Established Patterns Research Articles

Evolution of Cementite Substructure of Rails from Hypereutectoid Steel during Operation

Transmission electron microscopy methods were used to analyze the cementite substructure in the head of special-purpose long rails of the DT400IK category, made of hypereutectoid steel, after long-term operation on an experimental track on the Russian Railways ring (the tonnage was 187 million tons). It is noted that the study of various aspects of cementite—its structure, morphology, chemical composition, crystal lattice defects—is relevant. The steel structure is represented by three morphological components at a distance of 10 mm from the sample surface: lamellar perlite, fractured and fragmented perlite. The volume fraction of lamellar perlite in the material is 65%. It is shown that after operation, the cementite plates are bent and separated by ferrite bridges. In the plates of ferrite and cementite, a dislocation substructure is formed, which is of a chaotically distributed and network type in ferrite and of an ordered type in cementite. An increased density of dislocations at the ferrite–cementite interfaces compared to the volume of ferrite plates was noted. Two possible mechanisms of deformation transformation of lamellar perlite grains are indicated: fracture of cementite plates and carbon pulling out from the lattice of the carbide phase. It is indicated that in the dissolution of cementite plates, the interfacial boundaries of “α-phase-cementite” play an important role. The removal of carbon from cementite plates occurs most intensively near defects in ferrite and cementite. The formed nanosized particles of tertiary cementite are unevenly distributed in the ferrite plates; most of them are observed at the locations of ferrite subgrains and interfacial boundaries. This results in non-uniform diffraction contrast in dark-field images of cementite plates. Nanosized particles of cementite can be taken out into the interlamellar space of pearlite colonies in the process of dislocation slip, or they are formed as a result of deformation decomposition, which is less likely. The fragmentation of ferrite and cementite plates is revealed and azimuthal components of total misorientation angles are estimated. The mechanisms of mass transfer of carbon atoms over interstitial sites, deformation vacancies, dislocation tubes, grain boundaries and fragments are considered. According to all the established patterns of the cementite substructure transformation, a comparison with the results for rails made of hypoeutectoid steel was performed.

Elevation, canopy cover and grass cover structure patterns of seedling establishment in a subtropical post‐fire restoration

Abstract Ecological restoration is beneficial to ecological communities in this era of large‐scale landscape change and ecological disruption. However, restoration outcomes are notoriously variable, which makes fine‐scale decision‐making challenging. This is true for restoration efforts that follow large fires, which are increasingly common as the climate changes. Post‐fire restoration efforts, like tree planting and seeding have shown mixed success, though the causes of the variation in restoration outcomes remain unclear. Abiotic factors such as elevation and fire severity, as well as biotic factors, such as residual canopy cover and abundance of competitive understorey grasses, can vary across a burned area and may all influence the success of restoration efforts to re‐establish trees following forest fires. We examined the effect of these factors on the early seedling establishment of a tree species—māmane (Sophora chrysophylla)—in a subtropical montane woodland in Hawaiʻi. Following a human‐caused wildfire, we sowed seeds of māmane as part of a restoration effort. We co‐designed a project to examine māmane seedling establishment. We found that elevation was of overriding importance, structuring total levels of plant establishment, with fewer seedlings establishing at higher elevations. Residual canopy cover was positively correlated with seedling establishment, while cover by invasive, competitive understorey grasses very weakly positively correlated with increased seedling establishment. Our results point to specific factors structuring plant establishment following a large fire and suggest additional targeted restoration actions within this subtropical system. For example, if greater native woody recruitment is a management goal, then actions could include targeted seed placement at lower elevations where establishment is more likely, increased seeding densities at high elevation where recruitment rates are lower, and/or invasive grass removal prior to seeding. Such actions may result in faster native ecosystem recovery, which is a goal of local land managers.

