Pelli-Robson Test Research Articles

Accuracy of a commonly used mobile ophthalmology application's vision assessment tools in measuring five vision assessment parameters.

The use of mobile ophthalmology applications (MOA) is increasing, but many of these tools have not been validated. This study was performed to assess the accuracy of a popular MOA, Eye Handbook, in measuring five commonly-tested vision assessment parameters (distance visual acuity (DVA), near visual acuity (NVA), colour vision testing (CVT), contrast sensitivity (CS), and pupillary distance (PD)) was compared with traditional vision assessment methods (TVAM) [i.e. Snellen chart, Rosenbaum near card, Ishihara, Pelli Robson test, etc.] performed in the eye clinic setting. Prospective crossover clinical trial of 129 patients meeting inclusion criteria. Participants averaged significantly better DVA (p = 0.0008), NVA (p < 0.0001), and CVT (p = 0.0105) in the MOA than the TVAM, but all three MOA assessments were predictive of the TVAM values. CS was significantly better with the MOA (p < 0.0001). Linear regression and Spearman correlation tests were applied to assess the effect of CS on NVA, which showed no clear relationship between the difference in NVA and the difference in CS. PD using the two methods was in agreement with no significant difference (p = 0.2889). The studied MOA offers an effective means of measuring four common vision parameters: DVA, NVA, CVT, and PD. The MOA can potentially be used by eye care providers, health care providers, and patients, both as a screening tool with correction factor and to monitor ocular pathologies. Atypical MOA measurements should prompt testing in the clinic with formal TVAMs.

THE CORRELATION BETWEEN NEUTROPHYL-LYMPHOCYTE RATIO AND OPTIC NERVE FUNCTION IN METABOLIC SYNDROME PATIENTS

Background: The neutrophil lymphocyte ratio (NLR) is a new biomarker in predicting various cardiovascular disorders and was expected to be a biomarker for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) in metabolic syndrome (MetS) patients. Objective: This study aims to determine the correlation between NLR and optic nerve function in MetS patients. Methods: A cross sectional study involving 42 patients divided into 3 groups, consist of control group(14 patients, 28 eyes), MetS without NAION group(14 patients, 28 eyes) and MetS with NAION group(14 patients, 19 eyes). The study was conducted at Saiful Anwar General Hospital on January-March 2019. Optic nerve function evaluation includes visual acuity (VA) from Snellen chart, Retinal Nerve Fiber Layer(RNFL) from OCT, contrast sensitivity from Pelli Robson test, and visual field defect from Humphrey's perimetry. NLR was calculated and compared among groups using anova test. Then the correlation between NLR and optic nerve function was investigated using Pearson and Spearman test. Results: The NLR was significantly different among groups (p= 0.009), mean of control, MetS without NAION, and MetS with NAION groups 1.70, 1.86, and 2.40 respectively. There were signifficant negative correlation between NLR and visual field defect (p= 0.001,r= -0.487), contrast sensitivity (p= 0.015,r= -0.372), and VA (p= 0.041,r= -0.316), whereas positive correlation between NLR and RNFL statistically insignificant (p= 0.171, r = 0.215). Conclusion: There were signifficant negative correlation between NLR and visual field defect, contrast sensitivity, VA, whereas positive correlation between NLR and RNFL statistically insignificant. NLR is expected to be a potential biomarker for screening NAION in MetS patients.

Role of Visual Acuity &amp; Contrast Sensitivity in Early Diagnosis of Cognitive Impairment in Parkinson’s Disease

The study aims to evaluate the role of visual acuity and contrast sensitivity in early diagnosis of cognitive impairment in Parkinson’s disease. This cross sectional study was performed us- ing validated assessments on cognitive function using Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Visual acuity was assessed using LogMAR and contrast sensitivity using the Pelli-Robson test. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). One hundred patients presenting to the Neurology department for complaints satisfying the criteria for Parkinson’s disease at Saveetha Medical College and Hospital were randomly selected. The visual acuity and contrast sensitivity was found to be decreased in patients with low MMSE and MoCA scores, suggestive of visual function being a marker for progression of cognitive impairment in Parkinson’s disease. This could thereby be used in early diagnosis of dementia and in for- mulating a customised treatment plan for each individual. Parkinson’s disease has a deleteri- ous effect on various aspects of a person’s life, not just the motor functions. This in turn harms the day to day activities of the individuals, mainly the older age group and results in psychological disorders, like anxiety and depression. Therefore, this study aims to establish visual function as a marker for cognitive impairment in Parkinson’s disease, with the hopes of improving the quality of life of patients with this disease, thus revamping their purpose and outlook of their lives.

