Have Sex Research Articles

Efficacy of sexual stimulation in the treatment of distal ureteral stones: A meta-analysis

IntroductionThis study aimed to compare the clinical efficacy of sexual stimulation with that of placebo in the treatment of distal ureteral stones. MethodsWe searched PubMed, Web of Science, Cochrane Library, and Google Scholar from January 1, 2000 to December 31, 2022 for studies comparing the efficacy of sexual stimulus with that of placebo for the treatment of distal ureteral stones. RevMan 5.3 software was used to pool the data. The study protocol was registered on PROSPERO (Registration Number: CRD42023432408). ResultsA total of six randomized controlled trials comprising 535 cases of distal ureteral stones were included in this study. Among these, 273 cases were associated with sexual intercourse or masturbation 3–4 times a week, while 262 cases only received symptomatic treatment. The pooled results showed that the 2-week [risk ratios (RR) = 1.77, 95 % confidence interval (CI): 1.34, 2.33] and 4-week [RR = 1.48, 95 % CI: 1.29, 1.69] ureteral stone expulsion rates of the sexually stimulated group were significantly higher than those of the placebo group (ps < 0.01). Additionally, sexual stimulation was associated with a shorter ureteral stone expulsion time [weighted mean differences (WMD) = −3.74, 95 % CI: −6.27, −1.22, p < 0.01] and a decreased prevalence of renal colic attacks [WMD = −0.61, 95 % CI: −1.01, −0.22, p < 0.01] compared with those of the placebo group. ConclusionAppropriate sexual stimulation can enhance the spontaneous expulsion of distal ureteral stones in patients presenting with tolerable pain.

ANALISIS PUTUSAN NOMOR 9/PID.SUS-ANAK/2023/PN.JKT.BRT TENTANG DAKWAAN PIDANA PERSETUBUHAN OLEH ANAK TERHADAP ANAK

Sexual intercourse with children is an act that occurs quite often in Indonesia today. This incident continues to increase over time, so it needs special attention from a legal perspective in Indonesia. The problem formulation of charges existence against the crime of sexual intercourse with children must be handled carefully and thoroughly by implementing applicable laws in order to get a fair decision. So the purpose of this study is to analyze the decision number 9 / pid.sus-anak / 2023 / pn, jkt.brt concerning the criminal charge of sexual intercourse by children against children. This analysis was carried out using the normative legal method with an analytical descriptive approach. The results and conclusions obtained in the decision Number 9 / Pid.SusAnak / 2023 / PN.Jkt.Brt, the Public Prosecutor filed an alternative charge against Children in Conflict with the Law using Article 81 paragraph (2) as the First Charge and Article 82 paragraph (1) Jo. Article 76E as the Second Charge. The appropriate article to be charged with ABH is Article 81 paragraph (1) which clearly describes the rule that everyone is prohibited from committing violence or threats of violence and forcing a child to have sexual intercourse with another person.

TESTIMONIUM DE AUDITU SEBAGAI DASAR PERTIMBANGAN HAKIM DALAM MEMUTUS TINDAK PIDANA PENCABULAN DAN PERSETUBUHAN ANAK

Decision No. 254/Pid.Sus/2023/Pn.Mks, which examined and adjudicated a case of sexual assault and intercourse, was based solely on Testimonium de auditu. The issue is to what extent the available evidence supports Decision No. 254/Pid.Sus/2023/PN.Mks in declaring the defendant not proven legally and convincingly guilty according to the applicable legal standards. The research method used involves secondary data and is structured using normative descriptive research techniques. The discussion and conclusion are that Asdar Muhammad should be charged with sexual assault and intercourse based on written evidence, witness statements, and testimony from a minor victim, according to the analysis conducted (Case No. 254/Pid.Sus/2023/PN.Mks). The importance of witness testimony compared to what is seen, heard, or experienced determines the severity of a case, based on Constitutional Court Decision No. 65/PUU-VIII/2010. However, Asdar Muhammad should have been found guilty of committing sexual assault or intercourse, rather than being declared not guilty, as stated in Constitutional Court Decision No. 65/PUU-VII/2010.