Informant-rated change in personality traits, psychological distress, well-being, and social connection with dementia

ObjectivesStudies of retrospective personality change with dementia consistently find caregivers report large changes in personality (e.g., increases in neuroticism) of their care recipients compared to before dementia. This work seeks to replicate the established pattern of personality change, extend it to change in psychological distress, well-being, and social connection, and evaluate whether changes vary by stage of dementia. MethodsCaregivers of people with dementia (N = 188) reported on the psychological and social health of their care recipient currently and how they were before they developed dementia. Personality was measured as five factor model traits. Psychological distress was measured as symptoms of depression and anxiety, perceived stress, and pessimism. Psychological well-being was measured as purpose in life, life satisfaction, happiness, self-efficacy, and optimism. Social connection was measured as loneliness, belonging, social support, and social strain. ResultsThere were substantial increases in neuroticism (d = 1.14) and decreases in the other four personality traits (d range=–0.85 to –1.37). There were significant increases in psychological distress (e.g., d = 1.07 for depression) and substantial decreases in well-being (e.g., d=–1.18 for purpose in life) and social connection (e.g., d=–1.12 for belonging). Change was apparent across dementia stage and generally larger in more severe dementia. DiscussionIn addition to personality, there are large retrospective changes in psychological distress, well-being, and social connection with dementia. These quantitative findings complement clinical observations of the natural history of psychosocial changes in people with dementia, and can inform families, clinicians, and researchers on commonly observed changes and improve interventions to mitigate dementia burden.

Interactional role negotiation among co-facilitators in an online design workshop

ABSTRACT Research has demonstrated the important role of co-teacher communication and planning, but relatively little is understood about co-teacher interactions during the act of teaching itself and how these interactions relate to educators’ positionings and ongoing identity development. This paper presents a case study of interaction between two co-facilitators of a team of Japanese youth during a week-long, synchronous, online workshop on human-centred design. One co-facilitator had several years of experience, and the other was a first-timer. Using positioning theory and discourse analysis, we show that the co-facilitators developed a relatively stable pattern of instructional authority delegation, or the social order that guides who has rights and responsibilities over which forms of instructional decision-making. We describe the delegation between the co-teachers in this study as involving ‘instructional content authority’ and ‘instructional language authority’, established through interactions of positioning early in the workshop. Then, we examine an interview activity later in the workshop that seemed to disrupt the established pattern. This work extends research on co-teacher communication and teacher learning to understand co-teacher interactions during live teaching, with potential implications for co-teacher preparation and the learning of less experienced co-teachers.

Establishment, Characterization and Expression Pattern of a Spleen Cell Line, SMSP, Derived from Turbot (Scophthalmus maximus)

Establishment, Characterization and Expression Pattern of a Spleen Cell Line, SMSP, Derived from Turbot (Scophthalmus maximus)

Research on the dynamic characteristics of rotor-bearing-seal system with breathing cracks under steam flow excited force

In order to reveal the influence of breathing-type straight cracks on the motion characteristics and stability of a turbine rotor-bearing-seal system. The study examines the motion characteristic of a cracked rotor system under different loads with different crack depths, the coupled thermal and dynamic loads. The research derives motion differential equations for the cracked system, considering nonlinear dynamic properties such as nonlinear stiffness and damping. The equations incorporate the nonlinear steam flow excited force obtained from numerical simulations. The resulting motion equations are solved using the Runge-Kutta method, and the accuracy of the investigation of nonlinear dynamic characteristics is validated through experimental comparisons. Based on these findings, the motion characteristics and stability of the cracked rotor system under different conditions are analyzed. The results indicate that the motion characteristics of the rotor are progressively altered by the crack depth, and at a certain depth, the motion deviates from the established pattern. The influence of cracks on rotor stability is predominantly notable in the 34–58% THA region and under high load conditions. Moreover, the chaotic characteristics of rotor motion is more significant after applied the coupled thermal and dynamic loads, and the stability of the 34–58% THA region is significantly worse.

