Background: Risky behaviors can have damaging consequences in physical or mental health in adolescents, even more causing the majority of adolescent morbidity and mortality. In line with the Problem behavior theory, the balance between protective and risk factors will define the proneness for problem behaviors. The purpose of this study was to assess the prevalence of risky behaviors in adolescents with psychiatric disorders and to assess the possible predictive role of the presence of a psychiatric diagnosis, age and gender. Methods: A questionnaire was developed, to assess environmental factors and risky behaviors in adolescents with psychiatric disorders who attended the Department of Child and Adolescent Psychiatry and Psychology in a general public hospital in Barcelona. Results: It was observed that almost half of the sample presented at least a second diagnose. It should be noted that more than half of the sample had had feelings of hopelessness and that almost half presented suicidal thoughts. A logistic regression analysis showed that, except for going on a restrictive diet and doing physical exercise to control or lose weight, all problem behaviors were predicted by constitutional and environmental factors, rather than by having a psychiatric diagnosis. Conclusion: Most of the risky behaviors were mainly predicted by environmental factors, such as having both parents present, restructured family, friends consume marijuana, peers’ opinion more valued than parents’ opinion or retaking a school year, and diagnostic categories had a low influence on the different risky behaviors. Out of these findings, it is evident that the Problem behavior theory was confirmed in a clinical sample and that there is need for screening tools on a regular base, to detect problem behaviors, protective and risk factors in each adolescent’s case,to do an improved prevention and intervention, promoting protective factors related to adolescent’s values and expectations, encouraging parental controls and support and boosting peer models of healthy behaviors.