Erectile Function and Sexual Activity Are Declining in the Younger Generation: Results from a National Survey in Japan.

Twenty five years have passed since the first national survey on erectile dysfunction (ED) in Japan. The Japanese Society for Sexual Medicine conducted a nationwide survey on the actual status of sexual function targeting men over 20 years old in Japan using validated questionnaires commonly used in clinical practice. Japanese men aged 20 to 79 years participated in our online epidemiological study on sexual dysfunction. Erectile status was assessed by direct questioning and specific questionnaires. Risk factors and frequencies of sexual intercourse, masturbation, nocturnal erections, and feeling sexual desire were assessed. The prevalence of these risk factors was compared between men with and without ED. Prevalence and frequencies were calculated for each 5-year age group. Main outcomes were the prevalence and number of patients with ED and simultaneous evaluation of age-related variations. Direct questioning of the men revealed that 13.0% felt troubled by ED. Although 81.0% of them had at least some ED symptoms based on a Sexual Health Inventory For Men score of ≤21, the prevalence of men with ED by Erection Hardness Score (EHS), the most appropriate questionnaire for Japanese with low sexual activity, was 30.9%, indicating that 14,012,596 men have ED. Most risk factors were related with ED, whereas frequencies of sexual intercourse, masturbation, nocturnal erections, and feeling sexual desire were affected by aging. However, the low frequency of these factors in the young generation was surprising. The EHS-based assessment revealed a prevalence of ED of 30.9%, which affected approximately 14 million men, and that the sexual desire, erection stiffness, orgasms, and satisfaction were lower than expected in young Japanese men, especially those aged 20 to 24 years, although those factors tended to worsen with aging. We believe that these findings actually reveal the current sexual status of men in Japan.

ТАКТИКА ВЕДЕНИЯ ПАЦИЕНТОК С ЭНДОМЕТРИОИДНЫМИ КИСТАМИ И БЕСПЛОДИЕМ. КЛИНИЧЕСКИЙ СЛУЧАЙ

Endometriosis is a widespread gynecological disease. There is evidence about the role of heredity in the development of endometriosis, this disease is more common in women whose relatives also suffered from endometriosis. Endometriosis occurs in 5-6% of women in the general population and in more than 50% of women suffering from infertility. Endometrioid ovarian lesion is one of the most common forms of genital endometriosis. The main symptoms of which are chronic pelvic pain, infertility and miscarriage, which leads to a significant decrease in the quality of life and ability to work, and a violation of the psychological status. Painful sensations caused by endometriosis during sexual contact can lead to interruption or avoidance of sexual intercourse and negatively affect the sexual health of endometriosis patients and their partners. Many researchers believe that the treatment of patients with endometriosis should be strictly individual and determined by the following factors: the age of the patient, the localization and prevalence of the pathological process, the severity of the clinical picture of the disease, the duration of the disease, the attitude to pregnancy. Timely diagnosis and treatment make it possible to achieve clinical recovery and prevent infertility. This article discusses current recommendations for the management of women with endometrioid ovarian cysts aimed at improving reproductive performance.

Sexual initiation age and related risk-taking behaviours among adolescents in urban secondary schools in Nairobi County

Risky sexual behaviour such as early sexual initiation, inconsistent condom use and sexual intercourse with multiple partners are relatively prevalent among youths in sub-Saharan Africa. Sexual intercourse is an important event in one’s life trajectory and the contributory factors are: proximate and distal environments. The proximate environment includes micro systemic influences such as one's attitudes and beliefs, and extends to one's family. The distal environment includes one's community and culture. However, there are core forces which influence personal choices and behaviours like the self, family and community, and networks and cultural influences. While there are a variety of factors that contribute to early sexual initiation, proper parenting behaviour has been identified as a key strategy for reducing adolescents’ risky sexual behaviours. Even though early sexual initiation process is subject to a number of barriers, there is still less focus on parenting behaviour and its relationship with early sexual initiation among adolescents. Therefore, this study applied social survey to assess sexual initiation age and its related risk-taking behaviors among the adolescents in urban secondary schools in Nairobi County. The study found the common period in which adolescents initiate sex and even befriend strangers as age (15-16years). The findings have shown that children are capable of initiating drug use at any given period. This suggests the need for parent to undertake close monitoring of their children at all ages to curb drug abuse and encourage health talk with them on the effects of drug use.

