Perception Of Fatigue Research Articles

A Comparative Study to Assess Post-COVID Fatigue and its Functional Limitations

Objectives: This work aimed to study the difference in the level of fatigue perception between cases and controls, who did not have COVID-19. This study sought to establish the impact of severity of infection with fatigue scores on the quality of life. Methods: This observational case-control study, recruiting 165 participants, both males and females, from Fazaia Ruth Pfau Medical College, Karachi, Pakistan, started from August 2022 to October 2023 after obtaining their consent. A total of 65 COVID-positive with 21.5% hospitalized and 78.5% non-hospitalized subjects were included. Post-COVID fatigue among the participants was compared using the validated Fatigue Severity Scale (FSS), Chalder Fatigue Scale (CFQ-11), and WHOQOL scale. Results: Participants in all groups reported fatigue on the Fatigue Severity Scale with Covid-positive (38.25 ±12.15) and Covid-negative (33.75±11.28) rate, with a significant p-value (0.031). According to CFQ, no significant difference (p=0.91) was found between fatigue scores of Covid positive and negative. However, a significant (p=0. 016) difference was observed between Covid-positive hospitalized (4.37±0.33) and non-hospitalized (1.98 ±0.22) subjects. QOL scores in different domains, including QOL General Health (7.18±1.54), physical (20.38±3.51), psychological (46.33±7.05), and social (9.98±1.94), were all significant (p=0.00) when compared between Covid positives and negatives. Conclusion: The study revealed that post-covid survivors experienced fatigue, which imposed limitations on different aspects of life, which was different from the fatigue of non-affected individuals.

Fatigue Among Cabin Crew and Work-Life Balance: A Qualitative Study in the Turkish Context

In the context of literature review, it can be observed that information regarding the fatigue levels of cabin crew generally relies on quantitative data obtained from the flight crew. Considering that cabin crew members also have their own personal lives, it is believed that managing work fatigue and achieving work-life balance are crucial for them to sustain their lives in a healthy manner. However, it is rarely investigated in the literature what the views of cabin crew members are regarding fatigue and what strategies can be employed to reduce fatigue. Therefore, in order to better understand the causes and consequences of cabin crew fatigue, participants' experiences related to fatigue and how fatigue affects work-life balance were examined through semi-structured interviews using phenomenological analysis. Twenty cabin crew employees participated in the study. The analysis revealed three main themes titled "Perception of fatigue in cabin crew members, The impact of fatigue on work-life balance and Strategies for coping with fatigue" along with eight sub-themes that elucidate these themes. Based on the findings, recommendations are provided at the individual and organizational levels to reduce fatigue in cabin crew members, ensure work-life balance, and enhance productivity.

Comparison Between Disability, Physical Performance, and Other Biopsychosocial Factors in Full-Duty Career Firefighters Working With and Without Current Low Back Pain.

Low back pain (LBP) is highly prevalent and a top cause of disability-related early retirement in firefighters. Those with a lifetime history of LBP have various deficiencies that are associated with increased injury risk and absenteeism. However, the influence of working with current LBP on disability, physical performance, and other biopsychosocial factors has not been fully characterized in this population. The purpose of this study was to compare anthropometric measures, exercise habits, physical fitness/performance, disability/work ability, and other biopsychosocial factors of firefighters working with and without current LBP. A cross-sectional study was conducted using baseline assessments from 419 full-duty career firefighters without documented work restrictions (age: 37.6 ± 8.8 y; 5 F, 414 M) who were enrolled in a regional wellness initiative in Southern California, USA. Current LBP status was determined by a questionnaire and confirmed by an interview. Anthropometric measures, patient-reported outcomes, and physical fitness tests were used to assess body mass index; body fat %; waist circumference; strengthening, cardiovascular, and flexibility exercise frequency; back and core muscular endurance; functional movement quality, perceived back-related disability, lift and carry ability, and firefighter task ability; sleep quality; and perceptions of fear and fatigue and catastrophic injustice experience. Scores for participants with and without current LBP were compared using analysis of variance and chi-square analysis. The point prevalence of current LBP was 19.81% (83/419). For the entire cohort, those with current LBP had significantly worse scores than those without current LBP for all assessed variables, except core muscular endurance and functional movement quality. These trends held up when analyses were stratified by age and obesity categories, and approximately half of the comparisons retained statistical significance. A significantly greater percentage of participants with current LBP were working with some level of back-related disability and/or perceived physical demand characteristics of work level below the required very heavy job demands. Nearly one-fifth of full-duty career firefighters without documented work restrictions reported having current LBP, and these individuals had deficits in several modifiable biopsychosocial factors across five health domains. These findings can help guide future research and implementation efforts in the fire service designed to improve performance, resiliency, work readiness, recovery, and quality of life, as well as to reduce impairment, disability, and absenteeism and increase presenteeism.

