Mechanism Of Penetration Research Articles

Research on damage mechanism and protection of the collision penetration of the thin-walled long rod structure.

Traffic accidents have been closely concerned by the society, and the serious traffic accidents caused by vehicle and guardrail collisions are one of the main manifestations. However, the research in the field of vehicle and guardrail collisions is mainly limited to the waveform guardrail on the expressway, and there is little research on the urban road guardrail, especially in the secondary damage caused by guardrails field. Moreover, the collision between vehicle and the rectangular guardrail of city road is easy to form thin-walled long rod, and it penetrates the driver's chest. To evaluate and analyze the injury results and mechanism of this phenomenon, a penetrating finite element model of chest bone characterized by Chinese human is established using the medical software (MIMICS) and engineering software (HYPERMESH). The model validation is mainly dependent on the corpse impact test. In addition, the software (LS-DYNA) is deployed to simulate the thin-walled long rod penetration. According to the analysis of the "PENETRATION," it is found that the cavity effect produced by the thin-walled long rod through the chest, and the degree of chest damage is related to the speed, angle, weight, and stability of the thin-walled long rod. The difference between the peak value of collision corpse experiment and simulation peak value is less than 5%, which implies that the model is reasonable. Besides, the simulation results also confirm the accident and medical diagnosis cases. As a common form of secondary injury in traffic accidents and a typical case of medical penetrating injury, the thin-walled long rod penetrating injury has important reference value for studies in both directions.

Contemporary management of penetrating renal trauma - A national analysis

IntroductionIndications for nonoperative management (NOM) after penetrating renal injury remain ill-defined. Using a national database, we sought to describe the experience of operative and nonoperative management in the United States and retrospectively examine risk factors for failure of NOM. Materials and MethodsThe TQIP database 2010–2016 was used to identify patients with penetrating renal trauma. Outcomes of patients treated with an immediate operation (IO) and NOM are described. Failure of NOM was defined as the need for a renal operation after 4 h from arrival. Univariate then multivariable regression analyses were performed to identify predictors of NOM failure. ResultsOut of 8139 patients with kidney trauma, 1,842 had a penetrating mechanism of injury and were included. Of those, 89% were male, median age was 28 years, and 330 (18%) were offered NOM. Compared to IO, NOM patients were less likely to have gunshot wound (59% vs 89% p < 0.001) or high-grade renal injuries [AAST 4–5] (48% vs 76%, p < 0.001). Lower rates of in-hospital complications and shorter ICU and hospital stays were observed in the NOM group. NOM failed in 26 patients (8%). Independent predictors of NOM failure included a concomitant abdominal injury (OR = 3.99, 95% CI 1.03–23.23, p = 0.044), and every point increase in AAST grade (OR = 2.43, 95% CI 1.27–5.21, p = 0.005). ConclusionsNOM is highly successful in selected patients. Concomitant abdominal injuries and higher grade AAST injuries predict NOM failure and should be considered when selecting patients for IO or NOM.

Narrowed pulse pressure predicts massive transfusion and emergent operative intervention following penetrating trauma

IntroductionThe early identification of hemorrhagic shock may be challenging. The objective of this study was to examine the utility of a narrowed pulse pressure in identifying the need for emergent interventions following penetrating trauma. MethodsIn this 2.5-year retrospective study of adult patients with a penetrating mechanism, patients with a narrowed pulse pressure (<30 mmHg) were compared to those without. Main outcomes measures were the need for a massive transfusion or emergent operation. ResultsThere were 957 patients, of which the majority were male (86%) and 55% presented with gunshot wounds. On multivariate analysis, a narrowed pulse pressure was associated with the need for massive transfusion (OR 3.74, 95% C.I. 1.8–7.7, p = 0.0003) and emergent surgery (OR 1.68, 95% C.I. 1.14–2.48, p = 0.009). ConclusionsA narrowed pulse pressure is associated with the presence of hemorrhagic shock and need for emergent interventions among patients with penetrating torso trauma.

