This study investigated ICT skills and participation in Zoom meetings for professional development among librarians in universities in South-South, Nigeria. Descriptive survey research design was used for the study. The population for the study was 158 librarians in the university libraries of 12 public universities in South-south, Nigeria. Total enumeration sampling techniques was used for the study. Data were collected using questionnaire. Pearson Product Correlation was used to analyse the data. The results revealed that there was significant relationship between ICT skills and frequency of participation in Zoom meetings for professional development among librarians in various areas of job; there was significant relationship between ICT skills and extent of the benefits librarians derive from participating in Zoom meetings for professional development; there was significant relationship between ICT skills and the extent of the barriers librarians encountered with participation in Zoom meetings for professional development. It was recommended that the librarians should improve their ICT skills through regular ICT training and computer practice so that they will be ICT compliant and maximally participate in Zoom meetings for professional development.