Injection Pattern Research Articles

Improving the spatial resolution of electrical impedance tomography using logical operation as post-processing

Abstract Electrical impedance tomography is a nondestructive tomographic technique used to estimate the internal structures of objects. Obtaining a tomograph image is synonymous with solving an inverse problem. Since the inverse problem is ill-posed, the obtained solution contains errors, resulting in degradation of the spatial resolution. This paper proposes a post-processing method to improve the spatial resolution. In the post-process, two tomograph images obtained using different solving parameters were logically combined. By combining tomograph images obtained with different hyperparameters and current injection patterns, the spatial resolutions regarding the position and size of foreign objects were improved.

A Three-Step Data-Driven Methodology to Assess Adherence to Basal Insulin Therapy in Patients With Insulin-Treated Type 2 Diabetes.

While health care providers (HCPs) are generally aware of the challenges concerning insulin adherence in adults with insulin-treated type 2 diabetes (T2D), data guiding identification of insulin nonadherence and understanding of injection patterns have been limited. Hence, the aim of this study was to examine detailed injection data and provide methods for assessing different aspects of basal insulin adherence. Basal insulin data recorded by a connected insulin pen and prescribed doses were collected from 103 insulin-treated patients (aged ≥18 years) with T2D from an ongoing clinical trial (NCT04981808). We categorized the data and analyzed distributions of correct doses, increased doses, reduced doses, and missed doses to quantify adherence. We developed a three-step model evaluating three aspects of adherence (overall adherence, adherence distribution, and dose deviation) offering HCPs a comprehensive assessment approach. We used data from a connected insulin pen to exemplify the use of the three-step model to evaluate overall, adherence, adherence distribution, and dose deviation using patient cases. The methodology provides HCPs with detailed access to previously limited clinical data on insulin administration, making it possible to identify specific nonadherence behavior which will guide patient-HCP discussions and potentially provide valuable insights for tailoring the most appropriate forms of support.

A numerical study on the optimization of the slit shape of a jet injection propeller

The shape of the slit that injects the jet from the surface of the propeller was optimized through numerical computations. The high-pressure drop on the propeller surface caused by jet injection could be improved by modifying the hydrofoil geometry of the propeller. As the cover length increased and the slit was located at the center of the propeller, the volume of jets leading to the trailing edge increased, and the propulsion performance was improved. As the height of the slit increased, the thrust increased due to the Coanda effect, and the torque decreased because of the thrust of the jet. The jet injection pattern differed according to the area of the slit and tunnel, which caused a difference in the propeller performance. The jet pattern changed according to the area of the slit and tunnel, leading to a change in propeller performance. It was effective in improving the efficiency by injecting from as wide an area as possible, and the efficiency was improved by approximately 2 % considering the pump efficiency through optimization of the slit shape.

A low-cost, portable 32-channel EIT system with four rings based on AFE4300 for body composition analysis

A proposed low-cost, portable, 32-channel (4 rings of 8-channel) Electrical Impedance Tomography (EIT) system based on the AFE4300 analog front-end for body composition measurement. Each ring allows obtaining the conductivity distribution of 4 cross sections, 4 cm apart; to analyze the behavior of conductivity in a volume. The switching of the 4 rings and the current injection and voltage measurement patterns are done with three Texas Instruments 74HC4067 multiplexers, which are managed by an ESP32 board. The proposed system has an average signal-to-noise ratio of 74.71 dB and a frame rate of 50 fps. The sensitivity tests to impedance and volume changes consisted of introducing 4 tubes of different diameters (2 steel and 2 polyvinyl chloride) into a tank with saline solution; then conductivity distribution images were generated in 4 cross-sections of the tank, using the algorithms Gauss-Newton and Noser. Finally, the global impedance index (GI) is calculated to estimate the volume of each tube inside the tank. The results show that the proposed system is highly sensitive to impedance and volume changes, being a promising system for monitoring tissues, and fluids biological.

Electrical impedance tomography for pulmonary function monitoring without dorsal electrodes

Electrical impedance tomography (EIT) is a non-invasive technology that can visualize conductivity changes inside human body in real time using multiple surface electrodes. For convenience of wearing and application, if no electrodes are attached to the back, a commonly used image reconstruction approach produces poor images of dorsal region. In this study, we developed a special current injection and voltage measurement pattern to well reconstruct the conductivity distribution inside the body even in the absence of dorsal electrodes. The proposed method has proven through numerical and phantom experiments.