Sense of smell reduction as factor for mammoth’s and other mammals extinction. Immunoglobulins as possible markers

One of the possible mechanisms for the extinction of animals during climate change could be a violation of the sense of smell due to the development of allergies when the flora changes. During the breeding season, susceptibility to odors is very important for animals. The development of allergies from plant pollen, changes in pollen's allergic toxicity, pollen's release period increasing or the emergence of a large quantity of flowering plants during climate change, could lead to decrements in sensitivity to odors in animals during the breeding season. This may explain the extinction of animals due to a decrease in sexual intercourse. Probably these changes in allergic responses of mammoths at period of climate changes led to a decrease in the mammoth population and, as a result, to their disappearance. For example, elephants have the most sensitive sense of smell. Immunoglobulin’s traces can provide information about the health of extinct animals. The search and characterization of immunoglobulins from extinct animals and comparison with the plant composition (pollen, plant remains) found with the animals can provide information about possible allergic diseases of these animals.The purpose of our article is to show that immunoglubulin’s fragments found in the remains of mammoths indicate the presence of possible allergic diseases in mammoths. Also, the purpose of this work is to propose a new evolutionary mechanism for the extinction of mammoths and other animals based on the disruption of communications between animals during the breeding season due to a decrease in the sense of smell and sensitivity to odors due to allergies to plants.

Criminal Law Enforcement Against Perpetrators of Sexual Intercourse with Biological Children

Criminal law enforcement is important in dealing with cases of incestuous sexual relations involving children, aiming to uphold justice and protect victims from harm. The main objective of this study is to examine the effectiveness of law enforcement in the jurisdiction of Tabanan Police in handling cases. Using empirical research methods, this study analyzes legal principles such as the rule of law, legislation theory, legal protection, legal responsibility, and legal effectiveness. This research focuses on a specific case documented in Police Report No. LP-B/35/VII/2020/B: LP-B/35/VII/2020/Bali/Res Tbn, in which the perpetrator, MSP, was charged with violating Article 81(3) of the Child Protection Law, in conjunction with Article 64(1) of the Criminal Code, or alternative provisions under the law. The results showed that there are significant challenges hindering effective law enforcement, particularly the lack of qualified law enforcement officers compared to the number of cases, which hinders optimal case handling in the jurisdiction of Tabanan District Police. This research argues that effective law enforcement is essential not only to sanction perpetrators but also to ensure justice and protect child victims from violence and crime. The implications of this study underscore the need for increased competence among law enforcement officials to effectively handle such sensitive cases. By bridging the gap between legal provisions and law enforcement, this research advocates for systemic improvements to strengthen the law enforcement framework in combating the crime of incest against children.

Higher Learning Female Scholars’ Knowledge and Usage of Emergency Contraceptive Pills in Dodoma Tanzania

