To investigate whether synthetic (s) glucocorticoids (GCs) administrated between 24th and 34th gestational weeks in pre-term labor, might precipitate labor, studies upon sGCs administration were reviewed. Physiology of endogenous glucocorticoids-related increase in fetal-maternal circulation and its association with labor, followed by a scoping review with studies on exogenous sGCs administrated for fetal lung maturation and the timing of labor were included. Methodology of systematic reviews was followed. MEDLINE, Cochrane library and Google Scholar databases were searched till October 2023, for original studies investigating administration of sGCs in pregnancies risking pre-term labor. Duplicates were removed and 1867 abstracts were excluded as irrelevant. Six controlled and four non-controlled studies were included. The index group consisted of 6001 subjects and 7691 controls in the former, while in the latter the index group consisted of 2069 subjects. In three out of the six controlled studies, gestational age at labor was significantly lower in sGCs-treated women than in controls, while in three studies gestational age at labor was lower in sGCs-treated women than in controls with a trend of statistical significance . In one study, gestational age at labor was significantly lower in controls than in sGCs-treated women. In the non-controlled studies, the majority of women delivered less than one week from the day of sGCs administration. In this scoping review, studies lack homogeneity. However, in the controlled studies, a pattern of earlier labor emerges among sGCs-treated pregnant women. The use of multiple courses of ante-natal sGCs appears to be associated to precipitated labor. Their use should be carefully weighed. Carefully designed trials should examine this still open scientific query.