Waste to wealth is today’s need, as waste generation has become humongous challenge for mankind now. In the present study kitchen waste from the Institute, hostel mess is used as raw material for ethanol, biogas, and manure production in a bio-refinery system. In the first step of the biorefinery the kitchen waste, which contains approximately 35% carbohydrates, was pretreated with 0.5 % H2SO4 to release sugars required for fermentation and 3.6 mg/ml of reducing sugars, and 0.46 mg/ml of pentose sugar. Enzymatic hydrolysis of the un-hydrolyzed biomass remnant after acid pretreatment at 30 °C with crude amylase (enzyme activity: 45.36 U/min/ml) obtained from Aspergillus niger followed by hydrolysis at 55 °C with crude cellulase (enzyme activity: 36.25 U/min/ml) and xylanase activity (activity: 11.25 U/min/ml) obtained from Trichoderma reesei produced 1.64 mg/ml and 1.66 mg/ml hexose and pentose sugar, respectively. Fermentation of the hydrolysate with S. cerevisiae and Pistia stipitis produced a 2.43% (v/v) ethanol yield. Anaerobic digestion of the unutilized solid biomass produced 270 ml/Kg biogas and 63.35 gm/Kg dry soil nutrient enhancer. The study suggested that the kitchen waste-based economically viable bio-refinery setup can be developed for the eco-friendly management and production of various valuable products from kitchen waste.