Exercise Capacity, Muscle Function, Functional Balance, and Cognitive Status in Patients with Post COVID-19 Syndrome Compared to Healthy Controls

Objective: There is limited data on the effect of post-COVID-19 syndrome on functional outcomes compared with healthy uninfected individuals. This study aimed to compare the muscle function, exercise capacity, and quality of life of patients with post-COVID-19 syndrome with that of healthy controls. Methods: Twenty patients with post-COVID-19 syndrome and twenty healthy controls participated in the study. The Incremental Shuttle Walk Test (ISWT) was used to measure exercise capacity, and the Timed Up and Go Test (TUG) was used to assess functional balance. Quadriceps muscle strength (QMS) and handgrip strength (HGS) were measured. Assessment tools included the McGill Pain Questionnaire (SF-MPQ) for pain, the Tampa Scale for Kinesiophobia (TSK) for movement fear, the Modified Medical Research Council Dyspnea Scale (mMRC) for dyspnea, the Fatigue Severity Scale (FSS) for fatigue perception, and the Cognitive Failures Questionnaire (CFQ) for cognitive status. Results: The mMRC dyspnea, TSK, FSS, SF-MPQ total scores, and pain severity of patients with post-COVID-19 syndrome were higher than those of healthy controls (p

Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood.

Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation and neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient in younger populations are unclear. This study examined the effects of liposomal ashwagandha supplementation on cognitive function, mood, and markers of health and safety in healthy young men and women. 59 men and women (22.7 ± 7 yrs., 74.9 ± 16 kg, 26.2 ± 5 BMI) fasted for 12 h, donated a fasting blood sample, and were administered the COMPASS cognitive function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Task, Corsi Block test, Stroop test) and profile of mood states (POMS). In a randomized and double-blind manner, participants were administered 225 mg of a placebo (Gum Arabic) or ashwagandha (Withania somnifera) root and leaf extract coated with a liposomal covering. After 60-min, participants repeated cognitive assessments. Participants continued supplementation (225 mg/d) for 30 days and then returned to the lab to repeat the experiment. Data were analyzed using a general linear model (GLM) univariate analysis with repeated measures and pairwise comparisons of mean changes from baseline with 95% confidence intervals (CI). Ashwagandha supplementation improved acute and/or 30-day measures of Word Recall (correct and recalled attempts), Choice Reaction Time (targets identified), Picture Recognition ("yes" correct responses, correct and overall reaction time), Digit Vigilance (correct reaction time), Stroop Color-Word (congruent words identified, reaction time), and POMS (tension and fatigue) from baseline more consistently with several differences observed between groups. Results support contentions that ashwagandha supplementation (225 mg) may improve some measures of memory, attention, vigilance, attention, and executive function while decreasing perceptions of tension and fatigue in younger healthy individuals. Retrospectively registered clinical trial ISRCTN58680760.