Biodistribution-based Administration of cGMP-compliant Human Umbilical Cord Mesenchymal Stem Cells Affects the Therapeutic Effect of Wound Healing.

Although mesenchymal stem cells (MSCs) are used as therapeutic agents for skin injury therapy, few studies have reported the effects of dosing duration and delivery frequency on wound healing. In addition, before the clinical application of MSCs, it is important to assess whether their usage might influence tumor occurrence. We described the metabolic patterns of subcutaneous injection of hUC-MSCs using fluorescence tracing and qPCR methods and applied them to the development of drug delivery strategies for promoting wound healing. (i) We developed cGMP-compliant hUC-MSC products with critical quality control points for wound healing; (ii) The products did not possess any tumorigenic or tumor-promoting/inhibiting ability in vivo; (iii) Fluorescence tracing and qPCR analyses showed that the subcutaneous application of hUC-MSCs did not result in safety-relevant biodistribution or ectopic migration; (iv) Reinjecting hUC-MSCs after significant consumption significantly improved reepithelialization and dermal regeneration. Our findings provided a reference for controlling the quality of MSC products used for wound healing and highlighted the importance of delivery time and frequency for designing in vivo therapeutic studies.

Laboratory study on the effect of stress cycling pattern and rate on seismicity evolution

Recent laboratory and field studies suggest that temporal variations in injection patterns (e.g., cyclic injection) might trigger less seismicity than constant monotonic injection. This study presents results from uniaxial compressive experiments performed on Red Felser sandstone samples providing new information on the effect of stress pattern and rate on seismicity evolution. Red Felser sandstone samples were subjected to three stress patterns: cyclic recursive, cyclic progressive (CP), and monotonic stress. Three different stress rates (displacement controlled) were also applied: low, medium, and high rates of 10−4 mm/s, 5 × 10−4 mm/s, and 5 × 10−3 mm/s, respectively. Acoustic emission (AE) waveforms were recorded throughout the experiments using 11 AE transducers placed around the sample. Microseismicity analysis shows that (i) Cyclic stress patterns and especially cyclic progressive ones are characterized by a high number of AE events and lower maximum AE amplitude, (ii) among the three different stress patterns, the largest b-value (slope of the log frequency-magnitude distribution) resulted from the cyclic progressive (CP) stress pattern, (iii) by reducing the stress rate, the maximum AE energy and final mechanical strength both decrease significantly. In addition, stress rate remarkably affects the detailed AE signature of the events classified by the distribution of events in the average frequency (AF)—rise angle (RA) space. High stress rates increase the number of events with low AF and high RA signatures. Considering all elements of the AE analysis, it can be concluded that applying cyclic stress patterns in combination with low-stress rates may potentially lead to a more favourable induced seismicity effect in subsurface-related injection operations.

Anatomically-Guided Botulism Toxin Injections for Enhanced Abdominal Muscle Relaxation Prior to Massive Inguinal Hernia Repair: A Case Report

BACKGROUND: The use of botulism toxin A (BTA) to augment abdominal muscle relaxation for surgical hernia repair is well described. However, guidance on the anatomic considerations to facilitate safe and ideal abdominal wall BTA injection patterns is limited. CASE REPORT: A 37-year-old man presented with a 26-cm inguinal hernia and abdominal content loss of domain. Due to high risk of incomplete abdominal closure, abdominal compartment syndrome, and prolonged postoperative ventilatory support, a multidisciplinary approach to surgical closure was sought with therapeutic input from a comprehensive pain clinic. The patient was injected with BTA into the bilateral internal and external oblique muscles 2 weeks preoperatively. The injection pattern design employed anatomic considerations for points of maximum abdominal wall tension and anticipated BTA spread. Subsequent muscle paralysis facilitated successful surgery with minimal tension upon closure. CONCLUSION: This case supports the safe and effective use of BTA for enhanced abdominal wall relaxation prior to major inguinal hernia repair. When considering BTA therapy for abdominal muscle relaxation augmentation, the choice of injection pattern should include points of maximum tension and injections of close-enough proximity for BTA spread and overlap to maximize procedure benefit, regardless of the location or type of abdominal wall hernia repair. KEY WORDS: Botulism toxin, abdominal muscle relaxation, hernia repair, inguinal hernia, regional anesthesia, case report

Applying a deep-learning surrogate model to simulate and compare achievable oil recovery by different waterflood scenarios

