People's Liberation Research Articles

Application and funding status of oral and craniofacial sciences research projects funded by National Natural Science Foundation of China from 2010 to 2021

Objective: Based on the application and funding status of National Natural Science Foundation of China (NSFC) in the field of oral and craniofacial sciences (H15), we analyzed the current status of basic research of the Oral and Craniofacial Sciences (OCS) in China, and provided the references for the sustainable and efficient funding of basic research and scientific frontier exploration in the field, supporting the construction of talents and teams, and enhancing the development of OCS in China. Methods: The data of both applied and funded grants of H15 in NSFC from 2010 to 2021 were analyzed, including the number of applications and funding, the amount of funding, the funding rate, the research direction and the supporting units. The status of basic research of H15 was summarized. Results: From 2010 to 2021, H15 received 15 060 applications and funded 2 569 grants. The overall funding rate of H15 was 17.06%, and the total funding amount was 114.030 5 million yuan. The applications and funded projects of H15 were mainly focused on the General Projects and Youth Science Fund Projects, accounting for 90.33% (13 604/15 060) and 88.71% (2 279/2 569) of the total number of applications and funded projects, and 78.05% 89 002.5/114 030.5 of the total funding amount. In terms of talent training, the National Science Foundation for Distinguished Young Scholars received 65 applications, and 6 were founded, with a funding rate of 9.23%. The National Science Foundation for Outstanding Young Scholars received 85 applications, and 13 were founded, with a funding rate of 15.29%. In recent years, the number of applications has gradually increased and the number of grants has remained relatively stable. Among the nine sub-categories of H15, the top three in terms of the number of applications and grants were H1502, H1504, and H1507. H1502 (repair and regeneration of oral and craniofacial tissue and organ defects) received 2 760 applications, and 510 were funded. H1504 (periodontal and oral mucosal diseases) received 2 475 applications, and 419 were funded. H1507 (restoration of tooth defects and loss, and correction of dental deformities) received 2 270 applications, and 367 were funded. Peking University and Sichuan University ranked first and second with 1 092 and 1 001 applications, respectively. The top five recipients were Sichuan University (327 items), Peking University (260 items), Wuhan University (204 items), Shanghai Jiao Tong University (198 items) and the Fourth Military Medical University of the People's Liberation Army (193 items). The funding rates were 32.67%, 23.81%, 23.02%, 21.69% and 29.11%, respectively. Conclusions: Under the support of NSFC, the basic research of oral and craniofacial sciences has been developed in an all-round way. In recent years, the talent training of all echelons has increased year by year, the research direction and geographical coverage is comprehensive, and project support organization has its own research focus and discipline advantages, making contributions to the realization of the goal of healthy China and the progress of world medicine.

Dismantling Anti-Black Racism With Unapologetic Boldness: Redefining Our Values and Living Them Out Loud

In her 2023 Society of Counseling Psychology (SCP) Presidential Address, Dr. Shavonne Moore-Lobban reflects on the work of the division to continue dismantling anti-Black racism. Through personal reflections of societal oppression and harm toward Black people, she calls on the SCP to engage in critical consciousness and center the liberation of Black people for the liberation of all people. Central to her message are redefined SCP values which she reviews and challenges SCP to boldly live out loud.

Doing The Work to Do the Work: Black Teacher Educators Learning to Heal and Healing to Teach

ABSTRACT In this study, we, both co-authors and Black teacher educators, explored our experiences imagining and practicing Black liberatory pedagogical praxes through the contours of anti-Black violence. Framed through engaged and healing-centered pedagogical conceptualizations, we use Black storytelling to present narratives of our storied experiences doing the work to do the work. In doing the work to do the work, we encourage other Black liberatory educators to both create and sustain individual and collective space(s) to build their sociopolitical analyses of oppression in their worlds, to remember Black movements and moments of the past that have transformed oppression, and to imagine more justice-centered pedagogical praxes that liberate themselves and their students. Doing the work to do the work is both theory and practice; we hope that Black educators and those supporting the liberation of Black peoples can contextualize our storied lives shared here in their own dreams and practices.