The Relationship between Specific Structure and Gas Permeability of Bromobutyl Rubber: A Combination of Experiments and Molecular Simulations

AbstractThe relationship between the specific structure and gas permeability of brominated poly(isobutylene‐co‐isoprene) rubber (BIIR) is investigated by a combination method of both experiments and molecular simulation. It is found that the various content of secondary allyl bromide isoprene (SABI) units exert an effect on transport behavior, including both diffusion and solution behavior of small molecule in BIIR, glass transition temperature, and vulcanization characteristics. The results show that a minimum value of permeability coefficient exists with the increase of SABI content. Moreover, more SABI in BIIR will lead to a rise in glass transition temperature and curing rate. It means that the gas permeability of BIIR can be further improved by adjusting composition of the copolymer BIIR. Meanwhile, this research may also provide useful information for understanding the penetration mechanism of oxygen in the BIIR matrix and supply a theoretical tool for designing high air tightness rubber materials.

Electrochemical Impedance Analysis on Hydrogen Penetration Mechanisms on Steel

Environmental degradation of steels associated with the hydrogen embrittlement has been a serious problem worldwide. The hydrogen evolution reaction (HER) on steel has been studied by some electrochemical methods [1-3] in order to explore the hydrogen penetration behavior on steel. In the present study, the electrochemical impedance spectroscopy was applied to the investigation of the hydrogen reaction mechanisms on steel because the time constants observed in impedance spectrum can be discriminated. The reaction scheme of HER on a metal were proposed to be a multistep as described below [4]. H+ + M + e- → MHads (1) MHads + H3O+ + e- → H2 + H2O + M (2) The reaction related to the hydrogen adsorption and absorption on steel was expressed by the following reaction [4]. MHads ↔ MHabs (3) In these reactions, the M is metal, the MHad is the hydrogen adsorption, the MHab is the hydrogen absorption. The first step (Eq. (1)) and the second step (Eq. (2)) are Volmer reaction and Heyrovsky reaction, respectively. The third step is the hydrogen penetration reaction on steel. The reactions (2) and (3) are competition reactions when the MHad generated by the reaction (1). In order to investigate these competition reactions, the Faraday impedance simulations were carried out based on these reactions. When the reaction rate constant of hydrogen penetration reaction is small compared to the HER, the capacitive loop related to the electrode/solution interface was observed in the high frequency range and the capacitive loop appeared in the low frequency range. In the case of the large reaction rate constant of hydrogen penetration compared to the HER, the impedance spectrum described the capacitive loop related to the electrode/solution interface in the high frequency range and the inductive loop in the low frequency range, respectively. These results indicated that the low frequency impedance is related to the rate-determining step of the reactions (2) or (3). The electrochemical impedance measurement of steel was performed under potentiotatic polarization in order to discuss the HER and the hydrogen penetration mechanisms on steel based on the results of simulations.

Experiments on interactions of molten steel with suboxidized corium crust for in-vessel melt retention

In the framework of the European IVMR project, dedicated to the assessment of In-Vessel Retention (IVR) strategy for high power reactors, VITI-CORMET tests, performed in VITI facility (CEA-Cadarache/PLINIUS Severe Accident Platform), intend to study the interaction between a molten 304L stainless steel droplet and suboxidized solid corium crust, referred to as C-70 ((U0.54, Zr0.46)O1.74). In the present paper, original experimental results on molten steel penetration through a corium crust are presented. Identification of penetration mechanisms is performed by SEM/EDX analyses, and has shown that molten steel can penetrate through pre-existing cracks or by a dissolution process. The latter is found to be the dominant penetration mechanism and involves material transport from the crust to molten steel. Penetration kinetics is studied by measuring the average penetration length at different exposure times. It is found that the penetration by dissolution decelerates with time, while U and Zr contents tend to reach an equilibrium value within the metallic droplet.

Molecular Dynamics and Metadynamics Insights of 1,4-Dioxane-Induced Structural Changes of Biomembrane Models.

1,4-Dioxane is a cytotoxic B2-type human carcinogen, a serious water pollutant produced solely by industrial activity. The effect of 1,4-dioxane on phospholipid membrane models composed of dipalmitoyl-phosphatidylcholine (DPPC) and its branched isomer (isodipalmitoyl-phosphatidylcholine, IPPC) was investigated using MD simulations. Clear and polluted membranes were compared by membrane parameters such as area per lipid (APL), volume per lipid (VPL), compressibility modulus, membrane thickness, and orderliness of lipid tails. While neat systems significantly differ from each other, the presence of the pollutant has the same effect on both types of lipid membranes. High density of dioxane appears in the vicinity of ester groups, which pushes away lipid headgroups from each other, leading to an overall change in lipid structure: APL and VPL grows, while the orderliness of lipid tails, membrane thickness, and compressibility modulus decrease. Orientational preferences of water and dioxane molecules were also investigated and different membrane regions have been specified according to the stance of water molecules. Free-energy profile for 1,4-dioxane penetration mechanism into DPPC membranes was carried out using metadynamics for two different concentrations of the pollutant (c1 = 7.51 g/dm3, c2 = 75.10 g/dm3), which showed that the higher the concentration is, the lower the free energy of penetration gets. Only a small free-energy barrier was found in the headgroup region and accumulation of dioxane is thermodynamically unfavored in the middle of the bilayer. The penetration mechanism has been described in detail based on the orientational preference of 1,4-dioxane molecules and the free-energy profiles.

