Perfect Collaboration Research Articles

Prevalence of Postural Deformities Among School Going Children in Rural Areas Due To School Furniture: A Cross-Sectional Study

Posture is an upright position that is generally kept against gravity. Body posture is influenced by many factors including general health, musculoskeletal alignment, body endurance, muscle strength, weight, height, fatigue, state of mind, and age etc. The perfect collaboration between segments of the body is called good posture. The imperfect collaboration between segments of the body is called bad posture. Abnormal body posture can cause various musculoskeletal disorders along with headache, fatigue, cervical and lumber pain. The prevalence of musculoskeletal disorders in school going children can be reduced by macro and micro ergonomic approach such as postural awareness, furniture design and bag pack loads carriage. School pupils sit for many of their classroom lessons and adopt different postures. An inappropriate body posture can destroy a student’s interest, even during the most stimulating lecture. School children attend schools for a considerable amount of time, 6 h a day on average. They spend the largest part of their time at school performing different related activities, which lead them to be seated on their seats constantly for a long time. Classroom furniture is usually not designed to accommodate the dimensions of the individual user. Considering that school is an ideal setting for the acquisition of healthy habits that can continue into adulthood, it is necessary to implement actions to identify ideal school furniture dimensions.

Revisiting Tantrasamuccaya: A Fundamental text for Kerala Tantra

Tantrasamuccaya of Chennas Narayanan Namboothiri is Kerala's most influential and widely practised ritual manual. It primarily deals with temple-related rituals, from constructing a new temple to installing and expiatory traditions. It is written in the Malayalam language. The author was considered to be an authority in the fields of mathematics and tantra. Tantrasamuchaya is still considered the authentic reference manual in temple architecture and rituals. The temple in Śaiva theology is conceived as a powerful, sacred space where various divine energies are invoked and worshipped for the benefit of all creation. Temple construction was a perfect collaboration between the Ācārya and the Sthapati, using the canonical texts of the śaivāgama-s and śilpa śāstra manuals. The rich temple-building culture of Hinduism seems to have been carried to foreign shores, at least in part with traders, merchants and emperors. Tantra is very close to actual practice. Things done come first, and interpretations come later. No Tantrika would expect to be able to move straight from ordinary life to the most exalted stages of internal symbolism by mere thought. Some people will say The Tantra represents a thoroughgoing, practical system for manipulating and focusing human libido, enhancing it and then withdrawing it entirely from the passing and valueness phenomena of the word and directing it instead to a transcendent object. According to Tantra, creation is sexual self-realisation through the activity of the goddess. Tantra is esoteric, and much of it is always kept secret. In all Indian ceremonies, pooja is the root activity. In Tantric Pooja, the most crucial point is that the symbolism of the whole ceremony is taken over and applied by the pujari to himself through an intense meditation on the significance of each act as he performs it. Innumerable works of Tantra contain references to basic pooja. The vessels and implements by the Tantric pujaris are often worshipped as devatha emblematic of the activities of the transmuted self.

Empirijska studija uslova rada i performansi produktivnosti posle implementacije kolaborativne robotike u procesu proizvodne montaže

Industry 4.0 has led to a widespread and impactful evolution of technology that is transforming industry and organizations in general. Collaborative robotics is considered one of the new features in this movement allowing humans and robots to work together in perfect collaboration. This paper presents the implementation of one collaborative robot in an assembly process and analyses its impact on performance and ergonomic work conditions. In terms of ergonomic conditions, the musculoskeletal risk was assessed, comparing both processes (without and with robotics support). The results demonstrated that collaborative robotics is a solution that allows improving the ergonomic work conditions throughout the assembly process.

20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life).

This paper summarizes a personal perspective on key learnings from projects the author was involved in over the last 20 years. For example, the discovery of macitentan, the most successful molecule to date from this personal collection, marketed by J&J for the treatment of pulmonary arterial hypertension (PAH). [1] Then the discovery of ACT-462206, a dual orexin receptor antagonist for the treatment of insomnia disorder with a serendipitously short story from the screening hit to the drug [2] followed by the identification of daridorexant, another dual orexin receptor antagonist. Daridorexant successfully passed first pivotal phase 3 clinical trial in April 2020 for the treatment of insomnia disorder [3] ("Good things come to those who wait"). Finally, ACT-451840, an antimalarial drug with a novel mechanism of action, identified in the perfect collaboration between academia and industry. The compound is in phase 2 clinical development. [4] In addition, the importance of the screening compound collection is briefly discussed, as a key asset for drug discovery. The measures Idorsia implemented to obtain valuable hits from high-throughput screening (HTS) campaigns are elaborated. [5] Drug discovery is a multi-disciplinary business with unlimited exciting challenges asking for excessive optimism when tackling them in a playful manner.

