Peak Locomotor Research Articles

Analysis of Peak Locomotor Demands in Professional Female Soccer Players: An Approach Based on Position and the Day of the Microcycle

Analysis of Peak Locomotor Demands in Professional Female Soccer Players: An Approach Based on Position and the Day of the Microcycle

Analysis of peak locomotor demands in women's football-the influence of different epoch lengths.

The quantification of peak locomotor demands has been gathering researchers' attention in the past years. Regardless of the different methodological approaches used, the most selected epochs are between 1-, 3-, 5- and 15-minutes time windows. However, the selection of these time frames is frequently arbitrary. The aim of this study was to analyse the peak locomotor demands of short time epochs (15, 30, 45, and 60 seconds) in women's football, with special emphasis over the high-speed metrics. During two seasons, the match physical performance of 100 female football players was collected with Global Positioning System units (STATSports Apex). Peak locomotor demands for the selected variables were calculated by using a 1-second moving average approach. For statistical procedures, linear mixed modelling was used, with total distance, high-speed running distance (>16 km∙h-1), sprint distance (>20 km∙h-1), and acceleration and deceleration distance (±2.26 m∙s-2) considered as the dependent variables and the epoch lengths (15, 30, 45, and 60 seconds) considered as the independent variables. A novel finding was the high ratio observed in the 15 seconds epochs of high-speed running distance and sprint distance (77.6% and 91.3%, respectively). The results show that most peak high-speed demands within 60 seconds are completed within just 15 seconds. Thus, intensity-related variables, such as high-speed metrics, would be better contextualised and adapted into training practices if analysed in shorter epoch lengths (15-30 seconds), while longer periods might be used for volume-related metrics (i.e., total distance), depending on the purpose of the analysis.

Need a break? The locomotor and tackle pacing profile and loads of women’s rugby league match-play following various between-match turnaround durations

ABSTRACT Objectives The study investigated the locomotor and tackle pacing profile and loads of female rugby league players following various between-match turnaround durations. Specifically, the study examined the (1) pacing of locomotor and tackle loads across the time-course of a match and; (2) whole-match and peak locomotor and tackle loads of match-play. Methods Microtechnology data were collected from elite female rugby league players (n = 172) representing all National Rugby League Women’s teams (n = 6 teams) across two seasons. Players were categorised into backs, adjustables, forwards or interchange players. Data was calculated for the whole-match (m), per minute (m.min−1) and peak (running: m.min−1; acceleration: m.s−2) locomotor and tackle loads (number and efficiency (%)) of match-play. The pacing as well as the locomotor and tackle loads of match-play were examined following short (≤6 days), normal (7 days) or long (≥8 days) turnarounds. Results The pacing profile of playing positions varied across short, normal and long match turnarounds. Trivial to moderate differences existed in the whole-match, per minute and peak locomotor loads across match turnaround durations (effect size ≤ 1.2). Conclusions Following various between-match turnaround durations (i.e., short, normal and long match turnarounds), there were variations in the locomotor and tackle pacing profile and loads whereby, the pacing profile of positional groups was more affected than the load profile. The findings can be used in applied settings to guide the recovery strategies and training plans of female rugby league players to optimise performance and wellbeing across various match turnaround durations.

The influence of age on the match-to-match variability of physical performance in women's elite football.

Introduction: The fluctuation of external match load throughout a season is influenced by several contextual factors. While some, have been deeply analysed in men's football literature, information is lacking on how other contextual elements, such as player's age or experience, may affect the match-to-match variability of locomotor activities. In fact, aging has been described as a multifactorial process with the potential to affect human performance. The aim of this study is to assess if the variability of match locomotor performances fluctuates according to the players' age. Methods: 59 female players from four top-level clubs were divided into three age groups and monitored during two seasons using GPS APEX (STATSports, Northern Ireland), with a sampling frequency of 10Hz, in 150 official matches to determine the coefficient of variation (CV) of full-match and 1-min peak locomotor demands of total distance (TD), high-speed running distance, sprint distance (SpD), accelerations, and decelerations. To test whether there was a group effect of age on match-to-match variability we used a one-way ANOVA with CV% as the independent variable. Results: CV values of full match variables ranged from 3.8% to 27.8%, with total distance (3.8%) in the peak age group and SpD (27.8%) in the pre-peak age group. Similarly, CV values of 1-min peaks ranged from 4.1% (post-peak group) in TD to 22.3% (peak group) in SpD. Discussion: The main finding was that there were no significant differences between the different age groups in the metrics analysed although trends indicate less variability in the post-peak age group.