Visual Performance After Unilateral Implantation of an Extended Depth-of-Focus Intraocular Lens in Patients With Unilateral Cataract.

To investigate the visual performance after unilateral implantation of an extended depth-of-focus intraocular lens (IOL) in patients with unilateral cataracts. In this prospective study, uneventful phacoemulsification with LuxSmart IOL (Bausch & Lomb) implantation was performed in 25 eyes of 25 patients with unilateral cataracts. At postoperative 1, 4, 12, and 24 weeks, uncorrected and corrected visual acuity at far, intermediate, and near distances and the spherical equivalent in manifest refraction were measured. A Visual Function Index and modified Visual Function Index questionnaire were used to investigate glare, spectacle dependence, and satisfaction at 24 weeks in the eye that had surgery. At 6 months postoperatively, uncorrected distance visual acuity was 20/20 (0.0 logMAR) in 96% of cases, distance corrected intermediate visual acuity was 20/32 (0.2 logMAR) in all cases (60 cm), and distance corrected near visual acuity was 20/32 (0.2 logMAR) in 60% of cases (40 cm). The patient satisfaction score was 100% based on the Visual Function Index questionnaire for far and intermediate distance, respectively. No patients complained of the permanent photic phenomenon. No patients reported bilateral imbalance. All of the patients became spectacle independent for most of their intermediate activities at 60 cm. A total of 96% of the patients reported 100% contrast sensitivity in the Pelli-Robson test. The unilateral implantation of this EDOF IOL seems to be tolerated and effective in improving the visual function of patients with unilateral cataract with limited optical side effects such as halos or glare, providing spectacle-independent vision from far to intermediate object distances. [J Refract Surg. 2023;39(8):518-523.].

Evaluation of the SpotChecks contrast sensitivity test in children.

The purpose of this study was to determine intrasession repeatability of a worksheet style contrast sensitivity test (SpotChecks) in children and agreement with an established contrast sensitivity test (Pelli-Robson). Forty-three children aged 4 to 12 years participated in this single visit study that included two administrations of the SpotChecks binocularly, a single administration of the Pelli-Robson test and other measures of visual performance such as high-contrast visual acuity. Test order was randomised, and participants wore their habitual correction (39 unaided, 4 wearing glasses) for testing. Bland-Altman plots were used to assess the test-retest repeatability of SpotChecks and its agreement with the Pelli-Robson test. Multiple linear regressions were performed to evaluate whether contrast sensitivity was related to participant characteristics such as age, sex and near binocular visual acuity. The mean difference in log contrast sensitivity (logCS) between two administrations of the SpotChecks was 0.01, with a coefficient of repeatability (1.96*SD of differences) of 0.14 logCS. The mean difference between SpotChecks and Pelli-Robson was 0.00 logCS with 95% limits of agreement of -0.19 to +0.20. For both tests, a statistically significant increase in logCS was associated with age (slopes were 0.02 logCS/year, p< 0.001 and 0.01 logCS/year, p= 0.02 for the SpotChecks and Pelli-Robson tests, respectively). The SpotChecks test shows good intrasession repeatability and excellent agreement with the Pelli-Robson test in children. Contrast sensitivity showed an increase in logCS with age in children for both tests.

Normative values of Pelli Robson contrast sensitivity test in southeast Iran: A tropical area

Introduction: This study aimed to evaluate the distribution of contrast sensitivity (CS) using Pelli Robson test in normal individuals over seven years old living in Zahedan and examine its relationship with age, gender, and refractive errors. Methods: In this cross-sectional study, simple sampling was performed on the patients aged over seven years and their attendants who had referred to Al-Zahra eye hospital in Zahedan. Complete ophthalmic examinations including vision and refraction assessment, biomicroscopy, and CS evaluation were carried out for all subjects. To evaluate CS, Pelli Robson chart was used at a distance of one meter. The logarithmic CS value of the last triplet in which the patient could accurately read two words was regarded as his/her CS value. Results: Of the 150 patients (300 eyes), 70 (46.66%) were male. The mean age of the subjects was 34.56±16.15 years (ranged from seven to 78 years). The mean and standard deviation of the CS score in two modes of monocular and binocular vision were 1.45±0.19 and 1.57±0.19 log unit, respectively. The mean CS score was not significantly different between men and women (P&gt;0.454), but it decreased significantly with the age (P=0.000). CS was higher in individuals with emmetropia than those with myopia and hypermetropia (P=0.000). There was also a significant correlation between cylinder magnitude and CS (P=0.000). Conclusion: Although Pelli Robson test evaluates CS at low and constant spatial frequencies, its distribution is significantly different among different age groups and even among individuals with different values of refractive errors.