#518 Fatigue in all stages of chronic kidney disease: patients’ experiences and needs for support

Abstract Background and Aims Fatigue is a commonly reported symptom in all stages of chronic kidney disease (CKD) and has a major impact on patients’ daily lives. Until now, predominantly qualitative research has contributed to our knowledge about CKD patients' experiences and perceptions of fatigue, and this knowledge is mostly constrained to the dialysis population. Therefore, the aim of this survey study was to explore in all stages of CKD: 1) patients’ experienced burden of fatigue, its impact on their daily lives, and presumed causes of their fatigue; 2) patients’ experiences and needs related to support, discussion and treatment of fatigue. Method In The Netherlands, a survey was constructed, consisting of twenty multiple-choice questions and six open-ended questions, to assess patients’ demographics; experiences, burden and impact of fatigue; presumed causes of fatigue; perceived social support; and experiences and needs regarding discussion and treatment of fatigue during routine nephrology care. This web-based survey was developed together with and distributed by the Dutch Kidney Patients Association, and all surveys were completed between 10 January 2023 and 23 July 2023. Descriptive statistics were used to summarize the results, also stratified by CKD population (CKD prior to kidney replacement therapy [KRT], dialysis, and kidney transplantation [KT]), sex (male and female), and age (18-50, 50-70, and ≥70 years). Results In total, 385 Dutch patients completed the survey. Participants had a mean (standard deviation) age of 58.2 (13.5) years and 42% was male. Overall, results were quite similar for all CKD populations: CKD prior to KRT (n = 130), dialysis (n = 39), and KT (n = 216). More specifically, fatigue was often experienced in the previous month (range percentages across the CKD populations: 92-100%) and present for longer than 6 months (77-92%). The most frequently reported presumed cause of fatigue was related to the reduced kidney function (41%), followed by treatment-related factors (25%; e.g. medication and dialysis). Patients in all CKD populations reported a high burden of fatigue (76-87%) that belonged in the top three of most burdensome symptoms (79-87%). Compared to elderly patients, younger patients reported more often fatigue in mental, social, and emotional domains; hereby limiting them more often in education/work, social activities, and relationships/family life. In all age groups, the majority of patients experienced barriers in tasks within the household (71-83%). In 32% of all patients, fatigue was never or rarely discussed with the treating physician, with the most important reasons being that patients assumed fatigue is part of their disease, and the lack of attention and efforts from the physician to discuss or treat fatigue. Of those patients who did discuss fatigue, 67% did not receive any advice or treatment from their physician. Of those who did receive advice or treatment (e.g. physical exercise), most patients (58%) believed it did not help to feel less tired. Finally, patients prior to KRT, women, and patients aged 18-50 years, reported more often receiving insufficient social support (42-65%;37-60%). Many of them desired acknowledgment of their debilitating symptom burdens, and more information about treatments and coping strategies for fatigue and its consequences. Conclusion In all stages of CKD, patients experience a high fatigue burden and insufficient support for their fatigue. To address this high symptom burden and patients’ unmet needs, it is important to: structurally measure (the burden of) fatigue in all CKD stages (e.g. using PROMs), strengthen social support for patients who experience fatigue, ensure that symptoms such as fatigue are discussed during consultations, and improve multidisciplinary symptom management with special attention for embedding psychosocial educational support to deal with (the consequences of) fatigue. Further research is needed to develop and implement such multidisciplinary symptom (communication and treatment) strategies into routine nephrology care.

Structural relations of illness perception, fatigue, locus of control, self-efficacy, and coping strategies in patients with multiple sclerosis: a cross-sectional study

