Penicillin Anaphylaxis Research Articles

The use of procaine amide in the treatment and prevention of penicillin reactions.

Article1 April 1954THE USE OF PROCAINE AMIDE IN THE TREATMENT AND PREVENTION OF PENICILLIN REACTIONSPAUL B. JENNINGS, M.D., SIDNEY OLANSKY, M.D.PAUL B. JENNINGS, M.D.Search for more papers by this author, SIDNEY OLANSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-4-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past few years there has been an increasing number of penicillin reactions. The number is expected to continue increasing as more people are exposed to the drug, since they then will be likely to become sensitized. Anaphylactic reactions and even deaths have been reported.1It is apparent that there is a need for more satisfactory methods of treating these reactions and of preventing them in known reactors. Many forms of treatment have been used, but they have not proved to be entirely satisfactory. Among the most commonly used are the antihistaminics, ephedrine, epinephrine, intravenous procaine, ACTH and cortisone....Bibliography1. MayerMoskoSchutzOstermanSteenBaker PSMMPJFALHLA: Penicillin anaphylaxis, J. A. M. A. 151: 351-353 (Jan. 31) 1953. MedlineGoogle Scholar2. BordleyHarveyHowardNewman JEAMJEEV: Preliminary report on the use of ACTH in hypersensitive state, Proc. First Clinical ACTH Conference, 1950, The Blakiston Company, Philadelphia, pp. 469-478. Google Scholar3. HenslerWurlGillespie NMOAJO: The use of cortisone and ACTH in treating reactions to penicillin, U. S. Armed Forces M. J. 3: 199-206 (Feb.) 1952. MedlineGoogle Scholar4. PeinerWaldman LS: Effective therapy of severe penicillin reactions with sodium dehydrocholate. Clinical studies of liver dysfunction—XII, Am. Pract. and Digest Treat. 3: 293-296 (Apr.) 1952. MedlineGoogle Scholar5. KerrBrehm RMWF: Intravenous procaine. An evaluation of some of its uses, Postgrad. Med. 8: 444-453 (Dec.) 1950. CrossrefMedlineGoogle Scholar6. CohenKaufman AEJ: The use of procaine hydrochloride intravenously in the treatment of reactions to penicillin, J. Allergy 19: 68-70 (Jan.) 1948. CrossrefMedlineGoogle Scholar7. SchapiroSadove MMMS: Oral procaine hydrochloride therapy in asthma, Ann. Allergy 8: 85-89 (Jan.-Feb.) 1950. MedlineGoogle Scholar8. Luddecke H: Oral administration of procaine with ascorbic acid, with special reference to therapy of pruritus, Arch. Dermat. and Syph. 64: 9-11 (July) 1951. CrossrefGoogle Scholar9. Friedman TB: Personal communication to authors. Google Scholar10. Hellman E: Allergy to procaine amide, J. A. M. A. 149: 1393-1394 (Aug. 9) 1952. CrossrefMedlineGoogle Scholar11. StearnsCallahanEllis NSEJLB: Value and hazards of intravenous procaine amide (Pronestyl) therapy, J. A. M. A. 148: 360-364 (Feb. 2) 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 25, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTreatment of procaine amide intoxicationAntibiotikaAntibiotikaBenzathine Penicillin in the Management of the TreponematosesThe vexing urticaria problem: Present concepts of etiology and management 1 April 1954Volume 40, Issue 4Page: 711-720KeywordsAdrenocorticotropic hormoneAnaphylaxisDrugsEpinephrineMedical servicesPenicillin ePublished: 1 December 2008 Issue Published: 1 April 1954 PDF downloadLoading ...

Severe immediate constitutional reaction to penicillin.

Although unfavorable reactions to penicillin therapy are well known, the occurrence and frequency of serious, life-threatening, immediate constitutional reactions are not generally recognized. The few published reports describe two principal types of prompt systemic reaction. Fatal and near-fatal penicillin anaphylaxis has recently been reviewed by Siegal, Steinhardt, and Gerber. 1 An anaphylactic-like shock state, occasionally fatal, was discussed in a recent issue ofThe Journalby Mayer and others, 2 and similar cases have been recorded. 3 An entirely different type of reaction, characterized by sudden weakness and angor animi and with no recognizable evidence of hypersensitivity or circulatory or respiratory disturbance, has been described by Batchelor, Home, and Rogerson. 4 The fact that Mayer's group observed six cases within a relatively short period of time and Batchelor's group encountered eight cases over an interval of seven months (an incidence of three cases per thousand injections) suggests that severe immediate

Advances in antibiotic therapy.

Excerpt Although the field of antibiotics is developing so rapidly as to render it almost kaleidoscopic, during recent months several topics of general interest have come into sharp focus. The subj...

Fatal and near-fatal penicillin anaphylaxis: Three new cases with a note on prevention

1. 1. One death and two cases of nonfatal anaphylactic shock due to penicillin are described. 2. 2. The fatality occurred in a patient with bronchial asthma. Three other known deaths attributable to penicillin anaphylaxis have also occurred in asthmatics. 3. 3. Two of these patients, including the one with a fatal reaction, had received penicillin many times before without indication of allergy. The third patient responded previously with immediate reactions to penicillin which went unheeded as a warning of anaphylaxis. 4. 4. A direct scratch test with aqueous crystalline penicillin was positive in one case, whereas similar tests were negative with aqueous procaine penicillin and 2 per cent procaine. Passive transfer tests were negative. 5. 5. Detailed precautions are suggested toward the prevention of penicillin anaphylaxis, particularly for asthmatic and penicillin-allergic persons. The avoidance of the indiscriminate use of penicillin, particularly by injection, is emphasized. The value of a systematic inquiry as to previous penicillin treatment and reactions as well as of the general allergic status is stressed. Certain refinements in the method of penicillin injection are suggested. The technique and interpretation of preliminary penicillin skin tests are discussed.