Soccer-drill specificity in top-class male players with reference to peak match locomotor demands

ABSTRACT To compare the locomotor demands of several ball/running drills with the official match peak, locomotor demands determined across different time-windows of the same duration in top-class male soccer players (n = 40). Total distance (TD), high-speed running (HSR, 15–20 km⋅h−1), very high-speed running (VHSR, 20–24 km⋅h−1), sprint and acceleration+deceleration (Acc+Dec >±3 m⋅s−2) distances were measured during training and official matches. A total of 9372 individual observations were classified as technical-tactical drills, small-sided games (SSGs), super-SSGs (pitch-area >340 m2·player), SSGs with rules modifications (SSGmodified), individual positional drills or running drills. The relative (m·min−1) TD, HSR, VHSR, sprint and Acc+Dec were compared with the peak locomotor demands determined during official matches across different time-windows (1, 2, 3, 4 and 5-min). Individual position-specific drill, super-SSGs, SSGmodified and running drills showed similar (P > 0.05) or higher (P < 0.05; ES:1.17/4.61) than match TD, HSR and VHSR, while sprint and Acc+Dec were lower (P < 0.05). Conversely, technical-tactical drills and SSGs showed lower (P < 0.05; ES:-1.00/-3.45) TD, HSR, VHSR, sprint and Acc+Dec than official match peak demands. Locomotor loads during technical-tactical drills and SSGs were lower than peak demands, particularly for VHSR and sprint. Since training intensity is a key factor for high-performance development, these results may help to prepare top-class players for the official match peak demands.

Monitoring physical match performance relative to peak locomotor demands: implications for training professional soccer players.

This study aimed to analyse physical performance relative to peak locomotor demands of match play. Data were collected during 13 professional soccer matches. Initially, the 1-minute peak values were registered in each match, including the percentage of the total distance (TD), high-speed running distance (HSRD), sprinting distance (SPD), and high-metabolic load distance (HMLD), and a total of high-intensity accelerations and decelerations (Acc+Dec). Secondly, the time (measured in minutes) spent at different percentage ranges for the 1-minute peak values registered in each match was calculated. Thirdly, the physical performance required in the different percentage ranges for the 1-minute peak values were obtained. Finally, the time and physical performance required above the 90-minute average demands were calculated. The 90-minute average for all playing positions represented ~53% of the total distance (TD), ~23.4% of high-metabolic load distance (HMLD), ~16% of high-speed running distance (HSRD), ~11% of the total of high-intensity accelerations and decelerations (Acc+Dec), and ~6% of sprinting distance (SPD) for the 1-minute peak values. Likewise, statistically significant differences (p < 0.05) in the physical performance and time spent between specific percentage ranges for the 1-minute peak locomotor demands were also noted. In addition, all the variables reported that the physical performance required for above 90-minute average demands were significantly greater (p < 0.05) than the 90-minute average demands. Therefore, these findings may guide the prescription of training intensity by considering the physical performance relative to the peak locomotor demands of match play.

Peak Locomotor Intensity in Elite Handball Players: A First Insight Into Player Position Differences and Training Practices.