Poster Session: Neural Correlates of the Visual Expectation of Active and Passive Touch.

The sense of touch is frequently paired with a visual stimulus that provides information on how the sensation will be experienced. This is true for both active touch-when a person moves to touch an object-and passive touch-when an object moves to touch a person. However, limited research has been conducted on how active and passive touch are processed by the cortex, as well as how prediction of the sensory experience influences that processing. Here, we use electroencephalography (EEG) to measure cortical activity while virtual reality creates the visual expectation of touching an object that is paired with vibrotactile feedback. In the active condition, the participant will reach toward and receive tactile input from the virtual object. In the passive condition, the virtual object will move toward and provide tactile input to the participant. This experiment will measure an electrophysiological phenomenon called the mismatch negativity (MMN), a distinct deflection in the EEG waveform shown to index a deviation from an established pattern in sensory stimuli. To elicit an MMN, we will manipulate the duration of the vibrotactile stimuli, with 80% being 100 ms long and 20% being 160 ms long. Our experiment is the first to assess the MMN in an active tactile context. Preliminary data (n=4) show a robust N1 component and MMN in response to active and passive touch. Further data collection is ongoing.

First Record of the Small-billed Elaenia (Elaenia parvirostris) for Western North America

The Small-billed Elaenia (Elaenia parvirostris) is a small flycatcher common on the Atlantic slope of South America. The species breeds below 1000 m elevation in open woodlands, gardens, and forest edges from southern Brazil to northeastern Argentina and migrates north to spend the nonbreeding season in the northern Amazon Basin. Since 2012, it has been documented as a vagrant to North America, with four records from the United States and Canada to date. On the basis of one photographed on Southeast Farallon Island on 4 September 2022, we record a fifth Small-billed Elaenia in North America, a first for California and the Pacific coast. Its novelty notwithstanding, it represents an outlier of an established pattern of vagrancy of tyrant flycatchers from South America reaching North America via overshooting or reverse migration.

Python API Misuse Mining and Classification Based on Hybrid Analysis and Attention Mechanism

APIs play a crucial role in contemporary software development, streamlining implementation and maintenance processes. However, improper API usage can result in significant issues such as unexpected outcomes, security vulnerabilities and system crashes. To detect API misuses, current methods primarily rely on comparing established API usage patterns with target points for automated detection, mainly based on pre-validated datasets. Nonetheless, there is a scarcity of publicly available datasets on API misuses and their corresponding fixes, which hinders data-driven research. Moreover, most existing techniques concentrate on statically typed languages, such as Java and C, with only a few addressing dynamic languages like Python effectively, due to difficulties in handling dynamic features. Therefore, it is essential to identify Python API misuses and their fixes automatically and promptly. In this paper, we introduce HatPAM, a Hybrid Analysis and Attention-based Python API-Misuse Miner, which (a) provides a method for automatically mining true-positive commits related to Python API-misuse fixes from GitHub and (b) presents the subsequent processing for classifying Python API misuses in true-positive cases. Particularly, HatPAM applies hybrid static analysis and introduces a structure-based attention mechanism to examine syntax, semantics and structural features in Python code context, and considers the consistency between code and developers’ natural intent to significantly reduce false-positive cases. Evaluation on six popular Python projects reveals that HatPAM outperforms various state-of-the-art baselines, achieving up to 92.2% Precision, 86.7% Recall and 89.3% F1-score, indicating its capability to identify and classify Python API-misuse commits.

Time regularities of strontium concentration in drinking groundwater distant from the sea coast.

