Cancer Incidence Patterns Research Articles

Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010–2017

BackgroundIt is known that geographic location plays a role in developing lung cancer. The objectives of this study were to examine spatio-temporal patterns of lung cancer incidence in Pennsylvania, to identify geographic clusters of high incidence, and to compare demographic characteristics and general physical and mental health characteristics in those areas.MethodWe geocoded the residential addresses at the time of diagnosis for lung cancer cases in the Pennsylvania Cancer Registry diagnosed between 2010 and 2017. Relative risks over the expected case counts at the census tract level were estimated using a log-linear Poisson model that allowed for spatial and temporal effects. Spatio-temporal clusters with high incidence were identified using scan statistics. Demographics obtained from the 2011–2015 American Community Survey and health variables obtained from 2020 CDC PLACES database were compared between census tracts that were part of clusters versus those that were not.ResultsOverall, the age-adjusted incidence rates and the relative risk of lung cancer decreased from 2010 to 2017 with no statistically significant space and time interaction. The analyses detected 5 statistically significant clusters over the 8-year study period. Cluster 1, the most likely cluster, was in southeastern PA including Delaware, Montgomery, and Philadelphia Counties from 2010 to 2013 (log likelihood ratio = 136.6); Cluster 2, the cluster with the largest area was in southwestern PA in the same period including Allegheny, Fayette, Greene, Washington, and Westmoreland Counties (log likelihood ratio = 78.6). Cluster 3 was in Mifflin County from 2014 to 2016 (log likelihood ratio = 25.3), Cluster 4 was in Luzerne County from 2013 to 2016 (log likelihood ratio = 18.1), and Cluster 5 was in Dauphin, Cumberland, and York Counties limited to 2010 to 2012 (log likelihood ratio = 17.9). Census tracts that were part of the high incidence clusters tended to be densely populated, had higher percentages of African American and residents that live below poverty line, and had poorer mental health and physical health when compared to the non-clusters (all p < 0.001).ConclusionsThese high incidence areas for lung cancer warrant further monitoring for other individual and environmental risk factors and screening efforts so lung cancer cases can be identified early and more efficiently.

Pancreatic cancer incidence and mortality patterns in 2006-2015 and prediction of the epidemiological trend to 2025 in China.

BACKGROUNDDue to dietary patterns, the aging population, and other high-risk factors, the occurrence of pancreatic cancer (PC) has been rapidly increasing in China.AIMTo present the epidemiological trends of PC in China over the past decade and the estimated trend in 2025 and to compare the international differences in PC morbidity and mortality.METHODSThis study used a series of nationally representative data from the National Central Cancer Registry of China (NCCR), the International Agency for Research on Cancer and the Institute for Health Metrics and Evaluation databases. Age-standardized data of the PC incidence and mortality from 2006 to 2015 in China were extracted from the NCCR database. Linear regression models were used to estimate the incidence and mortality rates of PC in 2025.RESULTSThe age-standardized rates of PC in China increased from 3.65 per 100000 in 2006 to 4.31 per 100000 in 2015 and were estimated to reach up to 5.52 per 100000 in 2025. The mortality went from 3.35 per 100000 in 2006 to 3.78 per 100000 in 2015, estimated to reach up to 4.6 per 100000 in 2025. The number of new cases and deaths was low before 45 years and the peak age of onset was 85-89 years. The incidence and mortality rates in men were higher than those in women regardless of the region in China. In addition, the incidence and mortality rates in China were higher than the average level around the world. Likewise, disability-adjusted life years attributed to PC in China were 197.22 years per 100000, above the average level around the world.CONCLUSIONThis study presented an increasing trend of PC in China and differences in morbidity, mortality and disability-adjusted life years between Chinese and global populations. Efforts need to be made to decrease the PC incidence and improve patient outcomes.

Incidence and Patterns of Liver Cancers in Sri Lanka from 2001 to 2010: Analysis of National Cancer Registry Data.

