The single-incision laparoscopic technique has become an increasingly popular alternative for conventional pediatric laparoscopic surgery. Ileocecectomy is a mainstay surgical therapy for pediatric Crohn disease. However, there are few descriptions on the technique and experience of single-incision laparoscopic ileocecectomy (SIL-I) in the pediatric population. We describe our technique and initial experience with SIL-I for the surgical management of pediatric patients with Crohn disease. Records of all patients with Crohn disease who underwent SIL-I between 2010-2012 were retrospectively reviewed. Variables including patient demographics, operative information, length of stay, and postoperative complications were collected. The operation is generally performed by placing an Olympus Triport 15®, first releasing adhesions and separating the terminal ileum from associated abscess, when one was present. The right colon is then mobilized distally around the hepatic flexure to the level of the duodenum. This gives adequate mobilization to allow a safe extracorporeal anastomosis. The proximal extent of disease is identified, and the mesentery is divided with the ligature to the level of the ileocecal valve. The small intestine is divided with a laparoscopic stapler. The port is removed, and the incision is extended to approximately 3.5 cm through the base of the umbilicus. The specimen is externalized, remaining mesentery to the cecum is taken, and the right colon is divided using a surgical stapler. The anastomosis is performed by creating a 12 cm, side-by-side, functional end-to-end stapled anastomosis. Thirty-one SIL-I cases (mean patient age 17 ± 4 years) were reviewed. The average time from diagnosis of Crohn disease to surgery was 4.8 ± 4.5 years. Seven patients (23%) were below the 5th percentile for weight preoperatively. The major indication for surgery was obstruction/stricture (n = 23) followed by refractory inflammatory disease (n = 18). Three patients had undergone prior abdominal operation. Twenty patients underwent epidural placement and four patients underwent ureteral stent placement under the same anesthetic prior to SIL-I. There were no operations where an additional laparoscopic port was placed; however, one operation required conversion to a midline laparotomy in the setting of extensive interloop abscesses, dense adhesions and interloop fistulae. All anastomoses were stapled extracorporeally. The mean operative time was 3.8 ± 1.1 hours. There were no intraoperative complications. Five postoperative complications were documented, including one superficial wound infection, 2 intraabdominal abscesses (1 within 30 days of operation, 1 more than 3 months post-procedure), 1 PICC-associated bacteroides bacteremia, and 1 small bowel obstruction. Average postoperative length of stay was 7.1 ± 2.9 days, and median length of follow up was 5.27 months. This is the largest reported series of SIL-I in the pediatric surgery population. Our presented technique is safe, effective, and may be adopted by any pediatric surgeon with laparoscopic experience. Further studies are necessary to demonstrate both cost-effectiveness and long-term outcomes of SIL-I versus conventional laparoscopic techniques.