AbstractSystematic phase formation studies in the system MnII/TeIV/O/‐(H) using either solid‐state reactions between stoichiometric MnO:TeO2 mixtures or hydrothermal reactions under basic conditions led to crystal growth of two polymorphs (α‐, γ‐) of MnTeO3, Mn6Te5O16, Mn15(TeO3)14(OH)2 and Mn3(TeO3)2(OH)2. Although α‐MnTeO3 and Mn6Te5O16 have been reported previously, crystal structure refinements were missing so far. Whereas α‐MnTeO3 crystallizes in a unique structure (space group Pbca, Z=16), Mn6Te5O16 (Pnma, Z=4) is isotypic with its Co‐homologue. The previously unknown phases γ‐MnTeO3 (Pbca, Z=8), Mn15(TeO3)14(OH)2 ( , Z=3) and Mn3(TeO3)2(OH)2 (P63mc, Z=4) all have isotypic relationships, namely with ZnTeO3, Co15(TeO3)14F2 and M3(TeO3)2(OH)2 (M=Ni, Co), respectively. Common to all crystal structures of the five manganese(II) oxidotellurate(IV) phases is the presence of [MnO5] or [MnO6] polyhedra and isolated trigonal‐pyramidal [TeO3] groups (except for one of the TeIV atoms in Mn6Te5O16 [TeO4] bisphenoids) as principal building units, which share corners and edges with the [MnO5/6] groups. The resulting three‐dimensional frameworks are dominated by the influence of the stereochemically active 5 s2 electron lone pair situated at the TeIV atom, leading to the formation of channels or interstices. Quantitative comparisons between the corresponding isotypic crystal structures are given.