Reservoir pressure depletion is a critical aspect leading to declined oil production. Water flooding becomes mandatory to increase the recovery efficiency from certain reservoirs. Establishing well placements, injection rates, and injection schedules enables improved fluid displacement in such reservoirs. Standard reservoir simulators are widely used to provide near-optimal scenarios for maximizing oil recovery. Such reservoir simulations involved numerous iterations and required significant computational effort. Also, the conventional machine learning methods provide a relatively high uncertainty to predict the considered problem. In this context, a deep-learning surrogate model comprising long short-term memory networks and densely connected networks is proposed to predict cumulative oil production using various waterflood injection well patterns, injection rates, and injection period information. The relevance test clarifies that the oil recovery mainly controls by water injection duration and injection pattern. A total of 1485 data records are considered to validate the model’s performance, demonstrating less than 3.5% absolute average relative error and a prediction versus actual value regression coefficient of 0.99989. In addition, the prediction accuracy of the proposed deep-learning model is also shown to outperform two well-known traditional machine-learning models (i.e. artificial neural networks and support vector regressions).

Research and Development of Capillary Imbibition Regularity in Ultra-Low Permeability Oil Reservoirs

Nowadays, Chinese economy is growing rapidly, and the petroleum industry is developing swiftly. The demand for oil and gas resources is increasing day by day. As the development process goes deeper, a significant portion of our country’s oil fields has entered the stage of high-water content and high recovery. Consequently, the direction of oil and gas exploration is gradually shifting towards unconventional reservoirs. Special low-permeability oil reservoirs in China exhibit characteristics such as low porosity, low permeability, fine pores, and natural fractures. Their recovery rates are low. Hence, the exploration and development of these special low-permeability oil reservoirs have become a critical challenge in today’s petroleum engineering domain. The urgent task is to find ways for high-yield, high-efficiency, and sustainable development of such reservoirs. In the development process of these special low-permeability oil reservoirs, capillary action plays a significant role. Capillary action allows the transportation of high-density crude oil within the reservoir, potentially enhancing the recovery rates of special low-permeability oil reservoirs. In recent years, both domestically and internationally, there has been extensive research on the mechanisms and patterns of water injection and capillary action. This paper delivers the research on capillary action in special low-permeability oil reservoirs, summarizes and organizes the progress and achievements in this field, aiming to deepen the understanding of this area and provide insights into future research directions.

Simulation studies on optimizing oil productivity in oil rim reservoirs under gas cap blow down production strategy

Gas cap blow down strategy is normally deployed for Ultra-thin oil rim reservoirs with huge gas caps due to extremely high gas oil ratios from wells in such reservoirs. The current state leads to loss of production from the oil reserves due to high initial reservoir pressure thus, reducing its net present value. Data on important factors essential to the productivity of oil rim reservoirs are used to build a heterogeneous ultra-thin reservoir with a time step of 10,000 days using the Eclipse software and its embedded correlations. The reservoir is subjected to a gas cap blowdown via a gas well, then an oil well is initiated into the model at onset and after time periods of 2000, 4000, 6000 and 8000 days to estimate the oil recovery. It is expected that due to the large nature of the gas cap, pressure decline will be drastic and leading to a low oil recovery, hence the injection of water and gas at different rates at the periods indicated. The results indicate an oil recovery of 4.3% during gas cap blow down and 10.34% at 6000 days. Peak oil recoveries of 12.64% and 10.80% are estimated under 30,000 Mscf/day at 4000 days and 1000 stb/day at 6000 days respectively. This shows an incremental oil recovery of 8.34% and 6.5% over that recorded during gas cap blow down. The results also indicate that the gas production at those periods was not greatly affected with an estimated increment of 257 Bscf recorded during 30,000 Mscf/day at 4000 days. All secondary injection schemes at the respective time steps had positive impact on the overall oil recoveries. It is recommended that extra production and injection wells be drilled, enhanced oil recovery options and injection patterns be considered to further increase oil recovery.

Simulation and Optimization of Surface Gas Injection Systems for Underground Gas Storage.