Fleureau, A, Rabita, G, Leduc, C, Buchheit, M, and Lacome, M. Peak locomotor intensity in elite handball players: a first insight into player position differences and training practices. J Strength Cond Res 37(2): 432-438, 2023-The aims of the study were to (a) describe the peak locomotor intensity sustained during handball matches and (b) compare them with small-sided games (SSGs) programmed during training in elite handball players. Small-sided game ( n = 342) and match ( n = 121) data were collected among 11 players (25 ± 7 years, 191 ± 8 cm, 89 ± 12 kg) belonging to an elite French Handball team. Players' locomotor activity was recorded using 20-Hz Local Positioning System. Peak total (TD[m]) and high-speed running distance (HS[m]) and mechanical load (Accel'Rate [a.u.]) were calculated during different time periods (1-15 minutes different rolling averages). A plot of log (locomotor variables) against log (time) allowed to obtain a straight line with a slope and an intercept for each variable. Between-position differences during matches and difference between matches and SSGs were assessed with linear mixed model and magnitude-based decisions. Almost certainly higher peak locomotor intensity (intercept) was found in Wingers (TD: 156 ± 13; HS: 96 ± 12; Accel'Rate: 13 ± 3) compared with other playing positions for TD (Back players: 127 ± 10; Pivots: 136 ± 13), HS (Back players: 56 ± 9; Pivots: 57 ± 11), and Accel'Rate (Back players: 11 ± 2; Pivots: 11 ± 2). However, no clear between-position difference was found regarding the slope. Additionally, none of the SSGs format produced an overload in peak locomotor intensity in comparison with matches (TD: 138 ± 16; HS: 66 ± 20; Accel'Rate: 12 ± 2). Because reaching the peak locomotor intensity sustained during match is not possible using SSGs, practitioners should consider using isolated conditioning drills (e.g., short or long intervals, repeated sprints). Moreover, specific attention should be paid for Winger's work supplementation because they present the highest peak locomotor intensity in the team.

The variability of physical match demands in elite women’s football

ABSTRACT Peak locomotor demands are considered as key metrics for conditioning drills prescription and training monitoring. However, research in female football has focused on absolute values when reporting match demands, leading to sparse information being provided regarding the degrees of variability of such metrics. Thus, the aims of this study were to investigate the sources of variability of match physical performance parameters in female football players and to provide a framework for the interpretation of meaningful changes between matches. 54 female players from four top-level clubs were monitored during one season. GPS APEX (STATSports, Northern Ireland), with a sampling frequency of 10 Hz, were used in 60 official matches (n = 393) to determine the full-match and 1-min peak locomotor demands of total distance (TD), high-speed running distance (HSRD), sprint distance (SpD), accelerations and decelerations (Acc/Dec) and peak speed (Pspeed). For each variable, the between-team, between-match, between-position, between-player, and within-player variability was estimated using linear mixed-effect modelling. With exception to SpD (29.4 vs. 31.9%), all other metrics presented a higher observed match-to-match variability in the 1-min peaks than in the full-match (6.5 vs. 4.6%; 18.7% vs. 15.9%; 12.9 vs. 11.7%; for TD, HSRD and Acc/Dec, respectively). With the exception of SpD, higher changes in 1-min peaks than in full-match values are required to identify meaningful changes in each variable. Different sources of variability seem to impact differently the match physical performance of female football players. Furthermore, to identify meaningful changes, higher changes in 1-min peaks than in full-match values are required.

The peak locomotor characteristics of Super League (rugby league) match-play

ABSTRACT This study quantified the position-, duration-, and phase-of-play specific peak locomotor characteristics of senior professional rugby league match-play at a multi-club level. Match-play data were collected from 378 male professional rugby league players, from 11 clubs, across two competitive seasons. A total of 9643 match-observations were analysed; 10-Hz instantaneous velocity and acceleration from Catapult S5 microtechnology units were aligned with video footage to determine to the phase-of-play and duration-specific peak locomotor characteristics (average running speed, relative high-speed running [HSR;>5.5 m·s−1], average absolute acceleration). Linear mixed effect models were used to determine positional differences for each dependent variable and differences between phases-of-play. Positional differences for the duration-specific and phase-of-play peak locomotive characteristics were identified. Fullbacks had greater peak HSR during defensive sets (86 ± 70 m·min−1) vs. all other positions (effect size = 0.26 to 0.49, small). Wingers demonstrated the greatest between phase differences with greater peak locomotor characteristics (effect size = 1.23 to 1.65, large) during attacking-defensive set transition vs. defensive sets. The multi-club normative data, and the differences identified, provides practitioners with valuable information for the consideration of training practices; the incorporation of phases-of-play enables greater consideration of technical-tactical factors whilst preparing players for the peak periods of competition.