The Survival of Mobile Firepower: An Uncertain Factor in Taiwan's Asymmetrical Defense

executive summary: This article considers the strategic importance of mobile firepower for Taiwan's asymmetrical defense and analyzes the geostrategic threats to the survival of Taiwan's mobile surface-to-air missiles (SAMs) and standoff firepower. main argumentIn the face of China's military superiority, Taiwan has adopted an asymmetrical approach to its defense that relies significantly on mobile SAMs and standoff firepower to deny People's Liberation Army (PLA) platforms, such as transport aircraft and landing ships, access to the island. Mobility presents a tactical advantage for Taiwan, as it renders Chinese surveillance more difficult. However, Taiwan's mobile units could be constrained or rendered immobile given the geographic environment in Taiwan, especially in urban regions like the Taipei metropolitan area. At the outbreak of a potential war with China, Taiwan's mobile units could face preemptive strikes, and concealing the deployed units for an indeterminate time while awaiting a PLA invasion would also be challenging. The amount of mobile firepower that Taipei can retain after PLA attacks may determine whether Beijing's invasion is successful, but with a narrow margin for losses and an incomplete buildup, Taiwan's mobile firepower may nevertheless not be adequate to redress the island's military inferiority. To consolidate the status quo in the strait, Taipei should strengthen its mobile firepower and Washington should offer critical support. policy implications • Although there is no clear minimum level of firepower that Taipei would need to retain in an attack scenario, the current margin is narrow. If the PLA efficiently neutralizes Taiwan's mobile units, Taiwan's asymmetrical defense would be significantly undermined or even fail. • Moving and hiding mobile units around Taiwan could be challenging, given that suitable routes in urban and mountainous areas are predictable and could be cut off. To thwart a potential PLA invasion, the mobile units would also need to be hidden for an indeterminate period, which could be difficult. The necessity of defending Taipei would further reduce the tactical flexibility of the mobile units. • China has various surveillance and attack means that could be used to neutralize Taiwan's mobile units and defensive means to lower the threat from mobile firepower. The efficacy of these measures and the extent to which Beijing could concentrate them for this mission is uncertain. • Third parties, particularly the U.S., are crucial in strengthening Taiwan's mobile firepower, especially in terms of quantity and evaluation.

Inflammatory Markers Showed Significant Incremental Value for Predicting Post-Hepatectomy Liver Failure in Hepatocellular Carcinoma Patients.

Post-hepatectomy liver failure (PHLF) remains a complication with the potential risk of mortality for hepatocellular carcinoma (HCC) patients. The systemic inflammatory response (SIR) has been demonstrated to be associated with a bad prognosis of liver cirrhosis and tumors. This study aims to evaluate the incremental prognostic value of inflammatory markers in predicting PHLF in patients with HCC. Clinical characteristics and variables were retrospectively collected in 2824 patients diagnosed with HCC who underwent radical hepatectomy from the First Medical Center of the General Hospital of the People's Liberation Army. A recently published prognostic model for PHLF was used as the reference model. The increase in AUC (ΔAUC), integrated discrimination improvement (IDI), and the continuous version of the net reclassification improvement (NRI) were applied for quantifying the incremental value of adding the inflammatory markers to the reference model. A p value < 0.05 was considered statistically significant. The reference PHLF model showed acceptable prediction performance in the current cohort, with an AUC of 0.7492 (95%CI, 0.7191-0.7794). The calculated ΔAUC associated with procalcitonin (PCT) was the only one that was statistically significant (p < 0.05), with a value of 0.0044, and demonstrated the largest magnitude of the increase in AUC. The continuous NRI value associated with the systemic immune-inflammation index (SII) was 35.79%, second only to GPS (46.07%). However, the inflammatory markers of the new models with statistically significant IDI only included WBC count, lymphocyte count, and SII. IDI associated with SII, meanwhile, was the maximum (0.0076), which was consistent with the performance of using the ΔAUC (0.0044) to assess the incremental value of each inflammatory variable. Among a wide range of inflammatory markers, only PCT and SII have potential incremental prognostic value for predicting PHLF in patients with radical resectable HCC.