Experimental study on the mechanisms of bentonite slurry penetration in front of a slurry TBM

Penetration of bentonite slurry reduces the effective support pressure at the tunnel face and thus the face stability during slurry shield excavation in saturated sand. The reduction of effective support pressure depends on the penetration distance of the bentonite slurry but also the hydraulic characteristics of the slurry-penetrated soil. The penetration of bentonite slurry, pressurized against saturated sand, therefore, was investigated in a laboratory set-up to improve the understanding of the mechanisms of two stages of the penetration: mud spurt and filter cake formation. The permeability of sand for bentonite slurry (kb), the permeability of filter cake for water (kc) and the Peclet number (Pe) at initiation of filter cake formation were calculated from the experimental results. It appeared that the values of kb and kc depend on the bentonite concentration of the slurry. Adding bentonite to the slurry decreases both kb and kc. Due to the thixotropic nature of the bentonite, the permeabilities estimated from the viscosity of fluid are approximately a factor 2 to 3 higher than the measured ones. The estimated Pe is a bit higher than the expected value. It was also found that filter cake is only formed on the surface of the sand in front of the shield tunnel, thus is very vulnerable to damage. The excess pore water pressure caused by slurry shield tunneling will only be negligible due to filter cake formation during standstill.

Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection.

Many viruses previously have been shown to have pressurized genomes inside their viral protein shell, termed the capsid. This pressure results from the tight confinement of negatively charged viral nucleic acids inside the capsid. However, the relevance of capsid pressure to viral infection has not been demonstrated. In this work, we show that the internal DNA pressure of tens of atmospheres inside a herpesvirus capsid powers ejection of the viral genome into a host cell nucleus. To our knowledge, this provides the first demonstration of a pressure-dependent mechanism of viral genome penetration into a host nucleus, leading to infection of eukaryotic cells.

Cracking mechanism and susceptibility of laser melting deposited Inconel 738 superalloy

Laser Melting Deposition (LMD) of Inconel 738 (IN738) superalloy is a promising process for the remanufacturing of gas turbines and aerospace engines, but the cracking has not been thoroughly understood and controlled. This paper conducts a comprehensive study on the cracking behavior by using optical microscope (OM), scanning electron microscopy (SEM), energy dispersion spectrum (EDS), electron backscatter diffraction (EBSD), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The results indicate that liquation cracking which follows the penetration mechanism is the major origin to those cracks. Whereas, at the propagation stage, ductility-dip cracking (DDC) is an important supplement to liquation cracking, especially at the triple junction points of grain boundaries (GBs) or the bottom of already formed liquation cracks. The cracks are very sensitive to GB morphology, the long-straight GBs which result from higher heat input or unidirectional scanning strategy are very vulnerable to cracking. Moreover, GB oxidation always plays an important role in accelerating crack propagation, the local protection from the cladding head is not enough for the LMD of IN738. For these factors, the test specimens which are bidirectionally deposited in an Argon (Ar) chamber with lower heat input achieve better tensile strengthen reaching 1093 to 1116 MPa.