Optimal contract design for the exchange of tradable truck permits at multiterminal ports

Truck Appointment System (TAS) is a very common IT system used by marine container ports. At multi-terminal ports, each terminal normally operates its TAS independently, and there is a lack of coordination on how time slots are allocated to trucks across TASs. This is one of the major reasons for truck congestions in port hinterland areas. In this study, a concept of Tradable Truck Permit(TTP), which is adapted from the early idea of Traffic Bottleneck Permit in urban traffic management, is introduced to coordinate the TASs operated by different terminals located in the same port. To further improve the utilisation of TTP, a game theoretical framework is developed to investigate the exchange of TTPs across terminals. The framework includes a centralised decision making mode for perfect collaboration and a decentralised decision making mode for contract-based collaboration. The centralised mode is used for benchmarking the performance of the contract in the decentralised decision making mode. It has been found that a bilateral buy-back contract can coordinate the exchange of TTPs. In other words, even when the decision on permit exchange is made by each terminal independently, the buy-back contact can generate the same amount of profits as perfect collaboration does as long as the parameters in the contract are set properly.

Résultats chirurgicaux à propos de 64 patients opérés pour dilatations des bronches

Bronchiectasis is a serious and disabling disease. Surgical treatment is an interesting alternative to be proposed early to patients in case of complications or deterioration of quality of life, despite an optimal medical treatment. Through this retrospective study and literature review, we analyze surgical results for bronchiectasis. We conducted a monocentric, retrospective, descriptive and analytical study in the Department of thoracic surgery of CHU Hassan II Fès, about 64patients operated for bronchiectasis during the period from January 2009to December 2016. There were 30men and 34women with an average age of 32years. Twenty six percent (26%) had a history of recurrent lung infection, and 17.18% would have been treated for pulmonary tuberculosis and declared cured. Productive cough (93%), morning chronic bronchorrhea (92%) and repeatedly hemoptysis (62.5%) were the main symptoms. On CT scanning, the bronchiectasis was unilateral and localized in 49cases. The right lung was involved in 27cases and the location was bilateral in 15cases. It was 38cystic bronchiectasis, 16cylindrical bronchiectasis, and 10mixed lesions predominantly cylindrical. The flexible bronchoscopy carried out in 34cases, had shown a carcinoid tumor in 1case, a bronchiolithiasis in 1case and a intrabronchial foreign body in 1case. The incision was a conservative posterolateral thoracotomy in all cases. The performed surgical procedure was lobectomy in 53% of patients. The morbidity rate was 32.80% and dominated by septic complications. After a mean follow-up of 20.52months, 2cases of recurrence minimal hemoptysis and 1case of renewed bronchorrhea are noted. For all other patients the outcome was favorable and no deaths have been noted to date. The surgery of bronchiectasis requires a perfect collaboration between the pulmonologist, the thoracic surgeon, the anesthesiologist, the biologist and particularly the physiotherapist for an optimal care of patients.

Escarre trochantérienne géante récidivante : une prise en charge médico-chirurgicale complexe

Pressure sores are a frequent complication in spinal injured people. Their treatment is often long and complex. We report the case of a 60-year-old man affected with complete paraplegia who developed a right trochanteric pressure ulcer complicated with osteoarthritis of the coxofemoral joint. The treatment was done in three steps. First, a large excision of necrotic tissues and a femoral head-neck resection is performed. Then, the defect is partly covered with a Gluteus Maximus and a Biceps Femoris myocutaneous flaps. Finally, the residual defect is covered with a cutaneous pedicled groin flap called McGregor's flap. Later, the patient showed a right para-scrotal pressure sore on a heterotopic ossification of the ischial tuberosity. McGregor's flap is rarely employed for treating trochanteric pressure sores. It was here the only pedicled flap available. It was necessary to autonomize it in order to get enough length and to place a hip external fixation. The para-scrotal pressure sore illustrates the fact that bone resection surgery lifts the weight-bearing zones and can lead to pressure sores in unusual locations. The surgical treatment of these "giant" pressure sores requires a perfect collaboration between teams of rehabilitation and several surgical areas. Without a good adherence of the patient, the treatment is doomed to fail.