Women's Rugby League: Positional Groups and Peak Locomotor Demands.

The aims of this study were to (a) use a data-based approach to identify positional groups within National Rugby League Women's (NRLW) match-play and (b) quantify the peak locomotor demands of NRLW match-play by positional groups. Microtechnology (Global Navigational Satellite System [GNSS] and integrated inertial sensors; n = 142 files; n = 76 players) and match statistics (n = 238 files; n = 80 players) were collected from all NRLW teams across the 2019 season. Data-based clustering of match statistics was utilized to identify positional clusters through classifying individual playing positions into distinct positional groups. Moving averages (0.5, 1, 2, 3, 5, and 10 min) of peak running and average acceleration/deceleration demands were calculated via microtechnology data for each player per match. All analysis was undertaken in R (R Foundation for Statistical Computing) with positional differences determined via a linear mixed model and effect sizes (ES). Data-based clustering suggested that, when informed by match statistics, individual playing positions can be clustered into one of three positional groups. Based on the clustering of the individual positions, these groups could be broadly defined as backs (fullback, wing, and center), adjustables (halfback, five-eighth, and hooker), and forwards (prop, second-row, and lock). Backs and adjustables demonstrated greater running (backs: ES 0.51–1.00; p < 0.05; adjustables: ES 0.51–0.74, p < 0.05) and average acceleration/deceleration (backs: ES 0.48–0.87; p < 0.05; adjustables: ES 0.60–0.85, p < 0.05) demands than forwards across all durations. Smaller differences (small to trivial) were noted between backs and adjustables across peak running and average acceleration/deceleration demands. Such findings suggest an emerging need to delineate training programs in situations in which individual playing positions train in positional group based settings. Collectively, this work informs the positional groupings that could be applied when examining NRLW data and supports the development of a framework for specifically training female rugby league players for the demands of the NRLW competition.

Locomotor characteristics of the women’s inaugural super league competition and the rugby league world cup

ABSTRACT Understanding the locomotor characteristics of competition can help rugby league (RL) coaches optimise training prescription. To date, no research exists on the locomotor characteristics of women’s RL. The aim was to compare whole match and peak locomotor characteristics of women’s RL competition at international (RL World Cup [WRLWC]) and domestic level (Super League [WSL]). Microtechnology data were collected from 58 players from 3-WSL clubs and 1-WRLWC team. Participants were classified into forwards (n = 30) and backs (n = 28). Partial least squares correlation analysis established which variables were important to discriminate between the level of competition (international vs. domestic) and positional group (forwards vs. backs). Linear mixed-effects models estimated the differences between standards of competition and positional group for those variables. International forwards were most likely exposed to greater peak 1-min average acceleration (standardised mean difference = 1.23 [0.42 to 2.04]) and peak 3-min average acceleration (1.13 [0.41 to 1.85]) than domestic forwards. International backs likely completed greater peak 1-min average acceleration (0.83 [0.08 to 1.58]) than domestic backs and possibly greater high-speed-distances (0.45 [−0.17 to 1.07]). Findings highlight the need for positional specific training across levels to prepare representative players for the increased match characteristics of international competition.

Biomechanical insights into the role of foot pads during locomotion in camelid species

From the camel’s toes to the horse’s hooves, the diversity in foot morphology among mammals is striking. One distinguishing feature is the presence of fat pads, which may play a role in reducing foot pressures, or may be related to habitat specialization. The camelid family provides a useful paradigm to explore this as within this phylogenetically constrained group we see prominent (camels) and greatly reduced (alpacas) fat pads. We found similar scaling of vertical ground reaction force with body mass, but camels had larger foot contact areas, which increased with velocity, unlike alpacas, meaning camels had relatively lower foot pressures. Further, variation between specific regions under the foot was greater in alpacas than camels. Together, these results provide strong evidence for the role of fat pads in reducing relative peak locomotor foot pressures, suggesting that the fat pad role in habitat specialization remains difficult to disentangle.

