Perception Of Duration Research Articles

Adherence and safety study in patients on treatment with capecitabine

BackgroundThe introduction of oral antineoplastic agents in therapeutics has caused a change in the treatment strategy against cancer. The objective of this study was to analyze the adherence in patients to treatment with capecitabine, their adverse events, and the overall health status of patients, as well as the relationship of these factors with adherence. MethodAn observational, prospective study at 7 months, in a cohort of patients on capecitabine treatment, including treatment initiations and continuations, regardless of diagnosis or indication. The data collected were: demographic variables (age, gender), diagnostic (breast cancer, colorectal cancer, gastric cancer, off-label), adherence (tablet count, Morisky test, Sackett test), safety (assessment of adverse events, clinical evaluation by the oncologist) and quality of life (performance status, SF-12 test). Data sources: electronic clinical records (IANUS®), dispensing program for outpatients (SILICON®) and interviews with patients. ResultsThere were 111 evaluable patients, with a mean age of 66.7 years (range 32-86), ECOG PS 1 in 76.6%. Adherence level: 78.4% (81.7% in the initiation sub-group vs. 72.5% in the continuation sub-group). Adverse events: skin toxicity (33.33%), asthenia (25.22%), gastrointestinal toxicity (24.32%) and neurological toxicity (24.32%), mostly G1. Health status, SF-12 test: subjective evaluation as “good” in 33.30% of cases. ConclusionsThe low level of adherence in the continuation sub-group can be associated with the duration of treatment, toxicities, clinical evolution, and perception of their health status. It is necessary to conduct individualized monitoring in this group of patients in order to obtain a favorable clinical response.

Contextual effects on duration perception are modality-specific.

The perception of magnitude, crucial for a mental representation of the physical world, is often subject to significant biases. Many of these biases are similar across sensory modalities, implying a generalized perception of magnitude. At the same time, some physical magnitudes might have a dedicated modality-specific calibration mechanism to enhance perceptual sensitivity. We examined this question of generalized versus modality-specific processes testing between- and within-modalities' contextual effects on the perception of magnitude. In a constant stimuli procedure, a central standard was embedded in shorter and longer contextual standards. These contextual standards were sampled in either a relatively wider or narrower range of durations. Participants were asked to determine which of the two consecutive durations was longer. Better perceptual sensitivity was found for narrower contexts, with stronger effects in trials in which the standard was presented first. Interestingly, narrower context enhanced sensitivity for standards within the same modality but had no effect on standards of another modality. A unidirectional transfer of contextual effects was observed under certain conditions from auditory, the dominant modality in performing temporal judgments, to vision. These results suggest that the perceptual system appears to develop modality-specific calibration mechanisms, most likely, to enhance perceptual sensitivity and maintain sensory specialization. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

An Accumulating Neural Signal Underlying Binocular Rivalry Dynamics.

During binocular rivalry, conflicting images are presented one to each eye and perception alternates stochastically between them. Despite stable percepts between alternations, modeling suggests that neural signals representing the two images change gradually, and that the duration of stable percepts are determined by the time required for these signals to reach a threshold that triggers an alternation. However, direct physiological evidence for such signals has been lacking. Here, we identify a neural signal in the human visual cortex that shows these predicted properties. We measured steady-state visual evoked potentials (SSVEPs) in 84 human participants (62 females, 22 males) who were presented with orthogonal gratings, one to each eye, flickering at different frequencies. Participants indicated their percept while EEG data were collected. The time courses of the SSVEP amplitudes at the two frequencies were then compared across different percept durations, within participants. For all durations, the amplitude of signals corresponding to the suppressed stimulus increased and the amplitude corresponding to the dominant stimulus decreased throughout the percept. Critically, longer percepts were characterized by more gradual increases in the suppressed signal and more gradual decreases of the dominant signal. Changes in signals were similar and rapid at the end of all percepts, presumably reflecting perceptual transitions. These features of the SSVEP time courses are well predicted by a model in which perceptual transitions are produced by the accumulation of noisy signals. Identification of this signal underlying binocular rivalry should allow strong tests of neural models of rivalry, bistable perception, and neural suppression.SIGNIFICANCE STATEMENT During binocular rivalry, two conflicting images are presented to the two eyes and perception alternates between them, with switches occurring at seemingly random times. Rivalry is an important and longstanding model system in neuroscience, used for understanding neural suppression, intrinsic neural dynamics, and even the neural correlates of consciousness. All models of rivalry propose that it depends on gradually changing neural activity that on reaching some threshold triggers the perceptual switches. This manuscript reports the first physiological measurement of neural signals with that set of properties in human participants. The signals, measured with EEG in human observers, closely match the predictions of recent models of rivalry, and should pave the way for much future work.