This paper confirms the regularities of the formation of increased concentrations of strontium (Sr) in fresh groundwater used for drinking water supply, depending on the time they are residen in the carbonate deposits of the aquifer. On average, every thousand years, the Sr concentration increases by 2.1-3.5mgL-1. In addition, high strontium content is positively correlated with altitude and well depth and negatively correlated with redox conditions in the aquifer. Large relief elevations are associated with the development of marginal moraine deposits from the Last Glacial Period composed predominantly of clay, which contributes to a decrease in water exchange. The high Sr content is associated with the dissolution of significant formations of celestite and strontianite, up to their ore occurrences. For this reason, the saturation indices (SIs) for celestite and strontianite correlate with TDS and rise to - 1.42 and 2.05, respectively. Low Sr values do not correlate with the residence time of groundwater in the aquifer or the depth of wells and tend to depressions in the relief, with a virtual absence of overlying sediments and positive Eh values, which indicates an active water exchange. The low level of Sr is associated with the dissolution of gypsum, calcite, and dolomite containing strontium as an impurity. This causes the SIs for gypsum, calcite, and dolomite to correlate with TDS, while for celestite and strontianite, the SI drops to - 5.02 and - 0.92, respectively. The established patterns make it possible to more reasonably choose places for the construction of water wells to obtain drinking water of standard quality.

Water Lifting and Outflow Gain of Kinetic Energy in Tropical Cyclones

Abstract While water lifting plays a recognized role in the global atmospheric power budget, estimates for this role in tropical cyclones vary from no effect to a major reduction in storm intensity. To better assess this impact, here we consider the work output of an infinitely narrow thermodynamic cycle with two streamlines connecting the top of the boundary layer in the vicinity of maximum wind (without assuming gradient-wind balance) to an arbitrary level in the inviscid free troposphere. The reduction of a storm’s maximum wind speed due to water lifting is found to decline with increasing efficiency of the cycle and is about 5% for maximum observed Carnot efficiencies. In the steady-state cycle, there is an extra heat input associated with the warming of precipitating water. The corresponding positive extra work is of an opposite sign and several times smaller than that due to water lifting. We also estimate the gain of kinetic energy in the outflow region. Contrary to previous assessments, this term is found to be large when the outflow radius is small (comparable to the radius of maximum wind). Using our framework, we show that Emanuel’s maximum potential intensity (E-PI) corresponds to a cycle where total work equals work performed at the top of the boundary layer (net work in the free troposphere is zero). This constrains a dependence between the outflow temperature and heat input at the point of maximum wind, but does not constrain the radial pressure gradient. We outline the implications of the established patterns for assessing real storms.

DENSITY OF HYDROCARBONS AND DEEP HEAT FLOW OF THE TERRITORY (SOUTHEAST OF WESTERN SIBERIA)

Link for citation: Krutenko D.S., Isaev V.I., Isaev S.G. Density of hydrocarbons and deep heat flow of the territory (southeast of Western Siberia). Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 7, рр. 148-163. In Rus. The relevance. According to the ruling theory for organic origin of petroleum, geothermal regime is considered to be the main factor, which is responsible for realization of potential for oil generation. Therefore, it is not irrelevant to develop geothermics as a method of exploration geophysics for forecasting and evaluating oil and gas potential. Forecast tasks are reduced to detection local geothermal anomalies and establishing its relation to hydrocarbon deposits. This method may make a good showing while supplementary exploration in the territories with well-developed infrastructure and a large amount of wells as it is based on modelling and analysing of available data and does not propose additional field works. The main aim: establishing qualitative and quantitative relations between deep heat flow and oil and gas potential, also between gradient zones of heat flow and localization of hydrocarbon fields in the west of Tomsk Region. Objects: thermal field and oil and gas potential in the west of Tomsk Region. Subjects. The thermal field is described with such parameters as deep heat flow density and horizontal gradient of heat flow. Hydrocarbon fields are divided depending on fluid type into oil, oil-gas-condensate and gas-condensate. Methods. The deep heat flow was determined through paleotemperature modelling. The grid with cells of 20×20 km was set on study territory in increments of 10 km. Heat flow values were determined in the centers of each cell using Kriging interpolation method. The absolute horizontal gradient of heat flow was calculated on the same grid using five spot formula. Quantitative parameter of oil and gas potential – hydrocarbon density – was determined on the same grid. Quantitative relations were investigated by correlation and regression analysis. Relationships of heat flow density and horizontal gradient of heat flow with localization of hydrocarbon fields of different fluid type were detected by one-way ANOVA test. Results. The main results of this study are established distribution patterns for deposits of different fluid type in thermal field. Correlation analysis showed highly significant correlation coefficients. The conclusion. Oil and oil-gas-condensate fields tend to the average heat flow values (52 mW/m2), while gas-condensate are associated with high heat flow values (57 mW/m2). The value of the absolute horizontal gradient of heat flow increases in row oil fields – oil-gas-condensate fields – gas-condensate fields. The difference between average values of gradient for all of field types is statistically significant. Therefore, we indicate appearance of geothermal quantitative criterion for forecasting fluid type of deposits in areas of high potential for hydrocarbons. Quantitative relation of high significance (r=0,53) between heat flow density and hydrocarbon density is established for high heat flow values (>56 mW/m2). Weak correlation (r=0,3) was indicated between horizontal gradient of heat flow and hydrocarbon density.