Foot pressure distribution in White Rhinoceroses (Ceratotherium simum) during walking.

White rhinoceroses (Ceratotherium simum) are odd-toed ungulates that belong to the group Perissodactyla. Being second only to elephants in terms of large body mass amongst extant tetrapods, rhinoceroses make fascinating subjects for the study of how large land animals support and move themselves. Rhinoceroses often are kept in captivity for protection from ivory poachers and for educational/touristic purposes, yet a detrimental side effect of captivity can be foot disease (i.e., enthesopathies and osteoarthritis around the phalanges). Foot diseases in large mammals are multifactorial, but locomotor biomechanics (e.g., pressures routinely experienced by the feet) surely can be a contributing factor. However, due to a lack of in vivo experimental data on rhinoceros foot pressures, our knowledge of locomotor performance and its links to foot disease is limited. The overall aim of this study was to characterize peak pressures and center of pressure trajectories in white rhinoceroses during walking. We asked two major questions. First, are peak locomotor pressures the lowest around the fat pad and its lobes (as in the case of elephants)? Second, are peak locomotor pressures concentrated around the areas with the highest reported incidence of pathologies? Our results show a reduction of pressures around the fat pad and its lobes, which is potentially due to the material properties of the fat pad or a tendency to avoid or limit “heel” contact at impact. We also found an even and gradual concentration of foot pressures across all digits, which may be a by-product of the more horizontal foot roll-off during the stance phase. While our exploratory, descriptive sample precluded hypothesis testing, our study provides important new data on rhinoceros locomotion for future studies to build on, and thus impetus for improved implementation in the care of captive/managed rhinoceroses.

Moult-related reduction of aerobic scope in passerine birds.

It is well established that the nutrient and energy requirements of birds increase substantially during moult, but it is not known if these increased demands affect their aerobic capacity. We quantified the absolute aerobic scope of house and Spanish sparrows, Passer domesticus and P. hispaniolensis, respectively, before and during sequential stages of their moult period. The absolute aerobic scope (AAS) is the difference between maximum metabolic rate (MMR) during peak locomotor activities and minimum resting metabolic rate (RMRmin), thus representing the amount of aerobic power above that committed to maintenance needs available for other activities. As expected, RMRmin increased over the moult period by up to 40 and 63% in house and Spanish sparrows, respectively. Surprisingly, the maximum metabolic rates also decreased during moult in both species, declining as much as 25 and 38% compared with pre-moult values of house and Spanish sparrows, respectively. The concurrent changes in RMRmin and MMR during moult resulted in significant decreases in AAS, being up to 32 and 47% lower than pre-moult levels of house and Spanish sparrows, respectively, during moult stages having substantial feather replacement. We argue that the combination of reduced flight efficiency due to loss of wing feathers and reduced aerobic capacity places moulting birds at greater risk of predation. Such performance constraints likely contribute to most birds temporally separating moult from annual events requiring peak physiological capacity such as breeding and migration.

The peak duration-specific locomotor demands and concurrent collision frequencies of European Super League rugby

ABSTRACTUnderstanding the most demanding passages of European Super League competition can optimise training prescription. We established positional and match half differences in peak relative distances (m·min−1) across durations, and the number of collisions, high-speed- and very-high-speed-distance completed in the peak 10 min period. Moving-averages (10 s, 30 s, 1 min, 5 min, 10 min) of instantaneous speed (m·s−1) were calculated from 25 professional rugby league players during 25 matches via microtechnology. Maximal m·min−1 was taken for each duration for each half. Concurrently, collisions (n), high-speed- (5 to 7 m·s−1; m) and very-high-speed-distance (> 7 m·s−1; m) were coded during each peak 10 min. Mixed-effects models determined differences between positions and halves. Aside from peak 10 s, trivial differences were observed in peak m·min−1 between positions or halves across durations. During peak 10 min periods, adjustables, full- and outside-backs ran more at high-speed and very-high-speed whilst middle- and edge-forwards completed more collisions. Peak m·min−1 is similar between positional groups across a range of durations and are maintained between halves of the match. Practitioners should consider that whilst the overall peak locomotor “intensity” is similar, how they achieve this differs between positions with forwards also exposed to additional collision bouts.