The effect of modality and order presentation of emotional stimuli on time perception.

Despite human accuracy in perceiving time, many factors can modulate the subjective experience of time. For example, it is widely reported that emotion can expand or shrink our perception of time and that temporal intervals are perceived as longer when marked by auditory stimuli than by visual stimuli. In the present study, we aimed at investigating whether the influence of emotion on time perception can be altered by the order in which emotional stimuli are presented and the sensory modality in which they are presented. Participants were asked to complete a time bisection task in which emotional stimuli were presented either acoustically or visually, and either before or after interval to be estimated. We observed a main effect of modality (longer perceived duration and lower variability in the auditory than in the visual modality) as well as a main effect of emotion (temporal overestimation for negative stimuli compared to neutral). Importantly, the effects of modality and emotion interacted with the order of presentation of the emotional stimuli. In the visual condition, when emotional stimuli were presented after the temporal intervals, participants overestimated time, but no differences between negative and neutral stimuli were observed when emotional stimuli were presented first. In the auditory condition, no significant effect of emotion on perceived duration was found. Results suggest that negative emotions affect our perception of durations acting at the decision-making stage rather than at the pacemaker one. No effect on time perception was observed for emotional auditory stimuli.

How cross–linguistic influence affects the use of duration in the production and perception of corrective and non–corrective focus types

AbstractSpeakers use corrective focus as an explicit way to correct misunderstandings in communication. We investigate whether immersive contact with a rhythmically different language affects the production and perception of duration as a cue to corrective and non–corrective focus. We tested twenty-eight native speakers and sixty-four native listeners of Urdu, half of whom lived in Germany and used German as a second language, and half lived in Pakistan. German is a stress–timed language with head–prominence marking and makes intensive use of duration to mark corrective focus, while Urdu is a syllable–timed language with edge–prominence marking, which uses duration differently from German to mark focus types. Results showed that the majority language, German, affected focus processing in Urdu differently across modalities: In production, focus marking was not affected by country of residence, while in perception, Urdu speakers living in Germany were more sensitive to duration in the corrective focus context than Urdu speakers in Pakistan. We analyze this as cross–linguistic influence and argue that contact with a stress–timed, head–prominence majority language (here: German) affects the cue weighting in the native language Urdu in perception but not (yet) in production.

Bioengineered Living Entities in Art: Aliveness, Duration, and Movement in Bricolage

Abstract Bricolage is a kinetic biological artwork first exhibited at the Perth International Arts Festival in 2020. The artists used stem cell technologies to create bioengineered living entities from donated human heart muscle cells. These living entities are suspended in an incubator from the ceiling and are made visible to gallerygoers, who watch the performance of cells generating and moving independently. This paper considers how the assemblage, animation, and performance of cells embedded in Bricolage highlight questions around the conceptualizations and perceptions of life, duration, animation, and aliveness.

Effects of interocular grouping demands on binocular rivalry.

Binocular rivalry (BR) is a visual phenomenon in which perception alternates between two non-fusible images presented to each eye. Transition periods between dominant and suppressed images are marked by mixed percepts, where participants report fragments of each image being dynamically perceived. Interestingly, BR remains robust even when typical images are subdivided and presented in complementary patches to each eye, a phenomenon termed interocular grouping (IOG). The objective of the present study was to determine if increasing grouping demand in the context of BR changes the perceptual experience of rivalry. In 48 subjects with normal vision, mean dominant and mixed percept durations were recorded for classic BR and IOG conditions with increasing grouping demands from two, four, and six patches. We found that, as grouping demands increased, the duration of mixed periods increased. Indeed, durations of dominant and mixed percepts, as well as percentage of time spent in dominant or mixed state, differed significantly across conditions. However, durations of global dominant percepts remained relatively stable and saturated at about 1.5 seconds, despite the exponential increase in possible mixed combinations. Evidence shows that this saturation followed a nonlinear trend. The data also indicate that grouping across the vertical meridian is slightly more stable than for the horizontal meridian. Finally, individual differences in speed of alternation identified during BR were maintained in all interocular grouping conditions. These results provide new information about binocular visual spatial integration and will be useful for future studies of the underlying neural substrates and models of binocular vision.

