The current problem is that many vocational school graduate students still need more skills. Students' skills and readiness are influenced by many factors including productive competence, internship, and family support. This research aims to analyze the influence of perceptions of productive competence, industrial work, and family support on vocational school students' work readiness, partially or simultaneously mediated by self-efficacy. This research is causal associative research with a quantitative approach. The total population in this study was 1132 students. The sample for this research was 296 respondents. The method used to collect data is a questionnaire. The instrument used to collect data was a questionnaire. The data analysis method used is descriptive and inferential statistical analysis. The data analysis technique used is Structural Equation Modeling (SEM). The research results show that students' perceptions of productive competence, industrial work practices, family support, and self-efficacy have a positive and significant effect on students' work readiness. Based on the results of the Sobel test, Self-Efficacy can mediate the influence of productive competence, industrial work practices, and family support on vocational school students' work readiness. It was concluded that perceptions of productive competence, industrial work, and family support influenced vocational school students' work readiness. The implication of this research is that family and school support is very necessary for students so that students have good work readiness.