Sanjeewa SeneviratneObjectives Varying trends in the incidence of liver cancer have been observed in many Asian countries. We conducted this study to examine trends in liver cancer incidence and histological patterns in Sri Lanka. Materials and Methods All newly diagnosed patients with liver cancer included in Sri Lanka National Cancer Registry during 2001 to 2010 were analyzed. Statistical Analysis Joinpoint regression analysis was performed. A p -value of less than 0.05 was considered statistically significant. Results Overall, 1,482 (male:female = 2.7:1; mean age = 57.5 years) liver cancers were analyzed. Majority were hepatocellular carcinomas ( n = 1,169; 78.9%), followed by intrahepatic cholangiocarcinomas ( n = 100; 6.75%). Highest incidence of liver cancer was observed in 70-74-year age group (5.1/100,000). Overall, the World Health Organization age-standardized rate (ASR) has increased during 2001 to 2004, from 0.6/100,000 (95% confidence interval [CI] = 0.48-0.72) to 1.0/100,000 (95% CI = 0.85-1.15), with an estimated annual percentage change (EAPC) of 17.8 (95% CI = 5.0-46.2); p > 0.05. From 2004 to 2010, a gradual decline in the incidence was observed. ASR in 2010 was 0.96 (95% CI = 0.81-1.1), with an EAPC of -0.9 (95% CI = -6.7 to 5.4); p > 0.05. Similar patterns of incidence change were observed in both genders. Conclusions Overall, the incidence of liver cancer appears to be steadily declining in Sri Lanka. Similar patterns of incidence change were observed in both genders. The actual decline is likely to be greater as it is likely that diagnostic scrutiny and reporting would have improved during the study period.

Global patterns in testicular cancer incidence and mortality in 2020.

With 74 500 new cases worldwide in 2020, testicular cancer ranks as the 20th leading cancer type, but is the most common cancer in young men of European ancestry. While testicular cancer incidence has been rising in many populations, mortality trends, at least those in high-income settings, have been in decline since the 1970s following the introduction of platinum-based chemotherapy. To examine current incidence and mortality patterns, we extracted the new cases of, and deaths from cancers of the testis from the GLOBOCAN 2020 database. In 2020, testicular cancer was the most common cancer in men aged 15 to 44 in 62 countries worldwide. Incidence rates were highest in West-, North- and South-Europe and Oceania (age-standardised rate, ASR ≥7/100 000), followed by North America (5.6/100 000 and lowest (<2/100 000) in Asia and Africa. The mortality rates were highest in Central and South America (0.84 and 0.54 per 100 000, respectively), followed by Eastern and Southern Europe, and Western and Southern Africa. The lowest mortality rates were in Northern Europe, Northern Africa and Eastern Asia (0.16, 0.14, 0.9 per 100 000, respectively). At the country level, incidence rates varied over 100-fold, from 10/100 000 in Norway, Slovenia, Denmark and Germany to ≤0.10/100 000 in Gambia, Guinea, Liberia, Lesotho. Mortality rates were highest in Fiji, Argentina and Mexico. Our results indicate a higher mortality burden in countries undergoing economic transitions and reinforce the need for more equitable access to testicular cancer diagnosis and treatment globally.

Long-Term patterns of cancer incidence among patients with and without type 2 diabetes in the United Kingdom

AimsStudies using contemporary cohorts are needed to assess the association between type 2 diabetes and cancer. MethodsUsing the United Kingdom Clinical Practice Research Datalink, we matched patients with type 2 diabetes between 1988 and 2019 to patients without type 2 diabetes. Poisson regression models were fit to estimate incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for cancer. In secondary analyses, we determined whether the strength of the association varied with calendar time and whether patients with type 2 diabetes had a higher incidence of being diagnosed with multiple cancers during the follow-up period. Results890,214 patients with type 2 diabetes were matched to an equal number of patients without type 2 diabetes. Patients with type 2 diabetes had a higher cancer incidence than patients without type 2 diabetes (IRR 1.19, 95% CI 1.18–1.21). The IRR was higher 2010 onwards (IRR: 1.25, 95% CI: 1.23–1.28) compared with the association in previous years. Overall, patients with type 2 diabetes had a 5% higher incidence of being diagnosed with multiple cancers (IRR: 1.05, 95% CI: 1.04–1.07). ConclusionsThe results of this large population-based study indicate that type 2 diabetes is associated with an increased risk of several cancers.

