Percentile Rank Research Articles

Enhancing portfolio risk management: a comparative study of parametric, non-parametric, and Monte Carlo methods, with VaR and percentile ranking

Enhancing portfolio risk management: a comparative study of parametric, non-parametric, and Monte Carlo methods, with VaR and percentile ranking

Reconnoitering LGU’s Potential as a Creative Innovation Center of Nueva Vizcaya Using CMCI

The Philippine Creative Industries Development Act (PCIDA) has identified the promotion of creative hubs and clusters as a key strategy to develop and support Philippine Creative Cities. This study assessed the potential of local government units (LGUs) in the province of Nueva Vizcaya to serve as creative innovation centers, utilizing the 2022 and 2023 Cities and Municipalities Competitiveness Index (CMCI) results, with the purpose of developing strategic actions to assist the LGUs in strengthening their potential and promoting stronger linkages and collaborations among stakeholders in the creative industries and the government. The study employed a mixed-methods approach, utilizing both quantitative and qualitative techniques. Percentile ranking was used to obtain the sum scores of the five main CMCI pillars – economic dynamism, government efficiency, infrastructure, resiliency, and innovation – to visualize the LGUs’ potential as creative innovation centers, with the 50th percentile serving as the benchmark. Comparative analysis was also performed to evaluate the potential of the LGUs as creative innovation centers in the province and determine their respective strengths and weaknesses. The results showed that the municipality of Bayombong is considered the potential LGU for a creative innovation center. The province of Nueva Vizcaya presented more strengths in the resiliency and innovation pillars, but more weaknesses were seen in the infrastructure pillar. Based on these findings, the researchers crafted proposed strategic actions to enhance the LGUs’ potential as creative innovation centers.

Can VO2max be accurately estimated using exercise-duration based prediction equations and a nomogram?

Abstract Study aim: The purpose of this study was to examine a large cohort of young Canadian adults to determine if exercise time from a maximal Bruce Treadmill Protocol could accurately predict measured VO2max values by inputting the total exercise time into prediction equations and a nomogram. Materials and methods: 550 kinesiology undergraduate student (280 male and 270 female) participants, with a mean body mass (BM) of 72.08 ± 15.05 kg, mean age of 21.16 ± 1.26 years old and mean height of 171.95 ± 10.25 cm completed a maximal graded exercise test to obtain their VO2max (measured). Predicted VO2max was calculated with various equations using the variable of total exercise test time. Linear regression models were created to determine how well the predicted VO2max values compared to the measured values. Results: Across all VO2max calculation methods, males obtained higher VO2max values on both the measured (49.89 ± 9.21 mL/ kg/min) and predicted values (46.04–55.40 mL/kg/min) and exercised for a longer duration of time (14.33 minutes) compared to females (40.89 ± 7.50 mL/kg/min, 38.87–48.36 mL/kg/min, 11.92 minutes). Classifications and percentile rankings were created using each measured and predicted method. Conclusions: The Healthy Persons Equation [6], Healthy Men and Women Equation [2], Active and Sedentary Women/Men Equations [10, 22] and nomogram [13] cannot accurately predict VO2max in healthy young adults, with R2 values between 0.38–0.50. The Healthy Persons Equation [6] was found to very closely mimic the seven-category classifications determined from the measured CPET VO2max values.

The transcriptomic expression pattern of immune checkpoints shows heterogeneity between and within cancer types.

Transcriptomic expression profiles of immune checkpoint markers are of interest in order to decipher the mechanisms of immunotherapy response and resistance. Overall, 514 patients with various solid tumors were retrospectively analyzed in this study. The RNA expression levels of tumor checkpoint markers (ADORA2A, BTLA, CD276, CTLA4, IDO1, IDO2, LAG3, NOS2, PD-1, PD-L1, PD-L2, PVR, TIGIT, TIM3, VISTA, and VTCN) were ranked from 0-100 percentile based on a reference population. The expression of each checkpoint was correlated with cancer type, microsatellite instability (MSI), tumor mutational burden (TMB), and programmed death-ligand 1 (PD-L1) by immunohistochemistry (IHC). The cohort included 30 different tumor types, with colorectal cancer being the most common (27%). When RNA percentile rank values were categorized as "Low" (0-24), "Intermediate" (25-74), and "High" (75-100), each patient had a distinctive portfolio of the categorical expression of 16 checkpoint markers. Association between some checkpoint markers and cancer types were observed; NOS2 showed significantly higher expression in colorectal and stomach cancer (P < 0.001). Principal component analysis demonstrated no clear association between combined RNA expression patterns of 16 checkpoint markers and cancer types, TMB, MSI or PD-L1 IHC. Immune checkpoint RNA expression varies from patient to patient, both within and between tumor types, though colorectal and stomach cancer showed the highest levels of NOS2, a mediator of inflammation and immunosuppression. There were no specific combined expression patterns correlated with MSI, TMB or PD-L1 IHC. Next generation immunotherapy trials may benefit from individual analysis of patient tumors as selection criteria for specific immunomodulatory approaches.

