<i>Introduction</i>: At the end of 2019, an acute infectious disease appeared, which first started in Wuhan, China. The risk of increased contagion and anxiety caused by it decreased the quality of life among adolescents. The purpose of this study is to investigate the effect of social support on the mental health of adolescents in the era of COVID-19. <i>Methodology</i>: This review was conducted by searching websites such as Scholar, SID, Magiran from 2019 to 2023. <i>Results</i>: Corona virus is a public health emergency and pneumonia caused by corona is a highly contagious and infectious disease. The most common initial manifestations are fever, cough, fatigue and myalgia. The WHO has announced that due to the prevalence of this disease among teenagers, the increase in deaths and quarantine of people can cause anxiety, which can be reduced with social support. According to the definition of social support, it means feeling of belonging, acceptance, love and affection. And it creates a safe relationship for every teenager. <i>Conclusion</i>: The evidence has shown that social support is one of the components that can directly and indirectly improve the mental health of adolescents, and reduce the negative effects caused by virus anxiety.