With the rapid development and popularization of sensing technology and information technology, the demand for intelligence in the oil and gas industry and gas storage has increased. The optimized operation of surface engineering is an important part of intelligence. To master the operation law of the surface engineering of gas storage, improve the production management level, and reduce the cost of gas injection, we investigated the simulation and optimization of a surface gas injection system for practical underground gas storage. We propose calculation formulas for gas injection well pressure separately according to the ideal gas equation of state, the van der Waals equation, and the R-K equation and verify them using actual data. By comparing the calculation error of the data and the complexities for both the equation and the calculation process, we finally choose the formula derived from the ideal gas equation of state as the constraint condition for our research. Moreover, we model the surface gas injection system by using the Aspen HYSYS simulation software. From the variation in the compressor power, we determine that the equalizing pressure injection pattern is the optimal injection pattern and the optimal number of injection wells is three. In addition, we examine the relationship between injection flow and well pressure with injection time under the optimal injection pattern. Finally, we obtain the functional formula of well pressure and injection flow with injection time. The results can provide not only a basis for the gas injection decision making of production systems but also a basic guarantee for the digital transformation and intelligent operation of enterprises.

The impact of polysubstance use patterns on engagement of substance use disorder treatment among emergency department patients at high risk of opioid overdose

BackgroundSubstance use patterns are diverse, and multiple substances are often involved in fatal and nonfatal overdoses. Additionally, polysubstance use is associated with greater difficulty accessing and remaining in substance use disorder (SUD) treatment. The aim of this study was to identify substance use patterns and determine their association with SUD treatment engagement among emergency department (ED) patients at risk of opioid overdose. MethodsThis was a sub-analysis of a randomized controlled trial comparing two behavioral interventions for individuals at two EDs in Rhode Island from 2018 to 2021. Past six-month substance use frequency for eight substances plus injection drug use was self-reported at trial enrollment, and SUD treatment engagement within 90 days after enrollment was obtained using administrative data linkages. Latent class analysis identified substance use patterns and multivariable log-binomial models estimated the association with SUD treatment engagement. ResultsAmong 607 participants, there were four substance use patterns: 1) low reported use (n = 295), 2) frequent injection and heroin use (n = 131), 3) high frequency broad polysubstance use (n = 62), and 4) low frequency broad polysubstance use (n = 119). Compared to participants with the low reported use pattern, those with the frequent injection and heroin pattern had a greater likelihood of SUD treatment engagement (adjusted risk ratio = 1.28; 95% confidence interval = 1.02–1.61). ConclusionsDistinct and meaningful polysubstance use patterns showed differential SUD treatment engagement after ED discharge. Nuanced relationships between substance use patterns and treatment highlight the necessity for tailored harm reduction, treatment, and recovery services.

Isothermal CO2 injection into water-saturated porous media: Lattice-Boltzmann modelling of pulsatile flow with porosity, tortuosity, and optimal frequency characterization

The Lattice Boltzmann Method (LBM) is used to simulate the isothermal injection of CO2 into a water-saturated, homogeneous porous medium. The complex multiphase flow is modeled using the 2D-pseudopotential Shan-Chen multiphase LBM. This work proposes a unique fluid-pulse technology similar to the one applied to enhance oil recovery with CO2 sequestration. This technology is different from classical CO2 sequestration in aquifers and, to our knowledge, has never been used before. The primary purpose is to investigate whether our LBM simulation allows the introduction of fluid-pulse CO2 injection patterns similar to those reported in the literature on hydrocarbon reservoirs and to evaluate the benefit of using such a technique compared to classical uniform injection. First, our simulations consider a transient homogeneous flow with uniform inlet velocity to determine the natural frequency of the instabilities triggered downstream of the interstitial pore array. Then, CO2 is injected at the inlet in a pulsating regime, varying the forcing frequency near and far from the natural frequency to determine its effect on CO2 penetration. Results demonstrate that a pulsatile injection effectively enhances CO2 sequestration in aquifers when forced with a characteristic frequency. However, this frequency resulting after CO2 is injected to displace the water differed from the natural frequency preliminarily obtained from the homogeneous water flow. Injecting at the characteristic frequency has proven an effective technique for boosting CO2 penetration into a water-saturated porous medium, with a significant enhancement estimated between 1.5% and 16% for a range of pulsatile amplitudes between 1% and 10%.