Racial Discrimination in Uncle Tom's Cabin and the "Black Lives Matter" Movement

Uncle Tom's Cabin and the "Black Lives Matter" movement are two different themes, but both are related to racial discrimination. For the novel, it depicts the story of a slave named Tom, and describes the pain and inequality brought about by the slavery through the experience of Tom and other characters. This novel caused great repercussions around the American Civil War, helped to promote the struggle against the slavery, and became one of the classics of world literature. While the "Black Lives Matter" movement advocates for equality, justice, and the elimination of violence and discrimination against the black people. The focus of this movement is to protest against violent or arbitrary actions against African Americans, such as illegal arrests, excessive use of force, or intentional killings. Although these two themes emerged in different historical and cultural periods, they share a common goal of opposing racial discrimination and pursuing equality and justice. Moreover, in the current era, the "Black Lives Matter" movement is more diverse and inclusive compared to past movements. By publishing anti-racial discrimination information on media and social media, and organizing, more people are involved in the fight against discrimination. They are all aimed at opposing and eliminating racial discrimination, and promoting the construction of a more equal, diverse, and just society. Due to different historical backgrounds and cultural characteristics, there are certainly differences in practice and ideology. This article explores the connection between the "Black Lives Matter" movement and Uncle Tom's Cabin, which both reflect the long-standing issues of racial discrimination and social injustice in American society. As a chronic disease of American society, although racial discrimination and social inequality are difficult to solve, it is necessary for us to conduct some detailed analysis on them. The connection between the novel and the movement indicates that the ongoing struggle for equality and justice is meaningful, that is, the liberation of black people can only be achieved through their own struggles.

Schistosomiasis: The Disease That Saved Taiwan.

From 1949 to 1950, an acute epidemic of schistosomiasis struck several elite units of the People's Liberation Army during the Chinese Civil War that were preparing for an amphibious invasion of Taiwan. The crucial delay brought by the sudden outbreak of the disease may have cost communist forces control of the strategic island, changing the geopolitical calculus of the Pacific in the decades since.

Multidisciplinary discussion and management of synchronous colorectal liver metastases: A single center study in China.

The multidisciplinary team (MDT) has been carried out in many large hospitals now. However, given the costs of time and money and with little strong evidence of MDT effectiveness being reported, critiques of MDTs persist. To evaluate the effects of MDTs on patients with synchronous colorectal liver metastases and share our opinion on management of synchronous colorectal liver metastases. In this study we collected clinical data of patients with synchronous colorectal liver metastases from February 2014 to February 2017 in the Chinese People's Liberation Army General Hospital and subsequently divided them into an MDT+ group and an MDT- group. In total, 93 patients in MDT+ group and 169 patients in MDT- group were included totally. Statistical increases in the rate of chest computed tomography examination (P = 0.001), abdomen magnetic resonance imaging examination (P = 0.000), and preoperative image staging (P = 0.0000) were observed in patients in MDT+ group. Additionally, the proportion of patients receiving chemotherapy (P = 0.019) and curative resection (P = 0.042) was also higher in MDT+ group. Multivariable analysis showed that the population of patients assessed by MDT meetings had higher 1-year [hazard ratio (HR) = 0.608, 95% confidence interval (CI): 0.398-0.931, P = 0.022] and 5-year (HR = 0.694, 95%CI: 0.515-0.937, P = 0.017) overall survival. These results proved that MDT management did bring patients with synchronous colorectal liver metastases more opportunities for comprehensive examination and treatment, resulting in better outcomes.

Critical realism as a fruitful approach to social work research as illustrated by two studies from the field of child and family welfare

ABSTRACT This paper argues the case for taking a critical realist (CR) approach to social work research. The normativity in social work is often under-communicated in the social sciences, resulting in research that has an unclear value base as its starting point. Social work practice promotes social change and people's development, empowerment, and liberation. By taking a CR of view as a starting point for researching social problems, the focus shifts towards explaining phenomena by revealing and discussing the mechanisms through which they are produced and maintained. Child welfare issues are argued to be “wicked problems”, on top of which the practice of social work itself is a complex field. Two studies from the field of child and family welfare are presented here to illustrate how CR has been fruitfully applied in research on such complex phenomena. These two studies comprise research on child protection assessment and parental high conflict.

Effect of far-infrared therapy device on arteriovenous fistula maturation and lifespan in hemodialysis patients: a randomized controlled clinical trial.