Using Continuous Glucose Monitoring and Data Sharing to Encourage Collaboration Among Older Adults With Type 1 Diabetes and Their Care Partners: Qualitative Descriptive Study.

Persons with diabetes use continuous glucose monitoring (CGM) to self-manage their diabetes. Care partners (CPs) frequently become involved in supporting persons with diabetes in the management of their diabetes. However, persons with diabetes and CP dyads may require more communication and problem-solving skills regarding how to share and respond to CGM data. The purpose of this study was to describe the experiences of persons with diabetes and CPs who participated in the Share "plus" intervention, which addresses dyadic communication strategies, problem-solving, and action planning to promote sharing of CGM data among the dyad. Ten dyads participated in the Share "plus" telehealth intervention. Participants were interviewed during and after the Share "plus" intervention. Thematic analysis was used to analyze interview data. During postsession interviews, dyads described feeling a sense of shared responsibility yet viewed the persons with diabetes as ultimately responsible for the disease. Additionally, dyads shared that communication patterns improved and were able to recognize the negative aspects of previously established communication patterns. Dyads reported communication focused on hypoglycemia episodes while also differing in the frequency they reviewed CGM data and set alerts. Overall, dyads expressed positive reactions to the Share "plus" intervention. Share "plus" was helpful in promoting positive CGM-related communication among dyads and encouraged more CP support. CPs play an important role in supporting older adults with type 1 diabetes. Communication strategies help support dyad involvement in CGM data sharing and self-management among persons with diabetes.

Analysis of body-to-pattern relationship using traditional pattern drafting techniques: implications for automated digital prototyping

ABSTRACT Digital prototyping was extensively employed in the clothing industry during the Covid-19 pandemic. Digital Prototyping can optimise the level of accuracy, where the engineered fit will be close to the accurate fit. However, digital prototyping will not succeed without applications of the underlying theories of manual pattern development. This paper aims to critically review the traditional pattern drafting techniques, including ease allowances, and transfer that tacit knowledge to 2D CAD pattern developments. Five established pattern drafting methods for women’s upper torso garments were selected and examined to check the reliability of body–to–pattern relationship. However, none of the techniques has accurate clothing fit, which implies that the current pattern drafting techniques do not explicitly consider the body-to-pattern relationship. Further, it was determined that traditional pattern drafting techniques could not directly translate to automated digital drafting. The key findings of this experimental research support future developments in automated digital prototyping.