BackgroundPatients with multiple sclerosis (MS) experience extensive problems due to fatigue and illness perception. Reducing these problems may improve these patients’ quality of life (QoL). Accordingly, the current study is aimed at investigating the mediating role of self-efficacy, locus of control, coping strategy, and outcome expectancy in the relationship between illness perception and fatigue severity in patients with MS.MethodsIn a cross-sectional analytical study, data of 172 MS patients were collected by self-report questionnaires including illness perception questionnaires (IPQ-R), Multiple Sclerosis Self-Efficacy (MSSES) scale, health locus of control (MHLC), coping strategies in MS(CMSS), outcome expectancy, level of physical activity (IPAQ-SF), patient activation measure (PAM-13) and fatigue severity scale (FSS). The data were analyzed using linear and multiple regression analysis in SPSS software version 24 (SPSS Inc., Chicago, IL, USA).ResultsThe final model explained 62% of the fatigue variance. Illness perception both directly and indirectly (through self-efficacy, physical activity level, internal health locus of control, patient activation, and negative coping strategies) could predict the participants’ fatigue severity. Among the mediating variables, internal health locus of control, self-efficacy, and negative coping strategies had the greatest impact, respectively. moreover, outcome expectancy variable did not a mediating role in the aforementioned relationship.ConclusionsTo enhance the well-being of MS patients and to improve the efficiency of treating MS related fatigue, a comprehensive treatment protocol is needed, encompassing psychological factors affecting fatigue severity.

Concentrated transdiagnostic and cross-disciplinary micro-choice based group treatment for patients with depression and with anxiety leads to lasting improvements after 12 months: a pilot study

BackgroundA concentrated transdiagnostic and micro choice-based group treatment for patients with depression and anxiety has previously shown to yield significant reduction in symptoms and increased level of functioning from pre to 3-month follow-up. In the present study, we report the results after 12 months follow-up.MethodsThis was a non-randomized clinical intervention pilot study, conducted in line with a published protocol. Sixty-seven consecutively referred patients, aged 19–47 (mean age 32.5, SD = 8.0) were included and completed treatment. All had a severity of their problems that entitled them to care in the specialist public mental health care. Self-reported age at onset of symptoms was 17.6 (SD = 7.9) years. Mean number of prior treatment courses was 3.5 (SD = 3.3; range 0–20). The main objective was to assess the treatment effectiveness by questionnaires measuring relevant symptoms at pre-treatment, 7 days-, 3 months-, 6 months- and at 12-months follow-up.ResultsValidated measures of functional impairment (WSAS), depression (PHQ9), anxiety (GAD7), worry (PSWQ), fatigue (CFQ), insomnia (BIS) and illness perception (BIPQ) improved significantly (p < .0005) from before treatment to 12 months follow-up, yielding mostly large to extremely large effect sizes (0.89–3.68), whereas some moderate (0.60–0.76). After 12 months, 74% report an overall improvement in problems related to anxiety and depression. Utilization of specialist, public and private mental health care was reported as nonexistent or had decreased for 70% of the patients at 12-month follow up.ConclusionsThe concentrated, micro-choice based group treatment approach yielded a highly clinically significant reduction in a wide range of symptoms already one week after treatment, and the positive results persisted at 12-month follow-up.Trial registrationClinicalTrials.gov Identifier: NCT05234281, first posted date 10/02/2022.

Understanding preventative behavior during prolonged crises: The role of color-coded maps and pandemic fatigue in COVID-19 risk management

The COVID-19 pandemic introduced the use of color-coded COVID-19 guidance maps to communicate varying levels of transmission based on local public health data and infrastructure capacity. This study explores the application of an extended Theory of Planned Behavior (TPB) to understand how color-coded COVID-19 guidance, pandemic fatigue, and risk perception influence intentions to seek COVID-19 risk information and engage in preventative behaviors. Through two separate studies comprising nationally representative samples in the U.S. (N = 169 and N = 148), conducted at different points during the pandemic, we examine the effect of these factors on intentions to seek COVID-19 risk information and intentions to engage in preventative behaviors. Study 1, conducted in November 2020, focused on these behavioral intentions before vaccine availability, while Study 2, conducted in March 2022, examined these behavioral intentions as the pandemic evolved and vaccines were widely accessible. Path analysis using OLS regression was used to evaluate the models proposed in each study. Our findings highlight that while color-coded risk maps significantly influenced preventive behavior intentions, their impact on information-seeking intentions was less consistent. Results surrounding the influence of pandemic fatigue are mixed, with pandemic fatigue leading to increased risk information seeking in Study 1 and greater preventative behavioral intentions in Study 2. This study offers implications and recommendations for public health officials responsible for communicating complex, prolonged, and location-specific health information.

