<h3>BACKGROUND CONTEXT</h3> Lumbar total disc replacement (TDR) is a treatment option with 30 years experience and extensive publications on clinical results. However, there are few publications on mid- and long-term mobility. There is also sparse literature on the quality of mobility or the difference between L4-S1 2-level TDR vs TDR/ALIF hybrid constructs. <h3>PURPOSE</h3> To measure mobility parameters in flexion-extension for two groups (L4-S1 TDR vs hybrid); compare motion at L4–L5; participation of pelvis mobility; global lumbar motion; and flexion-extension effectiveness by measuring L1 race. Besides determining the difference of mobility between TDR and hybrid, we discussed potential compensations above and below L5-S1 fusion/L4-L5 TDR, as compared to two-level TDR. <h3>STUDY DESIGN/SETTING</h3> Retrospective clinical study. <h3>PATIENT SAMPLE</h3> This study included 235 patients, operated between 2003-2013: 170 patients received 2-level TDR (TDR group) and 65 received L4-L5 TDR and L5-S1 ALIF (hybrid group). <h3>OUTCOME MEASURES</h3> Data collected included radiographic, neurological/physical assessment, self-evaluation using the Oswestry Disability Index (ODI) and visual analog back and leg pain scores (VAS). Complication, reoperation/revision rates, and perioperative data points were also assessed. <h3>METHODS</h3> Both groups were equivalent in age, body habitus and preoperative clinical parameters (ODI, VAS). Patient selection for evaluation was based on presence of clinical success criteria and pre- and postoperative sagittal X-rays and dynamic flexion-extension films at minimum 24-month follow-up. Pelvic parameters (Incidence, Pelvic Tilt, Sacral Slope) were measured. L4-L5 and L5-S1 flexion-extension range of motion (ROM) was measured pre- and postoperatively. Pelvic motion was determined by measuring sacral slope in flexion-extension. The influence on lumbar lordosis (L1-S1) was also analyzed. To show the effect the lumbopelvic complex has on global motion, we measured L1 race (flexion-extension L1 ROM). <h3>RESULTS</h3> The absolute motion and relative gain of 2-level TDR shows its superiority over hybrid constructs in all measured parameters. When L5-S1 is fused, there is no compensation from pelvic motion to overcome the loss of mobility. TDR group shows a pelvi-femoral ROM gain of 16.77°, vs a gain of only 6.11° in the Hybrid group. L5-S1 fusion also reduces L4-L5 TDR mobility in Hybrid group, compared to 2-level TDR, and decreases flexion compared to baseline. There is a mean reduction in ROM of 1.53° in Hybrid group vs 20.02° gain in TDR group. L1 race also reflects the superiority of 2-level TDR vs hybrid with a gain of 32.58° in TDR vs 4.68° in hybrid, demonstrating that reduced global motion is principally due to loss of L5-S1 motion. <h3>CONCLUSIONS</h3> This comparison between 2-level TDR and hybrid demonstrates a lack of compensation through lumbar mobility and pelvic motion when L5-S1 is fused, and debunks these preconceived ideas. Although clinical measures of activity (ODI) and pain (VAS back and leg pain) are equivalent between the groups, functional superiority of 2-level TDR is confirmed. Two new ROM parameters introduced here—pelvic motion and L1 race—must be integrated in all ROM studies as they quantify pelvic participation in mobility and the functional effectiveness of motion preservation. In this first long-term comparison of mobility between 2-level TDR vs L4-S1 hybrid, 2-level TDR demonstrates overall superiority. Consequently, 2-level TDR must be systematically indicated whenever TDR is indicated for both levels, and accepted as the "gold standard" for reimbursement purposes. <h3>FDA DEVICE/DRUG STATUS</h3> Prodisc L 1- and 2-level (Approved for this indication), Prodisc L hybrid constructs (Not approved for this indication)
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