Background and Study Aim. Grip strength is a crucial measure of human physical capability, affecting activities from daily tasks to athletic performance. Variations in arm position during grip strength measurement may influence the results, which has significant implications for both rehabilitation and functional assessment. This study explores the impact of different arm positions on grip strength to enhance understanding of human biomechanics and inform rehabilitation and sports training practices. Material and Methods. Forty right-handed male volunteers (mean age 18.27 ± 0.90 years) participated in the study. Grip strength was measured using a CAMRY Model: EH101 hand dynamometer. Measurements were taken across four arm positions: seated with elbow extension, 90-degree elbow flexion, 90-degree elbow flexion with pronation, and 90-degree elbow flexion with supination. Each position was tested three times. The highest recorded value for each position was used for analysis. Results. The dominant right hand exhibited higher grip strength across all positions compared to the non-dominant left hand. Significant differences were noted, with the greatest grip strength in the extension position. Statistical analysis using paired t-tests indicated significant differences (p < 0.001) between the right and left hands across all positions. Pearson correlation coefficients highlighted strong relationships between different arm positions. Multiple linear regression analysis showed significant predictors of grip strength variability based on arm position, age, and BMI. Conclusions. Arm position significantly influences grip strength performance, underscoring the importance of standardized positioning in ergonomics. Standardizing arm position can optimize performance and mitigate injury risks in activities requiring robust grip strength. These findings have practical implications for rehabilitation protocols, sports training programs, and ergonomic assessments. The results emphasize the need for consistency in grip strength evaluations to ensure accurate and reliable results.