Review and comparison of linear algorithms to quantify muscle fatigue based on sEMG signals

Surface electromyography techniques are widely used in field of motion analysis and ergonomics combining precise muscular activation assessment with low-invasiveness and wearability. The aim of this investigation is to identify the myoelectrical manifestations of fatigue and to compare the effectiveness of sEMG-based quantitative indices for fatigue assessment. The investigated indexes are the ARV and RMS signal amplitudes, the mean frequency, the median frequency, the Dimitrov index, the instantaneous mean frequency and Wavelet distribution-based WIRE51 index. Two different protocols were developed, and the activity of the lateral deltoid and middle trapezius muscles was recorded. The WIRE51 index is found to have the highest sensitivity in the detection of the difference between the repetitions of each exercise for both protocols. Due to the lack of a unified standard for the performance comparison of fatigue indices, a correlation analysis was carried out between the result provided by the indices and the subjective fatigue perception employing the RPE scale.

Virtual reality, face-to-face, and 2D video conferencing differently impact fatigue, creativity, flow, and decision-making in workplace dynamics

Digital communication technologies are rapidly evolving, and understanding their impact on group dynamics and cognitive performance in professional settings becomes central. This study investigates the psychological impact of different interaction settings—two-dimensional Video Conferencing (VC), Face-To-Face (FTF), and Virtual Reality (VR)—on group dynamics, cognitive performance, and aspects of well-being in a professional context. Utilizing a sample of 40 participants from a large Italian electricity transmission company, the study employs a within-subjects design to explore various metrics, including flow, creativity, fatigue and aspects of interaction. The results indicate that FTF interactions are optimal for idea generation and task absorption. VR, although initially more fatiguing for first-time users, fosters a more collaborative and peaceful environment, encouraging participants to engage more openly with each other. VC was found to be the least fatiguing, but also the least engaging in terms of task absorption and idea generation. Additionally, age-related differences were observed, particularly in the perception of motivational and emotional fatigue in the VR setting. The study provides empirical evidence supporting the integration of VR in professional settings for specific types of meetings, while also highlighting the limitations and areas for future research. These findings have implications for organizational well-being, cognitive ergonomics, and the evolving landscape of remote work technologies.

The Effects of Anchoring a Fatiguing Forearm Flexion Task to a High vs. Low Rating of Perceived Exertion on Torque and Neuromuscular Responses.

Ortega, DG, Housh, TJ, Smith, RW, Arnett, JE, Neltner, TJ, Schmidt, RJ, and Johnson, GO. The effects of anchoring a fatiguing forearm flexion task to a high versus low rating of perceived exertion on torque and neuromuscular responses. J Strength Cond Res 38(5): e219-e225, 2024-This study examined the torque and neuromuscular responses following sustained, isometric, forearm flexion tasks anchored to 2 ratings of perceived exertion (RPE). Nine men (mean ± SD: age = 21.0 ± 2.4 years; height = 179.5 ± 5.1 cm; body mass = 79.6 ± 11.4 kg) completed maximal voluntary isometric contractions (MVIC) before and after sustained, isometric, forearm flexion tasks to failure anchored to RPE = 2 and RPE = 8. The amplitude (AMP) and mean power frequency (MPF) of the electromyographic (EMG) signal were recorded from the biceps brachii. Normalized torque was divided by normalized EMG AMP to calculate neuromuscular efficiency (NME). A dependent t-test was used to assess the mean difference for time to task failure (TTF). Repeated-measures analysis of variances was used to compare mean differences for MVIC and normalized neuromuscular parameters. There was no significant difference in TTF between RPE = 2 and RPE = 8 (p = 0.713). The MVIC decreased from pretest to posttest at RPE = 2 (p = 0.009) and RPE = 8 (p = 0.003), and posttest MVIC at RPE = 8 was less than that at RPE = 2 (p < 0.001). In addition, NME decreased from pretest to posttest (p = 0.008). There was no change in normalized EMG AMP or EMG MPF (p > 0.05). The current findings indicated that torque responses were intensity specific, but TTF and neuromuscular responses were not. Furthermore, normalized EMG AMP and EMG MPF remained unchanged but NME decreased, likely due to peripheral fatigue and excitation-contraction coupling failure. Thus, this study provides information regarding the neuromuscular responses and mechanisms of fatigue associated with tasks anchored to RPE, which adds to the foundational understanding of the relationship between resistance exercise and the perception of fatigue.