Incidence Pattern and Geographical Distribution of Breast Cancer among Females Using Geographic Information System in Kermanshah Province, West Iran: First Data from A Population-Based Cancer Registry in Kermanshah.

Background: Breast cancer (BC) is the second most frequent cancer in females worldwide. In recent years, the incidence rates of BC have been increasing among Iranian women. This study aimed to examine the incidence of BC among females in Kermanshah province, west of Iran, based on the data taken from the Kermanshah Population-based Cancer Registry (KPCR) during 2014-2017. Methods: In this registry study, data were obtained from the KPCR, a high-quality cancer registry that collects data on various cancers using standard protocols all over Kermanshah province. The crude incidence rates (CRs) and age-standardized incidence rates (ASRs) of BC were determined per 105 person-years. Further, temporal trends were assessed using joinpoint regression analysis to describe the average annual percent change (AAPC) and 95% CIs. ArcGIS software was used to map the geographic distribution of BC incidence. Results: During 2014-2017, 1,177 new cases of BC were detected in Kermanshah province. Most of the females diagnosed with BC (cases/100,000, percentage) lived in Kermanshah county (900, 76%) compared to the other counties (277, 23%). The overall ASR of BC increased by 38.7 cases per 100,000 females-year (AAPC: 2.2; 95%CI 5.1-10.1; P=0.3). The lowest and highest ASRs were observed in 2015 (36.7/100,000) and 2017 (40.7/100,000), respectively. The maximum incidence of BC among females was reported in the age group 45-49 years. Conclusion: The BC trend for females increased from 2014 to 2017 in Kermanshah province across all age groups, especially in the age group 45-49 years. Thus, it is essential to take a series of effective health measures to prevent and control this cancer.

The Impact of Socioeconomic Inequality on Urological Cancer

Purpose: Socioeconomic inequality may contribute to different risk factors for cancers. This study aims to analyze the socioeconomic patterns of urological cancer incidence and mortality in Taiwan. Materials and Methods: Using data from the National Health Insurance, we designed a retrospective longitudinal cohort study of 3686 subjects who were newly diagnosed with bladder cancer (BC), kidney cancer (KC), and upper urinary tract cancer (UTUC) between 2000 and 2010. We analyzed patients' characteristics and mortality among the three cancers. Results: The average age of KC diagnosis was the youngest among the cancers. Moreover, KC tends to occur in patients with higher-income occupations who reside in urban areas. Both BC and UTUC were much more prevalent in patients with less socioeconomic means and those living in rural areas. Varied comorbidities showed different distributions among urological cancers. Although the extent was most prominent in KC, both overall mortality and cancer-specific mortality of the three cancers increased every year during the follow-up period. Conclusion: Our results demonstrate different patient characteristics and mortality among BC, KC, and UTUC in Taiwan.

Spatio-Temporal Pattern of Thyroid Cancer Incidence in South Kerala

Spatio-Temporal Pattern of Thyroid Cancer Incidence in South Kerala

Cancer in Five Countries of the Eastern Mediterranean Region: Epidemiological Trends and Risk Implications.

Cancer is a major public health problem and is the second leading cause of death around the world. The incidence rates of some cancer types rise dramatically with certain risk factors, a fact that is exemplified by the high susceptibility to lung cancer as a result of tobacco smoking. The frame of cancer as a preventable disease and the challenges of its treatment emphasize the need for specific risk preventive measures. Therefore, attempts are continuously carried out to provide a better understanding of the cancer incidence patterns and how the most common risk factors are implicated. This study aimed to compare the cancer incidence rates in Jordan, Lebanon, Palestine, Syria, and Iraq over 18 years (2000-2017) and relate the high estimates to certain risk factors to help decision-makers better prevent this disease. Graphical and numerical descriptive illustrations of the total incidence rates, age-specific incidence rates, and incidence by cancer type were generated using data obtained from the Global Health Data exchange database. Risk factors prevalence and their pathogenic role were sought using PubMed and science direct databases as well as the world bank data. Lebanon had the highest overall age-adjusted incidence rates with a gradual increase from 231 to 353 and the highest life expectancy mean of 77.5 years. Breast, lung, and colorectal cancers were the most common cancer types in both genders and all ages in the five countries with varied ratios that were consistent with the risk factors prevalent. The association between the spread of the studied risk factors and the high trends of the corresponding cancer types highlights the importance of targeted preventive measures and serve as a guide for evidence-based prevention strategies.