The reliability of asleep-awake-asleep protocol for intraoperative functional mapping and cognitive monitoring in glioma surgery

In this issue of Acta Neurochirurgica, Hansen et al. [9] proposed a new anaesthesiologic protocol for intrasurgical mapping “Awake craniotomies without any sedation: the awake-awake-awake technique”. They reported a series of 50 patients who underwent such “awake-awake-awake” craniotomy for resection of 49 tumors (46 gliomas, three metastasis) and one cavernoma in eloquent areas. Patients did not require any sedation and no or only low-dose opioid treatment. The authors have therefore to be congratulated for their results. Indeed, beyond the methodological aspect, the main message is that intraoperative electrical mapping should be universally implemented as standard of care for glioma surgery. This was demonstrated in a meta-analysis with 8091 adult patients who underwent resective surgery for supratentorial infiltrative glioma. It was shown that glioma resections using intrasurgical stimulation mapping were associated with fewer late severe neurologic deficits (less than 3.5 %) and more extensive resection, while they involved eloquent locations more frequently [3]. In this state of mind, awake surgery allows mapping of sensory-motor, visual, language and other cognitive functions, with a low rate of permanent neurologic worsening—less than 2 % in the recent series [4, 7, 10]. This is the reason why the awake period should be optimal, with a perfect collaboration of the patient. As a consequence, several issues may be discussed regarding the technical procedure advocated by Hansen et al. First of all, according to the authors, it seems that the classical “asleep-awake-asleep” technique has many drawbacks, side effects and risks. However, our team has recently published a prospective series with 140 patients who were operated on for a glioma involving eloquent area using “asleepawake-asleep” procedure, and demonstrated that no seizures, no swelling, no severe permanent neurological deficit and no mortality occurred (only one case of aspiration of gastric contents with a favorable outcome) [2]. These data confirmed the results we have already published in a previous retrospective study [4], demonstrating the reliability of “awake-asleep-awake” protocol. Nonetheless, in their experience, Hansen et al. [9] have reported a high rate of 16 % of seizures using their technique, with 16 % of new neurological deficits—which is a high rate in comparison with the recent literature (see above). In addition, they have also claimed that patients undergoing awake craniotomies had “anxiety and fears”, due to “terrifying noises and surroundings, immobility, loss of control, and the feeling of helplessness and being left alone”. Yet, in a recent prospective European Low Grade Glioma Network multicenter study with 105 patients, awake-asleepawake surgery was used in the vast majority of cases (eight operations were performed according to an asleep-awake protocol, but never using awake-awake-awake technique) [1]. We demonstrated that awake surgery was well tolerated, as neither intraoperative nor postoperative assessment revealed major disadvantages. Especially, pain levels on a 10-cm visual analogue scale were between 1.3 cm and 2.1 cm, while levels of anxiety were between 2.2 cm and 2.6 cm. In the same vein, Deras et al. observed only 0.7 of cooperation problem [2]. Thus, these findings demonstrate that asleep-awake-asleep protocol is also reproducible among institutions. H. Duffau (*) Department of Neurosurgery, Hopital Gui de Chauliac, Montpellier University Medical Center, 80 Av Augustin Fliche, 34295 Montpellier, France e-mail: h-duffau@chu-montpellier.fr

Raw Material Stock Analysis in a Supply Chain

Between regularity of production, selling goods and regularity of supply units need to be a perfect timing and a perfect collaboration. The paper presents the policies that can occur in each production systems, and the benefits that can be obtained from the collaboration between the systems elements. The competitive advantage is ensured through the harmonization of the three processes of the company and through the integration of the logistics chain of all upstream and downstream organizations in order to ensure a high level of consumer service at economical costs.

Evidence Over Barriers: Important But Not Enough

Overcoming the boundary conditions that impede the flow of evidence derived from research from academia to healthcare decision-makers in government and their agencies continues to be a challenge. But even the reduction/elimination of all such barriers and perfect collaboration are unlikely to yield what those of us in the "real world" yearn for, doing the right things right - policy and other decisions perfectly informed by evidence of what works and what doesn't to achieve a defined outcome. For that to happen, the calculus of decision-makers would have to exclude or evidence would have to trump political considerations, both large P and small p, an unlikely accomplishment in British Columbia or anywhere in our so-called healthcare system. That's reality!

Project Muskan : Social responsibility of the plastic surgeon

ABSTRACTAlthough exact statistics are not available, Indian plastic surgeons see around 7,00,000-8,00,000 burn admissions annually with around 10,00,000 cleft patients yet to be operated. In spite of this voluminous load, India does not have national health programs for the various deformities Indian plastic surgeons typically treat. As Plastic Surgeons, it is our social responsibility to treat these patients and bring ′ muskan ′ (smile in Hindi) back into their lives. Project Muskan was initiated as an innovative model for targeting these patients and is probably one of its kind in the field of plastic surgery in our country. It is unique because it is a perfect collaboration of government institutions, a Non Government Organization (NGO), and cooperative sectors providing free health care at the doorstep. Identification of the patients was done with the help of the extensive milk dairy network in the state of Gujarat. Provision of transport and other facilities was done by the NGOs and quality health care provision was taken care of by the government hospital. Project Muskan started from a single village but now covers around 3000 villages and tribal areas of Gujarat. It is a system that can be easily reproducible in all hospitals and has reestablished the faith of the common man in government institutes.