Effect of physical activity education on shoulder girdle pain and muscle strength in participants with fibromyalgia: a pilot experimental study.

In patients with fibromyalgia, exercise and education are recommended to decrease pain level and improve pain management. The latest scientific evidence recommends to focus interventions on the upper limb. The aim of this pilot study was to compare the immediate effect of physical activity education vs. a control group on pain and muscle capacity in fibromyalgia patients. Fifty-six participants with fibromyalgia were randomized into an experimental group and a control group. The intervention consisted in watching a five-minute video that provided information about fibromyalgia, pain, kinesiophobia and physical activity. The control group watched a neutral five-minute video about beavers in Quebec. Following the video, participants performed a muscular fatigue task consisting of a repeated unilateral shoulder abduction task. At baseline and following the muscular fatigue task, maximal voluntary contraction (MVC) in shoulder abduction was assessed as well as pain level and pressure pain threshold (PPT) in the upper limb. Electromyographic activity was also assessed for upper trapezius and middle deltoid muscles. Two-way repeated measures analysis of variance was used to compare the MVC, PPT, and pain level before and after the muscular fatigue task between groups. The experimental group showed a significantly lower increase in pain than the control group in the middle deltoid muscle (p = 0.002) when assessed by verbal pain rating scale. No significant interaction or main effect of Group and Time were observed for the pain level at the upper trapezius and elbow extensor muscles nor for any of the PPT measures. According to electromyographic data, the median frequency values indicate that neither group experienced muscle fatigue during the repeated contraction task. The preliminary results suggest that a short physical activity education video positively influenced middle deltoid pain following repeated abduction in participants with fibromyalgia. Electromyographic analysis showed no evidence of objective muscle fatigue, suggesting that there might be a partial disconnection between the perception of muscle fatigue and the physiological biomarkers associated with muscle fatigue.

Feasibility of application-based psychomotor vigilance testing to assess fatigue in doctors working night shifts and correlation with smartwatch assessed shift intensity

ObjectivesTo assess: (1) the feasibility of novel data collection methods (wearable technology and an application-based psychomotor vigilance test (PVT)), (2) the impact of night shift working on fatigue, both objective...

FUNCTIONAL ELECTRICAL STIMULATION COMBINED WITH VOLUNTARY CYCLING ACCENTUATES VO2 RESPONSE IN PEOPLE WITH ADVANCED MULTIPLE SCLEROSIS: A PILOT STUDY