Particle Orbits at the Magnetopause: Kelvin‐Helmholtz Induced Trapping

AbstractThe Kelvin‐Helmholtz instability is a known mechanism for penetration of solar wind matter into the magnetosphere. Using three‐dimensional, resistive magnetohydrodynamic simulations, the double midlatitude reconnection (DMLR) process was shown to efficiently exchange solar wind matter into the magnetosphere, through mixing and reconnection. Here we compute test particle orbits through DMLR configurations. In the instantaneous electromagnetic fields, charged particle trajectories are integrated using the guiding center approximation. The mechanisms involved in the electron particle orbits and their kinetic energy evolutions are studied in detail, to identify specific signatures of the DMLR through particle characteristics. The charged particle orbits are influenced mainly by magnetic curvature drifts. We identify complex, temporarily trapped trajectories where the combined electric field and (reconnected) magnetic field variations realize local cavities where particles gain energy before escaping. By comparing the orbits in strongly deformed fields due to the Kelvin‐Helmholtz instability development, with the textbook mirror‐drift orbits resulting from our initial configuration, we identify effects due to current sheets formed in the DMLR process. We do this in various representative stages during the DMLR development.

Capillary penetration mechanism and machining characteristics of lubricant droplets in electrostatic minimum quantity lubrication (EMQL) grinding

In this work, the machining performance of an electrostatic minimum quantity lubrication (EMQL) technology in grinding of Cr12 die steel was systematically investigated in terms of grinding temperature and forces and grinding ratio, as well as surface quality and microstructures. The intensity of charging voltage was varied in order to obtain an optimal grinding performance. A model of capillary penetration of lubricant droplets to the abrasive-workpiece interface was proposed to reveal the lubrication mechanism of EMQL. It was found that EMQL at an electrostatic voltage of 4 kV significantly reduced the grinding forces and surface roughness, but increased the grinding ratio by 24.8% in comparison with a conventional MQL technology. The improved performance was attributed to the fact that EMQL promoted the penetration of lubricant droplets, achieving a better interfacial lubrication with low friction and grinding heat. The EMQL was also believed to reduce the surface micro-hardness of workpiece materials by enhancing the migration of dislocations, hence improving the cutting effect of abrasive grains.

Graphynes: an alternative lightweight solution for shock protection.

The excellent mechanical properties of graphyne (GY) have made it an appealing candidate in the field of impact protection. We assessed the deformation mechanisms of monolayer GY nanosheets of different morphologies, including α-GY, β-GY, γ-GY and 6612-GY, under supersonic-velocity impacts (from 1 to 6 km/s) based on in silico studies. Generally, cracks initiate at the geometry center and the nanosheet experiences significant out-of-plane deformation before the propagation of cracks. Tracking the atomic von Mises stress distribution, it is found that its cumulative density function has a strong correlation with the magnitude of the Young’s modulus of the GYs. For nanosheets with a higher Young’s modulus, it tends to transfer momentum at a faster rate. Thus, a better energy dissipation or delocalization is expected during impact. This study provides a fundamental understanding of the deformation and penetration mechanisms of monolayer GY nanosheets under impact, which is crucial in order to facilitate their emerging applications for impact protection.

Molecular basis and potential applications of capsaicinoids and capsinoids against the elongation of etiolated wheat (Triticum aestivum L.) coleoptiles in foods

Capsaicinoids and capsinoids from dietary peppers have promising sensory properties and bioactivity, but the molecular basis of their penetration mechanism through cell lipid bilayers and its relationship to their bioavailability as food constituents are still poorly understood. Herein, statistically significant linear and quadratic quantitative structure-activity relationships were constructed to derive the essential structural elements required for their bioactivity against the elongation of etiolated wheat coleoptiles that mainly occurs via penetration. The resultant optimal models had high predictivity and reliability (r2 > 0.825 and r2pred > 0.950), which elucidate the importance of steric structural elements. Besides, their mechanistic hypothesis and rational design strategy were proposed, and the correlation between this bioactivity and their food-sensory properties was supposed. Finally, the bioactivity of newly designed analogs with methyl terminals and/or conjugated CC links was screened. Hopefully, this work would benefit the better understanding of their penetration mechanism and facile identification of bioactive analogs for designing food/drug formulations.

Bioavailability and ecotoxicity of metals in aquatic systems: critical levels of pollution

The bioavailability and ecotoxicity of metals depending on the geochemical factors of the aquatic environment are considered. For the most metals free ions have the greatest penetration with the exception of some mercury organometallic complexes it has been shown. The models for assessing the danger of pollution of the aquatic environment with metals based on thermodynamic calculations of free ions concentration, the ability of biological receptors to bind them and the toxicological properties of metals, are analyzed. The main mechanisms of penetration and elimination of metals and the cytotoxicity of non-essential elements are considered. A new method for determining critical levels of polymetallic water pollution based on measurements of the complexing ability of waters components and establishing dose-effect relationships between integral indicators of polymetallic water pollution and indicators of ecosystem “health” of ecosystems based on research in the Kola North are presented.

