You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 20101208 ARE ALL METABOLIC SYNDROME COMPONENTS RESPONSIBLE FOR PENILE HEMODYNAMICS IMPAIRMENT IN ERECTILE DYSFUNCTION PATIENTS? Nuno Tomada, Inês Tomada, Francisco Botelho, Francisco Cruz, and Pedro Vendeira Nuno TomadaNuno Tomada More articles by this author , Inês TomadaInês Tomada More articles by this author , Francisco BotelhoFrancisco Botelho More articles by this author , Francisco CruzFrancisco Cruz More articles by this author , and Pedro VendeiraPedro Vendeira More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.710AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) is a frequent disease that is mostly vasculogenic in nature. ED correlates with cardiovascular risk factors, being endothelial dysfunction the common link. Hypertension (HTA) and insulin resistance (IR) are the most important determinants of arteriogenic ED, and also components of metabolic syndrome (MetS). In this study, we aim to evaluate the impact of independent MetS criteria, on penile duplex parameters in men with ED. METHODS Consecutive patients (n=190) referred to a Unit of penile Doppler ultrasound were evaluated for cardiovascular risk factors and MetS (ATP III criteria). BMI was calculated. Each patient underwent a penile duplex Doppler ultrasound study after intracavernous injection of 20μg prostaglandin E1 to assess penile blood flow parameters. Data are expressed as mean±SD, and statistical significance is considered at P-level<0.05. Statistical analysis of clinical, laboratory, and penile duplex parameters was performed with SPSS® software. RESULTS Mean age, BMI and waist circumference were 56.0±11.4 years, 27.7±4.0 kg/m2 and 100.8±11.1cm, respectively. Obesity (BMI ≥ 30.0kg/m2), IR, HTA and hypercholesterolemia were identified in 22.1%, 29.0%, 46.0% and 51.0% of patients, respectively. Penile Doppler ultrasound was normal in 28.9%, arterial insufficiency in 57.9%, veno-occlusive dysfunction in 11.1%, and mixed in 2.1%. MetS was present in 21.3% of men, and 82.5% of them presented penile hemodynamics alterations, with mean peak systolic velocity (mPSV) significantly lower comparatively to no MetS patients (29.0 versus 35.7cm/s, P=0.008). Furthermore, excluding MetS patients, men with HTA and IR evidenced the lowest mPSV values (30.4 versus 37.6 and 30.5 versus 36.0 cm/s, P=0.001 and P=0.017, respectively). Multivariate analysis demonstrated that only HTA was significantly associated with diminished systolic velocities as independent clinical factors (P=0.004). CONCLUSIONS These results demonstrate that MetS is significantly associated with altered penile hemodynamics, which corroborate our previous findings. The high prevalence of vascular risk factors and MetS in patients with ED is also illustrated, with particular reinforcement to HTA and IR. Nevertheless, obesity, particularly waist circumference, was not individually associated with penile Doppler ultrasound impairment. Porto, Portugal© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e468 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nuno Tomada More articles by this author Inês Tomada More articles by this author Francisco Botelho More articles by this author Francisco Cruz More articles by this author Pedro Vendeira More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...