Background An emergency contraceptive pill (ECP) is one of the contraceptive methods that provide the last chance of preventing unplanned and unintended pregnancy once there is unsafe sexual intercourse. Higher learning scholars are at danger of getting an unwanted and unplanned pregnancy which poses a major public health concern and needs to be addressed. Therefore study examines higher-learning female scholars’ the level of knowledge and usage of Emergency Contraceptive pills in Dodoma Tanzania.  Methodology A Quantitative descriptive cross-sectional study and a multi-stage sampling technique were used to obtain 909 higher learning female scholars’ aged between 18 to 35 years old residing at Dodoma University, St. John, and College of Business Education in Dodoma, Tanzania. Data was collected using a self-administered questionnaire and analyzed using SPSS version 20  Results The Respondent rate was 99.7%. Among 906 respondents only 30.6% knew emergency contraceptive pills (ECP), 27.7% had never heard about emergency contraceptive pills and 19.5% had ever used ECPs. Among those with knowledge, 33.7% reported using emergency contraceptive pills while for those with no previous knowledge, 21.8% had used ECP. At CI of 95% and p&lt;0.05, the use of ECPs had statistical significance with age, level of education, marital status, ever heard of ECPs, level of knowledge, and sexual relationship.  Conclusion The results of the analysis of this study show that the level of knowledge and usage of emergency contraceptive pills among higher-learning female scholars’ in Dodoma Tanzania was low. At CI of 95, the use of ECPs had a statistical relationship with age, level of education, marital status, ever heard of ECPs, level of knowledge, and sexual relationship.

Impact of pre-conception diet on female infertility

Introduction and purpose Infertility is defined as a condition characterized by the inability to become clinically pregnant after 12 months of regular, unprotected sexual intercourse, or because a person's ability to reproduce, either as an individual or with his or her partner, is impaired. Infertility affects between 8% and 12% of couples of reproductive age worldwide. Fertility decline in women begins as early as age 25-30. The purpose of this article is to present the problem of infertility in women, possible diagnostic options, methods of prevention and treatment of infertility. We draw attention to the important role of a proper lifestyle, including diet in the fight against infertility. State of knowledge The article reviews the literature on infertility with special attention to the problem of infertility in women. Knowing the causes of infertility, it is possible to implement targeted diagnosis and then treatment. Attention is paid to the influence of proper diet on female fertility. Material and method A review of the literature available on PubMed and Google Schoolar was conducted. We focused on presenting different causes of infertility in women, diagnostic options, treatment methods depending on the cause of the problem. We paid special attention to proper diet and its impact on female fertility. Summary In our review, we presented how big a problem female infertility is. We managed to describe the current state of knowledge on the definition, epidemiology of fertility and infertility, and the main causes of female infertility. Based on a number of studies, we have proven the beneficial effects of a proper lifestyle with emphasis on a proper diet.

Assessment of targeted intervention programme under the National AIDS Control Program among men who have sex with men in India.

The population of men who have sex with men (MSM) in India is vulnerable to HIV/AIDS. India instituted a targeted intervention (TI) programme to reduce this vulnerability. We aimed to measure the assessment of the TI programme for MSM. The national Integrated Biological and Behavioural Survey (IBBS) was carried out in 2014-2015. We analysed MSM data from the IBBS and used bivariate and multivariate logistic regression to calculate the unadjusted and adjusted odds ratios with 95% confidence intervals. The use of a condom during their last sexual intercourse and consistent condom use during the previous month were considered indicators of programme effectiveness. The propensity score matching method was used to assess the effectiveness of the TI programme. The matched-samples estimate (i.e., average treatment effect on treated) for the use of condoms during their last sexual intercourse increased by 10.0% (0.10; 95% confidence interval [CI] 0.08-0.12), and consistent condom use during the previous month increased by 9.0% (0.09; 95% CI 0.07-0.10) among those who had received condoms from the peer educator/outreach worker compared with those who had not received condoms. The TI programme intervention among MSM was effective in reducing HIV risk behaviours, as evidenced by an increase in the use of condoms during their last sexual intercourse and consistent condom use during the last month.

Sexual behaviors and HIV-related knowledge among GBMSM: evidence from 2011 to 2021 in Hangzhou, China.