Arteriovenous fistula (AVF) is the first choice of vascular access for hemodialysis treatment, and its surgical maturity rate is not high, and its postoperative complications (mostly stenosis) significantly shorten its life. At present, there are few studies on treatment methods to improve the maturity and survival of AVF. In this study, the effect of far infrared therapy (FIR) on the maturity and longevity of arteriovenous fistula in hemodialysis patients was discussed, and the protective mechanism of AVF induced by FIR therapy was explored, aiming at exploring a new treatment method. The hemodialysis patients admitted to the 900th Hospital of the Chinese Joint Logistics Support Force of the People's Liberation Army from January 2021 to April 2023 were randomly divided into control group and intervention group, with 40 cases in each group. Among them, the control group was coated with mucopolysaccharide polysulfonate cream; Intervention group: The patients were treated with mucopolysaccharide polysulfonate cream and far infrared radiation at the same time. After 3 months' intervention, the arteriovenous fistula (vein diameter, mature time of arteriovenous fistula, blood flow controlled by pump during dialysis, blood flow of brachial artery during dialysis and the occurrence of complications of internal fistula (oozing, occlusion and infection) and the pain score (numerical rating scale, NRS) of the two groups were compared, and the curative effects were compared. There was no significant difference in general data between the two groups (P > 0.05), which indicated that the study was comparable. After 3 months' intervention, the vein diameter, pump-controlled blood flow and brachial artery blood flow in the intervention group were significantly higher than those in the control group (P < 0.05). And the maturity time, NRS score and complication rate of arteriovenous fistula were significantly lower than those of the control group (P < 0.05). The primary patency rate of AVF in the intervention group was higher than that in the control group, and the overall patency rate between the two groups was statistically significant (P < 0.05). As a promising new treatment method, far infrared therapy can effectively promote the maturity of AVF, increase venous diameter, pump controlled blood flow during dialysis, brachial artery blood flow during dialysis, and prolong the service life of AVF.

Guerrillas and Combative Mothers: Women and the Armed Struggle in South Africa

Siphokazi Magadla's Guerrillas and Combative Mothers rests on 40 life histories of women who joined armed struggles of many kinds to fight apartheid. The book is a result of her doctorate which in turn rests on work she did while being a research consultant at the Institute for Security Studies. In 2010, on the tenth anniversary of the United Nations' (UN's) adoption of Resolution 1325, Magadla and Chery Hendricks produced the documentary Women and Security Sector Transformation in South Africa (2010). Magadla interviewed Major General Ntsiki Memela-Motumi, then chief director of transformation management in the South African National Defence Force (SANDF); Thandi Modise, a previous chair of the Portfolio Committee on Defence in the National Assembly and; Mala Singh, former deputy national commissioner of the South African Police Service (SAPS). Memela-Motumi and Modise are both former combatants in Umkhonto weSizwe (MK). They provided rich accounts of how their experiences as women in MK informed their later roles in transforming the SANDF. However, the study also has a prior genesis in Magadla's own experience of being the daughter of a soldier in the Transkei Defence Force. He ended his military career at 40 after that force was integrated into the SANDF. Her mother, a psychiatric nurse, also made her aware of the unstable mental conditions of many soldiers who were demobilised from the various armed forces in the period around 1994. This personal knowledge plus the experience of working with the Institute for Security Studies (ISS) gives the impetus for an important study. It is a study arising out of the complicated and turbulent moment in time when seven armies were integrated. These seven armies include the South African Defence Force (SADF), MK, the Azanian People's Liberation Army (APLA) and the four 'homeland' armies. This was a period in which those who had chosen to fight apartheid were faced with the question of whether they were career soldiers or not; and whether a return to civilian life was possible now that there was no longer a war.

Analysis of prognosis and influencing factors of No. 253 lymph node metastasis in descending colon, sigmoid colon, and rectal cancer: a multicenter study

