This study is based on the biblical basis of Pentecostal missions, the direct connection between the baptism of the Holy Spirit and the life of being a witness of Christ based on Acts 1:8, and the anointing of the Holy Spirit and the Messianic proclamation of Christ based on Luke 4:18-19. Specifically, this paper discusses the missionary call to the poor, the oppressed, and the captives. Furthermore, it examines the historical and chronological change of the Pentecostal missions. In the early periods, the proclamation of the gospel accompanied by wonders and miracles was the main focus, but it gradually developed into a holistic mission that responded to social situations and included active actions for the marginalized and weak people. In this process, we discuss how the challenge facing Pentecostal missions lies in how the holistic Pentecostal ministry preserves the unique elements of this movement based on pneumatology.