INTRODUCTION &amp; AIMS Lower limb muscle weakness and reduced balance due to disease progression in multiple sclerosis (MS) may make robust aerobic exercise difficult. Functional electrical stimulation (FES) cycling combined with voluntary cycling may allow people with advanced MS to enhance the intensity of aerobic exercise. The aim of this study was to investigate the cardiorespiratory, power, and participant perceptions during acute bouts of FES cycling, voluntary cycling, and FES cycling combined with voluntary cycling (FES assist cycling). METHODS Participants with advanced MS (Expanded Disability Status Scale [EDSS] ≥ 6.0) undertook three exercise trials on a leg cycle ergometer. Trial 1: 30 minutes of FES cycling; Trial 2: two 10-minute bouts of voluntary cycling separated by 10 minutes rest; and Trial 3: a combination of trials 1 and 2 (FES assist cycling). Outcome measures included VO2, cycle power output, heart rate, exertion, and post-exercise perceptions of fatigue. RESULTS Ten people with advanced MS participated (9 female; age 52.4±9.98 y; EDSS 7.1±0.6). Average VO2 during the 30-minute trials was significantly higher for FES assist cycling compared to voluntary cycling (429.7 ± 111.0 vs 388.5 ± 101.0 mL/min, 95% CI 23.4 to 113.0 mL/min, p=0.01), with a large effect size (Hedges’ g=1.04). Participants reported similar perceptions of exertion at the end of each trial (p=0.14). There was no difference in self-reported fatigue at the end of each trial (p=0.21). CONCLUSION This study found FES assist cycling produced significantly higher VO2 values than voluntary cycling, although the clinical significance of these differences is unknown. Participants performed FES assist cycling at a self-reported levels of exertion consistent with moderate to vigorous intensity, however it was considered light-intensity exercise when expressed by METS. FES assist cycling was no more fatiguing post-exercise than the other modes.

EFFECTS OF A SINGLE HEART RATE-CLAMPED CYCLING SESSION UNDER SYSTEMIC HYPOXIA ON RECOVERY OF PHYSICAL AND PSYCHO-PHYSIOLOGICAL RESPONSES FROM EXERCISE-INDUCED FATIGUE

AIMS We investigated whether a single heart-rate clamped cycling session under systemic hypoxia affects the recovery of physical and psycho-physiological responses from residual fatigue compared to normoxia. METHODS On separate occasions, twelve trained males had countermovement jump height, leg stiffness, and perceptual fatigue assessed daily during a 3-d acute training camp scenario. On days 1 and 3, participants cycled for 60 min at a constant heart rate (80% of ventilatory threshold). On day 2, fatigue was induced through a simulated team game circuit (STGC), followed by a 60-min heart rate clamped cycling bout in either normoxia, hypoxia (simulated altitude ∼3500 m), or no cycling. RESULTS Compared to baseline, jump height decreased at all timepoints following the STGC (all p &amp;lt; 0.05). Leg stiffness and cycling power output only decreased immediately following the STGC, with a 48% further decrease in cycling power output in hypoxia compared to normoxia (p &amp;lt; 0.05). The well-being questionnaire showed that perceived fatigue, decreased sleep quality, and increased muscle soreness responses occurred on day 3 (p&amp;lt; 0.05). CONCLUSION In a pre-fatigued state, a single heart rate-clamped cycling session in hypoxia reduced mechanical output without affecting recovery of physical performance and perceptual measures from residual fatigue induced through team sport activity.

Clinical variables influencing the perception of fatigue in people with multiple sclerosis: a cross-sectional study using FSIQ-RMS

BackgroundPhysical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence the development of fatigue, such as gender, education, body mass index (BMI), Expanded Disability Status Scale (EDSS), disease duration, working status (Ws), physiotherapy (Ph), and disease-modifying therapies (DMTs). Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS) is a patient-reported outcome (PRO) that allows one to define the impact of fatigue in PwMS clearly. This study aimed to assess fatigue impact on PwMS by using FSIQ-RMS.MethodsThe participants were enrolled from May to July 2021 in MS Centers of Sant’Andrea Hospital and Policlinico Umberto I Hospital in Rome. Fatigue was evaluated using the FSIQ-RMS, validated, and culturally adapted in Italian. Clinical and demographic data were collected at the same time.ResultsWe enrolled 178 PwMS [Female 74.16%; RMS 82.58%, SPMS 17.52%]. FSIQ-RMS scores were significantly correlated with EDSS (p-value < 0.01). Analysis of variance between means showed a statistically significant difference between the BMI groups at the 24hours_FSIQ-RMS score and the 7days_FSIQ-RMS score (p < 0.01), with the lower BMI group having the highest scores. Furthermore, perceived fatigue significantly improved both in subjects performing Ph (p < 0.05) and in those who actively work (p < 0.01).ConclusionsThe use of FSIQ-RMS in a real-world setting confirmed that underweight and high levels of disability are closely related to fatigue. In addition, Ph and active Ws are strongly correlated with fatigue in PwMS.