Numerical Investigation of Combustion Mechanism with Multi-Position Injection in a Dual-Mode Combustor

To improve the flame propagation, combustion stability, and uniformity of the temperature field, multi-position injection is applied in a dual-mode combustor by controlling heat release in different locations. Using the chemical reaction of the finite rate combustion model and the detailed reaction mechanism of hydrogen combustion as described by Jachimowski, the influence of different multi-position injection patterns in a dual-mode combustor is analyzed. The one-equation Large Eddy Simulation (LES) turbulence model was chosen to define the sublattice turbulent viscous terms in a three-dimensional scramjet model. Based on a combustion chamber, the effect of the injection equivalent ratio (0.35–0.70), the relative position of the nozzle holes, and the injection pressure on the combustion process and flow field characteristics are analyzed with multi-position injection. The combustion efficiency, total pressure recovery coefficients, and pressure distribution under different operation conditions are compared. We observed that the combustion intensity increases and the upstream combustion shock string distance becomes greater with increased equivalent ratios. When the global equivalent ratio of multi-position injection remains unchanged, the arrangement of nozzles with the small injection spacing, i.e., two injection holes arranged face to face on the upper and lower walls, or the setting of multiple injection holes with the same pressure, can effectively increase the stability rate of the combustion flow field. In addition, the combustion efficiency at the outlet and the internal pressure of the combustion chamber in the stable state are also improved, relative to the increased total pressure loss.

Botulinum Toxin Utilization, Treatment Patterns, and Healthcare Costs Among Patients with Spasticity or Cervical Dystonia in the US.

Spasticity and cervical dystonia (CD) are movement disorders with considerable direct and indirect healthcare cost implications. Although several studies have discussed their clinical impact, few have calculated the economic burden of these disorders. This study aimed to understand treatment/injection patterns of botulinum toxins type A (BoNT-As) and the characteristics, healthcare resource utilization (HCRU), and costs among patients with spasticity or CD. Retrospective analyses were conducted using administrative healthcare claims from the IQVIA PharMetrics® Plus database, from October 1, 2015 to December 31, 2019. Eligible patients were selected based on Healthcare Common Procedure Coding System codes for BoNT-A (index date) and ICD-10 diagnosis codes for spasticity or CD with 6months of continuous enrollment pre-index and 12months post-index. Patients were stratified into adult spasticity, pediatric spasticity, and CD cohorts, and were evaluated for injection patterns, HCRU, and costs in the post-index period. Overall, 2452 adults with spasticity, 1364 pediatric patients with spasticity, and 1529 adults with CD were included. Total mean all-cause healthcare costs were US$42,562 (adult spasticity), $54,167 (pediatric spasticity), and $25,318 (CD). Differences were observed in the cost of BoNT-A injection visits between toxins, with abobotulinumtoxinA (aboBoNT-A) having the lowest injection cost across all indications. AboBoNT-A had the lowest injection visit costs across indications. These results are suggestive of real-world resource utilization patterns and costs, and, while helpful in informing insurers' BoNT-A management strategies, further research into cost differences is warranted.

Comparative studies on numerical sensitivity of different scenarios of enhanced oil recovery by water-alternating-gas (CO2) injection

Enhanced oil recovery by CO2 injection technology (CO2-EOR) plays a crucial role in enhancing oil production and the permanent sequestration of anthropogenic CO2 in depleted oil reservoirs. However, the availability of CO2 in oil field locations and its mobility in contrast with reservoir fluids are prime challenges in CO2-EOR. The cost of CO2 and its availability at the oil fields has prompted investigations on efficient injection of CO2 at the fields to achieve the best sweep efficiency possible. Injection strategies such as water-alternating-gas (WAG), simultaneous vertical and horizontal WAG, simultaneous water injection into the aquifer and vertical WAG, water and gas injection simultaneously but separately (SS-WAG), and water and gas injection simultaneously but not separately (SNS-WAG) play a significant role, as well as the purity of CO2. In this work, the significance of the above criteria was investigated individually and in combination. The coupled sequence of injection rate, soaking time, WAG ratio, and purity of injected CO2 for enhancement of oil production were delineated. A realistic reservoir simulation model conceptualizing the CO2-EOR system with five spot injection patterns was developed by the company CMG. The history-matched model that was developed was used to investigate the sensitivity of the coupled effects to the criteria listed above on oil recovery. Numerical investigations quantitatively emphasized that purity and soaking time of CO2 have an inverse effect in the oil production rate and that SNS-WAG resulted in a better oil production rate than SS-WAG.