Wingate normative-reference values for a large cohort of Canadian university students

Abstract Study aim: The Wingate Anaerobic Test evaluates anaerobic power and capacity. Used to assess performance, historically among athletic populations, its evaluative capacity for individuals of varying athletic abilities is limited by a lack of normative data based on large participant populations. This study developed Wingate normative-reference values based on a large-scale cohort that is representative of the Canadian university student population. Material and methods: Data were collected from 872 participants, aged 20 to 29 years (mean body mass index [BMI]: 24.44 kg/m2). Testing was completed on a cycle ergometer using a widely recognized protocol, with resistance set at 7.5% of participants’. An independent samples t-test was used to compared the means of dependent variables (i.e., peak power [PP], mean power [MP], and fatigue index fi) and test for statistical significance (p &lt; 0.05) between sexes, and Cohen’s d determined effect size. Results: Males had higher PP and MP (W and W · kg−1), whereas females exhibited lower FI (%). Statistically significant differences between sexes were observed for all variables. Conclusions: Collected data yielded normative-reference standards, including percentile rankings and performance classifications. These norms will allow for significant practical applications, including an effective method to assess anaerobic performance and health.

Decoding Success: Assessing the Online Pseudocode Interpreter through Users Insights

Pseudocode is vital in enhancing programming comprehension, making it an essential component of the Programming Logic Formulation (CS1) course. However, many CS1 students from various senior high school strands struggle with this concept, highlighting the need for additional learning resources. This research evaluated a pseudocode interpreter designed for first-year Information and Communications Technology (ICT) students at Iloilo Science and Technology University in Iloilo City, Philippines. Using random sampling, 147 first-year ICT students were selected to evaluate the software's user experience in usability, credibility, appearance, and loyalty using the Standardized User Experience Percentile Rank Questionnaire (SUPR-Q). Likewise, five ICT experts were selected using purposive sampling to evaluate the system's validity as instructional material based on its content and on the material's organization, form, and style using the university's Quality Form for Instructional Materials (IM). The user experience evaluation yielded positive results, with students unanimously agreeing on the software's ease of use, dependability, and user-friendliness. The expert evaluation confirmed the system's validity as instructional material, commending its content, organization, form, and style. These findings suggest that the pseudocode interpreter provides immediate benefits for students, offering a valuable learning tool. Moreover, the software has the potential to be adopted by other faculty members, promoting a more efficient and captivating learning experience. Future research could investigate how interpreters affect student learning and their usefulness in various educational settings.

High CTLA-4 transcriptomic expression correlates with high expression of other checkpoints and with immunotherapy outcome.