Seed sources and safe sites as drivers of Larix cajanderi regeneration following wildfire in the Siberian Arctic

AbstractLarix cajanderi forests, which occupy vast regions of Siberia, grow atop and protect carbon‐rich permafrost. Regeneration of these forests has important implications for long‐term feedbacks into the climate system and their regeneration is strongest following stand‐replacing fires. The goal of this project was to assess sources of regeneration limitation in L. cajanderi forests in northeastern Siberia. We focused on (1) regeneration potential of stands varying in tree density and (2) analyzing seedling establishment patterns in relationship to microsite conditions (safe sites) in the landscape. Seed sources were assessed through cone counts and stand surveys in the summers of 2017 and 2018 in 17 mature L. cajanderi stands. L. cajanderi recruitment patterns in relationship to safe site availability were assessed in 15 areas, spanning approximately 800 km2 along the northern portion of the Kolyma River (69.5477° N, 161.3641° E). Density of trees in a stand was negatively related to the number of cones that the average tree produced and stands of moderate density produced more cones per area than either high‐ or low‐density stands. L. cajanderi seedling establishment was facilitated by safe sites in the landscape. We discovered strong evidence that safe sites are considerably more important for seedling establishment in lowland sites than upland areas. The biological explanation for this pattern is presently unknown; however, we hypothesize this pattern is driven by persistently wet (marshy) soils in some lowland sites as a limiter of seedling establishment. Overall, these data suggest the potential for complex linkages between forest density, propagule availability, fire, safe sight colonization, and seedling establishment that may regulate long‐term dynamics in the understudied L. cajanderi forests of the Siberian Arctic.

The beta thalassaemia trait in Jamaica.

The objective of this study was to review the prevalence and features of the beta thalassaemia trait in Jamaican populations. Screening of 221,306 newborns over the last 46 years has given an indication of the distribution and prevalence of beta thalassaemia genes, and screening of 16,612 senior school students in Manchester parish, central Jamaica, has provided their haematological features. The prevalence of the beta thalassaemia trait predicted from double heterozygotes was 0.8% of 100,000 babies in Kingston, 0.9% of 121,306 newborns in southwest Jamaica, and 0.9% of school students in Manchester. Mild beta+ thalassaemia variants (-88 C>T, -29 A>G, -90 C>T, polyA T>C) accounted for 75% of Kingston newborns, 76% of newborns in southwest Jamaica, and 89% of Manchester students. Severe beta+ thalassaemia variants were uncommon. Betao thalassaemia variants occurred in 43 patients and resulted from 11 different variants of which the IVSII-849 A>G accounted for 25 (58%) subjects. Red cell indices in IVSII-781 C>G did not differ significantly from HbAA, and this is probably a harmless polymorphism rather than a form of beta+ thalassaemia; the removal of 6 cases in school screening had a minimal effect on the frequency of the beta thalassaemia trait. Red cell indices in the beta+ and betao thalassaemia traits followed established patterns, although both were associated with increased HbF levels. The benign nature of beta+ thalassaemia genes in Jamaica means that cases of sickle cell-beta+ thalassaemia are likely to be overlooked, and important clinical questions such as the role of pneumococcal prophylaxis remain to be answered.

Wisdom of the Established Pattern

Wisdom of the Established Pattern

Bioconversion protein and energy in feed into meat productivity of the young sheep

Satisfying the physiological need of body for nutrients in strict accordance with medical standards is an important task to improve the structure of nutrition and its energy value. The level of providing a person with protein animal origin is only 65% established norm. Therefore, the problem of increasing volume its production is considered relevant for nutriciology. In this regard, breeders pay special attention to identifying animal genotypes that meet these requirements, and for this it is necessary to conduct a comprehensive assessment quality of the meat productivity, taking into account transformation main nutrients feed into edible parts of the body.
 Evaluation of the efficiency animal transformation feed nutrients into body tissues is based on the use of exchange energy feed, and stored energy in form protein and fat. The study of their bioconversion into meat products makes it possible to develop rational technologies for directed rearing, pasture feeding and intensive fattening young sheep.
 This article presents results of the analysis accumulation nutrients in body and energy bioconversion with protein into the meat products of young sheep Akzhaik breed in conditions sharply continental climate of the Western region Kazakhstan. The established pattern of changes protein content in body experimental individuals is due to a decrease in the intensity of its synthesis and activation process fat deposition. According to our information, with the age of young animals, the coefficient bioconversion of feed energy into energy edible parts carcass increased to 28%, while protein, on contrary, decreased to 89%.

