Introduction/Background Despite the fact that the modern 3D simulators have basic scenarios of acute blood loss, adaptation of the scenarios to specialization of trainees and increase of realism are necessary. Methods “Acute blood loss- hemorrhagic shock” is developed and used by trainees at MSC of Siberian State Medical University. The scenario consists of sections such as: 1) Skills - collection of information (documents, personnel of ambulance and hospital department, other information source); patient assessment; monitoring (heart rate, pulse, blood pressure, auscultation of the lungs etc.) diagnosis; sequence of actions, efficiency assessment of therapy; 2) Information for an assistant: a) preparation of manikins (Susie S2000, Hal S3000 or Noelle S575, choice of manikin depends on specialization of trainees). The assistant has to fill the venue system and bladder, to lubricate the manikin’s airway and urethra; b) preparation of medical equipment and instruments for the scenario (stethoscope, blood pressure cuff, sets for airway management, ventilators, oxygen and ways of delivery, patient monitors, perfusors, vacuum suction, etc.); c) preparation of special materials (bandages, gloves, antiseptic, systems for intravenous infusion, nasogastric probe, Blackmor’s probe, urinary catheters, syringes, infusion solutions, containers with blood, albumin, epinephrine and other drugs). Vials of distilled water are used instead of real drugs. To achieve maximum realism during simulations colorants are added into the vials (if necessary) and labels are stuck; 3) Guide for operator (description of simulation process): a) stages of the scenario (the physiological parameters of a patient-simulator: respiratory pattern and rate, rhythm, heart rate, temperature, blood pressure, cyanosis and other); b) duration of stages; c) the variety of transition to next stage. Clinical parameters of the simulator, described by qualified doctors (expert), are based on guidelines. Scenario consists of several clinical stages: 1 = Normal state, 2 = Acute blood loss (Hypovolemya), 3 = Shock Compensation, 4 = Shock Decompensation, 5 = Agony, 6 = Asistolia, 7 = Stabilization of the state (level 1), 8 = Stabilization of the state (level 2), 9 = Persistently stabilized patients state or patient’s death. Correct conducting of diagnosis and therapy leads to stabilization on any stages of the scenario. Number of required actions to help depends on the patient state (scenario stage). Incorrect conducting of diagnosis and therapy leads to death of the patient (robot simulator). Variants of scenario development: a) preoperative preparation and examination; b) postoperative intensive care; c) conservative therapy, if there is no indication for surgery. Transition to the next stage is implemented automatically or by operator (according to manipulations of trainees). Therefore, an operator has to know the clinical pattern of diseases and to be able to evaluate trainees manipulations; 4) Information for trainees (briefing). To motivate trainees, three variants of the scenarios are developed (for surgeons, internists and obstetricians); 5) Additional information (analysis Results, X-ray and ultrasound investigations, etc.) is given to trainees on request. During simulation audio video control is conducted. Moreove,r there is a checklist for every trainees group wherethe trainer notes duration of decision making, performing of manipulations, drugs and its doses (in obedience to National Standards). The checklist is used for debriefing, then trainees have opportunities of retraining. Results: Conclusion Basic scenarios require adaptation to trainee’s specialization. It is necessary to describe participant’s duties in details for preparation of simulation. Use of real medical equipment of ICU and drug imitation are provided to add realism of simulation training. Special clinical training of simulation operator (engineer) is necessary. Scenarios should be created by qualified doctors (expert). Audio-video control and checklist make debriefing more reasonable. Ninety two percent of trainees that studied at MSC of Siberian State Medical University in 2012 (n=458), gave a positive assessment of scenarios. Disclosures None.