Domain-general but not speech-specific auditory duration perception predicts pseudoword reading in adults.

Associations between reading performance and duration perception have been found both for domain-general and speech-specific duration perception. However, research seems limited to children and, critically, the predictive value of the two duration perception modalities has not been compared so far. In the present study we compared the weight of domain-general (comparison of time intervals defined by beeps) vs. speech-specific duration perception (pre-attentive EEG responses to consonants with different durations) as statistical predictors of reading in a sample of 46 neurotypical adults (18-43 years old) with 13 years of schooling on average. Reading included word and pseudoword decoding, as well as reading comprehension. We ran one regression model with domain-general and speech-specific duration perception as predictors for each of the three reading skills. Pseudoword decoding was the only reading skill that was significantly predicted by duration perception, and this happened for domain-general duration perception only. A complementary analysis adding 26 typically developing and 24 dyslexic adults to the main sample (n = 96 in total) showed the same pattern of results in dyslexics, but not in added controls. Our findings strengthen the idea that duration perception is important to phonological encoding and its use in grapheme-to-phoneme conversion, given that only pseudoword decoding was predicted by the interval comparison task. The irrelevance of speech-specific duration perception tones down the possibility that accurately perceiving the length of speech sounds is crucial to skilled reading.

Duration perception for visual stimuli is impaired in dyslexia but deficits in visual processing may not be the culprits

Dyslexics underperform controls in estimating and comparing time intervals defined by visual stimuli. Accuracy in vision-based duration perception requires efficient processing of visual events because these will define the onset and offset of time intervals. Since dyslexics have difficulties processing dimensions of visual stimuli like luminance contrasts and motion, we do not know the extent to which these visual deficits are responsible for their difficulties in judging time intervals. To address this gap, we asked adults with dyslexia and matched controls to perform an interval comparison task involving five different types of visual stimuli with different levels of challenge regarding luminance contrasts and motion. If the expected disadvantage of dyslexics in visual duration perception increased for stimuli requiring increased luminance or motion processing, this would indicate that visual processing plays a role. Results showed poorer time discrimination in dyslexics, but this disadvantage did not change according to stimulus type. Complementary analyses of oculomotor behavior during the task suggested that the poorer timing performance of dyslexics may relate instead to attention and/or engagement with the task. Our findings strengthen the evidence in favor of visual duration perception deficits in dyslexia, but not the hypothesis that these result from purely visual problems.

Pulpectomy vs. Pulpotomy as Alternative Emergency Treatments for Symptomatic Irreversible Pulpitis-A Multicenter Comparative Randomised Clinical Trial on Patient Perceptions.

There needs to be more general agreement on the most effective treatment for the emergency patient with Symptomatic Irreversible Pulpitis (SIP). This equivalence randomised clinical study compared the clinical efficiency, as an urgent treatment, of pulpotomy (POT) and pulpectomy (PEC) in the permanent teeth with SIP. The primary outcome was pain management, and the secondary outcome was the patient's perception of duration, comfort, and satisfaction. 80 patients were blindly and randomly allocated into two equal parallel groups, the control group treated by PEC and the test group by POT. Data were collected through numerical rating scales (NRS) during the intervention and 6, 24, and 72 h post-op. Non-parametric tests were used to analyse the data. The Brunner-Longer models were adopted for longitudinal data and the analysis of variance (ANOVA)-type statistical was used. The mean preoperative pain levels for the whole sample scored 5.8 ± 2.8 and significantly decreased to 2.1 ± 2.4 at 6 h, 1.5 ± 2.1 at 24 h, and 1.3 ± 2 at 72 h, without any differences between the groups. No significant differences were found in the patient's perception of treatment discomfort or duration between the groups. Three days after the intervention, patient satisfaction was high, with 9.2 ± 1.7 and 9.1 ± 2 in the PEC and POT groups, respectively. Self-reported pain was the only variable penalising the patient's final satisfaction. The current randomised control trial (RCT) showed that both pulpectomy and pulpotomy effectively eliminate pain and achieve high levels of patient satisfaction. Furthermore, the patient's perceptions of the duration and discomfort of the two treatments were similar. Given that pulpotomy is a faster and more straightforward technique, it may be recommended as a viable and pragmatic option for treating emergency patients with symptomatic irreversible pulpitis.