Associations of dual sensory impairment with incident mobility and ADL difficulty.

There is a dearth of studies examining the associations of objectively measured dual sensory impairment (DSI) with incident mobility and activities of daily life (ADL) difficulty longitudinally. Cox proportional hazards models were used to examine the associations of DSI and single sensory impairment (hearing, vision) with incident mobility difficulty (many problems or inability to walk ¼ mile and/or climb 10 steps) and ADL difficulty up to six years of follow-up among 2020 participants of the Health, Aging, and Body Composition Study, a cohort of older adults aged 70-79 years from Pittsburgh, PA and Memphis, TN. Vision impairment (VI) was defined as impaired visual acuity (20/50 or worse on Bailey-Lovie distance test) and contrast sensitivity (<1.3 log units on Pelli-Robson test), and hearing impairment (HI) was defined as pure-tone average in better-hearing ear >25 decibels. Models were adjusted by age, race, sex, education, diabetes, depressive symptoms, hypertension, gait speed from 20-meter walk, global cognition score, prevalent cardiovascular disease, and body mass index. There were 23% with DSI (n=459). DSI was associated with increased risk of both incident report of mobility (hazard ratio [HR]=2.25, 95% confidence interval [CI]: 1.47, 3.43), and ADL difficulty (HR=2.26, 95% CI: 1.50, 3.40). Neither VI nor HI alone was associated with risk of either outcome. DSI is associated with increased risk of incident mobility and ADL difficulty. Rehabilitation and adaptive environmental changes for individuals living with DSI may be important to maximize mobility and daily function.

Progressive changes in visual function after Descemet Membrane Endothelial Keratoplasty

AbstractPurposeTo compare progressive changes in visual function parameters in patients with Fuchs entothelial dystrophy (FED) who underwent Descemet Membrane Endothelial Keratoplasty (DMEK). To compare visual results after DMEK with visual function parameters in healthy subjects without corneal pathology.MethodsThirty patients (30 eyes) with FED who underwent DMEK surgery were included in the study. All subjects underwent best corrected visual acuity (BCVA) evaluation using the ETDRS optotype in photopic and scotopic conditions, and contrast sensitivity (CS) assessment using the CSV 1000 and the Pelli Robson test in different lighting conditions, preoperatively, at 1 and 6 months after surgery. Thirty eyes of 30 healthy controls were evaluated using the same protocol and compared with the patients’ final postsurgery data.ResultsA significant improvement in all visual function parameters was observed in patients 1 month (p &lt; 0.05) and 6 months (p &lt; 0.05) after DMEK, compared with preoperative levels. No significant differences were observed between patients and healthy controls in the lowest spatial frequency of 3cpd (photopic, p = 0.891; mesopic, p = 0.064; mesopic with glare, p = 0.786). Healthy controls had significantly higher BCVA in photopic and scotopic conditions (p = 0.015, p = 0.03, respectively), better CS measured with the CSV 1000 test in the spatial frequencies of 6 cpd, 12 cpd and 18 cpd and with the Pelli Robson test (p = 0.002).ConclusionsDMEK improves visual function parameters in patients with FED in the first month after surgery. Patients who underwent DMEK present similar contrast sensitivity to healthy subjects in lower frequencies. However, the rest of the values assessed were significantly lower in DMEK patients compared to healthy controls 6 months after surgery.

