significantly lower in the cerebellar and right hemisphere lesion group compared to the healthy control group. Total score, naming and grammar scores in the ADD test were significantly lower in the cerebellar lesion group compared with the healthy control group. There was no difference between cerebellar and right hemisphere lesions in terms of ADD score, ADD subtests and narrative parameters. Conclusion In Turkish-speaking individuals with cerebellar lesions, verbal productivity may be interrupted by effort behaviours, and standard aphasia assessment tests may reveal impaired grammar and naming performance without a diagnosis of aphasia. In addition to reduced efficiency in verbal production, facial recognition may be impaired. We found no difference between individuals with lesions in the cerebellum and right hemisphere. This suggests that ischemic damage may affect different components of language independently of the diagnosis of aphasia.

Effects of natural reduced water on cognitive functions in older adults: A RCT study

Oxidative stress and diabetes increase the risk of cognitive decline and dementia. Natural reduced water contains active hydrogen (hydrogen radicals), eliminates reactive oxygen species, and has antidiabetic effects. However, whether natural reduced water affects human cognitive function is unknown. Therefore, we implemented a double-blind intervention experiment in which participants consumed 1 L of natural reduced water or tap water daily for 6 months. The participants were healthy older adults living in Japan. The intervention group showed significant improvements in cognitive functions of attention function (p < 0.01) and short-term memory (p < 0.05). These results indicate that the continuous intake of natural reduced water improves several cognitive functions.

The role of family health, socio-economic status, and heritability of neurodevelopmental disorders in the severity of cognitive dysfunctions in school-age children with ADHD

Introduction and objective: Little is known about the association between socioeconomic status, alcohol and tobacco use, and specific cognitive functions, like attention, working memory or executive functions in attention-deficit/hyperactivity disorder. We aimed to determine if socioeconomic adversity and unhealthy family behaviours are predictors of cognitive functions in children with attention-deficit/hyperactivity disorder. Materials and methods: We tested 176 Polish children with attention-deficit/hyperactivity disorder aged 10–13 using the PU1 Battery of Cognitive Functions, while the children’s parents completed a questionnaire on socioeconomic status and alcohol and tobacco use at home during their child’s life stages. We applied cluster analysis of family types and moderation analysis that tested the heritability of neurodevelopmental disorders in family interactions. Results: We identified three family types that raise children with attention-deficit/hyperactivity disorder: 1) families with higher socioeconomic status, lower level of unhealthy family behaviours, and average levels of children’s cognitive functioning, 2) families with low socioeconomic status, high level of unhealthy family behaviours, and average levels of children’s cognitive functioning, and 3) families with average socioeconomic status, low level of unhealthy family behaviours and low level of children’s cognitive functioning. We found no statistically significant associations between family predictors, the moderator variable, and cognitive functions in children with attention-deficit/hyperactivity disorder. Conclusions: The results of our study contrast with the large amount of evidence that shows a link between cognitive dysfunctions in children with attention-deficit/hyperactivity disorder and socioeconomic status and alcohol and tobacco use.

Comparison of Virtual Reality Exergames and Nature Videos on Attentional Performance: A Single-Session Study.

This study aimed to investigate the acute effects of a single session of a VR exergame (Beat Saber) and a VR nature video (Ireland 4K) on attentional performance, using the Flanker and Attentional Blink (AB) tasks. The objective was to assess whether these VR interventions could enhance attentional control, as measured by improvements in response times and accuracy. A total of 39 psychology students, aged 19-25, were randomly assigned to one of three groups: VR exergame, VR nature video, or control. Participants completed the Flanker and AB tasks before and after the intervention. A repeated measures design was employed to analyze changes in response times and accuracy across pre- and post-test sessions. The study revealed significant improvements in response times and accuracy across all groups in the post-test measures, indicating a strong training effect. In the AB task, shorter stimulus onset asynchrony (SOA) led to decreased accuracy and slower response times, emphasizing the difficulty in processing closely spaced targets. The interaction between Type and Group in response times for target stimuli suggested that the intervention types differentially influenced processing speed in specific conditions. The findings suggest that while brief VR interventions did not produce significant differences between groups, the training effect observed highlights the influence of task-specific factors such as SOA and target presence. Further research is needed to explore whether longer or repeated VR sessions, as well as the optimization of task-specific parameters, might lead to more pronounced cognitive benefits.

Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways.

Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI. Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles. Patients completed the Attentional Function Index six times over two cycles of chemotherapy. Using findings from a previous latent profile analysis, subgroups of patients with high versus low levels of CRCI were evaluated (i.e., High versus Low CRCI profiles). Gene expression was quantified using either ribonucleic (RNA)-sequencing or microarray analyses and pathway impact analyses were performed. Signaling pathways were defined using the Kyoto Encyclopedia of Genes and Genomes database. A total of 508 patients had data available for analysis. Of the 261 patients in the RNA-sequencing sample, 48.7% were in the High class and 51.3% were in the Low class. Of the 247 patients the microarray sample, 46.6% were in the High class and 53.4% were in the Low class. Pathway impact analyses identified seven perturbed pathways related to neurotransmission (i.e., glutamatergic synapse, GABAergic synapse, dopaminergic synapse, serotonergic synapse, long-term depression, cholinergic synapse, retrograde endocannabinoid signaling). This study is the first to describe associations between self-reported CRCI in patients receiving chemotherapy for breast, gastrointestinal, gynecological, or lung cancer and seven neurotransmission pathways. These findings provide new insights into potential targets for mechanistically based interventions.

Whole-Body Vibration Affects Hippocampal Choline Acetyltransferase and Synaptophysin Expression and Improves Spatial Memory in Young Adult Mice.

Beneficial effects of whole-body vibration (WBV) on brain and musculoskeletal health in mice have been demonstrated, but underlying mechanisms remain relatively unrevealed. WBV improves attention and memory performance in mice, putatively through stimulation of the cholinergic system. Here, we investigated the effects of WBV on the septo-hippocampal cholinergic system. Young C57BL/6 mice (8 weeks old) were subjected to 10 min WBV/day (mechanical vibration: 30 Hz; ~0.1-μm peak-to-peak displacement), 5X/week for 5 weeks. In Experiment 1, choline acetyltransferase (ChAT)-immunoreactivity in the septum and hippocampus was analyzed either 2 or 24 h after the last WBV session. Pseudo-WBV-treated mice (same handling procedure as WBV, but no vibrations) served as controls. In Experiment 2, the longitudinal profile of ChAT-immunoreactivity was analyzed in the hippocampus after 1, 2, 3, 4, or 5 weeks of WBV. In addition, synaptophysin immunostaining was performed at either 2 and 5 weeks of WBV. Mice housed 1/cage during the entire experiment served as controls. The balance-beam test was used to monitor the functional impact of WBV. In Experiment 3, a Y-maze reference-memory test was performed after 5 weeks of WBV to obtain a functional cognitive outcome measure of WBV. Pseudo-WBV treated mice served as controls. In Experiment 1, ChAT-immunoreactivity was significantly enhanced after the last WBV session of the 5-week period. This was found in the septum, Cornu Ammonis 1 (CA1), CA3, and dentate gyrus, and was dependent on layer and time-point (2 or 24 h). Experiment 2 revealed that, ChAT-immunoreactivity was lower after 2 weeks of WBV, whereas it was significantly higher after 5 weeks (similar to in Experiment 1). Immunostaining for synaptophysin, a marker for synaptic density, was also significantly higher after 5 weeks of WBV, but not significantly lower after 2 weeks, as was ChAT. WBV-treated groups performed significantly better than did controls on the balance beam from week 3 onwards. Experiment 3 showed that WBV-treated mice had better spatial-reference memory performance in the Y-maze test than did pseudo-WBV controls. Our results indicate that WBV stimulates the septo-hippocampal cholinergic system in a gradual and dynamic way that may contribute to improved spatial-memory performance. This finding suggests that WBV, by upregulation of the septo-hippocampal cholinergic system, may be considered a valuable therapeutic strategy to enhance brain functions in aging, neurodegenerative, and other brain diseases.

Neuropsychological impact of Sanda training on athlete attention performance.

Sanda, a martial art that primarily involves punching, kicking, and throwing techniques, requires athletes to maintain high levels of concentration during combat. Sanda principally involves striking the opponent to secure victory, with trauma frequently occurring to the head; however, it remains unclear whether prolonged training enhances or impairs the athletes' attentional capacities. This study aimed to investigate the impact of Sanda training on athletes' attention by employing attention network tests. A retrospective analysis was conducted on 37 professional Sanda athletes from a certain sports academy; 38 college students from the same institution majoring in physical education were recruited as the control group. Control participants had no prior experience in Sanda training, and the Sanda and control groups were matched in terms of sex, age, and education level. The Attention Network Test (ANT) was administered to both groups to compare differences in efficiency across the alerting, orienting, and executive control networks. Compared to the control group, the Sanda athletes exhibited significantly higher executive control network efficiency values and executive control network efficiency ratios (P < 0.05). There were no significant differences between the Sanda group and the control group regarding the efficiency values of the alerting and orienting networks (P > 0.05). Additionally, total accuracy and total reaction time between the Sanda athletes and control participants showed no statistically significant differences (P > 0.05). Sanda practice has detrimental effects on attention, including a decrease in the efficiency of the executive control network and a prolongation of the total reaction time. Therefore, athletes should improve attention training and use head protection to prevent frequent head impacts during training.