Connected Yet Cognitively Drained? A Mixed-Methods Study Examining Whether Online Vigilance and Availability Pressure Promote Mental Fatigue

This mixed-methods study investigates whether online vigilance promotes mental fatigue, and whether this effect is greater when under pressure to be available online. Additionally, it examines whether passively sensed smartphone behavior can serve as a digital proxy for online vigilance. Data were collected from 1,315 adult participants, who received 84 experience sampling questionnaires over 14 days, providing 67,762 usable datapoints on individuals’ perceptions of momentary online vigilance, mental fatigue, and availability pressure. Additionally, the smartphone use of 834 participants was passively monitored. Findings revealed both a momentary and lagged association between self-reported online vigilance and self-reported mental fatigue. Availability pressure was not a significant moderator, but did predict mental fatigue directly and indirectly, by promoting online vigilance. We found behavioral smartphone use features were weakly associated with self-reported online vigilance and mental fatigue. Overall, this study provides initial support that online vigilance may play a role in the development of mental health conditions such as burnout via its tendency to promote one of its precursors, mental fatigue.

A research on an improved fuzzy approximate entropy algorithm for EMG-based shoulder and neck muscle fatigue detection

A robust muscle fatigue algorithm plays a pivotal role in depicting the degree of muscle fatigue in both time-series EMG signal graphs and spectral graphs, aligning with human perception. While the fuzzy approximate entropy (fApEn) algorithm has been enhanced from the foundation of approximate entropy (ApEn) through the incorporation of fuzzy affiliation, concerns persist regarding the threshold value and the algorithm’s application range. This study extracts EMG signals across varied time durations and head-down angles, employing enhanced signal preprocessing techniques and optimizing the fApEn algorithm. Furthermore, real-time fatigue perceptions of subjects were recorded using the rating of perceived exertion. Experimental outcomes reveal that the EMG signal, post-wavelet analysis preprocessing, demonstrates promising noise reduction capabilities. Notably, the fApEn algorithm exhibits considerable enhancements through the identification of an optimal threshold using the gradient descent algorithm and a machine learning strategy.

Gaps in kidney stone disease management: From clinical theory to patient reality.

With nephrolithiasis projected to affect 25% of the global population in the next three decades, there is an urgent call for innovative management strategies to prevent and reduce stone recurrence. This study aims to explore the evolving management needs in nephrolithiasis from both patient and healthcare provider perspectives. An expert-collaborative online survey comprising 10 targeted questions on kidney stone management was developed and disseminated. This survey was designed to gather comprehensive insights from patients, physicians and dietician and other person in the field of nephrolithiasis. Analysis of responses from 120 participants, including 45 nephrologists, 38 dieticians, 11 urologists, and 14 kidney stones patients followed in our hospital, revealed critical insights. A significant 97.5% emphasized the necessity of optimizing daily water intake, and 94.1% recognized the need for practical dietary modifications. Additionally, 88.3% of respondents found timely hydration reminders beneficial. Notably, monitoring urine color and pH was valued by 85% and 84.3% of the participants, respectively. A striking disparity emerged in the perception of fatigue and wellness monitoring, with 65% of patients prioritizing fatigue monitoring, a view less shared by healthcare professionals. Similarly, 71% of patients deemed wellness monitoring essential, highlighting a gap in understanding between patients and their caregivers. This study underscores the critical need for more tailored guidance on hydration strategies and the promise of remote urine parameters monitoring in nephrolithiasis management. The findings strongly advocate for a patient-centered approach, aligning medical recommendations with patient lifestyles and experiences, to enhance the effectiveness of nephrolithiasis management.