Project <i> Muskan</i> : Social responsibility of the plastic surgeon

Although exact statistics are not available, Indian plastic surgeons see around 7,00,000–8,00,000 burn admissions annually with around 10,00,000 cleft patients yet to be operated. In spite of this voluminous load, India does not have national health programs for the various deformities Indian plastic surgeons typically treat. As Plastic Surgeons, it is our social responsibility to treat these patients and bring ‘muskan’ (smile in Hindi) back into their lives. Project Muskan was initiated as an innovative model for targeting these patients and is probably one of its kind in the field of plastic surgery in our country. It is unique because it is a perfect collaboration of government institutions, a Non Government Organization (NGO), and cooperative sectors providing free health care at the doorstep. Identification of the patients was done with the help of the extensive milk dairy network in the state of Gujarat. Provision of transport and other facilities was done by the NGOs and quality health care provision was taken care of by the government hospital. Project Muskan started from a single village but now covers around 3000 villages and tribal areas of Gujarat. It is a system that can be easily reproducible in all hospitals and has reestablished the faith of the common man in government institutes.

Optimal business policies for a supplier–transporter–buyer channel with a price-sensitive demand

As the third party logistics partners (carriers) taking a more and more significant role in supply chain practices and customer service performance improvement, there is an emerging need for the studies on optimal channel coordination policies for business processes involving not only supplier and buyer (retailer), but also transportation partners. In this paper, we explicitly add a transportation partner with concave cost functions into the analysis for supplier–buyer channel coordination policies, and analyse the impact of coordination and pricing policies on supply chain profitability. The market demand is assumed to be a decreasing convex function of buyer's selling price (x), D(x)=d/x2. Under this assumption, we quantify the improvement on total supply chain profitability when moving from a non-cooperative environment to a fully cooperative environment, and show that the joint annual profit of three partners in a cooperative environment can be at least twice of what may be achieved by three independently operated companies in a leader–follower business game. While in a real-world business environment, a perfect collaboration is hard to achieve, this result can be used to provide a quick estimation on the upper bound on the budget for profit sharing or discount offers among the supply chain partners.

Banking of the human heart valves and the arteries at the European homograft bank (EHB) – Overview of a 14-year activity in this International Association in Brussels*

Processing of the human heart valves and arteries has been carried out at the European Homograft Bank (EHB) in Brussels since 1989 and 1991, respectively. Heart valve donors of 0-65 years were classified in (1) Beating heart donors (BHD), of which recipients of heart transplantation (RHT) and multiorgan donors (MOD) after brain death, and (2) non-beating heart donors (NBHD) with warm ischaemic time (WIT) of less then 6 h. Past history of the donors has been checked for malignant and chronic diseases, as well as biology for transmissible and infectious diseases. Perfect collaboration has been established with the transplant coordinators and transplant teams of the implanting centres. Dissection, decontamination, cryopreservation and storing in fluid nitrogen has been carried out in accordance with the Belgian and European Standards of cardiovascular allografts. During this period, a total of 2.828 hearts, 28 predissected valves and 616 batches of arteries arrived in the EHB. 3.537 valves and 1.137 different arteries were accepted for implantation. The main reasons for tissue rejection were morphology, contamination and cuts during the tissue retrieval or dissection. A huge network of different hospitals in Belgium and elsewhere in Europe and Switzerland were included in this process. Pulmonary allografts were not sent for implantation in the left ventricular outflow tract after 1998, since the early and mid-term results after 76 implantations were disappointing. The number of implanted aortic and pulmonary allografts remains stable from year to year, however the number of the allografts used for Ross operation is still increasing. Since the results of the follow up were disappointing, we still only require the implantation and immediate postoperative results, whereas the follow-up information only for specific study purposes.

Quand et comment faut-il opérer une craniosténose ?

Craniosynostoses are a group of diseases, the presentation of which differs markedly on account of the cranial suture involved. Their impact is cosmetic, cerebral, and ophthalmologic. Syndromic craniosynostoses associate a more or less pronounced faciostenosis, which requires surgical correction as well, because of cosmetic, ophthalmologic or airway problems. Surgical treatment depends on the type of the craniosynostosis and the patientˈs age; ideally, the child should be operated between 3 and 12 months. This surgery requires a perfect collaboration between neurosurgeon, plastic surgeon, and anaesthesiologist. Surgical correction allows in large measures the preservation of intellect, sight, and body image.

L’archéologue devant les moyens offerts par l’archéométrie

Loïc Langouet. The archaeology before the means given by archaeometry. To resolve their problematics for the best, archeaologists appeal more and more to the sciences of the nature (physics, chemistry, geology, botany, zoology, etc...)- This had led to a development of the pluridisciplinarity. However some progress remain to be done for a perfect collaboration between specialists in archaeology and archaeometry. Especially, it would be necessary to define deontology rules for ground research.