Pentaerythritol Trinitrate Research Articles

アクリル酸トリニトロペンタエリトリットとスチレンおよびメタクリル酸メチルとの共重合

アクリル酸トリニトロペンタエリトリットとスチレンおよびメタクリル酸メチルとの共重合

Pentaerythritol trinitrate metabolism by the rat

Rats were studied after being given a single dose of 14C-pentaerythritol trinitrate by gavage. The labeled components of the blood, urine and gastrointestinal tract were identified by thin-layer chromatography and assayed quantitatively by radioscanning. Pentaerythritol trinitrate was found to be absorbed and excreted rapidly by the rat. The drug metabolites were pentaerythritol, pentaerythritol mononitrate and pentaerythritol dinitrate. Comparisons of the data with the results of similar studies with pentaerythritol tetranitrate (PETN) and nitroglycerin showed that pentaerythritol trinitrate was absorbed much faster than PETN and almost as quickly as nitroglycerin, and that the urinary excretion of pentaerythritol trinitrate proceeded at the highest rate. Additionally, pentaerythritol trinitrate was the only one of the three drugs which passed intact into the urine.

Effect of acute coronary occlusion on myocardial nutritional circulation in swine.

ARTICLESEffect of acute coronary occlusion on myocardial nutritional circulation in swineBB Howe, and MM WinburyBB Howe, and MM WinburyPublished Online:01 May 1969https://doi.org/10.1152/ajplegacy.1969.216.5.1069This article has been correctedMoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Related ArticlesEffect of acute coronary occlusion on myocardial nutritional circulation in swine 01 Dec 1969American Journal of Physiology-Legacy ContentCited ByIn vivo relation of intramyocardial blood volume to myocardial perfusion. Evidence supporting microvascular site for autoregulation.Circulation, Vol. 85, No. 2Effects of acute coronary occlusion on hemodynamics in an adjacent coronary artery in dogsThe American Journal of Cardiology, Vol. 54, No. 8Regional coronary venous flow responses to transient coronary artery occlusion in human beingsJournal of the American College of Cardiology, Vol. 2, No. 1Coronary hemodynamics during percutaneous transluminal coronary angioplastyThe American Journal of Cardiology, Vol. 49, No. 7BLOOD FLOW AND RELATIVE TISSUE OXYGENATION OF NORMAL AND PARTIALLY ISCHAEMIC MYOCARDIUM: EFFECT OF CO 2Clinical and Experimental Pharmacology and Physiology, Vol. 5, No. 6Prolonged epicardial mapping of myocardial infarction: The effects of propranolol and intra-aortic balloon pumping following coronary artery occlusionThe Journal of Thoracic and Cardiovascular Surgery, Vol. 72, No. 6Distribution of myocardial blood flow in the exercising dog with restricted coronary artery inflow.Circulation Research, Vol. 38, No. 2Intracoronary nitroglycerin, pentaerythritol trinitrate and dipyridamole on intramyocardial oxygen tensionMicrovascular Research, Vol. 4, No. 3 More from this issue > Volume 216Issue 5May 1969Pages 1069-1074 Copyright & PermissionsCopyright © 1969 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1969.216.5.1069PubMed5768054History Published online 1 May 1969 Published in print 1 May 1969 Metrics

Quantitative Recovery of Radioactivity from 14C-Pentaerythritol Tetranitrate Administered to Rats

A single dose of 14-C-labeled pentaerythritol tetranitrate(PETN) was administered orally to fasted rats, and the level of radioactivity was determined 24 hr. later in the blood, liver, gastrointestinal tract(GIT), urine, and carcass. One group of treated rats was housed to permit collection of expired CO2 which was also assayed for 14C. It was possible to account for all of radioactivity administered. More than 40 per cent of the drug was absorbed, and about 25 per cent of the 14C was excreted into the urine. The blood, GIT, and urine, were also assayed quantitatively for PETN and its metabolites. The blood contained pentaerythritol and its mono- and dinitrates. Urine contained these metabolites and also a trace of pentaerythritol trinitrate. The GIT contained PETN and pentaerythritol. A single dose of 14-C-labeled pentaerythritol tetranitrate(PETN) was administered orally to fasted rats, and the level of radioactivity was determined 24 hr. later in the blood, liver, gastrointestinal tract(GIT), urine, and carcass. One group of treated rats was housed to permit collection of expired CO2 which was also assayed for 14C. It was possible to account for all of radioactivity administered. More than 40 per cent of the drug was absorbed, and about 25 per cent of the 14C was excreted into the urine. The blood, GIT, and urine, were also assayed quantitatively for PETN and its metabolites. The blood contained pentaerythritol and its mono- and dinitrates. Urine contained these metabolites and also a trace of pentaerythritol trinitrate. The GIT contained PETN and pentaerythritol.

Polarographic Determination of Pentaerythritol Trinitrate in Presence of Nitroglycerin

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarographic Determination of Pentaerythritol Trinitrate in Presence of NitroglycerinW. M. Ayres and G. W. LeonardCite this: Anal. Chem. 1959, 31, 9, 1485–1487Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://doi.org/10.1021/ac60153a021RIGHTS & PERMISSIONSArticle Views24Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (402 KB) Get e-Alerts Get e-Alerts

Energy requirements for the ignition of seven solid explosives

The minimum energy, delivered in a 3 ms interval, just sufficient to ignite 1 cm 2 of explosive has been investigated for the cases of trinitrotoluene, tetryl, cyclo-trimethylene trinitramine (RDX), pentaerythritol trinitrate (PETN), blasting gelatin, lead azide, and lead styphnate. Absolute values, which may be somewhat in error due to extensive corrections necessary in interpreting experimental data, range from greater than 0·4 cal/cm 2 for TNT to less than 0·1 cal/cm 2 for lead styphnate. Relative values are considered more reliable since errors in data analysis tend to cancel. A device is described for generating hot gas by adiabatic compression, together with experimental and analytical techniques for determination of ignition energies.