Aims: To determine peanut disease control and yield response to inpyrfluxam applied at various timings during the growing season.
 Study Design: Randomized complete block design with 4 reps.
 Place and Duration of Study: Field studies were conducted from 2016 through 2020 in the south Texas peanut growing region near Yoakum (29.276o N, 97.123o W).
 Methodology: Fungicides were applied with a CO2-propellant sprayer. The spray boom was equipped with three D2-23 hollow-cone spray nozzles per row with the middle nozzle centered over each plant in the row and another nozzle located as such to spray on each side of the plant to provide thorough coverage with a spray volume was 187 L ha-1. Some studies included a non-treated control while other studies included chlorothalonil only at 1.26 kg ha-1 as the comparison treatment. Each plot consisted of four rows spaced 97 cm apart and 7.9 m long.
 Results: Inpyrfluxam applied twice in a 4 to 5 fungicide spray program in combination with chlorothalonil provided early leaf spot control as good as or better than the standards of chlorothalonil plus either azoxystrobin alone or azoxystrobin plus benzovindiflupyr applied 2 times. Control of Rhizoctonia pod rot, caused by Rhizoctonia solani Kuhn, with inpyrfluxam at 0.04, 0.05. 0.075, or 0.1 kg ai ha-1 applied 2 times during the growing season was comparable to two applications of azoxystrobin at 0.22 kg ai ha-1. Control of southern blight, caused by Sclerotium rolfsii Sacc., with one to two applications of inpyrfluxam at 0.05 to 0.1 kg ha-1 was comparable to azoxystrobin plus benzovindiflupyr. Peanut yield response was influenced by the level of soilborne and foliar disease control exhibited with each fungicide program, as those programs which provided the best control also produced the highest yield.
 Conclusion: These studies show the ability of inpyrfluxam to provide control of multiple diseases found in southwest peanut production.