The interactive effects of drawing task, prompt format, and visual aids on video-based learning: Attention and drawing accuracy as mediators

This study investigated the effects of open- and closed-book learning conditions either accompanied by visual aids or without on learners’ attention, drawing accuracy, and learning performance. Participants were 127 undergraduate learners randomly assigned to view either an open- or closed-book prompt, who then watched either a video lecture accompanied by visual aids or one without (i.e. visuals provided vs. no visuals). The results showed that for learners who were provided with visual aids, compared to the open-book condition, those in the closed-book condition demonstrated higher eye blink rate as well as improved immediate and delayed test scores. However, this advantage was not observed in the condition with no visual materials. Mediation analysis showed that increased immediate test scores in the visuals provided condition was due partly to improved drawing accuracy. Multiple mediation analyses showed that the open-book with visuals provided condition led to lower eye blink rate, increased fixation count, and improved drawing accuracy, which collectively resulted in decreased immediate test performance. These findings have implications for educators and instructional designers regarding how to tailor effective learning strategies; specifically, educators could consider using closed-book learning conditions with visual aids to enhance learners’ attention and improve their learning performance.

The role of focused attention in learning from early childhood to late adolescence: Implications of neonatal brainstem compromise following preterm birth.

This comprehensive longitudinal study explored for the first time the interrelations between neonatal brainstem abnormalities, focused attention (FA), and learning-following a preterm cohort (N = 175; 46.3% female; predominantly White) from birth (2003-2006) to 17 years. The findings indicated that FA during early childhood was associated with language outcomes in toddlerhood (n = 131) and academic and attention self-report indices in late adolescence (n = 44). Pilot assessments indicated that FA at 17 years (n = 25) was also associated with concurrent academic and attention functioning. Structural equation modeling analyses revealed that neonatal brainstem functioning, manifested in auditory brainstem response patterns, was associated with early-life FA competence, which affected learning development. Implications underscore the essential role of early brainstem function and FA in shaping childhood learning trajectories.

Waiting Time Control Chart for M/G/1 Retrial Queue

Retrial queues are used extensively to model many practical problems in service systems, call centers, data centers, and computer network systems. The average waiting time is the main observable characteristic of the retrial queues. Long queues may cause negative impacts such as waste of manpower and unnecessary crowding leading to suffocation, and can even cause trouble for customers and institutions. Applying control chart technology can help managers analyze customers’ waiting times to improve the effective performance of service and attention. This paper pioneers the developing and detailed study of a waiting time control chart for a retrial queue with general service times. Two waiting time control charts, the Shewhart control chart, and a control chart using the weighted variance method are constructed in this paper. We present three cases for the Shewhart control chart in which the service time obeys special distributions, such as exponential, Erlang, and hyper-exponential distributions. The case of an exponentially distributed service time is also presented for the control chart using the weighted variance method. Based on the numerical simulations conducted herein, managers can better monitor and analyze the customers’ waiting times for their service systems and take preventive measures.

Cognitive processing speed improvement after cochlear implantation.

Untreated hearing loss has an effect on cognition. It is hypothesized that the additional processing required to compensate for the sensory loss affects the cognitive resources available for other tasks and that this could be mitigated by a hearing device. The impact on cognition of cochlear implants (CIs) was tested in 100 subjects, ≥60 years old, with bilateral moderately-severe to profound post linguistic deafness using hearing aids. Data was compared pre and 12 and 18 months after cochlear implantation for the speech spatial qualities questionnaire, Mini Mental State Examination (MMSE), Trail making test B (TMTB) and digit symbol coding (DSC) from the Wechsler Adult Intelligence Scale version IV and finally the timed up and go test (TUG). Subjects were divided into young old (60-64), middle old (65-75) and old old (75+) groups. Cognitive test scores and times were standardized according to available normative data. Hearing significantly improved pre- to post-operatively across all age groups. There was no change post-implant in outcomes for TMTB, TUG or MMSE tests. Age-corrected values were within normal expectations for all age groups for the TUG and MMSE. However, DSC scores and TMTB times were worse than normal. There was a significant increase in DSC scores between baseline and 12-months for 60- to 64-year-olds (t[153] = 2.608, p = 0.027), which remained at 18 months (t[153] = 2.663, p = 0.023). The improved attention and processing speed in the youngest age group may be a consequence of reallocation of cognitive resources away from auditory processing due to greatly improved hearing. The oldest age group of participants had cognition scores closest to normal values, suggesting that only the most able older seniors tend to come forward for a CI. Severe to profoundly deaf individuals with hearing aids or cochlear implants were still poorer than age-equivalent normally hearing individuals with respect to cognitive flexibility, attention, working memory, processing speed and visuoperceptual functions. Due to a lack of data for the TUG, TMTB and DSC in the literature for hearing impaired individuals, the results reported here provide an important set of reference data for use in future research.