Considering that many new HIV infections are transmitted by homosexual behaviors, gay, bisexual, and other men who have sex with men (GBMSM) are more likely to be infected with HIV than other groups due to the higher risk associated with unprotected anal intercourse. It is important to explore the changes in sexual behaviors and HIV-related knowledge among GBMSM in the last 10 years, which could provide evidence for improving public health interventions to reduce HIV infections. The study sought to explore the changes of 3 sexual behaviors and HIV knowledge among men who have sex with men from 2011 to 2021. Data were collected from national HIV sentinel surveillance among GBMSM in Hangzhou conducted between 2011 and 2021. Univariate and multivariate logistic regression were used to analyze the associated factors of sexual behaviors. The variation trend of variables was evaluated based on the linear trend test in the regression model. A total of 5111 GBMSM with an average age of 32.00years were incorporated in the analysis. From 2011 to 2021, the HIV-related knowledge score of GBMSM ranged from 6 to 7.5, and it increased significantly (P trend < .001). The rate of homosexual sex in the past 6months remained at a high level (75.06%-82.75%). Homosexual behavior was associated with a higher HIV-related knowledge score (P = .004). Heterosexual sex was associated with an increase in the old age, married persons, and domicile outside the province (P < .05). Commercial sex was associated with an increase in drug users (P <.001). In the past 10 years, HIV-related knowledge of GBMSM increased and the rate of unprotected sex was at a high level among GBMSM, especially in heterosexual behaviors. Moreover, the likelihood of having homosexual behaviors is raised with the increasing HIV-related knowledge. Conducting precise behavioral interventions for GBMSM are crucial for preventing HIV infection.

Investigations into the Concentrations and Metabolite Profiles of Doping Agents and Antidepressants in Human Seminal Fluid Using Liquid Chromatography-Mass Spectrometry.

Exogenous substances, including drugs and chemicals, can transfer into human seminal fluid and influence male fertility and reproduction. In addition, substances relevant in the context of sports drug testing programs, can be transferred into the urine of a female athlete (after unprotected sexual intercourse) and trigger a so-called adverse analytical finding. Here, the question arises as to whether it is possible to distinguish analytically between intentional doping offenses and unintentional contamination of urine by seminal fluid. To this end, 480 seminal fluids from nonathletes were analyzed to identify concentration ranges and metabolite profiles of therapeutic drugs that are also classified as doping agents. Therefore, a screening procedure was developed using liquid chromatography connected to a triple quadrupole mass spectrometer, and suspect samples (i.e., samples indicating the presence of relevant compounds) were further subjected to liquid chromatography-high-resolution accurate mass (tandem) mass spectrometry. The screening method yielded 90 findings (including aromatase inhibitors, selective estrogen receptor modulators, diuretics, stimulants, glucocorticoids, beta-blockers, antidepressants, and the nonapproved proliferator-activated receptor delta agonist GW1516) in a total of 81 samples, with 91% of these suspected cases being verified by the confirmation method. In addition to the intact drug, phase-I and -II metabolites were also occasionally observed in the seminal fluid. This study demonstrated that various drugs including those categorized as doping agents partition into seminal fluid. Monitoring substances and metabolites may contribute to a better understanding of the distribution and metabolism of exogenous substances in seminal fluid that may be responsible for the impairment of male fertility. SIGNIFICANCE STATEMENT: This study demonstrates that doping agents as well as clinically relevant substances are transferred/eliminated into seminal fluid to a substantial extent and that knowledge about drug levels (and potential consequences for the male fertility and female exposure) is limited. The herein generated new dataset provides new insights into an important and yet little explored area of drug deposition and elimination, and hereby a basis for the assessment of contamination cases by seminal fluid in sports drug testing.

Penyuluhan Kesehatan tentang Kanker Serviks pada Wanita Usia Subur (WUS) di Desa Kertawinangun Kecamatan Kedawung Kabupaten Cirebon