Psychophysiological stress influences temporal accuracy.

Distortions of duration perception are often observed in response to highly arousing stimuli, but the exact mechanisms that evoke these variations are still under debate. Here, we investigate the effect of induced physiological arousal on time perception. Thirty-eight university students (22.89 ± 2.5; 28 females) were tested with spontaneous finger-tapping tasks and a time bisection task (with stimuli between 300 and 900ms). Before the time bisection task, half of the participants (STRESS group) performed a stress-inducing task, i.e., the Paced Auditory Serial Addition Test (PASAT), whereas the other participants (CONTROL group) performed a control task, the Paced Auditory Number Reading Task (PANRAT). The PASAT induced a greater heart rate, but not electrodermal, increase, as well as a more unpleasant and arousing state compared to the PANRAT. Moreover, although the two groups presented a similar performance at the finger-tapping tasks, participants in the STRESS group showed better temporal performance at the time bisection task (i.e., lower constant error) than the controls. These results indicate that psychophysiological stress may alter the subsequent perception of time.

Heterogeneity in Perceptions of the Temporal Duration of External Events: The Case of the COVID-19

Heterogeneity in Perceptions of the Temporal Duration of External Events: The Case of the COVID-19

Serial dependence in timing at the perceptual level being modulated by working memory.

Recent experiences bias the perception of following stimuli, as has been verified in various kinds of experiments in visual perception. This phenomenon, known as serial dependence, may reflect mechanisms to maintain perceptual stability. In the current study, we examined several key properties of serial dependence in temporal perception. Firstly, we examined the source of the serial dependence effect in temporal perception. We found that perception without motor reproduction is sufficient to induce the sequential effect; motor reproduction caused a stronger effect and is achieved by biasing the perception of the future target duration rather than directly influencing the subsequent movement. Secondly, we ask how working memory influences serial dependence in a temporal reproduction task. By varying the delay time between standard duration and the reproduction, we showed that the strength of serial dependence is enhanced as the delay increased. Those features of serial dependence are consistent with what has been observed in visual perceptual tasks, for example, orientation perception or location perception. The similarities between the visual and the timing tasks may suggest a similar neural coding mechanism of magnitude between the visual stimuli and the duration.

The speed and temporal frequency of visual apparent motion modulate auditory duration perception

In the present study, we investigated how the perception of auditory duration could be modulated by a task-irrelevant, concurrent visual apparent motion, induced by visual bars alternating between left and right sides. Moreover, we examined the influence of the speed and temporal frequency of visual apparent motion on the perception of auditory duration. In each trial, the standard visual stimuli (two vertical bars) were presented sequentially, except that visual apparent motion was included in the fourth stimulus. A tone was presented simultaneously with each visual stimulus, while the fourth tone was presented with varied duration. Participants judged whether the fourth tone lasted longer than the other four tones. In Experiment 1, the speed of visual apparent motion (Fast vs. Slow) was manipulated by changing the interval between two bars. The mean point of subjective equality (PSE) in the Slow apparent motion condition was larger than that in the Static condition. Moreover, participants tended to overestimate the duration only in the Static condition, i.e., time dilation effect, which disappeared under apparent motion conditions. In Experiment 2, in addition to speed, we controlled the temporal frequency of apparent motion by manipulating the number of bars, generating four conditions of visual apparent motion (Physical-fast, Perceived-fast, Perceived-slow, vs. Static). The mean PSE was significantly smaller in the Physical-fast condition than in the Static and Perceived-slow conditions. Moreover, we found a time compression effect in both the Perceived-slow and Static conditions but not in the Perceived-fast and Physical-fast conditions. These results suggest that the auditory duration could be modulated by the concurrent, contextual visual apparent motion, and both the speed and temporal frequency of the task-irrelevant visual apparent motion contribute to the bias in perceiving the auditory duration.