CTLA-4 impedes the immune system's antitumor response. There are two Food and Drug Administration-approved anti-CTLA-4 agents - ipilimumab and tremelimumab - both used together with anti-PD-1/PD-L1 agents. To assess the prognostic implications and immunologic correlates of high CTLA-4 in tumors of patients on immunotherapy and those on non-immunotherapy treatments. We evaluated RNA expression levels in a clinical-grade laboratory and clinical correlates of CTLA-4 and other immune checkpoints in 514 tumors, including 489 patients with advanced/metastatic cancers and full outcome annotation. A reference population (735 tumors; 35 histologies) was used to normalize and rank transcript abundance (0-100 percentile) to internal housekeeping gene profiles. The most common tumor types were colorectal (140/514, 27%), pancreatic (55/514, 11%), breast (49/514, 10%), and ovarian cancers (43/514, 8%). Overall, 87 of 514 tumors (16.9%) had high CTLA-4 transcript expression (⩾75th percentile rank). Cancers with the largest proportion of high CTLA-4 transcripts were cervical cancer (80% of patients), small intestine cancer (33.3%), and melanoma (33.3%). High CTLA-4 RNA independently/significantly correlated with high PD-1, PD- L2, and LAG3 RNA levels (and with high PD-L1 in univariate analysis). High CTLA-4 RNA expression was not correlated with survival from the time of metastatic disease [N = 272 patients who never received immune checkpoint inhibitors (ICIs)]. However, in 217 patients treated with ICIs (mostly anti-PD-1/anti-PD- L1), progression-free survival (PFS) and overall survival (OS) were significantly longer among patients with high versus non-high CTLA-4 expression [hazard ratio, 95% confidence interval: 0.6 (0.4-0.9) p = 0.008; and 0.5 (0.3-0.8) p = 0.002, respectively]; results were unchanged when 18 patients who received anti-CTLA-4 were omitted. Patients whose tumors had high CTLA-4 and high PD-L1 did best; those with high PD-L1 but non-high CTLA-4 and/or other expression patterns had poorer outcomes for PFS (p = 0.004) and OS (p = 0.009) after immunotherapy. High CTLA-4, especially when combined with high PD-L1 transcript expression, was a significant positive predictive biomarker for better outcomes (PFS and OS) in patients on immunotherapy.

Usability Evaluation of Tokopedia Application Version 3.242 Using System Usability Scale (SUS) Method

Indonesia is currently experiencing rapid growth in the e-commerce sector. Its One of the existing e-commerce is the Tokopedia application, Users of this application reach more than 10 million users so that there are a lot of positive and negative reviews given by users. After manually analyzing there are still many negative reviews on the application, not only that, there are still other problems found such as expeditions that cannot be selected, then payment methods that cannot COD or pay on the spot, and sometimes force closes that come out by themselves suddenly. Therefore, researchers tried to conduct a study on Tokopedia application user satisfaction with the SUS method to measure the level of usability of the application. System Usability Scale (SUS) method to evaluate its usability aspect. The evaluation results showed that the app earned an SUS score of 55, with a percentile rank of about 30%, placing it at grade D. Although still above average, the slight difference with the standard SUS score (68) indicates a potential improvement. In interpretation based on nature (Adjective), the application is in the OK category, with the level of acceptance (Acceptable) is in the Marginal category. The Net Promoter Score (NPS) results show the Detractor category, indicating a tendency to lack user enthusiasm for the application. Further evaluation is needed to identify aspects of usability that affect user perception and cause unsatisfactory NPS categories. Future research can design improvement strategies based on these findings, with the aim of increasing SUS scores and changing the NPS category to be more positive

From Monologue to Dialogue: The Pursuit of Relationship Centered Communication Across a Large, Integrated Healthcare System.

By listening to the "voice" of patients, Northwell Health, New York's largest healthcare organization, took an evidence-based approach to empowering physicians and advanced care providers. The Relationship Centered Communication course utilizes experiential learning to strengthen patient-centered communication and empathy skills to elicit provider-patient relationships grounded in partnership. This case study highlights (1) The pragmatic cultural journey requiring visionary leadership, strong collaborations, and an evolving educational strategy. (2) Over the course of 6 years, 3300+ providers were educated in this evidence-based communication course. (3) As a result, Northwell's Hospital Consumer Assessment of Healthcare Providers and Systems "Communication with Doctors" domain has increased by 22 percentile rank points, when compared nationally to peers, in addition to other notable patient experience metric improvements within ambulatory medical practice.

The Latency of Auditory Event-Related Potential P300 Prolonged in School-Age Students with Unilateral Hearing Loss in a Mandarin Learning Environment.

Our study investigated the differences in speech performance and neurophysiological response in groups of school-age children with unilateral hearing loss (UHL) who were otherwise typically developing (TD). We recruited a total of 16 primary school-age children for our study (UHL = 9/TD = 7), who were screened by doctors at Shin Kong Wu-Ho-Su Memorial Hospital. We used the Peabody Picture Vocabulary Test-Revised (PPVT-R) to test word comprehension, and the PPVT-R percentile rank (PR) value was proportional to the auditory memory score (by The Children's Oral Comprehension Test) in both groups. Later, we assessed the latency and amplitude of auditory ERP P300 and found that the latency of auditory ERP P300 in the UHL group was prolonged compared with that in the TD group. Although students with UHL have typical hearing in one ear, based on our results, long-term UHL might be the cause of atypical organization of brain areas responsible for auditory processing or even visual perceptions attributed to speech delay and learning difficulties.