Cervical cancer is a primary malignant tumor originating from squamous epithelial cells or cells originating from the vagina and urethra, usually occurring in the cervix or cervix which is located between the uterus and the sexual canal (vagina). According to WHO 2018, cervical cancer is the fourth leading cause of death in women throughout the world, estimated at 570,000, while new cases in 2018 or 6.6% of all cancers in women. Human papilloma virus or commonly called (HPV) is known to cause cervical cancer which can be transmitted through sexual intercourse, infection with several types of viruses, and personal hygiene. Symptoms of cervical cancer can be recognized by the presence of fluid from the birth canal, namely abnormal vaginal discharge, contact bleeding (bleeding during intercourse), and feeling pain during coitus / sexual intercourse as well as bleeding even after entering menopause. Early symptoms of pre-cancerous conditions are generally characterized by the discovery of abnormal cells. These abnormal cells develop into cervical cancer and then the following symptoms of cervical cancer appear; the appearance of pain and bleeding during sexual intercourse (contact bleeding), abnormal vaginal bleeding, such as bleeding outside the menstrual cycle, bleeding between regular menstrual periods, menstrual periods that are longer and more abundant than usual, bleeding after menopause, vaginal discharge excessive and abnormal, if the cancer has spread to the pelvis, the patient will suffer from complaints of pelvic pain, difficulty urinating, and enlarged kidneys. Cervical cancer can be prevented 100% by HPV vaccination, using condoms, avoiding tobacco consumption, and early detection and treatment of precancerous lesions.

Integrating Sexual and Reproductive Health Equity Into Public Health Goals and Metrics: Comparative Analysis of Healthy People 2030's Approach and a Person-Centered Approach to Contraceptive Access Using Population-Based Data.

The Healthy People initiative is a national effort to lay out public health goals in the United States every decade. In its latest iteration, Healthy People 2030, key goals related to contraception focus on increasing the use of effective birth control (contraceptive methods classified as most or moderately effective for pregnancy prevention) among women at risk of unintended pregnancy. This narrow focus is misaligned with sexual and reproductive health equity, which recognizes that individuals' self-defined contraceptive needs are critical for monitoring contraceptive access and designing policy and programmatic strategies to increase access. We aimed to compare 2 population-level metrics of contraceptive access: a conventional metric, use of contraceptive methods considered most or moderately effective for pregnancy prevention among those considered at risk of unintended pregnancy (approximating the Healthy People 2030 approach), and a person-centered metric, use of preferred contraceptive method among current and prospective contraceptive users. We used nationally representative data collected in 2022 to construct the 2 metrics of contraceptive access; the overall sample included individuals assigned female at birth not using female sterilization or otherwise infecund and who were not pregnant or trying to become pregnant (unweighted N=2760; population estimate: 43.9 million). We conducted a comparative analysis to examine the convergence and divergence of the metrics by examining whether individuals met the inclusion criteria for the denominators of both metrics, neither metric, only the conventional metric, or only the person-centered metric. Comparing the 2 approaches to measuring contraceptive access, we found that 79% of respondents were either included in or excluded from both metrics (reflecting that the metrics converged when individuals were treated the same by both). The remaining 21% represented divergence in the metrics, with an estimated 5.7 million individuals who did not want to use contraception included only in the conventional metric denominator and an estimated 3.5 million individuals who were using or wanted to use contraception but had never had penile-vaginal sex included only in the person-centered metric denominator. Among those included only in the conventional metric, 100% were content nonusers-individuals who were not using contraception, nor did they want to. Among those included only in the person-centered metric, 68% were currently using contraception. Despite their current or desired contraceptive use, these individuals were excluded from the conventional metric because they had never had penile-vaginal sex. Our analysis highlights that a frequently used metric of contraceptive access misses the needs of millions of people by simultaneously including content nonusers and excluding those who are using or want to use contraception who have never had sex. Documenting and quantifying the gap between current approaches to assessing contraceptive access and more person-centered ones helps clearly identify where programmatic and policy efforts should focus going forward.