Small-Sided Games in Elite Soccer: Does One Size Fit All?

To compare the peak intensity of typical small-sided games (SSGs) with those of official matches in terms of running demands and mechanical work (MechW) over different rolling average durations and playing positions. Data were collected in 21 players (25 [5] y, 181 [7] cm, and 77 [7] kg) belonging to an elite French football team. SSG data were collected over 2 seasons during typical training sessions (249 files, 12 [4] per player) and official matches (n = 12). Players' locomotor activity was recorded using 5-Hz Global Positioning System. Total distance(m), high-speed distance (HS, distance above 14.4km·h-1, m), and MechW (a.u.) were analyzed during different rolling average periods (1-15min). The SSGs examined were 4v4+goalkeepers (GKs), 6v6+GKs, 8v8+GKs, and 10v10+GKs. Peak total distance and HS during 4v4, 6v6, and 8v8 were likely-to-most likely lower than during matches (effect size: -0.59 [±0.38] to -7.36 [±1.20]). MechW during 4v4 was likely-to-most likely higher than during matches (1-4min; 0.61 [±0.77] to 2.30 [±0.64]). Relative to their match demands, central defenders performed more HS than other positions (0.63 [±0.81] to 1.61 [±0.52]) during 6v6. Similarly, central midfielders performed less MechW than the other positions during 6v6 (0.68 [±0.72] to 1.34 [±0.99]) and 8v8 (0.73 [±0.50] to 1.39 [±0.32]). Peak locomotor intensity can be modulated during SSGs of various formats and durations to either overload or underload match demands, with 4v4 placing the greatest and the least emphasis on MechW and HS, respectively. Additionally, in relation to match demands central defenders and central midfielders tend to be the most and least overloaded during SSGs, respectively.

Octopamine cyclic release and its modulation of visual sensitivity in crayfish

The biogenic amine octopamine (OA) modulates invertebrate behavior by changing neuronal responses from sensory inputs to motor outputs. However, the OA modulation of visual sensitivity and its possible coupling to diurnal cycles remains unexplored. Here we studied the diurnal variations in the OA levels in the hemolymph of the crayfish Procambarus clarkii, its release from the structures in the eyestalk and its modulation of the retinal light sensitivity. The hemolymph concentration of OA and its amino acid precursor tyrosine was measured by high-resolution liquid chromatography; OA varied along the 24-hcycle. The peak value appeared about 2h before the light offset which preceded the peak locomotor activity. OA was found in every structure of the eyestalk but displayed higher levels in the retina–lamina ganglionaris. Moreover, OA was released from isolated eyestalks at a rate of 92nmol/eyestalk/min and a calcium-dependent release was evoked by incubation in a high potassium solution. OA injected into dark-adapted crayfish or applied to the isolated retina at concentrations of 1, 10 and 100μM produced a proportionally increasing reduction in the amplitude of the photoreceptor light responses. These OA concentrations did not affect the position of the visual accessory pigments. Our results suggest that OA release in the crayfish eyestalk is coupled to the 24-hcycle to regulate the diurnal reduction of the photoreceptor sensitivity and to favor the expression of exploratory locomotion during the dark phase of the circadian cycle.

What do metabolic rates tell us about thermal niches? Mechanisms driving crayfish distributions along an altitudinal gradient.