Nanomodification of structure of non-ferrous metals in mode of superdeep penetration

Abstract. Purpose. To e stablish a mechanism of ultra - deep penetration of substances and to establish the relationship between the parameters of microparticles of micronic smeasures and the deep penetration into reinforced fibers. Basic factors that determine a competitiveness between the producers of construction materials is a row of such indexes, as creation of new effective technologies of production and materials with the new complex of physical and chemical and mechanical properties, cost of energy cutting on the production of new materials and other. One of economically expedient and competitive directions there is development of new technology of creation of composition materials that can be realized in the conditions of high-energy and dynamic influence on matrix material. An effective physical “instrument” that changes physical parameters in the volume of solid is a process of super-deep penetration of microparticless in metals. Methodology. The copper, brass , aluminium alloy AK12 w ere used as samples for matrix material research and subjected it to dynamic processing in ultra - deep penetration mode . The schlifs before and after treatment were examined using electron microscopy, microanalysis, X- ray and phase analysis , mass spectrometry and other physical methods. Findings. In alloys of multi - colored non -ferrous metals in ultra - deep penetration mode , the voluminous doping of parts has been implemented both through the use of microparticles of different compositions and by synthesized new chemical elements and their isotopes. The use of ultra - deep penetration allowed the creation of highly - experienced alloys of non -ferrous metals with a concentration of doping elements from 0,35 mas. % to 26 mas. %. Originality. It has been established that during the bombardment of non -ferrous metals microparticles of different compositions there is a microsecond reduction in the strength of the metal target and local nuclear reactions in the microparticle area. Practical value. The understand ing the mechanisms of ultra - deep penetration of microparticles and reactions of their interaction will allow to create new structural materials with unique properties for the industry. First set that under time micro and nanosecond co-operating of microparticless with metallic targets there are a saltatory decline of viscidity and local nuclear reactions and it will allow at further development of mechanisms of super-deep penetration will allow to create new construction materials and new energy sources.

Thermo-hydro-mechanical properties of bentonite-sand-graphite-polypropylene fiber mixtures as buffer materials for a high-level radioactive waste repository

In accordance with the conception of repository, the performance of buffer materials around the canister are critical to the long-term safe operation of deep geological repositories for high-level radioactive waste (HLW). To investigate the thermo-hydro-mechanical (THM) properties of bentonite-sand-graphite-polypropylene fiber (BSGF) mixtures as buffer material, the thermal and hydraulic conductivity, swelling and cracking, strength tests were conducted in this paper. From the microscopic, the heat transfer mechanism, penetration mechanism, swelling mechanism and shear mechanism of BSGF mixtures were investigated in detail. Results revealed that the addition of graphite and polypropylene fiber (PPF) can significantly improve thermal conductivity and strength of BSGF mixtures. Compared with bentonite-sand mixtures, the thermal conductivity, the unconfined compressive strength (UCS) and shear strength (cohesion) of BSGF mixtures increased by 20–68%, 12–23% and 21–48%, respectively. Nevertheless, the internal friction angle had little change. The addition of PPF controlled the width, area, and propagation of the cracks through the interlacing effect of the fibers. However, the addition of graphite and PPF can also hinder the development of swelling pressure and improve the hydraulic conductivity of BSGF mixtures. In addition, for BSGF mixtures used as buffer material of HLW storage, the sand content should be retained below 31% and 32% respectively to ensure the maximum swelling pressure and hydraulic conductivity to meet the requirements of the specification. From the view of heat dissipation and strength, sand content shall not exceed 30% and 27%, respectively. Therefore, the effective sand content should not exceed 27% considering the THM properties. This study provides a new buffer material for HLW deep geological repository and enhances the stability and functionality of HLW deep geological repository.

Dynamic Strength of Heavy 90W—7Ni—3Fe Alloy Produced by Spark Plasma Sintering

The dynamic strength of heavy 90W—7Ni—3Fe alloy (wt %) was studied on two types of specimens: formed from submicron powder by spark plasma sintering (SPS) and from coarse-grained powder with a particle size of ≈20 µm by standard liquid phase sintering (LPS). Mhe study shows that the dynamic strength of the LPS and SPS specimens ranges up to 2750 and 3150 MPa, respectively, and that the SPS projectiles at an impact velocity of 1200 m/s penetrate 60% deeper into a steel target than the LPS projectiles. The difference in the penetration depth results from different penetration mechanisms: piercing for the coarse-grained material and cratering for the fine-grained one.