Impact of Breakfast Consumption and Sleep Habits on Morning Attention and Concentration Among Health Professional Students.

Background Breakfast consumption and sleep habits are known to affect cognitive performance, yet their specific impact on health professional students' morning attention is underresearched. Objective The study's objective was to assess the influence of sleeping habits and breakfast eating habits on health professional students' morning attention span. Methodology A cross-sectional study was conducted with 323 undergraduate health professional students from medical colleges in Lahore, Pakistan. Participants completed an online questionnaire that gathered data on demographic characteristics, breakfast consumption patterns, sleep habits, and morning attention levels. Morning attention was measured using a self-reported scale where students rated their ability to concentrate during morning lectures on a five-point Likert scale ranging from "very poor" to "very good." Additional questions assessed the frequency and quality of breakfast consumption, sleep duration, sleep quality (using the Pittsburgh Sleep Quality Index), and daytime napping habits. Statistical analyses, including descriptive statistics and multiple regression analysis, were conducted using the IBM SPSS Statistics for Windows, Version 23 (Released 2015; IBM Corp., Armonk, New York, United States) to explore the relationships between breakfast and sleep habits and their effects on self-reported attention during morning lectures. Results Of the 323 participants, 78 (24.14%) never skipped breakfast, while 71 (22.93%) skipped breakfast regularly. Breakfast skippers exhibited poorer attention, with a coefficient of -0.45 (p = 0.0002). Students consuming a more nutritious breakfast demonstrated improved attention, with a coefficient of 0.32 (p < 0.0001). Regarding sleep, 196 students (60.68%) slept four to six hours; those with longer sleep durations had better attention (coefficient = 0.21, p = 0.020). Conversely, 271 participants (83.90%) reported that frequent daytime napping and poor sleep quality, including frequent nighttime awakenings, had a negative impact on attention, with coefficients of -0.30 (p = 0.007) and -0.28 (p = 0.005), respectively. Additionally, 161 students (49.84%) reported difficulty concentrating during morning lectures. Conclusion Regular consumption of a nutritious breakfast and sufficient sleep are crucial for maintaining optimal morning attention and cognitive performance among health professional students.

Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study

Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention performance. Eighty-nine healthy older adults (50–84 years, Mage 65.5 (SD=8.4) years, 74 f) underwent MRI brain scanning and completed two sustained attention tasks: a rapid visual information processing (RVP) task and sustained attention to response task (SART). Independent hierarchical linear regressions demonstrated that greater volumes of white matter hyperintensities (WMH) were associated with worse RVP_A’ performance, whereas greater grey matter volumes were associated with better RVP_A’ performance. Further, greater cerebral white matter volumes were associated with better SART_d’ performance. Importantly, mediation analyses revealed that both grey and white matter volumes completely mediated the relationship between ageing and sustained attention. These results explain disparate attentional findings in older adults, highlighting the intervening role of brain structure.

Cognitive function in dyslipidemia patients: exploring the impact of statins.

Evidence regarding the relationship between the use of statins and cognitive outcomes presents varying findings. This study aims to analyze the relationship between sustained statin use and cognitive performance in dyslipidemia patients. This study presents findings from the Beijing Ageing Brain Rejuvenation Initiative (BABRI) study, in which a cohort of community-dwelling dyslipidemia patients (Entire sample, N = 1,062, aged 50-86) was recruited. Participants were divided into two groups based on their sustained use statins (Statins group, N = 677) or not use any lipid-lowering agents (Untreated group, N = 385). Furthermore, the entire sample was stratified by age into the middle-aged sample (N = 451) and the older people sample (N = 611), following a similar categorization based on statin application. ANCOVA was used to evaluate the relationship between sustained statin use and cognitive function. Overall, in the total sample, the statins group demonstrated better cognition in overall cognition, memory, visuospatial ability, attention, executive function, and language domains compared to the untreated group. Moreover, the statins group only showed better performance in attention among the middle-aged sample. In the older people sample, statins group exhibited superior cognitive performance across various cognitive domains compared to untreated group. Among dyslipidemia patients in Beijing community, sustained statin users exhibited superior cognitive function across all domains compared to untreated individuals, with particularly noticeable improvements among those aged 65 and above. These findings underscore the protective effect of statins on cognitive function in dyslipidemia patients, highlighting significant benefits for the older people population.