Demographic Insights Into College-Going Students in India: A Morphological Analysis

Introduction: In the context of India's diverse culture and changing education system, it is crucial to understand the morphological characteristics of college students, especially with the government actively supporting sports through initiatives like the "Khelo India" program to aid young athletes. The purpose of the study was to investigate the morphological characteristics of college-level athletes and non-athletes in India. Methods: 287 college students have been randomly selected to acquire a comprehensive set of demographic and anthropometric data. Results: The study revealed significant differences in body mass index (p=0.004), endomorphy (p=0.001), ectomorphy (p=0.02), and body fat percentage (p=0.001). However, no significant difference in mesomorphy (p=0.09) was identified, and only minimal differences in fat-free mass (p=0.57) were observed. College-level athletes exhibit an ectomorphic-mesomorphic physique (2.9-3.9-3.0), characterized by a distinct blend of muscularity and leanness. Non-athletes are mesomorphic-endomorphs (5.0-4.3-2.4), exhibiting higher body fat content and muscularity. Athletes had a significantly lower body fat percentage, highlighting the positive influence of sports training and regular physical exercise on reducing adiposity. The analysis of percentile rankings provides comprehensive insights into the distribution of anthropometric metrics among athletes and non-athletes, assisting in customizing training regimens, identifying areas for potential improvement, and enhancing a comprehensive assessment of individuals' physical characteristics. Conclusion: The study sheds light on the crucial role of morphological traits in discerning differences between college-level athletes and non-athletes within the broader context of the "Fit India Movement." The study will help design an effective training module to improve the overall health of college students.

Impact of social vulnerability on comorbid COVID-19 and acute myocardial infarction mortality in the United States

The trajectory of several cardiovascular diseases (CVD), including acute myocardial infarction (AMI), has been adversely impacted by COVID-19, resulting in a worse prognosis. The Social Vulnerability Index (SVI) has been found to affect certain CVD outcomes. In this cross-sectional analysis, we investigated the association between the SVI and comorbid COVID-19 and AMI mortality using the CDC databases. The SVI percentile rankings were divided into four quartiles, and age-adjusted mortality rates were compared between the lowest and highest SVI quartiles. Univariable Poisson regression was utilized to calculate risk ratios. A total of 5779 excess deaths and 1.17 excess deaths per 100,000 person-years (risk ratio 1.62) related to comorbid COVID-19 and AMI were attributable to higher social vulnerability. This pattern was consistent across the majority of US subpopulations. Our findings offer crucial epidemiological insights into the influence of the SVI and underscore the necessity for targeted therapeutic interventions.

Assessing emotion beliefs with the Polish version of the Emotion Beliefs Questionnaire (EBQ): psychometric properties, norms, and links with emotional reactivity and psychopathology

Originally developed in English, the Emotion Beliefs Questionnaire (EBQ) is a self-report measure of beliefs about the controllability and usefulness of negative and positive emotions. In this study, we introduce the Polish version and examine its psychometric properties and links with emotional outcomes. Our sample was 914 Polish adults aged 18–70 from the general population. Confirmatory factor analysis was applied to verify the factor structure. Convergent and divergent validity were assessed based on the relationship between the EBQ and emotional reactivity traits as well as markers of anxiety, depression, and stress. We assessed internal consistency reliability. We also examined discriminant validity by conducting exploratory factor analyses of EBQ scores and emotional reactivity traits and psychopathology symptoms. We evaluated criterion validity by conducting a set of multiple regression analyses, examining whether EBQ scores could predict significant variance in psychopathology symptoms. Our factor analyses supported the EBQ’s factorial validity, conforming to the intended 4-factor structure (subscales: negative-controllability, positive-controllability, negative-usefulness, positive-usefulness), with support also found for a higher-order general factor (e.g., CFI = 0.941, RMSEA = 0.063). This structure was invariant across gender and age categories. The EBQ subscales correlated in expected directions with emotional reactivity traits and psychopathology symptoms. The EBQ showed good internal consistency reliability (α = 0.77–0.88) and discriminant validity. Beliefs about the uncontrollability of negative emotions were the strongest unique predictor of psychopathology symptoms. We also presented percentile rank norms for Polish adults. The Polish version of the EBQ appears to have strong psychometric properties and good clinical relevance.

