Perfect System Research Articles

Novel investigation on adsorption analysis of safranal interacting with boron nitride and aluminum nitride fullerene-like cages: Drug delivery system

This study illustrates the effective control of COVID-19 infection through the adsorption of safranal (SAF) on B16N16 and Al16N16 fullerene-like cages. The SAF adsorption onto the B16N16 and Al16N16 surfaces in gas, water (H2O), and chloroform (CHCl3) environments were assessed using density functional theory (DFT) and time-dependent (TD) density functional theory methods, analyzing the substrates and their complexes. The Al16N16/SAF complex exhibited the most negative binding energy and structural stability in the water phase compared to the B16N16/SAF complex at the PBE0-D3 level. The thermodynamic parameters indicated that the adsorption of SAF onto the fullerene-like cages is exothermic, particularly for the Al16N16/SAF complex. Additionally, the interaction of SAF with the fullerene-like cages in the water phase is more pronounced than in gas and chloroform environments. The complexes' energy gap (Eg) decreases in all three environments compared to the perfect systems, with a significant reduction of over 21 % in all phases. This substantial decrease in the energy gap suggests that the complexes have increased reactivity and sensitivity to SAF, likely due to a significant change in electronic conductivity. The results of molecular docking indicate that the Al16N16/SAF complex in the water phase exhibited a strong binding affinity compared to the other compounds studied. These findings suggest that the Al16N16/SAF complex holds promise as a potential inhibitor for COVID-19 and as a valuable material for biomedical applications and drug delivery systems.

How the Global Burden of Animal Diseases links to the Global Burden of Crop Loss: a food systems perspective.

Food systems comprise interconnected webs of processes that together transform inputs (land, labour, water, nutrients and genetics, to mention just a few) into outputs such as nutrition and revenue for human societies. Perfect systems do not exist; rather, global food systems operate in the presence of hazards, biotic and abiotic alike, and under the constraint of limited resources to mitigate these hazards. There are, therefore, inefficiencies in these systems, which lead to losses in terms of monetary, nutritional, health and environmental values and create additional negative externalities in the health, social and environmental spaces. Health hazards in the food system do not respect arbitrary distinctions between the crop and livestock sectors, which are highly interconnected. These linkages exist where one sector provides inputs to another or through substitution effects where supply in one sector influences demand in another. The One Health approach advocates investigating the intersectoral hazards in a highly interdisciplinary manner. This article provides a conceptual framework for integrating the methodologies developed by the Global Burden of Crop Loss and Global Burden of Animal Diseases initiatives to generate burden estimates for hazards in food systems that better account for interconnectivity and foster an improved understanding of food systems that is aligned with the interdisciplinary nature of the One Health approach. A case study related to maize and poultry sector linkages in the wider context of public and environmental health is presented.

Reflecting on the symmetry of ecosystem tipping points: The influence of trait dissimilarity and environmental driver dynamics in a simple ecosystem model.

Our understanding of the similarity in trajectories of ecosystem changes during different directions of environmental change is limited. For example, do the dominant organisms exhibit the same responses to different directions of environmental change, that is, do they exhibit symmetric responses? Here, we explore whether such response symmetry is determined and controlled by the symmetry in the features of the underlying biological system (i.e., system symmetry), such as in the network and strength of biotic and abiotic processes, and in symmetry of the environmental change (i.e., environmental symmetry). For this exploration, we developed and used a simple mathematical model of a microbial ecosystem driven by mutual inhibition in which we could vary the amount of system and environmental symmetry. Our results show that perfect system and environmental symmetry indeed produce perfect response symmetry. Moreover, introducing asymmetry in biological systems or in the environment proportionally increases response asymmetry. These findings suggest using symmetries in ecosystem structure and interaction strength to better understand and predict similarities in degradation and restoration phases of environmental change.