Improving Cognitive Function: Blood Transfusions and Neurological Benefits in HIV Management

HIV-associated neurocognitive disorders (HAND) continue to affect a significant number of individuals despite the widespread use of antiretroviral therapy (ART). This review explores the potential benefits of blood transfusions in improving cognitive function among HIV patients. Blood transfusions, primarily used to treat anemia, can enhance oxygen delivery to the brain, thereby ameliorating cognitive deficits. Anemia is a common comorbidity in HIV, and its correction through blood transfusions has been associated with improvements in attention, memory, and executive function. Beyond addressing anemia, blood transfusions may also offer neuroprotective effects by modulating systemic inflammation. Chronic inflammation, a hallmark of HIV infection, contributes significantly to neurocognitive decline. By reducing levels of pro-inflammatory cytokines, blood transfusions can potentially mitigate neuroinflammation and protect against neuronal damage. Clinical studies have shown that HIV patients receiving blood transfusions for anemia management exhibit slower cognitive decline, suggesting a broader role for transfusions in preserving neurological health. While promising, the use of blood transfusions in HIV management must be carefully considered due to associated risks such as transfusion reactions and iron overload. Keywords: HIV, cognitive function, blood transfusions, neurological benefits, neurocognitive disorders

The Impact of Listening to Background Music on Inhibition Control and Prefrontal Cortical Activation in Healthy Older Adults: A Study Using Functional Near-Infrared Spectroscopy.

Introduction Aging declines executive functions, including attentional function and inhibitory control, which is the ability to inhibit inappropriate or irrelevant responses. Certain types of background music are negatively correlated with cognitive function. The prefrontal network is correlated with task performance related to executive function. This study aimed to assess the impact of listening to background music on inhibition control and prefrontal cortical (PFC) activation measured using functional near-infrared spectroscopy (fNIRS) in healthy older people. Methods In total, 59 healthy volunteers, including 32 healthy older and 27 younger individuals (mean age ± standard deviation: 69 ± 7 and 32 ± 8 years, respectively), participated in this study. The participants completed the inhibition control task (the go/no-go task) and a similar task while listening to certain melodies of children's songs that are popular in Japan. Changes in cerebral blood flow in the PFC during each task were evaluated using multichannel fNIRS. The relative changes in oxygenated hemoglobin (oxy-Hb) levels during the no-go and go tasks under the music and no-music conditions were compared using a paired t-test. Among the channels with a significant difference in oxy-Hb levels during the go/no-go task between the music and no-music conditions in the older group, the correlation between changes in accuracy response and oxy-Hb levels was validated using Pearson's correlation test. Results The task accuracy was significantly reduced under the music condition compared with that under the no-music condition in the older group but not in the younger group. The accuracy reduction was significantly greater in the older group than in the younger group. In older people, the oxy-Hb levels in 20 channels located in the bilateral Broadman area (BA) 9 and BA46 in the dorsolateral prefrontal cortex and the bilateral BA10 in the frontal pole cortex significantly increased during the no-go tasks under the music condition. During the go/no-go task under the music condition, the decline in task accuracy was significantly correlated with increased oxy-Hb levels in six channels located in the bilateral BA10 in older people. Conclusion Background music induced the decline of inhibition control and increase of PFC activity in healthy older adults.

Attentional Information Routing in The Human Brain.

Brain-wide communication supports behaviors that require coordination between sensory and associative regions. However, how large-scale brain networks route sensory information at fast timescales to guide upcoming actions remains unclear. Using spiking neural networks and human intracranial electrophysiology during spatial attention tasks, where participants detected a target at cued locations, we show that high-frequency activity bursts (HFAb) serve as information-carrying events, facilitating fast and long-range communications. HFAbs emerged as bouts of neural population spiking and were coordinated brain-wide through low-frequency rhythms. At the network-level, HFAb coordination identified distinct cue- and target-activated subnetworks. HFAbs following the cue onset in cue-subnetworks predicted successful target detection and preceded the information in target-subnetworks following target onset. Our findings suggest HFAbs as a neural mechanism for fast brain-wide information routing that supports attentional performance.