Effects of catechine and epicatechine on visual function and retinal perfusion

AbstractPurposeThe aim of our study is to evaluate the effects of flavonoids catechine and epicatechine ot visual function, contrast sensitivity and retinal perfusion.MethodsIt’s a prospective cohort study. A total of 30 patients are subdivided into two cohorts. Group A: patients with no ophthalmic pathology and, Group B: patients with neovascular age‐related macular degeneration /nAMD/. We performed a full ophthalmic examination /best corrected visual acuity for distance and near, assessment of contrast sensitivity – Pelli Robson test, tonometry, biomicroscopy, ophthalmoscopy and optic coherence tomography – angiography OCT‐A/ before and two hours after consumption of 50 g dark chocolate with 100% cocoa content.ResultsResults of all the exams /visual acuity, contrast sensitivity, OCT‐A indexes for retinal perfusion/ are statistically processed.ConclusionsHigh content of flavonoids catechine and epicatechine in dark chocolate has beneficial impact on visual function, contrast sensitivity and retinal perfusion I Group A and Group B, with slight variation between two groups.

Contrast Sensitivity Measurement Tests and Methods

Contrast is a measure of the amount of lightness or darkness an object has in relationship to its background. Usually, it is described as Contrast Sensitivity (CS), which actually is the inverse of the contrast threshold. More often than not, stimulus set includes grating patterns of various sizes that are presented in a stationary manner or are dynamically presented by reversing the contrast at different rates.&#x0D; A variety of tests were developed, in order to asses and evaluate contrast sensitivity, in many different ways. A classical method, to check for contrast sensitivity, is the Pelli-Robson contrast sensitivity chart.&#x0D; The Bailey-Lovie contrast sensitivity chart is another letter chart that deals with differences in the number of letters read on the high and low contrast charts, with a main drawback, the necessity to follow the size of the letters.&#x0D; The Functional Acuity Contrast Test is designed to identify vision loss from a variety of disorders, many of which are not detected by high or low contrast Snellen Acuity tests. The MARS Letter Contrast Sensitivity Test shows good agreement with the Pelli-Robson test and possibly it may be the alternative to the Pelli-Robson chart, in clinical practice and research.

Test-retest Repeatability of the Ohio Contrast Cards.

The Ohio Contrast Cards are a repeatable test of contrast sensitivity, and they reveal higher contrast sensitivity for low-vision patients than is shown by the Pelli-Robson chart. This study aimed to compare the contrast sensitivity results and test/retest ±limits of agreement for the Ohio Contrast Cards and the Pelli-Robson letter contrast sensitivity chart on two challenging groups of participants, and to compare the Ohio Contrast Card results with grating acuity and the Pelli-Robson results with letter acuity. The Ohio Contrast Card and Pelli-Robson tests were each performed twice by two different examiners within one visit on 40 elder patients in Primary Vision Care (>65 years old) and 23 to 27 low-vision school-aged students. Grating acuity was measured using the Teller Acuity Cards (all participants), and letter acuity was measured using ClearChart (elders) or the Bailey-Lovie chart (students). The ±95% limits of agreement were similar for the Ohio Contrast Cards and the Pelli-Robson chart. The elders' limits of agreement were ±0.27 (Ohio Contrast Cards) and ±0.28 (Pelli-Robson); the students' limits of agreement were ±0.42 (Ohio Contrast Cards) and ±0.51 (Pelli-Robson). However, Ohio Contrast Card results were 0.41 log10 Michelson units more sensitive than the Pelli-Robson chart (over one line on the Pelli-Robson chart) for the elders and 0.90 log10 Michelson units (three lines on the Pelli-Robson chart) more sensitive for the elders (0.11 and 0.6 log10 Weber units, respectively). The Pelli-Robson results were correlated with letter acuities and Ohio Contrast Card results for both groups, and the Ohio Contrast Card results were correlated with Teller Acuity Card acuities for the elders. The Ohio Contrast Cards and Pelli-Robson chart are similarly repeatable. Both contrast sensitivity tests can provide additional clinical information that is not available through visual acuity testing, and Ohio Contrast Card may provide additional information not available from the Pelli-Robson chart.

Comparing the CamBlobs2 contrast sensitivity test to the near Pelli-Robson contrast sensitivity test in normally-sighted young adults.

