In order to clarify the performance degradation problem of fuel centrifugal pumps, a stochastic process-based performance degradation model modeling method is given with an aero-engine fuel centrifugal pump as the object of study, and the reliability assessment is carried out. First, the degradation modeling method based on stochastic process is given. Secondly, PumpLinx is utilized to obtain the performance degradation data of the centrifugal pump and perform data processing. Gamma and Wiener stochastic process models are given based on MATLAB. Finally, based on the centrifugal pump performance degradation data for centrifugal pump reliability assessment, and compare and analyze the advantages and disadvantages of the two modeling methods, and found that the degradation modeling method based on the Gamma process is more suitable for centrifugal pump reliability assessment.