Objectives: To analyze the influencing factors of No. 253 lymph node metastasis in descending colon cancer, sigmoid colon cancer, and rectal cancer, and to investigate the prognosis of No. 253 lymph node-positive patients by propensity score matching analysis. Methods: A retrospective analysis was performed on clinical data from patients with descending colon cancer, sigmoid colon cancer, rectosigmoid junction cancer, and rectal cancer who underwent surgery between January 2015 and December 2019 from the Cancer Hospital of the Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, Peking Union Medical College Hospital, General Hospital of the Chinese People's Liberation Army, and Peking University Cancer Hospital. A total of 3 016 patients were included according to inclusion and exclusion criteria, comprising 1 848 males and 1 168 females, with 1 675 patients aged≥60 years and 1 341 patients aged<60 years. Clinical and pathological factors from single center data were subjected to univariate analysis to determine influencing factors of No. 253 lymph node metastasis, using a binary Logistic regression model. Based on the results of the multivariate analysis, a nomogram was constructed. External validation was performed using data from other multicenter sources, evaluating the effectiveness through the area under the receiver operating characteristic curve and the calibration curve. Using data from a single center, the No. 253 lymph node-positive group was matched with the negative group in a 1∶2 ratio (caliper value=0.05). Survival analysis was performed using the Kaplan-Meier method and Log-rank test. The Cox proportional hazards model was used to determine independent prognostic factors. Results: (1) The tumor diameter≥5 cm (OR=4.496,95%CI:1.344 to 15.035, P=0.015) T stage (T4 vs. T1: OR=11.284, 95%CI:7.122 to 15.646, P<0.01), N stage (N2 vs. N0: OR=60.554, 95%CI:7.813 to 469.055, P=0.043), tumor differentiation (moderate vs. well differentiated: OR=1.044, 95%CI:1.009 to 1.203, P=0.044; poor vs. well differentiated: OR=1.013, 95%CI:1.002 to 1.081, P=0.013), tumor location (sigmoid colon vs. descending colon: OR=9.307, 95%CI:2.236 to 38.740, P=0.002), pathological type (mucinous adenocarcinoma vs. adenocarcinoma: OR=79.923, 95%CI:15.113 to 422.654, P<0.01; signet ring cell carcinoma vs. adenocarcinoma: OR=27.309, 95%CI:4.191 to 177.944, P<0.01), and positive vascular invasion (OR=3.490, 95%CI:1.033 to 11.793, P=0.044) were independent influencing factors of No. 253 lymph node metastasis. (2) The area under the curve of the nomogram prediction model was 0.912 (95%CI: 0.869 to 0.955) for the training set and 0.921 (95%CI: 0.903 to 0.937) for the external validation set. The calibration curve demonstrated good consistency between the predicted outcomes and the actual observations. (3) After propensity score matching, the No. 253 lymph node-negative group did not reach the median overall survival time, while the positive group had a median overall survival of 20 months. The 1-, 3- and 5-year overall survival rates were 83.9%, 61.3% and 51.6% in the negative group, and 63.2%, 36.8% and 15.8% in the positive group, respectively. Multivariate Cox analysis revealed that the T4 stage (HR=3.067, 95%CI: 2.357 to 3.990, P<0.01), the N2 stage (HR=1.221, 95%CI: 0.979 to 1.523, P=0.043), and No. 253 lymph node positivity (HR=2.902, 95%CI:1.987 to 4.237, P<0.01) were independent adverse prognostic factors. Conclusions: Tumor diameter ≥5 cm, T4 stage, N2 stage, tumor location in the sigmoid colon, adverse pathological type, poor differentiation, and vascular invasion are influencing factors of No. 253 lymph node metastasis. No. 253 lymph node positivity indicates a poorer prognosis. Therefore, strict dissection for No. 253 lymph node should be performed for colorectal cancer patients with these high-risk factors.

Civil War between the Ethiopian Government and the Tigray People's Liberation Front: A Challenge to Implement the Responsibility to Protect Doctrine

Civil War between the Ethiopian Government and the Tigray People's Liberation Front: A Challenge to Implement the Responsibility to Protect Doctrine

Exploration of the clinical application of combined endoscopic and laparoscopic surgery in early gastric cancer: 15 cases