Humans are rapidly altering thermal landscapes, so a central challenge to organismal ecologists is to better understand the thermal niches of ectotherms. However, there is much disagreement over how we should go about this. Some ecologists assume that a statistical model of abundance as a function of habitat temperature provides a sufficient approximation of the thermal niche, but ecophysiologists have shown that the relationship between fitness and temperature can be complicated, and have stressed the need to elucidate the causal mechanisms underlying the response of species to thermal change. Towards this end, we studied the distribution of two crayfishes, Euastacus woiwuru and Euastacus armatus, along an altitudinal gradient, and for both species conducted experiments to determine the temperature-dependence of: (1) aerobic scope (the difference between maximum and basal metabolic rate; purported to be a proxy of the thermal niche); and (2) burst locomotor performance (primarily fuelled using anaerobic pathways). E. woiwuru occupied cooler habitats than E. armatus, but we found no difference in aerobic scope between these species. In contrast, locomotor performance curves differed significantly and strongly between species, with peak locomotor performances of E. woiwuru and E. armatus occurring at ~10 and ~18 °C, respectively. Crayfish from different thermal landscapes may have similar aerobic thermal performance curves but different anaerobic thermal performance curves. Our results support a growing body of literature implying different components of ectotherm fitness have different thermal performance curves, and further challenge our understanding of the ecology and evolution of thermal niches.

In vivo potency and efficacy of the novel cathinone α-pyrrolidinopentiophenone and 3,4-methylenedioxypyrovalerone: self-administration and locomotor stimulation in male rats.

Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"). This study aimed to directly compare the efficacy and potency of alpha-PVP with that of MDPV. Groups of male Wistar rats were trained in the intravenous self-administration (IVSA) alpha-PVP or MDPV under a fixed-ratio 1 schedule of reinforcement. An additional group was examined for locomotor and body temperature responses to noncontingent administration of MDVP or alpha-PVP (1.0, 5.6, and 10.0 mg/kg, i.p.). Acquisition of alpha-PVP (0.1 mg/kg/infusion) IVSA resulted in low, yet consistent drug intake and excellent discrimination for the drug-paired lever. Dose substitution (0.05-0.25 mg/kg/infusion) under a fixed-ratio 1 schedule confirmed potency was similar to MDPV in prior studies. In direct comparison to MDPV (0.05 mg/kg/infusion), rats trained on alpha-PVP (0.05 mg/kg/infusion) responded for more infusions but demonstrated similar drug-lever discrimination by the end of acquisition. However, the dose-response (0.018-0.56 mg/kg/infusion) functions of these drugs under a progressive-ratio schedule of reinforcement reflected identical efficacy and potency. Peak locomotor responses to MDPV or alpha-PVP were observed after the 1.0 mg/kg, i.p. dose and lasted ∼2 h. Modest body temperature decreases were of similar magnitude (∼0.75 °C) for each compound. The potency and efficacy of MDPV and alpha-PVP were very similar across multiple assays, predicting that the abuse liability of alpha-PVP will be significant and similar to that of MDPV.

Cholinergic manipulation of motor disability and l-DOPA-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated common marmosets

Anti-cholinergic drugs are used in the treatment of Parkinson’s disease (PD) and they can improve motor disability in some patients and may alter the expression of dyskinesia. We report the effects of anticholinergic and pro-cholinergic agents administered alone and combined with L-DOPA, on motor function in 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated common marmosets. Administration of atropine to MPTP-treated marmosets, not previously exposed to L-DOPA, improved motor disability but this did not occur with other centrally acting anti-cholinergics. Motor disability was worsened by centrally acting pro-cholinergics. However, neither peripherally acting anti- nor pro-cholinergics produced any effect on motor disability or dyskinesia. In MPTP-treated marmosets previously primed with L-DOPA to exhibit dyskinesia, acute L-DOPA challenge induced both chorea and dystonia. In these animals, centrally acting anti-cholinergics including atropine and trihexyphenidyl reversed motor deficits, but induced chorea. Combined with L-DOPA, both centrally and peripherally acting anti-cholinergics reduced peak locomotor activity and produced more chorea than dystonia compared to L-DOPA alone. Centrally acting pro-cholinergics decreased locomotor activity, worsened motor disability and induced dystonia. Co-administered with L-DOPA, pro-cholinergics reduced locomotor activity and decreased chorea while increasing dystonia compared with L-DOPA alone. In conclusion, anti-cholinergics can increase chorea with and without L-DOPA but improve motor disability. Pro-cholinergics decrease the proportion of chorea when combined with L-DOPA, increase motor disability and antagonise L-DOPA’s effectiveness. These data suggest that there may be a case for revisiting the use of anti-cholinergic drugs in the treatment of PD.