Ultra-sensitive humidity sensing based on Coherent perfect absorber-lasing system

Abstract As a singularity in non-Hermitian physics, coherent perfect absorber-lasing (CPAL) point theoretically has an infinite quality factor and can detect small perturbations, so it has potential applications in ultra-sensitive sensors. However, in the radio frequency field, due to deviations in actual components, the system will deviate from the CPAL point and the performance will degrade significantly (the output coefficient amplitude is only 30 dB). At the same time, actual sensing research is also very lacking. Based on these, we demonstrate a CPAL-based sensor system that increases its output coefficient amplitude to 60dB. When using the lasing state as the sensing mode, it has a capacitance detection accuracy of 10 fF. Then a high-frequency capacitive humidity sensor based on polyaniline/graphene oxide/titanium dioxide film is designed. The heterojunction formed between these materials increases the number of active sites for adsorbing water molecules. With the ultra-high capacitance detection accuracy of the CPAL sensor system, it is finally able to distinguish a 1% relative humidity change at 20%RH (corresponding to a 20 fF capacitance change, or a 1.63 dB output coefficient change), showing potential sensing application prospects.

Remote refocusing for multi-scale imaging.

The technique of remote focusing (RF) has attracted considerable attention among microscopists due to its ability to quickly adjust focus across different planes, thus facilitating quicker volumetric imaging. However, the difficulty in changing objectives to align with a matching objective in a remote setting while upholding key requirements remains a challenge. We aim to propose a customized yet straightforward technique to align multiple objectives with a remote objective, employing an identical set of optical elements to ensure meeting the criteria of remote focusing. We propose a simple optical approach for aligning multiple objectives with a singular remote objective to achieve a perfect imaging system. This method utilizes readily accessible, commercial optical components to meet the fundamental requirements of remote focusing. Our experimental observations indicate that the proposed RF technique offers at least comparable, if not superior, performance over a significant axial depth compared with the conventional RF technique based on commercial lenses while offering the flexibility to switch the objective for multi-scale imaging. The proposed technique addresses various microscopy challenges, particularly in the realm of multi-resolution imaging. We have experimentally demonstrated the efficacy of this technique by capturing images of focal volumes generated by two distinct objectives in a water medium.

The Application of Differentiated Pricing Strategy in M&A Practice of Listed Companies

In recent years, with the continuous active market of listed companies M&A and reorganization, the phenomenon of differentiated transaction pricing M&A is very common. In order to quickly shorten the transaction process, the initial design of the transaction plan needs to pay attention to the demands of the transaction parties, and the application of differentiated pricing strategy meets the diversified needs of the transaction parties. Based on the historical wave of M&A and the development status of Chinese listed companies, this paper analyzes the applicability and defects of M&A pricing of Chinese listed companies from the point of view of the core issue in the M&A process. This paper studies the pricing problem from two aspects. First, starting from the deterministic system, it analyzes the pricing of M&A enterprises under the perfect market system. The second is from the actual situation of China, the use of AMPS model for analysis. The research results show that the practice of differentiated pricing strategy of listed companies can not only deepen the understanding of the role of corporate governance in M&A, but also promote the effective risk control and profit maximization of listed companies. The research significance is to have a further understanding of the M&A pricing of China's joint-stock enterprises.

Enhanced thermoelectric performance of graphene [formula omitted] junction nanoribbon

We study the thermoelectric transport of the graphene p−n junction under the perpendicular magnetic field. The Seebeck coefficient Sc, the thermoelectrical figure of merit ZT and the power-generation efficiency η are obtained by the Landauer–Büttiker formula combined with the nonequilibrium Green’s function method. Compared to the perfect graphene system, the graphene p−n junction has a zero-transport coefficient plateau (or the transport gap). The sudden jump of the transmission coefficient near the transport gap edge lead to very larger peaks of the Sc and ZT. Especially in the presence of a magnetic field, the perpendicular magnetic field applied to the p−n junction strongly suppresses the conductance, and enhances the Seebeck coefficient Sc and increases the ZT. Moreover, it is found that the Seebeck coefficient Sc and ZT are strongly dependent on the applied perpendicular magnetic field ϕ, the potential drop in the center region of the p−n junction and the center region length M of the p−n junction. This means that the thermoelectric performance of the graphene p−n junction can be easily regulated by changing the magnetic field and the center region lengths of the p−n junction. Finally, the power-generation efficiency η of the graphene p−n junction as a power generator is calculated. It is found that when the Carnot power-generation efficiency is greater than 30%, ZTM can still be greater than 10. The large ZTM value also maintains a high power-generation efficiency, which indicates that the graphene p−n junction has potential applications as thermoelectric devices.