Contrast sensitivity (CS) has been proposed as a potential method for patients to assess their vision at home. The CamBlobs2 contrast sensitivity test is meant to be performed easily in the clinic or at home. The purpose of this study was to determine the intra-visit coefficient of repeatability of the CamBlobs2 compared with the near Pelli-Robson test, and the limits of agreement between these two tests on normally-sighted subjects. Twenty-two normally-sighted subjects (mean age 28±4years) completed two trials of the near Pelli-Robson and CamBlobs2 contrast sensitivity tests within a single visit. Tests were performed monocularly on each eye in random order. Pelli-Robson tests were scored as 0.05logCS for each letter read correctly after deducting the first triplet. CamBlob2 tests were scored as the highest line where two or fewer blobs were marked correctly. The coefficient of repeatability was determined as 1.96 times the standard deviation of the difference between the two measurements using the same type of chart on the same eye. The limits of agreement between the two tests were evaluated using Bland-Altman analysis. The mean difference between intra-visit measurements for both the near Pelli-Robson and CamBlobs2 was less than 0.05logCS and the coefficient of repeatability was within ±0.20log CS for both left and right eyes. The mean±standard deviation differences between near Pelli-Robson and CamBlobs2scores was -0.08±0.08 (limits of agreement: -0.24 to 0.09) for right eyes and -0.05±0.10 (limits of agreement: -0.23 to 0.14) logCS for left eyes based on average measurements. The intra-visit repeatability of CamBlobs2 was consistent with the near Pelli-Robson contrast sensitivity test (±0.20logCS). With a 0.05 correction, the CamBlobs2scores showed excellent agreement with the near Pelli-Robson contrast sensitivity test.

Clinical outcomes with a low add multifocal and an extended depth of focus intraocular lenses both implanted with mini-monovision.

To compare the visual acuity, contrast sensitivity (CS), spectacle needs, photic phenomena, and quality of life parameters of patients bilaterally implanted with a low add multifocal (MIOL) or an extended depth of focus (EDOF) intraocular lens (IOL), both with intended mini-monovision. In this prospective, randomized, comparative study, patients were randomized to receive either Tecnis +2.75 D (ZKB00) (MIOL Group, n = 15) or Tecnis Symfony (ZXR00) (EDOF Group, n = 14) for bilateral implantation with mini-monovision (-0.50 D). Binocular logMAR uncorrected visual acuities (UVA), monocular defocus curves, CS with CSV 1000-E, and Pelli-Robson Test (PRT), spectacle needs and quality of life parameters with NEI RQL-42 questionnaire were evaluated at postoperative 1, 3, and 6 months. Results of MIOL and EDOF Groups at postoperative month 6 are as follows: distance (6 m) UVA -0.03 ± 0.05 and -0.05 ± 0.06 (p = 0.938), intermediate (60 cm) UVA, 0.04 ± 0.08 and -0.03 ± 0.07 (p = 0.046); near (40 cm) UVA, 0.22 ± 0.08 and 0.15 ± 0.07 (p = 0.046); near spectacle needs, 26.7% and 14.3% (p > 0.05), respectively. Better visual acuity was achieved in the EDOF Group between the defocus range of -0.50 and -1.75 D (p < 0.05). No significant difference was found regarding photic phenomena and CS evaluated with CSV 1000-E between the two IOL groups at 6 months after surgery (otherwise there are differences at 1 and 3 months in favor of EDOF). However, EDOF Group performed better in mesopic CS evaluated with PRT (p < 0.05). When implanted with mini-monovision better binocular uncorrected visual performance at intermediate and near distances achieved with EDOF than low add MIOL.

Bias of near-infrared light in evaluation of patients implanted with multifocal intraocular lenses.

To compare visual quality between subjective tests and optical devices using near-infrared (NIR) light in patients implanted with monofocal, multifocal and enlarged depth-of-focus (EDoF) intraocular lenses (IOLs). Cross-sectional study enrolling patients aged between 55 and 75 (axial length between 22 and 25mm) bilaterally implanted with Tecnis IOLs (Johnson & Johnson) four months previously: 40 patients (80 eyes) with monofocal ZCB00, 41 patients (82 eyes) with bifocal diffractive ZMB00 and 48 patients (96 eyes) with EDoF Symfony. They were examined using subjective and objective tests. The subjective tests comprised visual acuity (VA) with ETDRS charts, contrast sensitivity (CS) with Pelli-Robson and CSV-1000E tests, and clear vision range (CVR). The objective tests using NIR light were performed with the KR-1W wavefront analyzer and the OQAS. In the subjective tests, the monofocal group achieved the best outcomes in some of the VA and CS sections, while the bifocal group obtained the worst outcomes in some of the CS sections. In the objective tests, the bifocal group achieved the best results for VA and CS. Discrepancies between pseudoaccommodation range and CVR were found in the bifocal and EDoF groups. Assessment of visual quality using NIR light implies greater bias for diffractive lenses than for EDoF lenses. This bias may be even greater with devices using longer light wavelengths or Hartmann-Shack technology. The difference in wavelength between NIR and visible light leads to dimming of near-vision focus and magnification of distance focus.