How does it feel? Passage of time judgments in speeded RT performance.

The relationship between duration perception and the feeling of time passing (passage of time) is not yet understood. In the present study, we assessed introspective reaction times (RT) and passage of time judgments in a speeded RT task. Task difficulty was manipulated in a numerical comparison task by numerical distance (distance from the number 45) and notation (digit vs. word). The results showed that both effects were reflected in introspective RTs, replicating previous results. Moreover, passage of time judgments showed a very similar pattern, with slower passage of time for more difficult comparisons. These results suggest that in the millisecond range judgments of duration and passage of time largely mirror each other when participants introspect about their own RT performance.

Factors Related to Diet Adherence in Diabetes Mellitus Patients: A Scoping Review

Diabetes Mellitus (DM) is a disease that causes increased blood glucose levels or hyperglycemia. High blood glucose levels can be controlled by following a diet program. Adherence to diet is one of the keys to stabilizing blood glucose and preventing complications. Therefore, this study aimed to determine the factors associated with dietary adherence in patients with diabetes mellitus based on a literature study of 12 journals. Journal searches were carried out on Google Scholar, PubMed, ScienceDirect, and ProQuest using the keywords Factors AND Associated AND Diet OR Dietary AND Adherence OR Compliance AND Diabetes Mellitus. The journals were then assessed for quality using the Joanna Briggs Institute and analyzed using qualitative descriptive analysis. Based on the analysis, there is a relationship between intrinsic factors (age, gender, marital status, occupation, place of residence, education level, income/economic, family type, level of knowledge, BMI, duration of illness, perception, self-motivation, smoking, and family history of DM) of 71% and extrinsic factors (social support, family support, caregiver category, diet monitoring, and selection of food types) of 29%. Based on the results, it can be concluded that these factors are related to dietary compliance, so it is hoped that various nursing strategies can be designed to help people with diabetes mellitus improve their adherence to diets.
 Keywords: Dietary Compliance, Factors Associated, Diabetes Mellitus

Slowed alpha oscillations and percept formation in psychotic psychopathology.

Psychosis is in part defined by disturbances in perception. Recent investigations have implicated the speed of alpha oscillations observed in brain electrical activity as reflective of a sampling rate of the visual environment and perception. Although both slowed alpha oscillations and aberrant percept formation are evident in disorders of psychotic psychopathology such as schizophrenia it is unclear whether slow alpha accounts for abnormal visual perception in these disorders. To examine the role of the speed of alpha oscillations in perception in psychotic psychopathology we gathered resting-state magneto-encephalography data from probands with psychotic psychopathology (i.e., schizophrenia, schizoaffective disorder, and bipolar disorder with a history of psychosis), their biological siblings, and healthy controls. We appraised visual perceptual function without the confound of cognitive ability and effort through the use of a simple binocular rivalry task. We found a slowed pace of alpha oscillations in psychotic psychopathology that was associated with longer percept durations during binocular rivalry, consistent with the assertion that occipital alpha oscillations govern the rate of accumulation of visual information used to generate percepts. Alpha speed varied widely across individuals with psychotic psychopathology and was highly stable across several months indicating that it is likely a trait characteristic of neural function that is relevant to visual perception. Finally, a lower speed of alpha oscillation was associated with a lower IQ and greater disorder symptomatology implying that the effects of the endogenous neural oscillation on visual perception may have wider consequences for everyday functioning. Slowed alpha oscillations in individuals with psychotic psychopathology appear to reflect altered neural functions related to percept formation.

Consumer Expectations and Attitudes About Psychotherapy: Survey Study.