Objective: To investigate the application of combined gastroscopy and laparoscopy (dual scope) in the treatment of early gastric cancer. Methods: In this descriptive case series study, we retrospectively collected data on 15 patients with cT1b stage gastric cancer who had undergone combined laparoscopic and endoscopic surgery in the 900th Hospital of the People's Liberation Army of China from May 2020 to October 2022. The study cohort comprised nine men and six women of median age 59 (range: 47-76) years and median body mass index 20.9 (range: 18.3-26.2) kg/m2. Seven of the lesions were located on the lesser curvature of the gastric antrum and eight in the gastric angle. All lesions were biopsied for pathological examination and evaluated by endoscopic ultrasonography, followed by endoscopic submucosal dissection (ESD) and laparoscopic regional lymph node dissection. Studied variables included surgical and pathological features, postoperative factors, and outcomes. Results: In this group of patients, the median (range) operative time for ESD was 45 (30-82) minutes, the duration of laparoscopic lymph node dissection (45.1±8.6) minutes, and the median (range) intraoperative blood loss during lymph node dissection 30 (10-80) mL. Of the 13 patients with negative postoperative horizontal margins, four were stage SM1 and had no lymph node metastases (Stage SM1) and nine were Stage SM2, of which had one positive regional lymph node and two received additional standard distal gastrectomy with D2 lymphadenectomy concurrently because of positive ESD specimens (lymph node negative). No lymph node metastases were found in the surgical specimens of these patients. The remaining two patients had positive vertical margins; both had undergone concurrent standard distal gastrectomy with D2 lymphadenectomy. One of them was found to be lymph node positive (No. 3, one node). Four patients had impaired gastric emptying after dual-scope treatment, all of whom recovered well with symptomatic management; one patient with a suspected lymphatic leak was also managed conservatively. There were no cases of postoperative bleeding, abdominal infection, or incisional infection. At a median follow-up of 14 (6-26) months, no tumor recurrence or metastasis had been identified in any of the patients. Three patients had a grade B nutrition score 3 to 6 months after surgery, all of whom had undergone major gastrectomy, and two patients who had undergone dual-scope surgery reported an increase in acid reflux and belching after surgery compared with the preoperative period. Conclusion: A combined technique is safe and feasible for the treatment of early gastric cancer and is worthy of further exploration.

Sentence Versus Redemption and the ‘Spiritual World’ in Osiris Rising, Fragments, Why Are We So Blest? KMT: In the House of Life by Ayi Kwei Armah and Mama Day by Gloria Naylor

This paper attempts to evaluate the different characteristics in the spiritual world that act on human destiny in blacks ‘cosmology in Ayi Kwei Armah and Gloria Naylor’s fiction while justifying the awareness of black intellectuals in their different approaches to sentence and redemption for African cultural revival. It also exposes black people facing acculturation phenomena and the deconstruction of the ancestral home. However, it argues that the achievement of the struggle for African cultural revival will be possible if they take the initiative in finding out specific strategies that would culturally, socially and politically reconnect black with their indigenous cultural reality. Some of these stratagems include good cultural references, rootedness, unity, teaming work, and rationality. To examine blacks’ spirituality in its double vocation of sentence and redemption, this study uses theories of anti-colonialists and Afro-centrists that advocate total liberation and empowerment of black people while assessing the issues of the disgrace of both African and African-American people. Similarly, the insights and commitment of thinkers like Afro-centrists are well considered as additional elements in this work. Ultimately, the novels contend that in African spirituality there is a divine will owed to the ancestors that have the mission of watching over their people and judging them in several ways when they are satisfied through rituals or recognition. As the authors of the three books suggest, the appreciation of ancestral legacy and cultural advancement is an effective means of ensuring blacks ‘social welfare in their communities and elsewhere.

Long-term efficacy of deep brain stimulation of the subthalamic nucleus in patients with pharmacologically intractable epilepsy: a case series of six patients.

Epilepsy is one of the widespread neurological illnesses, and about 20-40% of epilepsy patients are pharmacoresistant. We aimed to assess the long-term efficacy of subthalamic nucleus (STN) deep brain stimulation (DBS) for drug-resistant epilepsy. We included pharmacologically intractable epilepsy patients who had STN-DBS at the Chinese People's Liberation Army General Hospital between June 2016 and December 2018. We retrospectively evaluated pre- and postoperative clinical outcomes, including seizure frequency, seizure type, anti-seizure medication, cognitive function, anatomical target coordinates, stimulation parameters, and adverse events following the surgical procedure. Six patients with a mean follow-up of 49.3 ± 10.2 months, were included. Seizure frequency decreased by an average of 64.0% after STN-DBS at last year follow-up (p = 0.046), and one patient (1/6) achieved seizure-free status. For seizure type, anti-seizure medication, and cognitive function, there were no significant differences between pre-and post-operation (p > 0.05). In terms of stimulation parameters, the pulse width, amplitude, and frequency were 58.3 ± 9.4 μsec, 2.5 ± 0.7 V, and 122.5 ± 15.7 Hz, respectively. None of the patients showed normal electroencephalography during the electroencephalography reexamination. There were no surgery-related complications, and chronic STN stimulation was generally well tolerated in five patients. However, one patient (1/6) had a difficulty of dyskinesia in the right arm. In conclusion, neuromodulation of the STN by DBS is a promising option for patients with pharmacologically intractable epilepsy, especially for whose epileptic zone originates mainly from the frontoparietal region and who are unsuitable for resective surgery. Further prospective multicenter studies with a larger sample size are necessary for further exploration.

