IntroductionEosinophilic oesophagitis (EoE) affects the quality of life (QoL) of the patients and their families. Specific quality of life questionnaires help to evaluate the QoL for this particular disease, as well as to make diagnostic or therapeutic changes in order to improve it. ObjectiveTo make a transcultural adaptation of the original English version of the Pediatric Eosinophilic Esophagitis Quality of Life Module (PedsQL EoE Module) into the Spanish language. MethodsThe PedsQL EoE Module questionnaire consists of 3 versions for parents and children from 5–7, 8–12, and 13–18 years, and one for parents of children from 2 to 4 years. It follows the international consensus methodology, consisting of performing independent translations of the original English version to Spanish, a consensus Spanish version, a back-translation into English, preliminary final version, as well as a cognitive interview with 5 parents and children of each age group in order to evaluate the comprehension of the questionnaire, and once the difficulties found are resolved, the final version. ResultsIn the cognitive interview, 15 children and 20 parents responded to all the questions. The time taken to complete the questionnaire seemed adequate to them, and the comprehension test was easy. The 5–7 years children group took the longest in responding and had more difficulty in understanding it. The overall satisfaction was high, and the questionnaire seemed to be a useful tool for them. ConclusionsAfter its validation, the transcultural adaptation to Spanish of the PedsQL EoE Module questionnaire can be applied in order to study the QoL of Spanish children with EoE.