Design of an Auxiliary Artificial Lymphatic Vessel in Treatment of Secondary Lymphedema Due to Breast Cancer.

Breast cancer is the most common malignant tumor that affects women in the United States, Europe, and Mexico. As an adverse effect when performing treatments for this condition, secondary lymphedema associated with breast cancer occurs in some cases. This complication occurs due to the interruption of lymphatic flow in the upper extremities in conjunction with other factors such as radiation, sedentary lifestyle, removal of lymph nodes, damage to lymphatic vessels, and others. This article reviews breast cancer incidence, mortality, and survival patterns, confirming that, specifically, lymphedema has high health, social, and economic impacts. Research demonstrates that it fundamentally affects women at an early age. In approximately a third of the cases, it becomes a chronic disease. Therefore, physical therapy is essential for a better quality of life in patients who survive this disease. Surgeries and manual and pharmacological treatments are the current procedures done to reduce to reduce the alterations suffered by patients with lymphedema; however, the success of the treatments depends on each patient’s characteristics. To face this problem, the design of a lymphatic vessel has been proposed to assist the mechanical failure of the damaged lymphatic system. In this work, the design methodology used for the blueprint of the lymphatic vessel is presented, as well as the computer analysis of fluid simulation and the selection of the proposed material, resulting in the production of a micrometric design. In the future, it is expected that a surgeon will be able to implant the design of the vessel to restore lymph flow through the lymphatic system, thus helping to combat lymphedema.

Excess Body Weight and Long-Term Incidence of Lung and Colon Cancer in Men; Follow-Up Study of 43 Years.

Most evidence for an association between excess body weight and cancer risk has been derived from studies of relatively short duration with little reference to the effect on tumor site. This study was designed to evaluate the association between categories of body mass index (BMI: <20, 20–25, 25–30, and >30 kg/m2) and the incidence of colon and lung cancer over 43 years of follow-up (1963–2006), in 10,043 men from the Israeli Ischemic Heart Disease (IIHD) prospective cohort (mean age at baseline 49.3 years, mean BMI 25.7 kg/m2). Data from the Israel National Cancer Registry was linked with the IIHD, and the Cox proportional hazards regression model was applied to analyze the relative risks for lung and colon cancer across BMI categories at baseline. Three hundred cases of lung cancer (2.9%) and 328 cases of colon cancer (3.3%) were diagnosed in the total population. Applying a multivariate model adjusted for age, smoking intensity, and total cholesterol, higher BMI category was associated with an increased risk of colon cancer [HR = 1.22 (95% CI 1.02–1.45)], and with a decreased risk for lung cancer [HR = 0.66 (95% CI 0.56–0.77)]. In this long-term follow-up study over four decades, we observed a consistent dose-response pattern between BMI and increased risk for colon cancer, but decreased risk for lung cancer. Specific associations between excess body weight and cancer risk may suggest different patterns of body fat and cancer incidence at a given site.