Efficacy analysis of anti-thymocyte globulin regimens with different timing strategies for matched sibling donor hematopoietic stem cell transplantation

Objective: To compare the effects of two administration time strategies for rabbit antihuman thymocyte immunoglobulin (rATG) of 5mg/kg total dose in matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) . Methods: This study retrospectively analyzed the clinical data of 32 patients who received MSD-HSCT with 5 mg/kg rATG conditioning regimen at the Department of Hematology of the First Medical Center of the People's Liberation Army General Hospital from October 2020 to April 2022. The patients were classified into two groups: the 4d-rATG group (16 cases), who received antithymocyte globulin (ATG) from day -5 to day -2, and the 2d-rATG group (16 cases), who received ATG from day -5 to day -4. Between the two groups, the transplantation outcomes, serum concentrations of active antithymocyte globulin (ATG) in patients from -4 days to 28 days after graft infusion (+28 days), and the reconstitution of lymphocyte subsets on days +30, +60, and +90 were compared. Results: The cumulative incidences of acute graft-versus-host disease at 100 days after graft infusion were 25.0% (95% CI 7.8% -47.2% ) and 18.8% (95% CI 4.6% -40.2% ) (P=0.605) in the 4d-rATG group and 2d-rATG group, respectively. The 1-year cumulative incidences of chronic graft-versus-host disease were 25.9% (95% CI 8.0% -48.6% ) and 21.8% (95% CI 5.2% -45.7% ) (P=0.896). The 1-year cumulative incidence of relapse was 37.5% (95% CI 18.9% -65.1% ) and 14.6% (95% CI 3.6% -46.0% ) (P=0.135), and the 1-year probabilities of overall survival were 75.0% (95% CI 46.3% -89.8% ) and 100% (P=0.062). The total area under the curve (AUC) of serum active ATG was 36.11 UE/ml·d and 35.89 UE/ml·d in the 4d-rATG and 2d-rATG groups, respectively (P=0.984). The AUC was higher in the 4d-rATG group than that in the 2d-rATG group (20.76 UE/ml·d vs 15.95 UE/ml·d, P=0.047). Three months after graft infusion, the average absolute count of CD8(+) T lymphocytes in the 4d-rATG group was lower than that in the 2d-rATG group (623 cells/μl vs 852 cells/μl, P=0.037) . Conclusion: The efficiencies of GVHD prophylaxis in MSD-PBSCT receiving 4d-ATG regimen and the 2d-rATG regimen were found to be similar. The reconstruction of CD8(+)T lymphocytes in the 2d-rATG group was better than that in the 4d-rATG group, which is related to the lower AUC of active ATG after transplantation.

Efficacy of non-surgical comprehensive treatment for locally advanced hypopharyngeal carcinoma with cervical esophagus invasion

Objective: To analyze the treatment effects and side effects of non-surgical comprehensive treatment for locally advanced hypopharyngeal carcinoma invading cervical esophagus. Methods: A retrospective analysis was performed on sixty-six patients with locally advanced hypopharyngeal carcinoma invade the esophagus. These patients were treated in the Department of Otolaryngology, Head and Neck Surgery of Chinese People's Liberation Army General Hospital between January 2011 and May 2022, including sixty-five males and one female, aged 43-71 years. Treatment regimen consisted of induction chemotherapy and concurrent chemoradiothrapy and epidermal growth factor receptor (EGFR)-targeted therapy, three of these cases were treated with programmed cell death 1 (PD-1) immunotherapy. The Kaplan-Meier method was used for survival analysis. Side effects were evaluated with the established CTCAE (Common Terminology Criteria for Adverse Events) 5.0 criteria. The factors affecting prognosis were analyzed by Cox multivariate regression analysis. Results: Sixty-four (97.0%, 64/66) patients completed the radiotherapy and chemotherapy plan. The most common grade three side effects were radioactive oropharyngeal mucositis (89.1%, 57/64) and leukopenia (23.4%, 15/64). Five (7.8%, 5/64) patients showed grade three hoarseness; two patients (3.1%, 2/64) suffered from grade three swallowing dysfunction and required feeding tube and intravenous nutrition; the remaining patients(89.1%) retained good vocal and swallowing functions. The overall survival (OS) of all patients was 81.5% after one year, 54.0% after three years, and 39.9% after five years; the progression-free survival (PFS) was 78.3% after one year, 54.9% after three years, and 42.6% after five years; local control rate (LCR) was 80.9% after one year, 62.5% after three years, and 52.0% after five years. T4a patients showed better OS, PFS and LCR than T4b patients, with statistically significant differences (χ2=8.10, 8.27, and 6.64, respectively, all P<0.05). Cox multivariate regression analysis showed that lymph node metastasis was an independent factor affecting prognosis (χ2=10.21, P<0.05). Conclusion: Non-surgical comprehensive treatment can provide with another option of radical treatment for locally advanced hypopharyngeal carcinoma with cervical esophagus invasion, offering the patients higher rate of larynx and esophageal preservation with tolerable side effects.

