The amplitude modulator with the function of converting electric signal to optical amplitude modulation is a key component in high-speed optical communication links. In this paper, we demonstrate a variety of two-dimensional graphene-integrated photonic crystal fiber modulators for efficient near-infrared amplitude modulation with ultra-low insertion loss. Taking the advantages of the perfect total internal reflection of the porous photonic crystal fiber and flexible tunability of the graphene conductivity, the modulation depth of 0.075 dB μm−1 with a low optical loss of 2.13 × 10−4 dB μm−1, a long propagation length of ∼20 mm and polarization-insensitive characteristics in a wide wavelength of 1.3 to 1.8 μm can be achieved. This high-performance modulator may have great potential applications in various high-speed telecommunication, interconnection, and graphene-based integrated photonic systems.