Peptidyl Chloromethyl Ketone Research Articles

Improved synthetic inactivators of plasmin

Synthetic inhibitors for plasmin of the peptidyl chloromethyl ketone type are described which have increased effectiveness due to side-chains which improve affinity to auxiliary binding regions of the active center

Irreversible inhibition and peptide mapping of urinary plasminogen activator urokinase

FEBS LettersVolume 140, Issue 1 p. 58-62 Full-length articleFree Access Irreversible inhibition and peptide mapping of urinary plasminogen activator urokinase M. Reboud-Ravaux, M. Reboud-Ravaux Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this authorG. Desvages, G. Desvages Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this authorF. Chapeville, F. Chapeville Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this author M. Reboud-Ravaux, M. Reboud-Ravaux Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this authorG. Desvages, G. Desvages Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this authorF. Chapeville, F. Chapeville Laboratoire de Biochimie du Développement, IRBM, tour 43, Université de Paris VII, 2, place Jussieu, 75221 Paris Cedex 05, FranceSearch for more papers by this author First published: April 05, 1982 https://doi.org/10.1016/0014-5793(82)80520-6Citations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume140, Issue1April 05, 1982Pages 58-62 ReferencesRelatedInformation

Inactivation of the plasminogen activator from HeLa cells by peptides of arginine chloromethyl ketone

The binding specificities of human urinary urokinase (EC 3.4.99.26) and HeLa cell plasminogen activator were studied using peptidyl chloromethyl ketone inhibitors. A 125I-labeled fibrin assay has been developed to yield kinetic information. Reagents of the sequence X-Gly-ArgCH 2Cl were the most effective. The susceptibility of the HeLa cell plasminogen activator differed from that of urokinase in several respects indicating the utility of this type of inhibitor in distinguishing between proteases of this specificity.