Although mental illness is common among adults in the United States, access to, and public perception of, mental health care continue to present as key barriers to care. Given the importance of attitudes toward, and perceptions of, mental health treatment in the successful access to mental health care and treatment of mental health issues, the primary goal of this survey study was to further investigate consumer perspectives of psychotherapy among adults in the United States; specifically, adding to the literature by investigating perceptions of both the general public and patients receiving telehealth. More specifically, the aims were to better understand openness to, and satisfaction with, therapy; perceptions, preferences, and expectations around therapy; and perceptions of psychotropic medication. An electronic survey was administered to current and former patients (those receiving psychotherapy) of Brightside, a nationwide telehealth company, as well as to the general public; both were convenience samples. Using the same survey questions, Brightside surveyed its own members (using Qualtrics; Qualtrics International Inc) and the general population (using SurveyMonkey's Audience tool; Momentive). This survey included questions about basic participant demographics, as well as questions about current mental health treatment, perceptions about therapy, and therapists' qualities. A total of 714 people completed the survey. The data were fairly evenly split between those collected from Brightside patients (368/714, 51.5%) and those collected from the general public (346/714, 48.5%). Combining both samples, overall participation was 67.1% (479/714) women; 73.1% (522/714) White, 7.3% (52/714) Asian, 6.7% (48/714) African American, and 7.4% (53/714) Hispanic or Latinx; largely aged 25 to 34 years (255/714, 35.7%) or 35 to 44 years (187/714, 26.2%); from either the Mid-Atlantic (131/714, 18.3%) or South Atlantic (129/714, 18.1%) regions of the country; and most (402/714, 56.3%) earning annual salaries of US $30,000 to US $100,000. There were generally favorable perceptions of both psychotherapy and psychiatric medication. Selecting a therapist as well as cost and insurance are the common factors in therapy that are important to patients. The most commonly held perception of psychotherapy duration was indefinite (250/714, 35%). Very few (58/714, 8.1%) thought that therapy typically lasts 1 to 3 months. Most of the participants (414/714, 58%) thought that evidence-based practice was important. Public education is needed to increase awareness of the typical duration and cost of psychotherapy. There seem to be generally favorable perceptions of both psychotherapy and psychotropic medication. Selecting a therapist as well as cost and insurance are the common factors in therapy that are important to patients. Practitioners and those marketing their services might consider using their marketing campaigns to counter some of the more common falsely held beliefs.

A purely visual adaptation to motion can differentiate between perceptual timing and interval timing.

It is unclear whether our brain extracts and processes time information using a single-centralized mechanism or through a network of distributed mechanisms, which are specific for modality and time range. Visual adaptation has previously been used to investigate the mechanisms underlying time perception for millisecond intervals. Here, we investigated whether a well-known duration after-effect induced by motion adaptation in the sub-second range (referred to as 'perceptual timing') also occurs in the supra-second range (called 'interval timing'), which is more accessible to cognitive control. Participants judged the relative duration of two intervals after spatially localized adaptation to drifting motion. Adaptation substantially compressed the apparent duration of a 600 ms stimulus in the adapted location, whereas it had a much weaker effect on a 1200 ms interval. Discrimination thresholds after adaptation improved slightly relative to baseline, implying that the duration effect cannot be ascribed to changes in attention or to noisier estimates. A novel computational model of duration perception can explain both these results and the bidirectional shifts of perceived duration after adaptation reported in other studies. We suggest that we can use adaptation to visual motion as a tool to investigate the mechanisms underlying time perception at different time scales.

The role of probability and duration in perception of speech sounds

When listeners are hearing sounds in the speech signal and have not yet heard enough acoustic cues to know what a sound is, they might predict the upcoming sound based on likelihood in the language or likelihood of occurrence after the preceding sound (overall and conditional probability of sounds). A related factor may be how long the sound goes on: listeners might be more able to identify sounds that go on longer because they have more time to hear the acoustic cues. However, additional duration may only be useful to listeners if it contains new acoustic cues (acoustic change). This paper investigates whether these factors have a role in how listeners perceive or predict sounds. This study presents further analysis of the perception data collected by the English Diphones project (Warner et al., 2014). The results show that listeners predict upcoming phonemes based on a guessing strategy, not based on lexical probability, with a small influence of syllable structure. Longer duration in itself does not produce better identification, but rather plays a role when important acoustic changes occur within the additional duration. The present study suggests that listeners use acoustic information rather than probability, and that they are sensitive to dynamic changes in spectral structure.