Coupled Hydromechanical Modeling and Assessment of Induced Seismicity at FWU: Utilizing Time-Lapse VSP and Microseismic Data

The objective of this work is to utilize integrated geomechanics, field vertical seismic profile (VSP) and microseismic data to characterize the complex subsurface stress conditions at the Farnsworth Unit (FWU). The model is based on a five-spot sector model extracted from a primary geomechanical model. The five-spot well injection pattern is characterized by extensive reservoir characterization data, such well logs, extracted cores and borehole geophone data, to facilitate the detailed examination of stress changes and microseismic event occurrences. The study utilizes field vertical seismic volumes acquired from the injection well 13-10A. The seismic volumes successfully provided snapshots of the behavior of the reservoir at distinct times. The use of VSP and microseismic data provided direct and indirect estimates of the dynamic stress changes occurring in the overburden, reservoir and underburden rock formations. In order to illuminate the stress regions and identify rocks that have undergone inelastic failure, microseismic event occurrences were utilized. Microseismic activity has been detected at the FWU; further study of its locations, timing, and magnitude was needed to deduce the nature of the changing stress state. The results of the study revealed that microseismic events were successfully modeled within the Morrow B formation. Moment magnitudes of seismic events were within the same magnitudes for events in the reservoir, suggesting the suitability of the model. The results of the study showed that the computed moment magnitudes for seismic events were insignificant to warrant safety concerns. The study findings showed the usefulness of coupled hydromechanical models in predicting the subsurface stress changes associated with CO2 injection. The knowledge gained from this study will serve as a guideline for industries planning to undertake underground CO2 storage, and characterize the subsurface stress changes.

Does Linear or Spot Injection Technique Matter in Upper Face Botulinum Toxin Type A Application? A Split-Face Randomized Trial.

Although the efficacy of botulinum toxin type A (BoNTA) has been shown to vary depending on injection layer, reconstitution volume, and BoNTA formulation, the effect of injection pattern has rarely been mentioned. The authors compared the therapeutic effects in patients treated with BoNTA with retrograde linear and traditional spot injection techniques. Twenty-eight participants were enrolled in a split-face, patient-blinded randomized clinical trial. Each patient received BoNTA injected with linear injection technique on one side and with spot injection technique on the other side. Outcomes included wrinkle improvement rates (WIRs) of the 2 injection techniques determined by wrinkle scores derived from an Antera 3-dimensional camera, muscle activity assessed by ultrasound, and patient-reported pain rating on a numeric rating scale. All participants completed the study. For forehead wrinkles, WIR on the linear side was significantly larger than that on the spot side at 1 week and 1 month ( P < 0.02). For glabellar wrinkles, WIR on the linear injection side was significantly larger than that on the spot side at 1 week ( P = 0.04). However, for periorbital wrinkles, WIR on the spot side was significantly larger than that on the linear side at 1 week ( P < 0.03). No significant difference was observed between the injection patterns in terms of muscle contraction and numeric rating scale pain scores. Compared with the traditional spot injection, retrograde linear injection was superior in reducing forehead lines and glabellar lines, but less effective in reducing periorbital lines when identical dosages were injected. Therapeutic, II.

Investigating Different Fluids and Injection Patterns on the Effect of Reservoir Rock Quality Alteration due to Swelling and Migration of Clay Minerals at Carbonate Reservoirs

Abstract Nowadays, with the progress in technology, the demand for fossil fuels has increased. Therefore, improving the oil recovery from the current oil reservoir is among the crucial issues. Formation damage is a well-recognized subject that causes a reduction in the productivity or injectivity of an oil well. Reducing or controlling formation damage can be effective in improving oil recovery. There are various mechanisms that cause formation damage such as fine migration and clay swelling. In this study, the simultaneous effect of fine migration and swelling on the permeability of a carbonate rock was investigated. Kaolinite and smectite(bentonite) minerals were selected as the representative case for migration and swelling, respectively. Primarily, bottle tests were conducted to study the effect of different fluids on the swelling potential of the kaolinite and smectite. According to the structural feature of the kaolinite, it has the smallest cation exchange capacity (CEC) and consequently a low swelling tendency. Therefore, it showed negligible swelling in the presence of all fluids. According to the high cation concentration of the formation water (FW) and seawater (SW), smectite did not show a high swelling effect. However, diluting the FW and SW increased the swelling tendency of the bentonite. Nanoparticles were not able to control the swelling of the bentonite according to their larger size than the spacing of clay layers. Zirconium oxychloride was also utilized as the swelling inhibitor which showed high efficiency. Eventually, different injection scenarios were tried using synthetic carbonate core samples with specific clay contents, and the best injection plan for formation damage control was determined.