ABSTRACT Research suggests that maladaptive perfectionism impedes the development of self-compassion, a self-attitude with numerous biopsychosocial benefits. The precise relationship between these constructs remains unclear, but accurate modeling could foster an understanding of the barriers that perfectionists experience to self-compassion, enabling focused interventions to be developed. This study used structural equation modeling within a convenience-sampled, general, population (n = 428; age = 34.3 yrs, SD = 12.1) to analyze how multidimensional perfectionism related to multidimensional self-compassion. The maladaptive perfectionism dimensions (Concern over Mistakes; Discrepancy) predicted lower levels of self-compassion and its positive dimensions (Self-kindness; Common Humanity; Mindfulness). Adaptive perfectionism also predicted higher levels of Self-judgment. Findings were discussed theoretically, and their utility for developing population-tailored, dual-focused, interventions aimed at reducing perfectionism and increasing self-compassion was explored.