The variations in the free surface of Lake Baikal at three stations (Bol’shie Koty, Listvyanka, and Baikal’sk) are measured. A modern recording method and an advanced technique of record processing are used. Based on 1-year-long observation data, the amplitudes of seiche oscillations and their seasonal changes are analyzed. It is found, in particular, that 67-min seiches are manifested in different seasons. Numerical calculations of seiches in Lake Baikal are made with the use of up-to-date bathymetric data on one-dimensional, plan, and spherical models. Spatial structures of oscillations with periods of 277, 152, 84, 67, and 59 min, corresponding to the well-expressed peaks of power spectral density, are studied. It is shown that the first four periods correspond to uninodal, binodal, trinodal, and quadrinodal longitudinal seiche modes of Lake Baikal. The periods of three solutions can correspond to the value of 59 min. The first of them is the seiche of the lake’s South Basin, and two others are characterized by significant amplitude growth in the Small Sea and Chivyrkui Bay.