Design and evaluation of a four-DoF upper limb exoskeleton with gravity compensation

Gravity compensation (GC) mechanisms are commonly employed to either support limb gravity in passive exoskeletons or decrease motor power for safe human-robot interaction in active exoskeletons. This paper proposes a four-degree-of-freedom (DoF) upper limb exoskeleton with a theoretically perfect GC system, incorporating three DoFs in the shoulder and one DoF in the elbow. Paired with the anthropomorphic structure, the compact and adjustable GC system housed within the exoskeleton's linkages, reduces limitations on the limb's motion range and facilitates the integration of actuators for an active system. First, the GC system is designed through the analysis of potential energy equations, employing five cable-pulley-spring based units interconnected by parallel and differential mechanisms. Subsequently, the mechanical structure of the exoskeleton is developed, and the theoretically perfect GC in the quasi-static state is verified through numerical calculations. Then, the prototype is fabricated, and its actual performance is evaluated through experiments. The experimental results demonstrate the effectiveness of the exoskeleton with GC. Finally, a potential solution for the integration of actuators is demonstrated, and the limitation of the proposed system is also well discussed.

A Framework for Extensive Content-Based Image Retrieval System Incorporating Relevance Feedback and Query Suggestion

Over the last decade, there is a huge amount of images in which visual information has become increasingly important. If the images are to be utilized, they must be organized into databases, from there it can be searched based on different criteria. Content-based Image retrieval (CBIR) frameworks have turned into a mainstream subject of exploration; for their ability to retrieve images based on the real visual content rather than by manually connected textual descriptions. In the CBIR framework, analysis and interpretation of image information in large and diverse image databases is evidently complex because there is no prior information on the size or scale of individual structures within the images to be analyzed. In CBIR, retrieval is based on visual image features, which can be extracted automatically from the images with the help of human intervention, namely a technique called relevance feedback. Nonetheless, an efficient way of differentiating the visual content of images is complex to produce. Therefore, rather than a perfect solution CBIR systems must be able to exploit a partial solution to the problem of image understanding. In this paper, there is implementation of a CBIR framework is introduced that not only tries to efficiently capture the user intent based on the feedback but also provide query suggestions that can help its users to pose better queries in order to retrieve desired results in an efficient manner. The proposed technique is straightforward to implement and scopes efficiently to huge datasets. Extensive experiments on diverse real datasets with image similarity measures have revealed the dominance of the proposed method over original algorithms.

Проблемные вопросы унификации современного российского права

This scientific work is devoted to the most common problems of unification of modern Russian law. Unification of law is the process of bringing various normative acts into a single system that ensures their interconnection and consistency. Such unification makes it possible to create a more perfect and effective system of law, ensuring equality before the law and protection of the rights and freedoms of citizens. However, despite significant progress in this direction, a number of problems still exist and require further improvement.

Жароміцні інтерметалідні сплави та особливості їх легування

The work considers the prerequisites for the development of creep-resistant and heat-resistant alloys, based on intermetallics, taking into account the optimal combination of their physical and mechanical properties, as well as structural characteristics. It is shown that there is a sufficient number of intermetallics, which have a density lower than iron-based alloys, which, in combination with high melting temperatures and heat resistance, makes them promising materials for aerospace application, in particular, for gas turbine engine parts manufacturing. The most suitable creep-resistant and heat-resistant intermetallics can be called aluminides and silicides of titanium, nickel and molybdenum. For these compounds, it is possible to combine high values of specific strength with alloying-favorable types of crystal lattice. One of the most important and common creep-resistant alloys based on intermetallics is Ni3Al with FCC lattice. For this material, complex optimized alloying is the main way to increase creep resistance. The heat resistance of such alloys is significantly increased by applying ceramic coatings. Titanium aluminides Ti3Al and TiAl mainly have only a low density among the advantages. Their fragility at room temperatures and tendency to superplasticity at high temperatures significantly limits their application. The impact of disadvantages may be reduced by applying thermomechanical processing of such materials, which aims to change their structure. Alloying titanium aluminides with a large amount of niobium was chosen as a solution that significantly reduced marked week sides of Ti-Al intermetallic alloys. As a result, this led to the creation of a new alloy based on intermetallic Ti2AlNb with a high set of operational characteristics. Mo-Si and Mo-Si-B can be considered as one of the most perfect systems for creating heat-resistant intermetallic alloys. They combine an acceptable density, high creep and heat resistance, which can be additionally increased by reinforcing with ceramic particles. Keywords: intermetallic-based alloys, creep resistance, alloying, Ni-Al, Ti-Al, Mo-Si, Mo-Si-B.