Risk Assessment and Factors Associated with Lung Cancer using GIS in Mae Ka Subdistrict, Muang District, Phayao Province, Thailand

Cancer is a major health problem in the developing countries. Variations of its incidence rate among geographical areas are due to various contributing factors. This study was performed to assess the spatial patterns of lung cancer incidence in the Mae Ka subdistrict, Muang district, Phayao province, based on lung cancer registry data and to determine geographical clusters. In this cross-sectional study, the cases of lung cancer were recorded from 2015 to 2020. Crude incidence rate was estimated based on age groups and sex in the province of the Mae Ka subdistrict. It uses spatial autocorrelation analysis (SAA) techniques to provide insight into the patterns, in terms of their geographical distributions and hotspot identification. Spatial autocorrelation analysis was performed in measuring the geographic patterns and clusters using GIS. In addition, local indicators of spatial association (LISA) and kernel density (KD) estimation were used to detect lung cancer hotspots using data at village level. Factors associated with the incidence of lung cancer was analyzed for behavior risk factors. Analysis of the spatial distribution of lung cancer shows significant differences from year to year and between different areas. The hotspot maps showed spatial trend patterns of lung cancer diffusion. Villages in the northern part revealed higher incidence. Furthermore, the spatial patterns during the years 2015, 2017 and 2019 were found to represent spatially clustered patterns, both at global and local scales. However, a clear spatial autocorrelation is observed, which can be of grate interest and importance to researchers for future epidemiological studies, and to policymakers for applying preventive measures.

Molecular epidemiology of liver cancer: Liver cancer incidence and mortality pattern worldwide

Primary liver cancer was the sixth most prevalent cancer and third leading cause of cancer mortality worldwide. The highest rates of incidence and mortality were reported in Eastern Asia and it was 2 to 3 times more common than females in most regions. The summary estimates of the global trends in incidence rates of liver cancer indicated decreasing trends in many Asian high-risk countries, however increasing trends for North American and European countries. Understanding the several involved cells signaling pathways in liver cancer pathogenesis provide an opportunity to identify novel targets that can be utilized for therapeutic and diagnostic modalities. At this time there are only a few effective strategies to prevent or treat liver cancer, and, therefore, a great deal of research is being conducted on liver cancer early detection and prevention. There are no widely recommended screening tests for liver cancer in people who are at average risk at this time. But, testing might be recommended for some people at higher risk. However researchers are studying ways to prevent or treat hepatitis infections before they cause liver cancers. Research into developing a vaccine to prevent hepatitis C is ongoing. Since population-based methods for screening the disease have not been introduced, the greatest focus should be placed on the predominant risk factors for the disease in older men, further studies should be conducted and high-risk provinces should be spotlighted.

SPATIAL STATISTICAL ANALYSIS OF FEMALE BREAST CANCER INCIDENCE IN IRAQ DURING 2000-2015

The spatial statistical analysis of breast cancer incidences across Iraq has not been explored in Iraq. This paper aimed to explore the spatial pattern and risk clusters of female breast cancer incidence from 2000 to 2015 in Iraq (except the Kurdish region). To enhance statistical stability and to access the changes over time, we split the data according to the geographical district into three periods (2000-2004, 2005-2009, and 2010-2015). The age-standardized incidence rates (ASRs) were calculated using the world standard population. Having obtained estimates ASRs, the global index of spatial autocorrelation (Moran’s statistic) was used to assess spatial dependence across districts for ASRs. Anselin local Moran’s statistic was used to identify spatial outliers. Additionally, we used Getis-Ord statistic to detect hotspots and coldspots over entire Iraq that represent clusters of districts with significantly high or low ASRs. A total of 44,496 cases were reported in 2000-2015 in Iraq, with an ASR of incidence of (32.81/100,000). The ASR incidence of breast cancer showed a significant average percentage change of 5.40% from 2002 to 2015. The spatial autocorrelation analysis showed insignificant positive spatial autocorrelation in 2000-2004, and significant positive spatial autocorrelation in 2005-2009, and in 2010-2015. This study identified four districts as high-risk areas for breast cancer during the two periods 2005-2009 and 2010-2015, including Al-Karkh, Al-Adhamia, Al-Rissafa, and Al-Sadir. This information can assist the allocation of health care resources and expand cancer prevention efforts.

Ethnicity and breast cancer in the UK: Where are we now?