Pan-cancer analysis of TIM-3 transcriptomic expression reveals high levels in pancreatic cancer and interpatient heterogeneity.

T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3), an immune checkpoint receptor, dampens immune function. TIM-3 antagonists have entered the clinic. We analyzed TIM-3 transcriptomic expression in 514 diverse cancers. Transcript abundance was normalized to internal housekeeping genes and ranked (0-100 percentile) to a reference population (735 tumors; 35 histologies [high≥75 percentile rank]). Ninety tumors (17.5%) demonstrated high TIM-3 expression. TIM-3 expression varied between and within tumor types. However, high TIM-3 expression was more common in pancreatic cancer (20/55 tumors, 36.4%; odds ratio, 95% confidence interval (pancreatic vs. other tumors) = 3.176 (1.733-5.818; p < 0.001, multivariate]). High TIM-3 also significantly and independently correlated with high PD-L1 (p = 0.014) and high CTLA-4 (p < 0.001) transcriptomic expression (multivariate). These observations indicate that TIM-3 RNA expression is heterogeneous, but more common in pancreatic cancer and in tumors exploiting PD-L1 and CTLA-4 checkpoints. Clinical trials with patient selection for matched immune-targeted combinations may be warranted.

SOCIOECONOMIC DISPARITIES IN PHYSICAL AND OCCUPATIONAL THERAPY HOME HEALTH CARE VISITS FOR PEOPLE WITH DEMENTIA

Abstract People living with Dementia (PLWD) utilize Home Health Care (HHC) services such as Physical Therapy (PT) and Occupational Therapy (OT), but little is known about service utilization patterns among PLWD from different socioeconomic backgrounds. We aimed to identify disparities in service utilization in PLWD in a HHC setting across socioeconomic backgrounds using a measure of geographic socioeconomic deprivation, the Area Deprivation Index (ADI). ADI is a composite measure of census variables describing socioeconomic disadvantage, reported as national percentile rank. This secondary analysis utilized data collected February 2017–May 2022 in a dementia symptom management clinical trial at a large, urban, Medicare certified nonprofit HHC agency in New Jersey. Demographic and service utilization data from 153 dyads of PLWD and caregivers was collected. PLWD’s area codes were used to calculate ADI. ADI national percentile was divided into quartiles, and PT and OT utilization for the highest quartile was compared to the three lowest quartiles using Poisson regression, consistent with previous literature. The highest quartile group was defined as ADI above the 36.5th percentile. ADI varied from 2nd to 73rd percentile, with a median of 24th percentile. Analysis controlled for pre-existing comorbidities using pre-trial Charlson Comorbidity Index scores, classified as high (&amp;gt;5), medium (3-4), or low (1-2). High ADI classification was associated with a 50.2% decrease in OT utilization (IRR=.498, CI=.348-.713), and 39.4% decrease in PT utilization (IRR=.606, CI=.485-.759). Further investigation of disparities in PT and OT utilization in HHC is needed, given the disproportionate burden of disease on socioeconomically distinct populations.

Vestibular function and balance performance in children with sensorineural hearing loss

ObjectiveBalance difficulties are common in children with sensorineural hearing loss (SNHL). For some of these children, concomitant vestibular deficits may impact postural control. This study aimed to explore vestibular function, functional balance and postural control, and the relationship between these measures in children with SNHL.DesignCross-sectional study quantifying peripheral vestibular function (vestibular evoked myogenic potentials [VEMP], video head impulse test), functional balance (Bruininks–Oseretsky Test of Motor Proficiency [BOT]) and postural control (static posturography with modified sensory inputs). The relationship between the degree of vestibular impairment, functional balance and postural control was explored.Study sampleEleven with SNHL, and 11 with normal sound detection (NSD) between 5 and 12 years of age.ResultsChildren with SNHL had varying degrees of vestibular dysfunction and differences in overall balance performance. Across all children, greater degrees of vestibular impairment were associated with significantly poorer functional balance and postural control performance for complex standing conditions (BOT percentile rank p = 0.001; compliant surface eyes open [EO]: p = 0.027; compliant surface eyes closed: p = 0.048).ConclusionsVestibular dysfunction in children with SNHL was variable. Vestibular impairment predicted poorer functional balance performance and postural control abilities, including differences in postural sway patterns.