Utilization of outpatient service of pneumoconiosis patients in Chongqing and its influencing factors

Objective: To understand the utilization and characteristics of outpatient services for pneumoconiosis patients within two weeks in Chongqing, and analyze the influencing factors, so as to provide reference for relevant policy making. Methods: From October 2020 to October 2022, 1771 pneumoconiosis patients who met the inclusion criteria were selected by multi-stage stratified random cluster sampling. A questionnaire survey was conducted on their basic situation, utilization of outpatient services within two weeks, treatment for pneumoconiosis-related symptoms, and selection of medical service institutions using χ(2)-test and logistic regression analysis. Results: All the 1771 pneumoconiosis patients were male, with the average age of (56.1±10.19) years old. In the pneumoconiosis patients were treated in outpatient department within 2 weeks.40.0% (204/510) of aged 41~50 years Rural patients accounted for 87.8% (448/510) ; 65.1% (332/510) of silicosis patients, 37.5% (191/510) of stage II patients, 75.1% (383/510) of patients did not continue to engage in dust work after diagnosis of pneumoconiosis, and 57.1% (291/510) of patients never had work-related injury insurance at work. The outpatient rate within two weeks of pneumoconiosis related assistance and subsistence allowance was 17.6% (90/510) and 12.5% (64/510), respectively. The average self-health score of the patients was (52.9±16.2). 28.2% of the patients had purchased work-related injury insurance; Among the 1204 patients who received the treatment within two weeks, 42.2% were in the outpatient department, 20.7% were in the inpatient department, and 36.9% were self-buyers. There was a significant difference between the different treatment methods of the patients (χ(2)=27.53, P<0.05). There was a significant difference in patients from different residence choosing to visit different medical institutions (χ(2)=13.97, P<0.05). The stage of pneumoconiosis, presence of complications, presence of work injury insurance, self-health score, and whether he/she has been hospitalized in the past year are the important factors affecting the outpatient treatment of pneumoconiosis patients. Conclusion: The utilization of outpatient service of pneumoconiosis patients is influenced by demographic sociology, social support and disease characteristics. The quality of occupational disease medical service in primary health institutions should be strengthened so that pneumoconiosis patients can get convenient and effective treatment. Establish a more perfect social security support system to reduce the disease burden of pneumoconiosis patients.

Molecular dynamics simulation analysis of energy deposition on the evolution of single crystal silicon defect system

The understanding of the evolution of subsurface damage layer (SDL) in monocrystalline silicon materials following energy deposition holds significant importance in guiding the service process of single-crystal silicon devices. Therefore, on the basis of previous studies on defect generation and evolution of perfect monocrystalline silicon system, the structure evolution of monocrystalline silicon nano-grinding defect system after energy deposition was analyzed by molecular dynamics simulation. The results show that with the energy deposition, part of the crystal structure undergoes a phase transformation, which leads to the increase in the volume of the material and the surface bulge. The thickness of the subsurface damage layer gradually increases, reaches a maximum at a power density of 15×108 W/cm2, and then decreases before increasing again. The impact of energy deposition on surface roughness exhibits an initial gradual increase followed by a subsequent decrease. The work reveals the evolution of sedimentary systems at the atomic level, thus contributing to the application of ultra-precision monocrystalline silicon mirrors and telescopes.

