Background: Healthcare big data has become an important strategic resource, and the study of applying it to the rational application of antimicrobial drugs is of great significance in improving and optimizing the various tasks of medicine and health and promoting the development of social health. Based on its own characteristics, the issue of data quality has important research value in promoting data output and application. Objective: To optimize the status quo of antimicrobial drug use in medical institutions, to explore the value of healthcare big data, and to explore the data governance methods in the era of digital intelligence in order to build a good ecosystem for the application of healthcare big data. Methods: This paper constructs a set of intelligent full-closed-loop antimicrobial rational application management platform integrated with data quality, adopts PDCA cycle management mode, analyzes the problems in the process of applying healthcare big data and gives the corresponding solutions, authorizes according to the personnel's duties, and guarantees the data security. Results: Since the platform went online in January 2021, the antimicrobial drug use intensity indicator of a hospital has decreased year by year from 38 to 34.4 as of June 2023, effectively standardizing the use of antimicrobial drugs. The time consumed for the statistics of antimicrobial use intensity related data has decreased from an average of 30min to 2min, which has significantly improved the work efficiency.Healthcare professionals are able to monitor indicator data in real time, with or without abnormal cases, and fully grasp the trend of indicators. At the same time, the patient's medication can be viewed at any time, and the condition can be grasped in a timely manner. Conclusions: The platform not only effectively solves the problem of information barriers, but also accurately determines the data source and statistical logic of indicator collection, reflecting the actual clinical diagnosis and treatment, and at the same time greatly reduces labor costs and optimizes the workflow.The practical experience of platform construction has important reference significance for the governance and application of healthcare big data, which provides data support and technical guarantee for the scientific, standardized and refined management of hospitals.