Land Conflict Resolution Efforts Of The Laman Kinipan Indigenous Community In Lamandau Regency By Alliansi Indigenous Peoples Of The Archipelago (Aman) To Support National Security

Issues regarding security have always been a trending topic to be discussed, especially topics concerning matters that may cause conflicts of interest. Security studies that discuss security elements continue to be developed by various stakeholders. Security within the Archipelago To achieve comprehensive national security, these elements of national security must be implemented in policy formulation. Land conflict is a threat to two elements of national security, namely human security and environmental security. The escalation of the potential threat of conflict shows a very significant increase, so it is necessary to look for a solution so that it does not develop into a vertical or horizontal conflict. This problem affects the security of human citizens and the threat of environmental damage due to destruction of forest areas due to deforestation is a form of threat to these elements of national security. This study aims to unravel the land conflict resolution efforts of the Laman Kinipan Indigenous Community in Lamandau District by the Alliance of Indigenous Peoples of the Archipelago. Qualitative research methods use a case study approach. Data collection techniques were in the form of interviews with the Indigenous Peoples Alliance of the Archipelago of Central Kalimantan, the Central Kalimantan Indonesian Forum for the Environment, and the Indigenous Territory Registration Agency as well as data collection through literature study techniques. The research shows that steps of AMAN and the Coalition of Justice for the Kinipan fighting for the liberation of indigenous peoples from various forms threats to human security, such as demanding the release of Effendi Buhing and the indigenous youth of Kinipan, and various other actions is an effort to guarantee human rights for the community Kinpan custom. This also makes indigenous peoples free from fear threat to human security.Until now, the expected form of output is recognition as a customary law community legitimized by the Regional Government Lamandau Regency, there is a decree from the Ministry of Environment Life and Forestry, and the realization of national security by the Community The adat of Laman Kinipan still cannot be felt by indigenous peoples. The output that has not been felt by the beneficiaries is Indigenous Communities The Kinipan page shows the implementation of this national security has not materialized. The conclusion is with the efforts of the Alliance of Indigenous Peoples of the Archipelago in resolution of the Laman Kinipan Land conflict with the stages of community organizing, visioning, planning, and implementation and evaluation to realize national security by being linked through elements of environmental security and human security.

The effect of sex differences on neointimal characteristics of in-stent restenosis in drug-eluting stents: An optical coherence tomography study

BackgroundPrevious studies have demonstrated that there are sex-related differences in atherosclerosis. However, in terms of the nature of in-stent restenosis (ISR) neointima, the effect of gender on the results is unclear. MethodsPatients with ISR of drug-eluting stents (DES) who underwent OCT examination in Senior Department of Cardiology of the Chinese People's Liberation Army General Hospital from March 2010 to March 2022 were included. The patients were divided into male and female groups. ResultsIn this study, a total of 230 DES-ISR patients and 249 DES-ISR target lesions were analyzed. OCT data showed that compared to females, males have a higher incidence of thin-cap fibrous atherosclerosis (TCFA) (37.4% [n = 77] vs. 9.3% [n = 4], p < 0.001) and in-stent neoatherosclerosis (ISNA) (82.0% [n = 169] vs. 62.8% [n = 27]). p = 0.005). In addition, a multivariate logistic regression analysis demonstrated that male was independently associated with a higher incidence of ISNA (OR: 2.659, 95% CI: 1.239–5.707; p = 0.012) and TCFA (OR: 4.216, 95% CI: 1.370–12.976; p = 0.012). ConclusionFor DES-ISR patients, the incidence of ISNA in female was significantly lower than that in male and vulnerability of neointimal pattern is lower in female than in male.