Patterns Of Maternal Weight Gain Research Articles

Diethylstilbestrol-Induced Perinatal Lethality in the Rat. I. Relationship to Reduced Maternal Weight Gain1

An analysis was performed to determine the mechanism of depressed maternal weight gain and its effect on perinatal lethality following prenatal exposure to diethylstilbestrol (DES). Pregnant Sprague-Dawley rats were dosed orally by gavage with DES or corn oil (control) during various intervals of gestation. The maternal weight-gain patterns of control and treated dams and the number of live offspring were recorded. The amounts of feed and water intake and feces and urine output in pregnant dams were measured, and metabolic rate and thyroid hormone levels were also determined. DES (at 45 micrograms/kg/day) was embryo- and fetolethal during implantation and parturition, and there was an accompanying decline in maternal weight. Growth of adult males, nonpregnant females, and weanlings of both sexes was also depressed. During pregnancy, the net intake of feed and water was not altered by the drug, but maternal serum thyroxine and metabolic rate were significantly elevated. Reduced metabolic efficiency, then, is the likely mechanism for weight depression. Reduction of maternal weight gain during pregnancy by DES is a diagnostic indicator of fetolethality, but is probably not causally related to it.

Patterns of maternal weight gain in pregnancy

A retrospective study of 1145 pregnant women showed that trends in mean maternal weight gain from the time of booking until delivery were not linear. Statistically significant lower rates of maternal weight gain were seen before 16 weeks, after 36 weeks and between 28 and 32 weeks gestation (P less than 0.05). The mean maternal weight gain was 10.71 kg (SD 4.3) and the mean weekly weight gain was 0.38 kg (SD 0.16). A wide variation of maternal weight gain was seen in women with a normal outcome. The mean weight gain in heavy (greater than 68 kg) and light (less than 55.4 kg) women was less than that in women whose weight was in the third quartile (60-68 kg, P less than 0.05). The mean maternal weight gain was less in young (less than 20 years) women than in older women (greater than 25 years; P less than 0.05), less in parous than in primigravid women from week 37 onwards (P less than 0.05), less in smokers than in non-smokers from 20 weeks onwards (P less than 0.05), and greater in hypertensive women (BP less than 140/90) than in normotensive women (P less than 0.05) from week 24 onwards. The mean weight gain in women who had small for gestational age (SGA) infants was not significantly different from that in women who had infants that were of appropriate size for gestational age. After taking into account infant and placental weight using multiple regression analysis, the factors that were associated with statistically significant differences in average weekly weight gain were parity, body mass index, smoking habit and raised blood pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

Diet restriction by pregnant women in Nigeria

The reasons for food aversions given by selected low income, illiterate women during pregnancy fell into four categories: health, tradition, economy and religion. More than two thirds of these mothers strongly avoided milk, cowpea seeds and bournvita for fear of having big babies which they thought would lead to difficult labor and cesarean section. Only one of the respondents associated infantile rickets with nutrition. Nutritional counseling, coupled with a fear-mechanism technique for a minimum of four months, served to correct these erroneous assumptions. The effects of the counseling sessions were evaluated by monitoring patterns of maternal weight gain and the baby's weight. The experimental group had a significant pattern of monthly weight gain (P < 0.02) and heavier babies (P < 0.01) than the control group. The authors conclude that diet restrictions of this nature can be modified positively through regular nutritional counseling and, in extreme cases, by the use of a fear-mechanism technique.