Evaluation of Varicocelectomy Operative Therapy for Infertile Couples at the UGM Academic Hospital

Background: Infertility is a condition of the male or female reproductive system characterized by failure to achieve pregnancy after 12 months or more of having regular sexual intercourse without contraception. Since 2013, Rumah Sakit Akademik UGM (RSA UGM) has providing varicocele therapy to infertile individuals. The Ivanissevich varicocelectomy procedure is used for varicocele therapy.Objective: This study intends to examine the management of varicocele patients at RSA UGM.Methods: This research is a retrospective study by opening medical records and interviews. The study population was all patients who underwent varicocelectomy surgery between 2013 and 2021. Data is presented in the form of graphs.Results: The distribution of varicocele lateralization showed that out of 35 respondents, 23 respondents (66%) had one side varicoceles and 12 respondents (34%) both sides varicoceles. The distribution based on successful pregnancy shows that out of 35 respondents, 10 respondent couples (29%) have already gotten pregnant, 25 respondents (71%) haven't gotten pregnant. The distribution of varicocele lateralization in respondents who have children shows that 70% of respondents are one side and 30% of respondents are both sides. Complications of discomfort revealed that 88% of research participants had no complaints of postoperative pain, whereas 11% occasionally suffered pain following varicocele surgery.Conclusion: Varicocele that is one side is more common. Patients with one side varicocele who have surgery are more likely to become parents than those with both sides varicocele. At RSA UGM, the varicocelectomy success rate is comparable to the worldwide success rate.Keywords: Varicocele, success rate, one side, both sides.

Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

Objectives To investigate all pregnancies and analyze the factors influencing pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound (HIFU). Materials and methods A total of 231 patients with adenomyosis who completed HIFU and wished to conceive were enrolled. The symptom improvement and information of pregnancy were recorded during the follow-up period. Factors influencing pregnancy outcomes were analyzed using multivariate regression analysis and survival analysis. Results After HIFU, 100 of 231 (43.3%) patients became pregnant within 96 months, including 77 (77/194, 39.7%) in natural and 23 (23/37, 62.2%) in vitro fertilization and embryo transfer (IVF-ET) pregnancies following gonadotropin-releasing hormone agonist (GnRHa). Among the 108 (46.8%, 108/231) infertile patients (defined as the failure to achieve pregnancy after 12 months of regular unprotected sexual intercourse, 40 primary infertility and 68 secondary infertility), 31 (28.7%) became pregnant. At the end of the follow-up, 70 successfully delivered 71 healthy babies. No uterine rupture occurred during pregnancy and delivery. Patients with pelvic adhesion and infertility history had a lower pregnancy chance than that of patients without pelvic adhesion and infertility history (OR < 1, p < 0.05). Patients with small adenomyotic lesion volume had a greater pregnancy chance than that of patients with large lesion volume (OR < 1, p < 0.05). IVF-ET following GnRHa had a better pregnancy chance (p < 0.05). Conclusions HIFU seems to have a beneficial effect on fertility of patients with adenomyosis. Pelvic adhesion, infertility history, and large adenomyotic lesion volume have adverse effects on pregnancy, but IVF-ET following GnRHa after HIFU could increase the pregnancy chance.

Pilot trial of a new self-directed psychological intervention for infertility-related distress

BackgroundNow affecting one in six couples in Canada, infertility is defined as a lack of conception after 12 or more months of regular, unprotected heterosexual intercourse. Infertility is associated with immense psychological burden, particularly for individuals assigned female at birth. Yet existing psychological interventions are not specialized to this population and have been shown to be only marginally effective at relieving distress related to infertility. Thus, a new online self-directed psychological intervention was co-created with a panel of women experiencing infertility, and ultimately consisted of six 10-min video modules addressing the cognitive, emotional, and interpersonal aspects of infertility-related distress.MethodsIn the current study, 21 women experiencing reduced quality of life related to infertility were recruited to participate in a one-arm pre-post pilot testing the feasibility, acceptability, and preliminary efficacy of the program. Participant adherence and retention were monitored, and participants rated the credibility of the program and the helpfulness of each module as well as provided feedback on the content and format of the program. Pre-to-post changes in fertility quality of life, anxious symptoms, depressive symptoms, and relationship satisfaction were examined.ResultsThe program modules were highly rated by participants, with average helpfulness ratings ranging from 7.5 to 8.2/10. Two participants became pregnant and therefore stopped prematurely, 79% of the remaining participants completed all six modules, and participants reported completing 52.8 (SD = 82.0) min of homework per week. Participants perceived the intervention as highly credible and generally approved of the format, length, and speed; however, 68% of participants had recommendations for additional content to be included in the intervention. While relationship satisfaction did not change significantly over time, large pre-to-post improvements in fertility quality of life, depression, and anxiety were observed (p < .001; Cohen’s ds = 0.9–1.3).ConclusionsThis self-directed intervention was well received and has the potential to be highly effective in reducing infertility-related distress, informing future development and optimization.Trial registrationClinicalTrials.gov, NCT05103982.