Outcomes from breast cancer for women in the UK have improved significantly over recent decades. These gains are largely attributable to a combination of earlier diagnosis and access to treatments delivered to patients by the National Health Service irrespective of cost. Ethnic minority groups make up almost fifteen percent of the UK population and there is concern however that these groups may have poorer outcomes from the disease. In this short report we seek to summarise what the current evidence tells us about the patterns of breast cancer incidence and outcomes in ethnic minority women in the UK in order to raise awareness about this topic and provide consideration for what future research is needed to address the gaps that may exist.

The impact of socio-economic and environmental factors on the spatial patterns of cancer incidence in Israel: A registry-based cohort study

BACKGROUND AND AIM: Spatial methods usually used to identify geographical health risk differences. Only a few studies used semi-individual latent multi exposure approach, to investigate the socioeconomic and environmental factors that explain cancer risk spatial patterns. Our aim is to evaluate spatial clusters of cancer and to determine the impact of both socioeconomic and environmental factors on the spatial patterns of cancer incidence in Israel by applying generalized additive models (GAMs). METHODS: The current study is a registry-based cohort study. The data include the 1995 Israeli Central Bureau of statistics census (N=1,066,714) linked to the Israeli Cancer Registry data. In addition, ambient exposures were determined including: particulate matter with a diameter size that is equal to or smaller than 2.5µm, normalized difference vegetation index derived from satellite data, nitrogen oxides. We first used the global and local Morans’ I in order to identify cancer incidence clusters. RESULTS:During 17 years of follow-up (1998-2015) there were 62,049 new cancer cases among 1,022,637 participants in the 1995 census. Cancer incidence were clustered by geographical area (global Moran’s I Index =0.054, p-value0.000). Cancer clusters were located mainly in the northern district of Israel (surrounding Haifa region) and in the center part of Israel (surrounding Tel-Aviv region). CONCLUSIONS:The spatial clusters of cancer incidence in Israel can be attributed to socioeconomic and environmental risk factors. Further analysis will be conducted to evaluate the spatial associations with the socioeconomic and environmental factors using spatial modeling. KEYWORDS: socio-economic factors, environmental epidemiology, spatial statistics, particulate matter, cancer incidence, green space

Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020.

BackgroundBreast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide but has patterns and trends which vary in different countries. This study aimed to evaluate the global patterns of breast cancer incidence and mortality and analyze its temporal trends for breast cancer prevention and control.MethodsBreast cancer incidence and mortality data in 2020 were obtained from the GLOBOCAN online database. Continued data from the Cancer Incidence in Five Continents Time Trends, the International Agency for Research on cancer mortality and China National Central Cancer Registry were used to analyze the time trends from 2000 to 2015 through Joinpoint regression, and annual average percent changes of breast cancer incidence and mortality were calculated. Association between Human Development Index and breast cancer incidence and mortality were estimated by linear regression.ResultsThere were approximately 2.3 million new breast cancer cases and 685,000 breast cancer deaths worldwide in 2020. Its incidence and mortality varied among countries, with the age‐standardized incidence ranging from the highest of 112.3 per 100,000 population in Belgium to the lowest of 35.8 per 100,000 population in Iran, and the age‐standardized mortality from the highest of 41.0 per 100,000 population in Fiji to the lowest of 6.4 per 100,000 population in South Korea. The peak age of breast cancer in some Asian and African countries were over 10 years earlier than in European or American countries. As for the trends of breast cancer, the age‐standardized incidence rates significantly increased in China and South Korea but decreased in the United States of America (USA) during 2000‐2012. Meanwhile, the age‐standardized mortality rates significantly increased in China and South Korea but decreased in the United Kingdom, the USA, and Australia during 2000 and 2015.ConclusionsThe global burden of breast cancer is rising fast and varies greatly among countries. The incidence and mortality rates of breast cancer increased rapidly in China and South Korea but decreased in the USA. Increased health awareness, effective prevention strategies, and improved access to medical treatment are extremely important to curb the snowballing breast cancer burden, especially in the most affected countries.

Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Background: Breast cancer is the highly prevalent malignancy and is a major killer in women around world. In India, there is substantial statistically significant increase in breast cancer incidence patterns. Women from under developed areas(883000 cases) have a significantly higher no. of cases than those from developed areas (794,000) [1]. There are various risk factors associated with breast malignancy. A variety of bio-chemical markers have been tested to determine the malignancy, for the early detection of carcinoma of different origin. LDH is the easiest and cheapest to calculate of all of these indicators.&#x0D; Objectives:&#x0D; &#x0D; To study the clinical profile of patient with breast&#x0D; To study the prognostic significance of LDH as tumor marker in breast&#x0D; To compare post-operative LDH level in patient undergoing surgery for carcinoma breast v/s patient undergoing neoadjuvant chemotherapy.&#x0D; Compare variation in preoperative baselines LDH levels and post-operative LDH levels.&#x0D; &#x0D; Methodology: It is a prospective observational study done on patients with breast cancer. It will be conducted at Dept. of General Surgery , J.N.M.C and AVBRH, Sawangi (Meghe), Wardha. The study will be conducted on patients with Carcinoma Breast.&#x0D; Results: To be assessed after the study.&#x0D; Conclusion: Serum LDH is a good prognostic marker of breast cancer.

Rates and trends in stage-specific prostate cancer incidence by age and race/ethnicity, 2000-2017.

The 2008 and 2012 United States Preventive Services Task Force (USPSTF) recommendations against prostate-specific antigen (PSA) screening have led to changes in the incidence pattern of prostate cancer. We sought to examine rates and trends in stage-specific prostate cancer incidence by age and race/ethnicity using the most recent data obtained from Surveillance, Epidemiology, and End Results (SEER) program. SEER*Stat version 8.3.6 was used to analyze annual prostate cancer incidence rates between 2000 and 2017 according to the SEER summary stage, age group, and race/ethnicity group. Incidence rates per 100,000 men were calculated and age-adjusted to 2000 US standard population. Annual percentage change (APC) was performed to identify the trend in prostate cancer incidence. Between 2008 and 2012, trends in incidence of overall and localized prostate cancer significantly declined in comparison with between 2000 and 2007 (APC, -5.4 and -6.0, respectively). However, there was an increase in the incidence rate of both overall and localized prostate cancer from 2014 to 2017 (43.3-46 and 34-34.9 per 100,000 men, respectively). The incidence of regional prostate cancer significantly increased between 2013 and 2017 (5.9-6.8 per 100,000 men; APC, 4.3). Distant disease incidence increased continually between 2008 and 2012 (2.9-3.3 per 100,000 men; APC, 2.3) and between 2013 and 2017 (3.4-4.3 per 100,000 men; APC, 6.0). In addition, these increases in incidence occurred in men of all stratified age and race/ethnicity groups, except for men aged <50 years and American Indian/Alaska Native men. This study demonstrates that the longer-term effects of USPSTF recommendations against PSA screening may have resulted in a reversal of downtrend in prostate cancer incidence, as incidence rates of overall and localized prostate cancer gradually increased from 2014 to 2017. Meanwhile, the trend in stage migration toward advanced disease increased incrementally.

Changing Pattern of Cancer Incidence in India

Introduction: Cancer registries are vital for understanding incidence and prevalence of cancer, as well as appropriate funding and control measures. Materials and Methods: The data of patients registered between 1996 and 2020 at a large urban cancer centre in Eastern India was used for analysis of cancer trends over time. Results: There were a total of 1,89,315 patients. The top 5 cancer sites over the most recent 5-year block (2016–2020) were lung, oral cavity, throat, stomach, and colorectum in males and breast, cervix, liver-gallbladder, oral cavity and ovary in females. There was a consistent rise in oral cavity cancers and lung cancer in males and a consistent rise in breast cancer and ovarian cancers in females. There was a consistent fall cervical cancers, which was overtaken by breast cancer in the mid-2000s as the leading cancer in women. Digestive cancers have doubled over the last 25 years, the commonest being stomach cancer and colorectal cancers. Conclusion: The data reflects India’s changing profile of cancer, with the increase of breast and ovarian cancers, as seen worldwide. Despite lack of a robust screening/vaccination programme, cervical cancer has declined. The rise in tobacco-associated cancers (lung and mouth) is a matter of concern.