On the Causal Effect of Fame on Citations

Papers published in finance and economics journals whose first authors are famous have more citations than papers whose second or third authors are famous. As a paper ages, its citation rate varies most with variation in the fame of the first author and less so with the fame of second and third authors. Author order is alphabetical, so these patterns are unrelated to underlying quality. The magnitudes we find are large; a three-author paper written by the most prolific author in economics and his two research assistants would increase, on average, its percentile rank by 30 percentage points if the prolific author was first rather than second or third. The effect is especially pronounced in three, rather than two, author papers, suggesting that burying a famous author in the “et al.” reduces citations the most. This paper was accepted by David Sraer, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.00840 .

A Vulnerability Index for Mitigation and Prevention of Diabetes Growth in India: A Disaggregated Analysis

ObjectivesThis study aimed to provide a vulnerability index (VI) for identifying vulnerable regions in different states of India, which may serve as a tool for state- and district-level planning for mitigation and prevention of diabetes growth in the country. MethodsUsing data on 13 indicators under 4 domains, we generated domain-specific and overall VIs at state (36 states/union territories) and district levels (640 districts) using the percentile ranking method. The association of diabetes with individuals’ socioeconomic status at different levels of regional vulnerability has also been observed through multivariable logistic regression models. ResultsOn a scale of 0 to 1, there are 13 states with an overall VI of >0.70, of which 5 states are from southern regions of India. A low VI has been achieved by socioeconomically backward states. We observed that prevalence rates and vulnerability levels for most of the top and bottom 11 states are in the same line. District-level analysis showed that the 20 most vulnerable and least vulnerable districts are mostly from coastal and socioeconomically backward states of the country, respectively. Furthermore, logistic regression revealed that rural adults and females are less likely to be diabetic in all vulnerability quartiles. The oldest, Muslims, wealthiest, widowed/deserted/separated, and those with schooling ≤12 years are significantly more likely to be diabetic than their counterparts. ConclusionThe constructed VI is vital for identifying vulnerable areas and planners and policy-makers may use this comprehensive index and domain-specific VIs to prioritize resource allocation.

Quality improvement initiative to improve communication domains of patient satisfaction in a regional community hospital with Six Sigma methodology

BackgroundCommunication gaps, whether incomplete or fragmented communication, have been the cause of many disasters in human civilisation. Coordination of healthcare is directly related to proper communication and handoffs among multidisciplinary...

Assessment of Lifecourse Social Exposome in Brain Bank Decedents

AbstractBackgroundThere is increasing evidence that the social exposome impacts the development of Alzheimer’s disease and related dementias (ADRD). The social exposome includes factors such as neighborhood disadvantage, and is thought to impact brain health across the lifecourse, particularly during sensitive life stages such as early childhood. Residential histories are required to assess dosage and timing of exposures, yet are rarely categorized and linked to brain bank cohorts. Our objective was to characterize the lifecourse neighborhood disadvantage across two Alzheimer’s Disease Research Center (ADRC) brain banks.MethodAfter abstracting publicly available residential data, we constructed residential histories using validated metrics of neighborhood disadvantage, nationwide Area Deprivation percentile rankings (ADI), constructed for each census timeframe from 1910‐present, to measure lifecourse social exposome time‐concordantly aligned to participant life‐year. ADIs were linked for all available years between birth and death, ranging from age 0 to 103. Greater ADI values denote living in higher neighborhood disadvantage. These ADIs were linked to the residential histories for each decedent and used to calculate two sensitive life stages: ages 0‐19 and 40‐60. A repeated measures one‐way ANOVA determined variance in ADI both within and between these sensitive life stages.ResultThis sample contained 1309 decedents from two brain. To date, 1230 decedents have been linked to at least one ADI timepoint, with an average of 81% (71‐88%) of all life‐course years accounted for via ADI linkage. The mean ADI for the 0‐19 period was 23.5 (SD = 22.3, 5.0‐36.9), while the 40‐60 period was 22.0 (21.6, 5.0‐34.0). A repeated measures one‐way ANOVA found a statistically significant difference in ADI between the two windows of time.ConclusionTissue banked samples are not typically characterized on social determinants of health. Here we show that determining lifecourse social exposomes are feasible using publicly available data. To our knowledge, this is the first time such characterization has been successfully performed. Efforts to link decedents to ADI timepoints are still ongoing, which will reduce missingness, enhance measurement precision, and allow for comparison between all life stages. This work provides a unique methodology for assessing the social exposome in relation to ADRD brain pathology.