Bioavailability and Ecotoxicity of Metals in Aquatic Systems: Critical Contamination Levels

Bioavailability and ecotoxicity of metals and their relation to geochemical conditions in aquatic environments were considered. It was shown that free ions are the most penetrative species of most metals, except for organometallic complexes of some metals, for example, mercury. We analyzed models for the assessment of the hazard of metal contamination of water environments using the results of thermodynamic calculations of free ion concentrations, the ability of biological receptors to bind them, and the toxic properties of the metals. A concept was developed on the main mechanisms of metal penetration and excretion and cytotoxicity of nonessential elements. A new method was proposed for the estimation of critical levels of polymetallic contamination of water on the basis of measurements of water complexation capacity and determination of the dose–effect relations between the integrated characteristics of the polymetallic contamination and indicators of the health of the ecosystems (in situ) from the results of investigations in the northern Kola Peninsula.

Abstract 3624: Improved intratumor drug delivery and therapeutic efficacy in pancreatic cancer by albumin-Cisplatin complex

Abstract Background: The tumor microenvironment in pancreatic cancer is widely known for its abundant stroma and lacking of tumor blood vessels. Many effective therapeutic agents evaluated in vitro failed to show any benefits in vivo due to the inefficient drug delivery into the tumors. Albumin was reported to naturally accumulate in several types of solid tumors including sarcomas, lung cancer, etc. In this study, we systematically investigated the tumor accumulation and penetration of albumin in pancreatic cancer, and evaluated whether albumin could improve the intratumor drug delivery and therapeutic efficacy by albumin-drug complex. Methods: We prepared a red fluorescence dye (6-TMR)-labeled albumin and studied the tumor accumulation and penetration of albumin in both orthotopic xenograft and the genetically engineered KPC mouse model by in vivo fluorescence imaging and confocal microscope. To further investigate the drug delivery capacity of albumin in pancreatic cancer, we used Cisplatin as a model drug and prepared albumin-Cisplatin complex. Organ and intratumor drug distribution of Cisplatin were measured by ICP-MS and LA-ICP-MS imaging, respectively. Results: Albumin-6-TMR showed tumor-selective accumulation in both orthotopic xenograft and KPC tumors, with about 50-fold higher radiant efficiency than that of free 6-TMR in KPC tumors at 12 h. Intriguingly, the confocal results indicated that albumin-6-TMR could penetrate into the interior of tumor tissues and stay for at least 72 h while no obvious fluorescence was seen in free 6-TMR group. The mechanism of albumin accumulation and penetration in pancreatic tumors is still under investigation. Moreover, administration of albumin-Cisplatin complex significantly reduced Vd by nearly 25 times and increased AUC of Cisplatin in plasma by 33 times, and improved the MRT and AUC of Cisplatin in orthotopic xenograft tumors by 10 and 29 times, respectively. The LA-ICP-MS imaging was being used to confirm intratumor penetration and distribution of Cisplatin in KPC tumors. Finally, albumin-Cisplatin complex exhibited reduced systemic toxicity (the maximum tolerated dose was more than 60 mg/kg of Cisplatin, i.v.) and enhanced inhibition of tumor growth in subcutaneous PANC-1 xenograft mouse models. Importantly, albumin-Cisplatin complex prolonged the survival of orthotopic MIA PaCa-2 xenograft mouse models compared with free Cisplatin. Conclusion: In summary, we have shown for the first time that albumin as a drug carrier could improve intratumor drug delivery in both orthotopic xenograft and KPC tumors. And albumin-Cisplatin complex could significantly reduce systemic toxicity and improve therapeutic efficacy of Cisplatin in preclinical pancreatic cancer models. Together, albumin can be a promising drug carrier and provides a new insight into anti-cancer drug delivery in pancreatic cancer. Citation Format: Chao Kong, Junxiao Ye, Zhengsheng Liu, Weijian Kong, Mengnan Sun, Huiqin Liu, Fang Yuan, Feng Qian. Improved intratumor drug delivery and therapeutic efficacy in pancreatic cancer by albumin-Cisplatin complex [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3624.