CMR reclassifies patients with suspected myocardial infarction with non-obstructive coronary arteries (MINOCA)

Abstract Funding Acknowledgements Type of funding sources: None. Objectives This study sought to assess the role of cardiac magnetic resonance (CMR) in investigating patients presenting with suspected acute coronary syndrome (ACS) and non-obstructed coronary arteries. Methods Consecutive patients presenting to a tertiary cardiology centre with suspected ACS and non-obstructed coronary arteries and referred for CMR were retrospectively identified. A comprehensive imaging protocol was performed to include cines, T2-weighted, and late gadolinium enhancement (LGE) sequences. Final CMR diagnosis was based on established patterns of tissue characterisation from myocardial oedema and LGE imaging, with patients grouped into five: myocardial infarction, myocarditis, Takotsubo syndrome, cardiomyopathy, and a normal CMR. Results A total of 888 patients were identified. The mean age across the cohort was 57 years (SD ±15.9 years) with 51% female patients. Median time to CMR from acute presentation was 21 days (Figure 1). Aetiology of presentation was uncertain in more than half of patients referred for CMR (483, 54.1%). Of patients with an initial uncertain aetiology, CMR was able to identify an underlying diagnosis in 74.9%. Diagnosis across the whole cohort was reclassified in 691 patients (77.8%), with overall diagnostic yield (CMR identified underlying aetiology for presentation) of 75.6%. (Figure 2). Conclusions In a large single-centre cohort of patients presenting with suspected ACS and non-obstructed coronary arteries, diagnostic yield with CMR was high at 76%. CMR reclassified nearly 80% of patients. Our results highlight the importance of CMR in the diagnostic pathway of suspected ACS and potential implications on clinical management.

In silico analysis of the solute carrier (SLC) family in cancer indicates a link among DNA methylation, metabolic adaptation, drug response, and immune reactivity.

Introduction: The oncogenic transformation is driven by genetic and epigenetic alterations influencing cancer cell fate. These alterations also result in metabolic reprogramming by modulating the expression of membrane Solute Carrier (SLC) transporters involved in biomolecules trafficking. SLCs act as tumor suppressors or promoters influencing cancer methylome, tumor growth, immune-escape, and chemoresistance. Methods: This in silico study aimed to identify the deregulated SLCs in various tumor types compared to normal tissues by analyzing the TCGA Target GTEx dataset. Furthermore, the relationship between SLCs expression and the most relevant tumor features was tackled along with their genetic regulation mediated by DNA methylation. Results: We identified 62 differentially expressed SLCs, including the downregulated SLC25A27 and SLC17A7, as well as the upregulated SLC27A2 and SLC12A8. Notably, SLC4A4 and SLC7A11 expression was associated with favorable and unfavorable outcome, respectively. Moreover, SLC6A14, SLC34A2, and SLC1A2 were linked to tumor immune responsiveness. Interestingly, SLC24A5 and SLC45A2 positively correlated with anti-MEK and anti-RAF sensitivity. The expression of relevant SLCs was correlated with hypo- and hyper-methylation of promoter and body region, showing an established DNA methylation pattern. Noteworthy, the positive association of cg06690548 (SLC7A11) methylation with cancer outcome suggests the independent predictive role of DNA methylation at a single nucleotide resolution. Discussion: Although our in silico overview revealed a wide heterogeneity depending on different SLCs functions and tumor types, we identified key SLCs and pointed out the role of DNA methylation as regulatory mechanism of their expression. Overall, these findings deserve further studies to identify novel cancer biomarkers and promising therapeutic targets.