Magnitude of Transfusion Transmissible Infections and Associated Factors Among Blood Donors at the Woliso Blood Bank, Oromia, Ethiopia: Across-Sectional Study

&amp;lt;i&amp;gt;Background: &amp;lt;/i&amp;gt;Blood transfusion is an effective treatment for saving millions of lives, even though transfusion-transmissible infections are the major problem. The prevalence of transfusion-transmissible infections varies between different geographical populations. This study aims to assess the prevalence of transfusion-transmissible infections and associated factors among blood donors at Woliso Blood Bank, South West Shewa Zone, Oromia, Ethiopia. &amp;lt;i&amp;gt;Method: &amp;lt;/i&amp;gt;An institutional-based cross-sectional study design was conducted. A structured and pre-tested questionnaire was used to collect data through a face-to-face interview. The data was entered in Epi Data version 3.1, and exported to STATA version 17.0 for data cleaning and analysis. A binary logistic regression analysis was performed to identify factors associated with outcome variables. Odd ratios along with the 95% confidence interval were used to present the finding and statistical significance was reported with a p-value of 0.05. &amp;lt;i&amp;gt;Results: &amp;lt;/i&amp;gt;The overall prevalence of transfusion-transmissible infections was 9.5% (95% CI 6.3-12.9%). Participants without formal education [AOR=4.84; 95% CI= 1.09, 21.46], unprotected sexual intercourse with multiple partners [AOR=4.77; 95% CI= 1.38, 16.44], and participants with a lower frequency of blood donation [AOR=2.85; 95% CI: 1.16, 6.99] were significantly associated with transfusion transmissible infections. &amp;lt;i&amp;gt;Conclusions: &amp;lt;/i&amp;gt;The prevalence of transfusion-transmissible infections was high in this study area. Educational level, unprotected sexual intercourse with more partners, and a number of blood donations were found to be independent predictors of transfusion-transmitted infections. Blood banks and regional health offices should work to mobilize the community and improve health promotion through prevention and control considering the associated factors identified.

The Context Matters: Women's Experiences of Their Partner's Odor in Intimate and Sexual Encounters.

Research shows that male body odor plays an important role in women's mate choice and that olfactory abilities are associated with women's sexual functioning. What remains unclear is what types of partner's odor actually shape women's experience during intimate activities. This study therefore explored women's experience associated with the partner's various odors and investigated how they affect women's intimate and sexual encounters. We performed semi-structured individual interviews with 20 single women and 20 women in a long-term relationship. Thematic analysis revealed four key natural odor types of the partner: body odor, sweat, genital odor, and semen odor. Further, we have identified three main types of fragrance odor (cologne, shower gel, and laundry agents) and investigated their perception in both intimate (hugging, kissing, cuddling, lying side by side) and sexual (intercourse, oral sex, ejaculation) contexts. Both partner's natural odor and fragrance affected women's emotional state (ranging from pleasant to unpleasant) and behavioral response (ranging from approach to avoidance of partner). Women's odor perception was frequently context-dependent, so that even mostly negatively perceived odors (e.g., semen, genital odor) were often accepted as part of sexual encounter. Finally, women's perception was negatively modified by partner's specific sweat (after workday, workout, or when the partner is ill) during intimate encounters. Our results highlight the complexity and interindividual variability of partner's odor perception.