HUBUNGAN LAMA PAPARAN INHALASI ORGANICSOLVENT TERHADAP PENURUNAN PENGLIHATAN WARNA DAN SENSITIVITAS KONTRAS

&lt;p&gt;&lt;em&gt;Chronic inhalation of organic solvents causes retinal toxicity such as decreased color vision and contrast sensitivity because organic solvents cause damage to photoreceptor function, changes in cortical or retinal neurotransmitter systems such as glutamate, dopamine and acetylcholine and changes in function in parvo, magno and coniocellular cells.&lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;strong&gt;&lt;em&gt;Method&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: The sample of this study consisted of 45 gas station operators who were divided into 3 groups, namely those who worked 1 year&lt;/em&gt;&lt;em&gt;-&lt;/em&gt;&lt;em&gt;5 years, 5 years&lt;/em&gt;&lt;em&gt;-&lt;/em&gt;&lt;em&gt;10 years and &lt;/em&gt;&lt;em&gt;&amp;gt;&lt;/em&gt;&lt;em&gt;10 years. All subjects underwent &lt;/em&gt;&lt;em&gt;q&lt;/em&gt;&lt;em&gt;uantitative color vision examination by calculating the value of the color confusion index (CCI) using Fansworth D15. Contrast sensitivity examination is by determining the log contrast sensitivity value using the Pelli-Robson test.&lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;strong&gt;&lt;em&gt;Results&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: CCI values&amp;gt; 1.00 and log contrast sensitivity values &amp;lt;1.65 were found in officers who worked for &lt;/em&gt;&lt;em&gt;&amp;gt;&lt;/em&gt;&lt;em&gt;10 years by 12 subjects (80%). Statistically there is a significant relationship between the duration of work with the decrease in color vision and contrast sensitivity (P Value 0,000).&lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;strong&gt;&lt;em&gt;Conclusion&lt;/em&gt;&lt;/strong&gt;&lt;em&gt;: There is a significant relationship between the duration of exposure to organic solvents with a decrease in color vision and contrast sensitivity in operator officers who work &lt;/em&gt;&lt;em&gt;&amp;gt;&lt;/em&gt;&lt;em&gt;10 years.&lt;/em&gt;&lt;/p&gt;

Progressive Functional and Neuroretinal Affectation in Patients With Multiple Sclerosis Treated With Fingolimod.

To evaluate the effect of fingolimod in visual function and neuroretinal structures in patients with multiple sclerosis (MS) for a period of 1 year. This longitudinal and observational cohort study included 78 eyes of 78 patients with MS treated with fingolimod. All subjects were evaluated every 3 months during 12 months and compared with 32 patients treated with interferon beta. All patients were examined for high-contrast and low-contrast (2.5% and 1.25%) visual acuity (VA), contrast sensitivity vision (CSV) (using Pelli-Robson and CSV-1000E tests), color vision (Farnsworth D-15 and L'Anthony D-15 desaturated tests), and retinal structural measurements (retinal nerve fiber layer [RNFL] and ganglion cell layer [GCL] thickness) using optical coherence tomography (OCT) technology. Patients with MS treated with fingolimod for a period of 1 year showed significant reduction in 100% and 1.25% contrast VA (P = 0.009 and 0.008, respectively), an alteration of contrast sensitivity and color perception (Pelli-Robson test, CSV-1000E test, Farnsworth D-15 desaturated test, and L'Anthony D-15 desaturated test; P < 0.001), GCL thickness reduction (P = 0.007), and an average macular central thickness increase of 2.6 μm (P = 0.006). Patients with MS treated with interferon beta did not show significant changes in visual function tests neither in macular thickness measurements, but they showed a significant reduction in GCL and RNFL thicknesses. The reduction in neuroretinal structures observed by OCT was significantly higher in the interferon-beta group, but patients treated with fingolimod showed a significant increase in macular central thickness and a reduction in low contrast vision (P < 0.001). Patients with MS treated with fingolimod and with no clinically observable macular edema show a significant change in visual function parameters and average macular central thickness increase compared with those treated with interferon beta. These findings are probably due to subclinical macular edema produced by fingolimod, which might be considered as an indicator for pharmacovigilance of sphingosine-1-phosphate inhibitors to be improved.

Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests.

The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients with iAMD and 24 controls) were included and underwent several functional assessments: Best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Vanishing Optotypes Acuity Charts (MAC), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts (IReST) and mesopic and dark-adapted microperimetry (S-MAIA, CenterVue, Padova, Italy). Groups were compared using non-parametric Wilcoxon rank sum tests and ROC analyses. Linear regression was used to control for confounding. Results showed that all visual function test performances except the IReST were significantly reduced in iAMD patients compared to controls (p < 0.05). These effects did not alter after controlling for age and sex. Best discrimination between iAMD and controls yield the combination of LLVA and contrast sensitivity as well as MAC-VA and contrast sensitivity (ROC area under the curve 0.95 and 0.93, respectively). Our results suggest that LLVA, MAC-VA, contrast sensitivity and mesopic and dark-adapted microperimetry can capture visual impairment characteristic for iAMD. Best discrimination against iAMD is achieved with a combination of two tests.

Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular Degeneration.

PurposeTo assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD).MethodsA total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes from healthy controls) were recruited in this cross-sectional study. All subjects underwent several functional assessments: best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the Pelli–Robson test, reading speed using the International Reading Speed texts, and mesopic and dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence tomography using an approach based on convolutional neural networks. The relationship between drusen volume and visual function was assessed with linear regressions controlling for confounders.ResultsMean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P < 0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and dark-adapted microperimetry were significantly negatively associated with the overall drusen volume (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid deposits, MAC-VA and mesopic and dark-adapted microperimetry were still significantly associated with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively).ConclusionsOur results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry, might indicate structural changes related to drusen volume in early stages of AMD.

Variability of diabetic macular edema in correlation with hypertension retinopathy in patients with diabetes mellitus and essential hypertension

Objective. This study aimed to determine the possible relationship between variability of diabetic macular edema associated with hypertension retinopathy in patients with type 2 diabetes mellitus and essential high blood pressure, in correlation with contrast sensitivity. Material and Methods. In order to accomplish the objective, this retrospective study evaluated the progression of diabetic macular edema in patients with high blood pressure during day time through measurements of the total macular volume and central macular thickness using optical coherence tomography and contrast sensitivity variations measured through Pelli Robson test, four times a day, along with glycemia and blood pressure measurements. Results. Our results showed a statistically significant correlation between the values of glycemia and central macular thickness, and between contrast sensitivity and macular thickness at every tested hour. Conclusions. The study revealed many statistically significant correlations involving blood pressure, blood glucose levels, Pelli Robson test and central macular thickness. Abbreviations: OCT = optical coherence tomography; DME = diabetic macula edema; SD-OCT = spectral domain optical coherence tomography; LOCS = lens opacities classification system; LE = left eye; ANOVA = analysis of variance.

Evaluation with angiography by optical coherence tomography of patients with multiple sclerosis

AbstractPurposeTo evaluate the microvascular changes in the superficial plexus of the retina and peripapillary plexus in patients with relapsing‐remitting multiple sclerosis (RR MS) by optical coherence tomography angiography (OCT‐A).MethodA prospective study was performed in a total of 75 patients. The control group consisted of 84 eyes of 42 subjects without any ocular disease. The study group was formed by 66 eyes of 33 patients with RR MS. Visual function was evaluated by visual acuity with Bailey‐Lovie optotype and contrast sensitivity with Pelli Robson test. The Deep Range Image (DRI) Triton, Swept Source OCT (Topcon Eye Care Company) was used to analyze vascular density of superficial plexus of the retina and the peripapillary area using (OCT‐A).ResultsThe nasal, temporal, superior and inferior parafoveal areas of RR MS patient group showed a significant decrease in vascular flow compared with the control group (p = 0.024, 0.039, 0.001 and &lt;0.014 respectively). No significant differences were found in the peripapillary plexus between controls and patients groups.ConclusionsThere is a vascular reduction in the macular zone at the superficial plexus level in patients suffering RR MS.