Geometries, electronic structures, mechanical properties and stabilities of Fe128Hen and Fe127VacHen: An uniaxial compression effect

Owning to the factors of external mechanical loads and high heat flux deposition, various degrees of strain or stress are inevitably introduced into the structural materials of nuclear fusion reactors. The uniaxial compression effects on the geometries, electronic structures, mechanical properties, and stabilities of Fe128Hen and Fe127VacHen were studied by first-principles calculations in this work. The results show that the lattice suffers from a noticeable inclination or disorder as the strain reaches 15%. The maximum stress of the stress–strain curves implied that the mechanical characteristics decay considerably as the number of He atoms increases, but the presence of a vacancy mitigated this effect. Compressive strain decreases the stability of Fe atom in the perfect pure Fe system, but it slightly elevates the monovacancy formation energy from Fe128He3 onward. According to the binding energy of He-He, compressive strain enhanced the aggregation of He. The migration barriers of an interstitial He atom exhibit anisotropy under uniaxial compressive strain, which was explained by the variations of the surrounding architectures.

Characterization of two different alginate-based bioinks and the influence of melanoma growth within

Extrusion-based bioprinting is an established method in biofabrication. Suitable bioinks have fundamentally different compositions and characteristics, which should be examined, in order to find a perfect model system. Here, we investigate the effect of two alginate-based, yet unalike 3D-printed bioinks, pre-crosslinked alginate-dialdehyde gelatin (ADA-GEL) and a mixture of alginate, hyaluronic acid, and gelatin (Alg/HA/Gel), on the melanoma cell line Mel Im and vice versa in terms of stiffness, shrinkage, cellular behavior and colony formation over 15 days. Rheological stiffness measurements revealed two soft gels with similar storage moduli. The cells did not have a significant impact on the overall stiffness, whereas ADA-GEL (2.5/2.5%) was significantly stiffer than Alg/HA/Gel (0.5/0.1/3%). Regarding the shrinkage of printed constructs, cells had a significant influence, especially in ADA-GEL, which has covalent bonds between the oxidized alginate and gelatin. Multi-photon microscopy exhibited proliferation, cell spreading and migration in ADA-GEL with cell–cell and cell–matrix interaction, dissimilarly to Alg/HA/Gel, in which cells formed spherical, encapsulated colonies. Scanning electron microscopy and histology showed degradation and multi-layered growth on ADA-GEL and fewer examples of escaped cells on Alg/HA/Gel. Both gels serve as proliferation bioink for melanoma with more necrosis in deeper Alg/HA/Gel colonies and differences in spreading and matrix interaction. These findings show the importance of proper characterization of the bioinks for different applications.

Research on the Construction of Intelligent Library Micro-services System

With the advancement of the construction of smart libraries in China, grasping the new opportunities of scientific and technological revolution, providing micro-services based on their own resources to meet users' knowledge and information needs has become an important way for libraries to improve their own resource utilization, realize service upgrading and show their own value. Among many cutting-edge technologies, small programs based on micro-services have won the favor of the construction of smart library micro-services because of their characteristics of no download and instant search. However, at present, there are still many problems in smart library micro-services, such as lack of innovation in service content, single application of small program and lack of perfect service system. Therefore, it is necessary and urgent to deeply explore and study smart library micro-services.

Enhancing the Usability, Visibility, and Responsiveness of an Airline Reservation System: A User-Centered Design Approach

This paper presents the idea, design, and prototype of a flight search and airline booking system based on the perspective of user-centered design. The system is first sketched roughly on paper in the form of a sketched plan and implemented through the proper system by connecting with the rapid API to develop a responsive web application. Booking travel tickets is a hassle and quite stressful because there is a chance that the webpages take time, and several decisions to make, hard to choose a discounted or less expensive flight, and the user will have to put in a lot of effort with many browser tabs may leave open. If a user is looking for the lowest travel options within a range of dates, they need to search a lot of websites looking for better options. As UX designers, it is our responsibility to do some user research and identify the problem areas, then we will recommend some design options based on the research findings. After that, we will create a wireframe and prototype before jumping into web design by collecting all the requirements and analyzing the problems. We will be focusing on UI controls such as location picker, date picker, color contrast, accessibility, and so on. In this paper, we present the design and development of a user-centered flight search and booking system for the airline industry. Our goal is to create a system that would meet the needs and preferences of a diverse set of users. This paper will summarize the design, development, and implementation of an airline reservation system. We have used bubble.io to design the overall system and MYSQL as the database management system for this webpage. Our objective is to upgrade the current website by improving the usability, visibility, and responsiveness of the functions that the user will experience while buying a flight ticket. We have generated and managed the design documentation and a perfect user-based online flight booking system.

Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial

ObjectivesThis randomized controlled trial compared the efficacy and tolerability of danzhixiaoyao pills in the accurate treatment of patients with burning mouth syndrome (BMS).MethodCollect a total of 78 patients (75 female patients and 3 male patients) from the oral mucosa department who were considered eligible fromOctober 2020 to October 2022.The patients were randomized and divided into trial group and control group.The trail group received danzhixiaoyao pills and mecobalamine tablets while the control group was given mecobalamine tablets.The Visual Analogue Scale (VAS), Beck Anxiety Inventory(BAI), Beck Depression Inventory (BDI), Oral Health Impact Profile (OHIP-14), Traditional Chinese medicine(TCM) syndrome integral and adverse reactions were performed at baseline and after 2, 4, and 6 weeks of treatment. Descriptive statistics, including the Wilcoxon rank-sum test and the Chi-square test for median comparisons between different times, were used.Result1.After treatment, the VAS, BDI,OHIP-14, and TCM syndrome integral in the trial group had a significant decrease than the control group(P< 0.05).However, there was no statistical difference in the BAI scores between the two groups (P> 0.05). 2.According to the efficacy determination criteria , the total effective rate of the test group was 73.68% , the control group was 52.94% and the recurrence rate was 0. There was a significant difference between the two groups (Z=-2.688, P < 0.05). The results showed that the curative effect of test group was better than that of control group.3. No adverse effects occurred in patients in either group.ConclusionDanzhixiaoyao pills has demonstrated to have a positive effect in relieving BMS symptoms and in improving a patient's overall quality of life with no AEs compared with the control group. The efficacy evaluation systems that can be verified and complementary in this study provide a perfect, effective and referential evaluation system for the use of Chinese patent medicine in the treatment of oral mucosal diseases.Trial RegistrationRegistry name: Chinese Clinical trail RegistryRegistration number: ChiCTR2000038189Date of Registration: 2020-09-13Please visit (https://www.chictr.org.cn/showproj.html?proj=61462) to the protocol.

INSPIRE: INvestigating Stellar Population In RElics – VI. The low-mass end slope of the stellar initial mass function and chemical composition

ABSTRACT The INSPIRE project has built the largest sample of ultra-compact massive galaxies (UCMGs) at 0.1 &amp;lt; z &amp;lt; 0.4 and obtained their star formation histories (SFHs). Due to their preserved very old stellar populations, relics are the perfect systems to constrain the earliest epochs of mass assembly in the Universe and the formation of massive early-type galaxies. The goal of this work is to investigate whether a correlation exists between the degree of relicness (DoR), quantifying the fraction of stellar mass formed at z &amp;gt; 2, and the other stellar population parameters. We use the Full-Index-Fitting method to fit the INSPIRE spectra to single stellar population (SSP) models. This allows us to measure, for the first time, the slope of the IMF, as well as stellar metallicity [M/H], [Mg/Fe], [Ti/Fe], and [Na/Fe] ratios, and study correlations between them and the DoR. Similarly to normal-sized galaxies, UCMGs with larger stellar masses have overall higher metallicities. We found a correlation between the IMF slope and the DoR, that, however, breaks down for systems with a more extended SFH. An even stronger dependency is found between the IMF and the fraction of mass formed at high-z. At equal velocity dispersion and metallicity, galaxies with a higher DoR have a larger dwarf-to-giant ratio, i.e. a bottom heavy IMF, than that of low-DoR counterparts. This might indicate that the cosmic epoch and therefore different formation scenarios influence the fragmentation of the star formation cloud and hence might be the explanation for IMF variations detected in massive ETGs.

Reflections on the Use of Big Data Analysis to Enhance the Level of Grassroots Supervision Work in the Construction of Smart Customs -- Research on Supervision Scenario Innovation in Digital Government Construction

In the construction of smart customs, how to use the idea of digital government to strengthen the supervision and control of grassroots power has become a new mode indispensable for customs to improve its governance capacity in the era of big data. I study the significance of big data analysis on supervision in the construction of smart customs, the main structural characteristics, the current problems and measures, so as to make a better combination of big data analysis and grass-roots supervision, so as to establish a more efficient and more perfect supervision system, so that the supervision mechanism can run better, and to build a good cage of power.