The purpose — to explore prevalence and clinical particularities of the pediatric multiple sclerosis in Bashkortostan Republic. Material and methods. The data of 21 children with multiple sclerosis were analyzed. The data were provided by the Republican Centre of the multiple sclerosis (Ufa) and outpatient records of the Kuvatov’s Republican Clinical Hospital (Ufa). All children were examined out patiently at the Neurology Department at the Republican Children’s Clinical Hospital (Ufa) and the polyclinics of the Republican Clinical Hospital (Ufa). Diagnosis «multiple sclerosis» (MS) was issued by McDonald criteria (2017). Results. MS affects female children more often. City residents are hit much more frequently. The onset occurs among senior schoolchildren in most cases. Most of the patients have remitting course of MS. Conclusion. The main epidemiological indicators of childhood onset MS in the Republic of Bashkortostan are comparable to those in neighboring regions of Russia, and the observed changes reflect the global trends. The study confirmed the findings of other authors on the main characteristics of childhood MS. Pediatric patients require a specialized approach to the diagnosis and careful monitoring of neurological symptoms in order to timely identify multiple sclerosis.